INTRODUCTION

NUMBTRON INJECTION contains Mecobalamin which belongs to the group of medicines called Vitamins. It is used to treat diabetic neuropathy (nerve damage caused by diabetes), peripheral neuropathy (peripheral nerve damage that affects hands, feet and arms), and megaloblastic anaemia (blood disorder) that occurs due to vitamin B12 deficiency in affected individuals.

NUMBTRON INJECTION is not recommended for use in patients allergic to Mecobalamin, and/or Cobalt. Before receiving NUMBTRON INJECTION, inform your doctor if you have Leber's disease (inherited form of vision loss), low potassium level (with associated signs such as muscle twitches/cramps, low blood pressure), optic nerve disease (swelling and nerve damage to the eyes), and kidney/liver problems.

NUMBTRON INJECTION should be used with caution in pregnant and breastfeeding women. It is not recommended for use in children and adolescents (aged below 18 years) unless it is clearly necessary and is advised to be used with caution in elderly patients (aged 65 years and above) after consulting the doctor.

The most common side effects of receiving NUMBTRON INJECTION are headache, nausea, vomiting, diarrhoea, loss of appetite, skin rash, and/or hot flushes. Consult your doctor if any of these symptoms worsens.

USES OF NUMBTRON INJECTION

• Treats diabetic and peripheral neuropathies
• Treats megaloblastic anaemia (caused by vitamin B12 deficiency)

HOW NUMBTRON INJECTION WORKS

NUMBTRON INJECTION works by aiding in the synthesis of myelin (lipid rich material that covers nerve fibres) which helps in protecting the nerve fibres and thereby providing relief from diabetic & peripheral neuropathy in affected individuals.   It also promotes nucleic acid synthesis in the bone marrow which helps in the maturation and division of erythroblasts thus preventing poor production of red blood cells and thereby improving megaloblastic anaemia in affected individuals.

DIRECTIONS FOR USE

NUMBTRON INJECTION will be given to you only by a doctor or a nurse into a muscle as an intramuscular injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF NUMBTRON INJECTION

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult your doctor and inform them if the symptom gets worse.

Nausea And Vomiting

Receive NUMBTRON INJECTION with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Talk with your doctor if the condition worsens.

Headache

If NUMBTRON INJECTION causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving NUMBTRON INJECTION. If it lasts more than a week or severe, inform your doctor.

WARNING & PRECAUTIONS

PREGNANCY

Use with Caution

NUMBTRON INJECTION should be used with caution in pregnant women. Consult your doctor before receiving NUMBTRON INJECTION.

BREASTFEEDING

Use with Caution

NUMBTRON INJECTION should be used with caution in breastfeeding women. Consult your doctor before receiving NUMBTRON INJECTION.

KIDNEY

Use with Caution

NUMBTRON INJECTION should be received with caution in patients with kidney problems. Consult your doctor before receiving the medicine.

LIVER

Use with Caution

NUMBTRON INJECTION should be received with caution in patients with liver problems. Consult your doctor before receiving the medicine.

ALLERGY

Contraindicated

Do not receive NUMBTRON INJECTION if you are allergic to Mecobalamin, Cobalt, and/or any other ingredients of this medicine.

USE IN PEDIATRICS

Monitoring required

NUMBTRON INJECTION is not recommended for use in children and adolescents (aged below 18 years) unless it is clearly necessary. Consult your doctor before receiving the medicine.

USE IN GERIATRICS

Use with Caution

NUMBTRON INJECTION should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving the medicine.

INTERACTIONS

A. Drug - Drug interactions:

Before receiving NUMBTRON INJECTION, inform your doctor if you are receiving any of the following medicine:

• neomycin (used to prevent/treat bacterial skin infections)
• amino salicylic acid (used to treat tuberculosis)
• cimetidine (used to treat ulcers of stomach and intestines)
• colchicine (used in the treatment of gout

Overdosage:

NUMBTRON INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

SYNOPSIS

MORE INFORMATION

• Keep NUMBTRON INJECTION out of reach of children
• Store NUMBTRON INJECTION at room temperature

FAQs ABOUT NUMBTRON INJECTION

Q. What is NUMBTRON INJECTION used for?

A. NUMBTRON INJECTION is used to treat diabetic neuropathy (nerve damage caused by diabetes), peripheral neuropathy (peripheral nerve damage that affects hands, feet and arms), and megaloblastic anaemia (blood disorder) that occurs due to vitamin B12 deficiency in affected individuals.

Q. How NUMBTRON INJECTION is administered?

A. NUMBTRON INJECTION will be given to you only by a doctor or a nurse into the muscle as an intramuscular injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Q. What are the side effects of NUMBTRON INJECTION?

A. The most common side effects of receiving NUMBTRON INJECTION are headache, nausea, vomiting, diarrhoea, loss of appetite, skin rash, and/or hot flushes. Consult your doctor if any of these symptoms worsens.

Q. How NUMBTRON INJECTION works?

A. NUMBTRON INJECTION works by aiding in the synthesis of myelin (lipid rich material that covers nerve fibres) which helps in protecting the nerve fibres and thereby providing relief from diabetic & peripheral neuropathy in affected individuals.   It also promotes nucleic acid synthesis in the bone marrow which helps in the maturation and division of erythroblasts thus preventing poor production of red blood cells and thereby improving megaloblastic anaemia in affected individuals.

Q. Does NUMBTRON INJECTION cause headache?

A. Yes, NUMBTRON INJECTION causes headache as it is the commonest side effect associated with the use of NUMBTRON INJECTION. If such side effect experienced after receiving the medicine, then try to take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving NUMBTRON INJECTION. If it lasts more than a week or severe, then inform your doctor.

REFERENCES

1. K.D. Tripathi. Drugs affecting blood and blood formation, Vitamins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 606.

2. Amrita Sil, Hrishikesh Kumar, Rahul Deb Mondal, Sidharth Sankar Anand, Anirban Ghosal, Ashis Datta, Sandesh V Sawant, Vaibhavi Kapatkar, Ganesh Kadhe,Sameer Rao. A randomized, open labeled study comparing the serum levels of cobalamin after three doses of 500 mcg vs. a single dose methylcobalamin of 1500 mcg in patients with peripheral neuropathy.  NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. August 2018. [Accessed on 4th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037815/

3. Emmanuel Andrès, Thomas Vogel, Laure Federici, Jacques Zimmer, Ecaterina Ciobanu, and Georges Kaltenbach. Cobalamin Deficiency in Elderly Patients: A Personal View. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. May 2008.  [Accessed on 4th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672039/

4. KINESIS BIOCARE. Vitkin-1500 INJECTION. [Accessed on 4th November 2022] https://www.kinesisbiocare.in/vitkin-1500-injection-methylcobalamin-1500mcg-injection--4429240.html

5. Integrated Laboratories Pvt Ltd. Inebion-1500. [Accessed on 4th November 2022] https://integratedlaboratories.in/methylcobalamin-injectionintebion-1500/

USEFUL DIAGNOSTIC TESTS

• Nerve conduction test
• Complete blood count