OBETIFORD 10 Tablet 10's

Liver Diseases Rx required
OUT OF STOCK

Best Price* ₹ 140.00 MRP ₹ 175.00
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: Leeford Healthcare Ltd (Generics) * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

OBETIFORD 10 contains Obeticholic acid which belongs to the group of medicines called Farnesoid X receptor agonists. It is used to treat primary biliary cholangitis (also known as primary biliary cirrhosis) in adults, either by itself or together with other medicine (called ursodeoxycholic acid).

Primary biliary cholangitis is a chronic disorder in which the bile ducts in your liver are slowly destroyed. When these ducts are destroyed, bile (fluid that aids in digestion and absorption of vitamins) builds up in the liver leading to inflammation and scarring. It is also known as primary biliary cirrhosis.

OBETIFORD 10 is not recommended for use in pregnant women and consult your doctor before taking OBETIFORD 10 if you are breast-feeding women. OBETIFORD 10 is not recommended for use in children and adolescents (under 18 years of age) and should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking OBETIFORD 10.

Prior to treatment with OBETIFORD 10 your doctor may advice you to take blood test to understand your existing condition like liver function. The most common side effects of taking OBETIFORD 10 are stomach pain, tiredness, dizziness, constipation, dry skin and fast or irregular heartbeat. Consult your doctor if any of the symptom worsens.

USES OF OBETIFORD 10

  • Treats primary biliary cholangitis in adults

HOW OBETIFORD 10 WORKS

OBETIFORD 10 works by reducing the production and build-up of bile in the liver and also reduces the inflammation of the liver. Therefore, as a result it helps to improve liver function.

DIRECTIONS FOR USE

Take OBETIFORD 10 as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF OBETIFORD 10

COMMON

  • stomach pain
  • feeling tired
  • itching of skin
  • thyroid hormone irregularity
  • dizziness
  • fast or irregular heartbeat (palpitations)
  • pain in the mouth and throat
  • constipation
  • dry skin
  • dryness, irritation, redness, crusting or drainage of the skin (eczema)
  • rash
  • pain in joints
  • swelling in the hands and feet
  • fever

RARE

Stop taking OBETIFORD 10 and contact your physician immediately if you experience any of the following side effects:

  • severe itching (pruritus)
  • worsening of liver problems (symptoms include swelling of stomach-area due to fluid build-up, yellowing of your skin or white of the eyes, black, tarry, or bloody stools, coughing up or vomiting blood, or your vomit looks like coffee grounds, mental changes such as confusion, sleepier than usual or harder to wake up, slurred speech, mood swings, or changes in personality)
  • severe symptoms such as stomach-area pain, nausea, vomiting, diarrhoea, loss of appetite or weight loss, new or worsening fatigue, weakness, fever, and chills, light-headedness, less frequent urination

HOW TO MANAGE SIDE EFFECTS

Stomach pain:

Try to take rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.

Constipation:

Take fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom gets worse.

Dizziness:

Try to rest and relax and get enough sleep. Try to avoid driving or operating any tools or machines while you are feeling dizzy. Limit your consumption of alcohol, as it can aggravate your dizziness. Consult and inform your doctor if the symptom does not improve.

Tiredness:

Drink plenty of fluids and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if the symptom does not improve.

Skin rash:

Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin after consulting the doctor. Consult your doctor if the symptom worsens.

WARNING & PRECAUTIONS

PREGNANCY

OBETIFORD 10 is not recommended for use in pregnant women. Consult your doctor before taking OBETIFORD 10.   

BREASTFEEDING

It is not known whether OBETIFORD 10 passes through breast milk. Consult your doctor before taking OBETIFORD 10.

DRIVING AND USING MACHINES

OBETIFORD 10 has no or negligible influence on your ability to drive or use machines.

LIVER

OBETIFORD 10 is not recommended for use in patients with complete blockage of the biliary tract (liver, gall bladder and bile ducts). Consult your doctor before taking OBETIFORD 10.

ALLERGY

Do not take OBETIFORD 10 if you are allergic to Obeticholic acid or any of the other ingredients of this medicine.

OTHERS

Before taking OBETIFORD 10 inform your doctor if you:

  • have itching that is difficult to tolerate

Use in paediatrics:

OBETIFORD 10 is not recommended for use in children and adolescents. Consult child’s doctor for advice.

Use in geriatrics:

OBETIFORD 10 should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking OBETIFORD 10.

INTERACTIONS

A. Drug-Drug interactions:

Before taking OBETIFORD 10, inform your doctor if you are taking any of the following medicines:

  • bile acid binding resins such as cholestyramine, colestipol, colesevelam (used to lower blood cholesterol levels)
  • theophylline (used to prevent and treat wheezing)
  • tizanidine (used to relieve the stiffness and restriction of muscles)
  • warfarin (used to prevent and treat blood clots)

Overdosage:

If you or anyone else accidentally take too much of OBETIFORD 10, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage include yellowing of the skin.

SYNOPSIS

Drug :  

Obeticholic acid

Pharmacological Category :  

Farnesoid X-receptor agonist

Therapeutic Indication :  

Primary Biliary Cholangitis

Dosage Forms :  

Tablet

MORE INFORMATION

  • Keep OBETIFORD 10 out of reach of children
  • Store at room temperature

FAQs ABOUT OBETIFORD 10

Is OBETIFORD 10 safe to use in patients with liver problems?

OBETIFORD 10 is not recommended for use in patients with complete blockage of the biliary tract (liver, gall bladder and bile ducts). Consult your doctor before taking OBETIFORD 10.

What is OBETIFORD 10 used for?

OBETIFORD 10 is used to treat primary biliary cholangitis (also known as primary biliary cirrhosis) in adults, either by itself or together with other medicine (called ursodeoxycholic acid).

What common side effects are seen with OBETIFORD 10?

The most common side effects of taking OBETIFORD 10 are stomach pain, tiredness, dizziness, constipation, dry skin, fast or irregular heartbeat, fever, swelling in hands and feet, throat and mouth pain, skin rash and itching, joint pain and fever. Consult your doctor if any of the symptom worsens.

Is OBETIFORD 10 safe to use in pregnant and breast-feeding women?

OBETIFORD 10 is not recommended for use in pregnant women and it is not known whether OBETIFORD 10 passes through breast milk. Consult your doctor before taking OBETIFORD 10 if you are planning to get pregnant or breast-feeding women.

Does OBETIFORD 10 cause constipation?

Yes, OBETIFORD 10 may cause constipation in some individuals. To manage this side effect, try taking fiber rich foods in your diet such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if the symptom gets worse.

REFERENCES

1. James E. Barrett. Handbook of Experimental Pharmacology. The pharmacology of bile acids and their receptors. 1st edition. 2019. Page – 13.

2. Frederik Nevens, Pietro Andreone, Giuseppe Mazzella, Simone I Strasser, Christopher Bowlus, Pietro Invernizzi, Joost P H Drenth, Paul J Pockros, Jaroslaw Regula, Ulrich Beuers 1, Michael Trauner, David E Jones, Annarosa Floreani, Simon Hohenester, Velimir Luketic, Mitchell Shiffman, Karel J van Erpecum, Victor Vargas, Catherine Vincent, Gideon M Hirschfield, Hemant Shah, Bettina Hansen, Keith D Lindor, Hanns-Ulrich Marschall, Kris V Kowdley, Roya Hooshmand-Rad, Tonya Marmon, Shawn Sheeron, Richard Pencek, Leigh MacConell, Mark Pruzanski, David Shapiro, POISE Study Group. A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis. NIH. National Library of Medicine, National center for biotechnology information. Pubmed.gov. August 2016. [Accessed on 8th August 2022] https://pubmed.ncbi.nlm.nih.gov/27532829/

3. Intercept Pharmaceuticals. Study Evaluating the Efficacy and Safety of Obeticholic Acid in Subjects With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (REVERSE). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on March 2008] [Accessed on 8th August 2022] https://clinicaltrials.gov/ct2/show/NCT03439254

4. Almac Pharma Services. Electronic Medicines Compendium (EMC). [Revised in March 2018] [Accessed on 8th August 2022] https://www.medicines.org.uk/emc/files/pil.2561.pdf

5. Intercept Pharmaceuticals, Inc. U.S. Food & Drug Administration. [Revised in January 2018] [Accessed on 8th August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/207999s003lbl.pdf

PRODUCT DETAILS

    Country Of Origin
    India
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