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INTRODUCTION
OPIPRIME 100MG TABLET contains Opipramol which belongs to the group of medicines called Antidepressants. OPIPRIME 100MG TABLET is used to treat generalised anxiety disorder and somatic disturbances (a mental health condition in which a person feels significantly distressed about physical symptoms such as pain or fatigue and has abnormal thoughts, feelings and behaviours in response to them). Generalised anxiety disorder is a mental health disorder that produces fear, worry, and a constant feeling of being overwhelmed. It is characterized by symptoms such as excessive, persistent, and unrealistic worry about everyday things.
Opipramol works by binding to certain receptors (sigma receptor) in the brain and spinal cord, as a result it works in the N-methyl-D-aspartate (NMDA) receptor system and influences the neurotransmitters glutamate and dopamine (messenger substances in the brain) and produces a calming and anxiety-relieving effect followed by enhancement of mood.
OPIPRIME 100MG TABLET should be used during first trimester of pregnancy unless clearly advised by your doctor and it is not recommended for use in breastfeeding women. Contact your doctor before taking it. OPIPRIME 100MG TABLET is not recommended for use in patients with liver or kidney disease, heart problems such as pre-existing high-grade atrioventricular block or supraventricular or ventricular conduction disturbances, acute urinary retention, untreated glaucoma, brain damage and fits.
OPIPRIME 100MG TABLET should be used with caution in children (above 6 years of age) and child’s doctor may adjust the dose depending upon body weight. The most common side effects of taking OPIPRIME 100MG TABLET are fatigue, dry mouth, stuffy nose and low blood pressure. Contact your physician if any of the symptoms worsen.
USES OF OPIPRIME 100MG TABLET
Treats:
- generalised anxiety disorder
- somatic disturbances
HOW OPIPRIME 100MG TABLET WORKS
OPIPRIME 100MG TABLET works by binding to certain receptors (sigma receptor) in the brain and spinal cord, as a result it works in the N-methyl-D-aspartate (NMDA) receptor system and influences the neurotransmitters glutamate and dopamine (messenger substances in the brain) and produces a calming and anxiety-relieving effect followed by enhancement of mood.
DIRECTIONS FOR USE
Take OPIPRIME 100MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF OPIPRIME 100MG TABLET
COMMON
- tiredness
- dry mouth
- stuffy nose
- low blood pressure
- orthostatic dysregulation (low blood pressure when standing up from sitting or lying position)
UNCOMMON
- dizziness
- drowsiness
- micturition disorders (such as increased frequency of urine, urgency and loss of bladder control)
- difficulty in focusing nearby objects
- tremor
- weight gain
- thirst
- allergic skin reactions (rash, urticaria)
- erectile impotence (inability to maintain erection)
- ejaculation disorders
- constipation
- fast heart rate
- palpitation (sensation of heart beating too hard or fast or irregularly)
RARE
- agitation
- headache
- tingling or prickling sensation in arms or feet
- confusion and delirium (in elderly after abrupt withdrawal)
- edema (fluid retention)
- galactorrhea (excessive flow of milk)
- urinary retention
- restlessness, sweating
- insomnia
- stomach discomfort
- taste disturbances
- paralytic ileus (impaired motor activity of bowel)
- nausea, vomiting
- collapsed state
Stop taking OPIPRIME 100MG TABLET and contact your physician immediately if you experience any of the following side effects:
- fever, flu like symptoms, chest pain, and hypersensitivity reactions including delayed reactions
HOW TO MANAGE SIDE EFFECTS
Constipation
Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom does not improve.
Dizziness Or Drowsiness
Lie down until dizziness passes away and then move slowly and carefully. Take plenty amount of rest and drink plenty of fluids. Consult your doctor if the symptom does not improve or worsens.
Headache
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Take this medicine with, or just after, a meal or snack and stick to simple meals and do not eat oil rich or spicy food. Consult your doctor if the symptom does not improve.
Tiredness
Drink plenty of fluids and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if the symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredOPIPRIME 100MG TABLET can be used with caution in pregnancy, especially in the first trimester of pregnancy only if considered clearly necessary. Contact your doctor before taking OPIPRIME 100MG TABLET.
BREASTFEEDING
ContraindicatedOPIPRIME 100MG TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk in small amounts. Contact your doctor before taking OPIPRIME 100MG TABLET.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines after taking OPIPRIME 100MG TABLET as it may change responsiveness of normal functions.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking OPIPRIME 100MG TABLET as it may cause drowsiness.
KIDNEY
ContraindicatedOPIPRIME 100MG TABLET is not recommended for use in patients with kidney disease. Contact your doctor before taking OPIPRIME 100MG TABLET.
LIVER
ContraindicatedOPIPRIME 100MG TABLET is not recommended for use in patients with liver disease. Contact your doctor before taking OPIPRIME 100MG TABLET.
ALLERGY
ContraindicatedDo not take OPIPRIME 100MG TABLET if you are allergic to opipramol or to other ingredients of this medicine.
HEART DISEASE
ContraindicatedOPIPRIME 100MG TABLET is not recommended for use in patients with pre-existing high-grade AV block or supraventricular or ventricular conduction disturbances. Contact your doctor before taking OPIPRIME 100MG TABLET.
USE IN PEDIATRICS
Use with CautionOPIPRIME 100MG TABLET should be used with caution in children above 6 years of age and dose may be adjusted depending upon body weight. Consult child’s doctor for advice.
OTHERS
OPIPRIME 100MG TABLET is not recommended for use, if you have:
- acute urinary retention
- acute delirium
- untreated narrow angle glaucoma
- prostatic hypertrophy with urinary retention
- paralytic ileus (obstruction of intestine due to paralysis of the intestinal muscles)
- brain damage
- cerebrovascular insufficiency
- epilepsy
- pyloric stenosis (opening between the stomach and small intestine thickens)
- bowel obstruction
- rare hereditary problems such as galactose intolerance, lapp lactase deficiency, glucose-galactose malabsorption and sucrose-isomaltase insufficiency
Before taking OPIPRIME 100MG TABLET, inform your doctor if you:
- low potassium levels
INTERACTIONS
A. Drug-Drug interactions:
Before taking OPIPRIME 100MG TABLET, inform your doctor if you are taking any of the following medicines:
- neuroleptics such as chlorpromazine, haloperidol, risperidone and fluphenazine (medicines used to treat schizophrenia and other psychoses)
- barbiturates Ex. phenobarbitone, methylphenobarbital and phenytoin (medicines used for fits)
- benzodiazepines Ex. alprazolam, diazepam (medicines used to treat anxiety and panic disorders)
- anticholinergics such as trihexyphenidyl, benztropine and monoamine oxidase inhibitor (MAO) inhibitors like selegiline, rasagiline (medicines used to treat parkinson’s disease)
- fluoxetine and fluvoxamine (medicines used to treat depression and anxiety disorders)
- beta-blockers such as propranolol (medicines used to treat hypertension and heart diseases)
- propafenone, quinidine (used to treat heart rhythm disorders)
- tricyclic antidepressants Ex. imipramine, desipramine (medicines used to treat depression)
- analgesics (medicines used to treat pain) Ex. ibuprofen, diclofenac
- guanethidine, clonidine (medicines used to treat high blood pressure)
- cimetidine (medicines used to treat gastric ulcers)
- warfarin (medicines used to treat or prevent blood clots)
- sympathomimetics like dobutamine (medicines used for decompensated heart failure)
Overdosage:
If you or anyone else accidentally take too much of OPIPRIME 100MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are dizziness, drowsiness, restlessness, insomnia, altered consciousness, temporary confusion, increased anxiety, impaired coordination, convulsions (fits), low urine output, low or no urine production, fast or slow heart rate, atrioventricular block (type of heart block), respiratory depression and rarely cardiac arrest.
SYNOPSIS
| Drug | : | Opipramol |
| Pharmacological Category | : | Antidepressants |
| Therapeutic Indication | : | Generalised anxiety disorder, Depression, Somatic disturbances |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep OPIPRIME 100MG TABLET out of reach to children
- Store OPIPRIME 100MG TABLET at room temperature
FAQs ABOUT OPIPRIME 100MG TABLET
Q: What is OPIPRIME 100MG TABLET used for?
A: OPIPRIME 100MG TABLET is used to treat generalised anxiety disorder, and somatic disturbances. It is used in adults and in children above 6 years of age. Consult your doctor before taking OPIPRIME 100MG TABLET if you have any pre-existing disease condition or problems.
Q: What are the common side effects of taking OPIPRIME 100MG TABLET?
A: The most common side effects of taking OPIPRIME 100MG TABLET are fatigue, dry mouth, stuffy nose, low blood pressure, and orthostatic dysregulation (low blood pressure when standing up from sitting or lying position). Contact your physician if any of the symptoms worsen.
Q: Is OPIPRIME 100MG TABLET safe during pregnancy?
A: OPIPRIME 100MG TABLET should be used with caution in pregnancy, especially in the first trimester of pregnancy only if considered clearly necessary. Contact your doctor before taking OPIPRIME 100MG TABLET if you are pregnant or planning to become pregnant.
Q: Can I drive after taking OPIPRIME 100MG TABLET?
A: Do not drive or operate any machines after taking OPIPRIME 100MG TABLET as it may change responsiveness of normal functions. You may ask someone to drive for you or consult your doctor for further precautions.
Q: Can OPIPRIME 100MG TABLET be used in patients with heart problems?
A: OPIPRIME 100MG TABLET is not recommended for use in patients with heart problems such as pre-existing high-grade atrioventricular block (type of heart block) or supraventricular or ventricular conduction disturbances. Contact your doctor for advice before taking OPIPRIME 100MG TABLET.
REFERENCES
1. Christof Schaefer, Paul Peters, Richard K. Mille. Tri- and tetracyclic antidepressants. Drugs during Pregnancy and lactation. Third edition. 2015. Page – 302.
2. Maximilian Gahr , Christoph Hiemke, Bernhard J Connemann. Opipramol. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. March 2017. [Accessed on 25th June 2022] https://pubmed.ncbi.nlm.nih.gov/28320023/
3. Klaus Gerlach, Thomas Uhlig, Jasmin Plathof, Andre Klassen, Klaus-Dieter Stoll, Peter Schmucker, Michael Hueppe. Effects of opipramol as an evening anaesthesiologic premedication. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2022. [Accessed on 25th June 2022] https://pubmed.ncbi.nlm.nih.gov/12422064/
4. Torrent Pharmaceuticals Ltd. Jolivel (Opipramol Dihydrochloride Tablets). [Revised in August 2015] [Accessed on 25th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2744.pdf
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Liver function test
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 20 Mar 2023 | 09:03 AM(IST)
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