OPTIDOZ Tablet is used in the treatment of hypertension (high blood pressure) in patients who are not controlled on monotherapy (single drug therapy) or dual therapy (double drug therapy).

OPTIDOZ Tablet may also be prescribed for other conditions as determined by your doctor.

• Amlodipine Besylate belongs to a group of medicines known as calcium channel blockers. Amlodipine Besylate prevents the calcium from moving into the blood vessel wall thereby preventing tightening of blood vessel walls. This reduces the blood pressure and improves symptoms of chest pain.

• Telmisartan belongs to a group of medicines known as angiotensin II receptor antagonist. Telmisartan relaxes the blood vessel walls, thus reducing the blood pressure. Telmisartan, also has a role in preventing coronary artery diseases.

• Hydrochlorothiazide belongs to group of medicines called thiazide diuretics also known as “water tablets”. It removes excess fluid by making the kidney produce more urine, thereby reducing the blood pressure.

OPTIDOZ Tablet act additively to reduce the blood pressure.

• The dosage of oral tablets of OPTIDOZ Tablet depends on the age, weight and medical condition of an individual. Take OPTIDOZ Tablet as prescribed by your doctor.
• You must swallow the tablet with a glass of water. Do not chew the tablet.
• Take your daily dose at same time (preferably at breakfast).
• Do not take the tablet with grapefruit juice (it can lead to increase in amlodipine concentration which would increase the lowering of the blood pressure).
• OPTIDOZ Tablet is not recommended for children and adolescent under 18 years of age.
• Do not discontinue the medication without consulting a doctor.
• If you miss a dose of OPTIDOZ Tablet, please take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

If you have taken an overdose of OPTIDOZ Tablet, please contact your doctor immediately.

Symptoms of overdose may include the following:

• Dizziness
• Fast or slow heart rate
• Hypotension

Drugs that interact with OPTIDOZ Tablet:

• Aliskiren
• Amantadine
• Antidepressants
• Atropine, Biperiden
• Baclofen, Tubocurarine
• Calcium supplements
• Cyclosporin, Tacrolimus
• Cisapride
• Colesevelam
• Dantrolene
• Diphemanil
• Diltiazem, Verapamil
• Erythromycin, Clarithromycin, Rifampicin
• Halofantrine
• Ketoconazole, Itraconazole
• Lithium
• Other medicines for treatment of high blood pressure
• Potassium supplements and salt substitutes containing potassium
• Simvastatin
• NSAIDs (non-steroid anti-inflammatory drugs)
• St John's wort

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

Most common side effects of OPTIDOZ Tablet are:

• Upper respiratory tract infection
• Sore throat and nose
• Urinary tract infection, urge to pass urine
• Dizziness
• Headache
• Awareness of heartbeat, low blood pressure
• Nausea, diarrhoea, constipation, cramps
• Joint swelling, ankle swelling
• Tiredness

Please contact your physician immediately if you have

• allergic reactions (swelling of the face, mouth, larynx (voice box), itching and rash);
• severe light-headedness or fainting;
• angioneurotic oedema (red, burning, itching areas on skin near eyes, lips, hands, feet and inside of throat, hoarseness of voice, difficulty in breathing);
• low levels of serum potassium;
• severe skin allergies such as blisters on skin, mouth, lips, eyes and genitals (commonly called Steven Johnsons syndrome);
• persistent diarrhoea which causes weight loss;
• decrease in vision.

This is not a comprehensive list of side effects. Consult your doctor to know more about other possible side effects.

Seek doctor’s advice before taking any other drug or herbal products while on OPTIDOZ Tablet.

You are advised not to take OPTIDOZ Tablet if

• it has passed the expiry date of the medicine printed on the pack.
• the foil or packaging is torn or shows signs of tampering or there is discoloration.

Tell your doctor if

• you are allergic to OPTIDOZ Tablet or to any ingredients of this medicine.
• you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
• you have diabetes related kidney problem.
• you are taking an ACE inhibitor (Enalapril, Lisinopril, Ramipril).
• you are taking any medicine containing Aliskiren.
• you have diabetes.
• you have previous history of angioedema.
• you are under dialysis.
• you have renal artery stenosis (narrowed blood vessel in kidney) or have had a kidney transplant.
• you have liver disease.
• you have a heart disease or problem with valves and muscles of your heart.
• you are on low salt diet.
• your blood potassium levels are low.
• you have a poor functioning adrenal gland.
• you have systemic lupus erythematosus (SLE) (an autoimmune disease).
• you have asthma.
• you have skin rash after being in the sun.
• you are planning a surgery or any procedure.
• you are pregnant or trying to conceive or are breastfeeding.

If you have taken an overdose of OPTIDOZ Tablet, please contact your doctor immediately.

Symptoms of overdose may include the following:

• Dizziness
• Fast or slow heart rate
• Hypotension

1. How should OPTIDOZ Tablet be stored?

OPTIDOZ Tablet does not require any special storage conditions. Keep the medicine away from sunlight and do not freeze the medicine. Keep the medicine out of reach from children.

2. Can I drive while taking OPTIDOZ Tablet?

OPTIDOZ Tablet causes drowsiness, dizziness and headache and affects the driving ability. Avoid driving if you are taking OPTIDOZ Tablet.

3. Should I follow any special dietary instructions while taking OPTIDOZ Tablet?

Do not take grapefruit or grapefruit juice while on Amlodipine Besylate + Hydrochlorothiazide. + Telmisartan. Apart from this, there are no dietary restrictions if you are taking Amlodipine besylate + Hydrochlorothiazide + Telmisartan.

4. Can I drink alcohol while taking OPTIDOZ Tablet?

No, it is not advisable to consume alcohol while on OPTIDOZ Tablet, as it can make you dizzy, sleepy or tired.

5. Is OPTIDOZ Tablet addictive?

No, OPTIDOZ Tablet is not addictive. But do not take it without consulting your doctor.