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INTRODUCTION
NORTIMER 10 TABLET contains Nortriptyline which belongs to the group of medicines called Antidepressants. It is used in adults to treat and relieve the symptoms of depression.
Depression is a mental illness characterized by sad mood, loss of interest and pleasure, low energy, worthlessness, guilt, slowed mental or physical activities, change in appetite or sleep, profound sadness, and even suicidal thoughts.
Avoid consumption of alcohol during treatment with NORTIMER 10 TABLET. NORTIMER 10 TABLET is not recommended for use in patients having heart or liver diseases, or mania.
Before taking NORTIMER 10 TABLET, inform your doctor if you have thyroid problems, diabetes, fits, glaucoma (increased pressure in the eye), or an enlarged prostate. The safety of NORTIMER 10 TABLET for use during pregnancy has not been established. NORTIMER 10 TABLET is not recommended for use among breastfeeding women, therefore consult your doctor before taking.
NORTIMER 10 TABLET is not recommended for use in children and adolescents (under 18 years of age). If you have thoughts of harming or killing yourself at any time, contact your doctor or go to hospital immediately.
The most common side effects of taking NORTIMER 10 TABLET are allergic reaction, chest pain, headache, dizziness, or confusion. Contact your doctor if any of the symptoms worsen.
USES OF NORTIMER 10 TABLET
- Treats and relieves the symptoms of depression
HOW NORTIMER 10 TABLET WORKS
NORTIMER 10 TABLET works by interrupting the reabsorption of serotonin and norepinephrine (neurotransmitters) within your brain, which enables a higher supply of neurotransmitters for your brain to regulate the mood and Increased regulation of chemicals maintains a balance mood.
DIRECTIONS FOR USE
Take NORTIMER 10 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking NORTIMER 10 TABLET unless your doctor advises you to stop.
SIDE EFFECTS OF NORTIMER 10 TABLET
COMMON
- dry mouth
RARE
Stop taking NORTIMER 10 TABLET and contact your doctor immediately if you experience any of the following side effects:
- sudden wheeziness, trouble breathing, swelling of the eyelids, face or lips, rash, or itching, especially affecting your whole body
- signs of heart attack (sudden chest pain spreading to the neck or arm, with breathlessness and a clammy feeling)
- signs of stroke (sudden collapse, numbness or weakness in the hands or legs, headache, dizziness and confusion, trouble in vision and swallowing, slurred, mixed up or loss of speech)
- inflammation of the liver, yellowish skin or whites of your eyes, dark urine, pale stools, tiredness, fever, nausea, weakness, drowsiness, stomach pain
- thoughts of harming or killing yourself
- paralysed intestine (constant constipation with a swollen stomach, fever, vomiting)
- effects on blood or bone marrow (the number of red cells, white cells and platelets are reduced and can cause bruising, bleeding, pallor or persistent sore throat and fever)
WARNING & PRECAUTIONS
PREGNANCY
NORTIMER 10 TABLET should be used with caution in pregnant women as the safety of for use in them has not been established. Before taking this medicine, inform your doctor if you are pregnant, think you may be pregnant or are planning to get pregnant. Consult with your doctor before taking NORTIMER 10 TABLET.
BREASTFEEDING
NORTIMER 10 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy machines if you feel altered alertness after taking NORTIMER 10 TABLET.
ALCOHOL
Avoid consumption of alcohol while taking NORTIMER 10 TABLET.
LIVER
NORTIMER 10 TABLET is not recommended in patients with severe liver disease. Consult your doctor before taking it.
ALLERGY
Do not take NORTIMER 10 TABLET if you are allergic to Nortriptyline or any other ingredient of this medicine.
HEART DISEASE
NORTIMER 10 TABLET is not recommended in patients who had recent heart attack or heartbeat disorder. It should be used with caution in patients with other heart disease. Consult your doctor before taking it.
OTHERS
NORTIMER 10 TABLET is not recommended for use if you:
- have mania
Before taking NORTIMER 10 TABLET, inform your doctor if you:
- feel suicidal or aggressive
- are agitated, overactive, or have schizophrenia
- have a thyroid condition
- have a history of fits
- have glaucoma
- have an enlarged prostate
- are about to have electroconvulsive therapy (electric shock)
- have diabetes
- are going to receive an anaesthetic (for an operation)
- have lactose intolerance
Use in pediatrics:
NORTIMER 10 TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking it.
Use in geriatrics:
NORTIMER 10 TABLET should be used with caution in elderly patients as they might need some dose adjustments. Consult your doctor before taking it.
INTERACTIONS
A. Drug - Drug interactions:
Before taking NORTIMER 10 TABLET, inform your doctor if you are taking any of the following medicine:
- medicines used to lower blood pressure (Ex. guanethidine, debrisoquine, bethanidine, clonidine)
- barbiturates (used for anxiety or to induce sleepy) Ex. secobarbital, pentobarbital
- other medicines used to treat depression (Ex. fluoxetine, phenelzine, selegiline, amitriptyline)
- cimetidine (used to treat acidity and ulcers)
- medicines used to treat mental illness (Ex. chlorpromazine, fluphenazine)
- carbamazepine (used to treat fits)
- medicine used to treat heartbeat disorders (Ex. propafenone, flecainide, encainide, quinidine)
- valproic acid (used to treat fits and bipolar disorder)
- medicines used to treat severe pain (Ex. buprenorphine, morphine)
- medicines used to treat cough and cold (Ex. ephedrine, isoprenaline, noradrenaline, phenylephrine, phenylpropanolamine)
- medicines used to prevent pain during surgeries (Ex. propofol, midazolam)
Overdosage:
If you or anyone else accidentally take too much of NORTIMER 10 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage of NORTIMER 10 TABLET may include confusion, restlessness, agitation, disturbed concentration, transient visual hallucinations, dilated pupils, hyperactive reflexes, stupor (near unconsciousness), drowsiness, muscle rigidity, vomiting, or hypothermia.
SYNOPSIS
| Drug | : | Nortriptyline |
| Pharmacological Category | : | Tricyclic Antidepressant |
| Therapeutic Indication | : | Depression |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep NORTIMER 10 TABLET out of reach of children
- Store NORTIMER 10 TABLET at a temperature below 25°C
FAQs ABOUT NORTIMER 10 TABLET
What is NORTIMER 10 TABLET used for?
NORTIMER 10 TABLET is used in the treatment of depression for restoring the chemical imbalance in the brain and enhances mood and behavior.
Is NORTIMER 10 TABLET good for nerve pain?
NORTIMER 10 TABLET relieves persistent pain by increasing the amount of specific chemical substances in the nervous system, reducing pain messages arriving in the brain. It is especially good for nerve pain, such as burning, shooting, or stabbing pain, and for pain that keeps you awake at night.
Can NORTIMER 10 TABLET cause liver damage?
Yes, NORTIMER 10 TABLET can cause inflammation of the liver, resulting in yellowing of your skin or whites of your eyes, dark urine, pale stools, tiredness, fever, nausea, weakness, drowsiness, and abdominal pain, along with test results showing abnormal liver function. If you experience these symptoms, consult your doctor immediately.
Is NORTIMER 10 TABLET safe for elderly?
Yes, NORTIMER 10 TABLET is recommended for treating depression in older patients. The dose and duration of the medicine will be decided by the doctor. However, consult your doctor before taking the medicine.
Can NORTIMER 10 TABLET cause weight gain?
Yes, taking NORTIMER 10 TABLET of low-modest doses for long term can cause considerable weight gain and significantly interfere with the ability to provide long-term maintenance therapy. If you find any difficulty, please consult your doctor.
Can I take opioids with NORTIMER 10 TABLET?
Consult your doctor before taking any other medicine along with NORTIMER 10 TABLET. Opioids may interact with NORTIMER 10 TABLET and you may experience symptoms like uncontrollable rhythmic contractions of muscles, including eye muscles, agitation, hallucinations, too much sweating, shaking, increased muscle tension, or body temperature above 38°C. Inform your doctor if you experience any of these.
Is NORTIMER 10 TABLET safe to use in pregnancy?
The safety of NORTIMER 10 TABLET for use during pregnancy has not been established. Before taking this medicine, inform your doctor if you are pregnant, think you may be pregnant or are planning to get pregnant.
Can I take NORTIMER 10 TABLET while driving?
NORTIMER 10 TABLET may affect alertness. Drive or use heavy machinery cautiously until you’re aware of how this medicine affects you. If you feel this medicine affect your ability to drive or use machines, inform your doctor immediately.
What if I forget to take a dose of NORTIMER 10 TABLET?
If you forget to take a dose of NORTIMER 10 TABLET, take it as soon as you remember. Do not take the medicine twice to make up for the forgotten dose. Inform your doctor if you have missed several doses.
Can I stop taking NORTIMER 10 TABLET?
Do not stop taking NORTIMER 10 TABLET or change the dose without telling your doctor first.
If you suddenly stop taking the medicine, you may feel nauseous, have a headache or feel generally unwell.
Can NORTIMER 10 TABLET cause nausea?
Yes. NORTIMER 10 TABLET may interfere with liver function and cause nausea and other side effects. If you feel nauseous, take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if you persistently feel sick.
REFERENCES
1. KD. Tripathi. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 454.
2. Gagindip Merwar, Jonathan R. Gibbons, Seyed Alireza Hosseini, Abdolreza Saadabadi. Nortriptyline. NCBI US National Library of Medicine, National Institute of Health. May 2022. [Accessed on 12th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK482214/
3. Andrew A Nierenberg, George I Papakostas, Timothy Petersen, Karen E Kelly, Brian M Iacoviello, John J Worthington, Joyce Tedlow, Jonathan E Alpert, Maurizio Fava. Nortriptyline for treatment-resistant depression. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 2003. [Accessed on 12th May 2022] https://pubmed.ncbi.nlm.nih.gov/12590621/
4. Anfarm Hellas SA. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 12th May 2022] https://www.medicines.org.uk/emc/files/pil.2423.pdf
5. Taro Pharmaceutical Industries Ltd. Nortriptyline. Dailymed. [Revised in October 2022]. [Accessed on 12th May 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=90a6bfcf-faf9-21c0-e053-2995a90ad69f
6. Nortriptyline. Johns Hopkins Medicine. [Revised in 2007] [Accessed on 12th May 2022] https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/peripheral_nerve/patient_info/nortriptyline_2007.pdf
7. Nortriptyline. MedlinePlus. [Revised in August 2017] [Accessed on 12th May 2022] https://medlineplus.gov/druginfo/meds/a682620.html#:~:text=Nortriptyline%20is%20used%20to%20treat,needed%20to%20maintain%20mental%20balance
AUTHOR DETAILS
Written By Dr. Priyanka Goel, BDS
Last updated on 02 Dec 2022 | 06:06 PM(IST)
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