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NOKICEF O TABLET is a combination of Cefixime and Ofloxacin which belongs to the group of medicines called Antibiotics. It is used in adults to treat typhoid fever (infection caused by Salmonella typhi, accompanied by high fever, stomach pain, headache and diarrhea).
NOKICEF O TABLET is also used to treat bacterial infections of the respiratory tract (Ex. tonsillitis, pharyngitis and bronchitis), middle ear (otitis media), reproductive organs (gonorrhea) and urinary tract.
Before taking NOKICEF O TABLET, inform your doctor if you have any heart, liver or kidney problems, diabetes or fits. NOKICEF O TABLET should be used with caution in pregnant and breastfeeding women so, consult your doctor before taking it.
Avoid consumption of alcohol during treatment with NOKICEF O TABLET, as it may impair your ability to concentrate and react. The most common side effects of taking NOKICEF O TABLET are indigestion, nausea, stomach pain, vomiting, diarrhea gas, etc. Consult your doctor immediately if any of the symptoms worsen.
NOKICEF O TABLET treats typhoid fever and bacterial infections that occur in:
NOKICEF O TABLET kills the infecting bacteria where Cefixime interferes with the formation of bacterial cell walls and forms holes in them and Ofloxacin inhibits a bacterial enzyme involved in repairing and replicating the DNA (genetic material) of bacteria, thus making the organism unable to reproduce or repair themselves.
Take NOKICEF O TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of NOKICEF O TABLET for you depending upon your age, body weight and disease condition. Do not stop taking NOKICEF O TABLET unless your doctor advises you to stop.
Stop taking NOKICEF O TABLET and contact your doctor immediately if you experience any of the following side effects:
Take NOKICEF O TABLET with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. If nausea persists, contact your doctor.
Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like eating – you don't have to eat or avoid any specific foods. Do not take any medicine for vomiting without your doctor's consultation. If vomiting does not get better, contact your doctor.
Drink lots of fluids, like water or fruit juice to maintain hydration. Check with your doctor before taking any medicine for diarrhea. If diarrhea does not get better, contact your doctor.
Try to rest and relax. Eat and drink slowly or try eating smaller meals more frequently. Keep a heat pad on your stomach. If your stomach still aches, contact your doctor.
Raise your head and shoulders up while sleeping to prevent stomach acid from coming up. Do not eat 3 to 4 hours before going to sleep and avoid tea, coffee, cola or alcohol. If indigestion does not improve, contact your doctor.
Lie down until dizziness is improved, then get up slowly. Don’t hurry and move slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. If dizziness persists, consult your doctor.
Avoid hot showers because hot water can further irritate your skin. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash gets worse.
NOKICEF O TABLET should be used with caution in pregnant women. Consult your doctor for advice.
NOKICEF O TABLET should be used with caution in breastfeeding women. Consult your doctor for advice.
Do not drive or operate any machines if you experience fits, confusion, feeling less alert or aware of things than usual, unusual muscle movements or stiffness after taking NOKICEF O TABLET.
Avoid consumption of alcohol during treatment with NOKICEF O TABLET, as it may impair your ability to concentrate and react.
NOKICEF O TABLET should be taken with caution if you have kidney problems. Consult your doctor for advice.
NOKICEF O TABLET should be taken with caution if you have liver problems. Consult your doctor for advice.
Do not take NOKICEF O TABLET if you are allergic to Cefixime, Ofloxacin, other quinolone or cephalosporin antibiotics or any of the other ingredients of this medicine.
NOKICEF O TABLET should be taken with caution if you have aortic aneurysm or large vessel peripheral aneurysm (an enlargement or "bulge" of a large blood vessel), aortic dissection (a tear in the aorta wall), leaking heart valves, any vascular disorders, history of heart attack, weak heart, problems with your heartbeat or any other heart problems. Consult your doctor for advice.
Do not take NOKICEF O TABLET if you:
Before taking NOKICEF O TABLET, inform your physician if you:
Use in Paediatrics:
NOKICEF O TABLET is not recommended for use in children and adolescents (younger than 18 years of age). Consult your child’s doctor for advice.
Use in Geriatrics:
NOKICEF O TABLET should be used with caution in the elderly (above 60 years of age). Consult your doctor for advice.
A. Drug-Drug interactions:
Before taking NOKICEF O TABLET, inform your doctor if you are taking any of the following medicines:
If you or anyone else accidentally take too much of NOKICEF O TABLET, consult your doctor immediately or visit the nearby hospital.
|Pharmacological Category||:||Cephalosporins, Fluoroquinolones|
|Therapeutic Indication||:||Bacterial infections|
Q: Can NOKICEF O TABLET be given to children?
A: No. NOKICEF O TABLET is not recommended for children and adolescents below 18 years of age. Consult your child’s doctor for advice. The doctor will decide an appropriate dose or recommend a suitable alternative treatment for your child.
Q: What if I forget to take a dose of NOKICEF O TABLET?
A: If you forget to take a dose of NOKICEF O TABLET, take it as soon as you remember. However, omit the missed dose if it's almost time for the next one. Do not take NOKICEF O TABLET two times to make up for the missed dose.
Q: Can I stop taking NOKICEF O TABLET if I feel better?
A: Do not stop taking NOKICEF O TABLET without talking to your doctor, even if you feel better, as the infection may come back or get worse again. Consult your doctor for further advice.
Q: Can NOKICEF O TABLET be taken in pregnancy?
A: NOKICEF O TABLET should be used with caution in pregnancy. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking NOKICEF O TABLET.
Q: Can I take other medicines with NOKICEF O TABLET?
A: Before taking NOKICEF O TABLET, inform your doctor if you are taking, have taken or might take any other medicine, including prescription, over the counter or any herbal medicine, as these might cause serious side effects by interacting with each other.
1. KD. Tripathi. Antimicrobial drugs. Essentials of Medical Pharmacology. Eighth edition. 2019. Page – 763, 778.
2. Tiwaskar M. Cefixime-ofloxacin Combination in the Management of Uncomplicated Typhoid Fever in the Indian Community Setting. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. March 2019. [Accessed on 6th January 2023]. https://pubmed.ncbi.nlm.nih.gov/31304712/
3. Bakthavatchalam YD, Kumar DT, Tayubi IA, et al. In vitro efficacy and in silico analysis of cefixime-ofloxacin combination for Salmonella Typhi from bloodstream infection. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. September 2017. [Accessed on 6th January 2023]. https://pubmed.ncbi.nlm.nih.gov/28650129/
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5. Lupin Limited. U.S. Food and Drugs Administration. [Revised in March 2017] [Accessed on 6th January 2023]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/202091s005,203195s006lbl.pdf
6. Malik Lifesciences Pvt. Ltd. Omnix O Tablets (Cefixime + Ofloxacin). [Revised in December 2019] [Accessed on 6th January 2023]. https://www.ciplamed.com/content/omnix-o-tablets
7. Alpha Drugs. Sefmax-O (Cefixime + Ofloxacin). [Accessed on 6th January 2023]. https://www.alphadrug.in/product/cefixime-and-ofloxacin-tablets/
8. Advacare Pharma. Cefox Care (Cefixime 200mg + Ofloxacin 200 mg tablet). [Accessed on 6th January 2023]. https://www.advacarepharma.com/en/pharmaceuticals/cefixime-ofloxacin-tablets
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