Ontic Syrup 30ml

Vomitting/Emesis Rx required
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Best Price*  ₹ 28.26
MRP ₹35.32
(Inclusive of all taxes) * Mkt: Corona Remedies Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

ONTIC contains Ondansetron which belongs to a group of medicines called anti-emetics, which help to stop feeling or being sick. It is indicated to prevent and treat nausea and vomiting induced by cytotoxic therapy and radiotherapy and post-operative nausea and vomiting. This medicine works by blocking the action of serotonin levels in the brain which causes nausea and vomiting during chemotherapy or any other surgery.

Cytotoxic chemotherapy triggers the release of serotonin from the enterochromaffin cells of the small intestine. The released serotonins stimulate the vagal afferents through the 5-HT3 receptors and initiate the vomiting reflex. Ondansetron is a selective 5-HT3 receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. It works by blocking serotonin in the brain which causes nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

Always take ONTIC exactly as directed by your doctor. Before taking this medicine, tell your doctor if you have liver, kidney or heart problems, pregnant women and breastfeeding mothers. Your doctor will decide the right dose depends on your child’s age and body weight. The common side effects are headache, constipation and dizziness.

USES OF ONTIC

  • Cancer chemotherapy-induced nausea and vomiting
  • Postoperative nausea and/or vomiting

HOW ONTIC WORKS

ONTIC is a selective 5-HT3-receptor antagonist which blocks serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. It works by blocking serotonin in the brain which causes nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

DIRECTIONS FOR USE

Always take ONTIC exactly as your doctor has told you. Do not mix medicine with anything (even water) before swallowing it. Shake well before use. It can be taken with or without food.

SIDE EFFECTS OF ONTIC

SERIOUS

  • sudden wheezing and chest pain or tightness
  • swelling of the eyelids, lips, mouth, tongue or throat
  • difficulty breathing
  • skin rash
  • fits (seizures)
  • chest pain
  • temporary loss of vision

COMMON

  • headache
  • sensation of flushing and warmth
  • constipation

RARE

  • dizziness or light headedness
  • blurred vision
  • disturbance in heart rhythm

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and drink plenty of fluids.

Constipation:

Add fruits, vegetables whole grains and other high-fiber foods to your normal diet.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

WARNING & PRECAUTIONS

PREGNANCY

ONTIC is not recommended in the first trimester of pregnancy unless necessary. Consult your doctor for advice.

BREASTFEEDING

ONTIC is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor. 

DRIVING AND USING MACHINES

Do not drive or operate any machines while taking this medicine as it may cause dizziness or faintness.

LIVER

ONTIC should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.

ALLERGY

Do not take if you are allergic (hypersensitive) to Ondansetron.

HEART DISEASE

ONTIC should be used with caution in patients suffering from uneven heart beat or any other active heart diseases. Consult your doctor for advice.

OTHERS

Inform your doctor if you have or had,

  • blockage in your gut or suffer from severe constipation
  • surgery to the adenoids or tonsils
  • problems with the levels of salts in blood like potassium and magnesium

INTERACTIONS

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

  • apomorphine (used to treat Parkinson’s Disease)
  • phenytoin, carbamazepine (used to treat epilepsy)
  • rifampicin, erythromycin (an antibiotic)
  • tramadol (used to treat pain)
  • medicines used to treat heart problems such as abnormal heart beats (anti-arrhythmics) and high blood pressure (betablockers)
  • anthracyclines, trastuzumab (used to treat cancer)
  • ketoconazole (used to treat fungal infection)

SYNOPSIS

Drug :   Ondansetron
Pharmacological Category :   Selective 5-HT3 Receptor Antagonist
Therapeutic Indication :   Cancer chemotherapy-induced nausea and vomiting, Postoperative nausea and/or vomiting
Dosage Forms :   Tablet, Injection, Syrup

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT ONTIC

Does ONTIC stop vomiting?

It is a highly potent antiemetic drug that is effective in preventing chemotherapy-and radiation-induced nausea and vomiting.

How quickly does ONTIC work?

It starts working within half an hour to 2 hours, which dissolves rapidly into the bloodstream and starts showing its effect.

Can use ONTIC during breastfeeding?

It is not recommended during breastfeeding unless necessary. Consult your doctor for advice.

REFERENCES

1. KD Tripathi MD. 5-HT, its antagonists and drug therapy of migraine. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 171.

2. Sharkey KA, Wallace JL. Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 1341-1342.

3. Katzung BG. Histamine, Serotonin, & the Ergot Alkaloids. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page – 285.

4. A Cheng. Emergency department use of oral Ondansetron for acute gastroenteritis-related vomiting in infants and children: Pediatrics in child health. March 2011; [Accessed Jan 6, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077311/

5. Apollo Pharma Ltd. Transdermal Limited. Electronic Medicines Compendium (EMC); [Revised March 2020] [Accessed Jan 6, 2021] https://www.medicines.org.uk/emc/files/pil.9704.pdf

6. Focus Pharmaceuticals Limited. Penn Pharmaceutical Services Ltd. Electronic Medicines Compendium (EMC); [Revised Jan, 2020] [Accessed Jan 6, 2021] https://www.medicines.org.uk/emc/files/pil.3369.pdf

7. GlaxoSmithKline. Sep, 2011. U.S. Food & Drug Administration; [Accessed Jan 6, 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020103s030,020605s014,020781s014lbl.pdf

PRODUCT DETAILS

    Net Qty
    1
    Item Weight
    40
    Ingredient
    ONDANSETRON 2MG/5ML
    Hsn Code
    30049035
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