INTRODUCTION

NIZONIDE DT 200MG contains Nitazoxanide which belongs to a group of medicines called antiprotozoal agents. It is used to treat diarrhoea caused by Giardia lamblia or Cryptosporidium parvum. Diarrhoea is passing loose or watery bowel movements more frequently and occurs when the lining of the intestine is unable to absorb fluid, or it actively secretes fluid.

Nitazoxanide inhibits the growth of sporozoites and oocysts of Cryptosporidium and trophozoites of Giardia and interferes with pyruvate ferredoxin oxidoreductase (PFOR) which is essential to anaerobic energy metabolism. PFOR enzyme from G. lamblia reduces nitazoxanide by transfer of electrons in the absence of ferredoxin. Thus, the DNA-derived PFOR protein sequence of C. parvum develops to be similar to that of G. lamblia.

Before taking this NIZONIDE DT 200MG, tell your physician if you have liver, kidney or heart problems, are pregnant or breastfeeding. This medicine is not suitable for use in children and adolescents below 12 years of age. The common side effects are headache, vomiting and stomach upset or pain.

USES OF NIZONIDE DT 200MG

• Treats Diarrhoea caused by Giardia lamblia or Cryptosporidium parvum

HOW NIZONIDE DT 200MG WORKS

Nitazoxanide belong to a class of medications called antiprotozoal agents which works by stopping the growth of certain protozoa that cause diarrhoea.

DIRECTIONS FOR USE

Always take NIZONIDE DT 200MG as instructed by your doctor. Swallow whole and do not crush or chew. It should be taken with food.

SIDE EFFECTS OF NIZONIDE DT 200MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and drink plenty of fluids. Apply a wet or cold cloth to forehead and rest in a quiet, comfortable, dark room.

Vomiting:

Drink clear or ice-cold drinks and eat light, bland foods, avoid sweets.

Stomach pain:

Place a warm bottle or heated bag on your abdomen and drink plenty of clear fluids and water.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking,

• warfarin (treats blood clot)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT NIZONIDE DT 200MG

What if I forget to take a dose of NIZONIDE DT 200MG?

If you miss a dose, take it as soon when u remember, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose.

How long should I take NIZONIDE DT 200MG?

The dose and duration vary from person to person and will be decided by your doctor. Do not stop taking without the advice of your doctor even if you feel better.

Is NIZONIDE DT 200MG safe?

It is safe if used in the dose and duration as prescribed by your doctor.

REFERENCES

1. KD Tripathi MD. Antimicrobial drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 840.

2. Phillips MA, Stanley SL Jr. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 1432-1433.

3. Rosenthal PJ. Antiprotozoal Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 918.

4. Nishith Singh and S Narayan. Nitazoxanide : A Broad Spectrum Antimicrobial. July 21, 2011. [Accessed on June 15, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920633/

5. LeAnne M. Fox, Louis D. Saravolatz. Nitazoxanide: A New Thiazolide Antiparasitic Agent. April 15, 005, Volume 40, Issue 8, 15 April 2005, Pages 1173–1180. [Accessed on June 15, 2021] https://academic.oup.com/cid/article/40/8/1173/320667

6. Romark, L.C. 2002. [Revised on April, 2017] [Accessed on June 15, 2021] https://www.alinia.com/wp-content/uploads/2017/08/prescribing-information.pdf

USEFUL DIAGNOSTIC TESTS

• Stool Examination R/M