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NIRORAB D TABLET is a combination of Domperidone and Rabeprazole which belongs to the group of medicines called Dopamine Antagonists and Proton pump inhibitors respectively. NIRORAB D TABLET is used to treat Gastro-Esophageal Reflux Disease (GERD) among patients who have not responded adequately to rabeprazole alone.
GERD is a chronic digestive disease in which the stomach acid frequently flows into the esophagus leading to irritation of lining of food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.
NIRORAB D TABLET can also be used to treat peptic ulcers caused by H. pylori infection or NSAIDs use. Peptic ulcers are painful sores that develop on the linings of the stomach, esophagus or intestines. Symptoms include stomach pain, flatulence, indigestion, vomiting and fatigue.
Along treatment with NIRORAB D TABLET, try to eat less spicy foods and drink plenty of water or fluids. Avoid smoking or alcohol consumption as it may aggravate your existing condition.
Patients receiving long-term treatment with NIRORAB D TABLET should be kept on regular surveillance to rule out the risk of hypomagnesaemia (decreased magnesium levels in blood) and bone fracture, predominantly in the elderly patients and in patients with other recognized risk factors. Before taking NIRORAB D TABLET inform your doctor if you have any liver, kidney or heart problems. Your doctor may reduce the dose or suggest an alternative therapy.
NIRORAB D TABLET is not recommended for use in pregnant or breastfeeding women and in children (aged less than 18 years). It should be used with caution in elderly patients (above 65 years of age).
The most common side effects of taking NIRORAB D TABLET are nausea, vomiting, stomach pain, diarrhea or constipation. Consult your doctor if any of these symptoms worsen.
NIRORAB D TABLET reduces stomach ulcers and acid reflux, where rabeprazole acts by inhibiting the secretions of stomach acid and domperidone acts by increasing bowel movements and facilitating gastric emptying, thus leading to rapid symptom relief and healing of stomach ulcers and esophageal lesions.
Take NIRORAB D TABLET as advised by your physician. Swallow NIRORAB D TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Stop taking NIRORAB D TABLET and contact your doctor immediately if you experience the following side effects:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. Consult your doctor if the symptom did not improve.
Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.
NIRORAB D TABLET is not recommended for use during pregnancy. Consult your doctor before taking NIRORAB D TABLET.
NIRORAB D TABLET is not recommended for use in breast-feeding women. Consult your doctor before taking NIRORAB D TABLET.
Do not drive or operate any machines if you experience sleepiness, confusion or less control over your movements. Consult your doctor before taking NIRORAB D TABLET.
Avoid consumption of alcohol while taking NIRORAB D TABLET, as it could aggravate your existing condition.
NIRORAB D TABLET is not recommended for use in patients with kidney impairment. Consult your doctor before taking NIRORAB D TABLET.
NIRORAB D TABLET is not recommended for use in patients with moderate or severe liver impairment and it should be used with caution in patients with liver problems. Consult your doctor before taking NIRORAB D TABLET.
Do not take NIRORAB D TABLET if you are allergic to Domperidone or Rabeprazole.
NIRORAB D TABLET is not recommended for use in patients with heart problems such as prolongation of QT interval or congestive heart failure. Consult your doctor before taking NIRORAB D TABLET.
NIRORAB D TABLET is not recommended for use if you:
Before taking NIRORAB D TABLET, inform your physician if you:
Use in pediatrics:
NIRORAB D TABLET is not recommended for use in children and adolescents (aged less than 18 years) due to lack of safety and effectiveness. Consult your doctor for advice.
Use in geriatrics:
NIRORAB D TABLET should be taken with caution in elderly patients (aged 65 years or above). Consult your doctor before taking NIRORAB D TABLET.
A. Drug-Drug interactions:
Before taking NIRORAB D TABLET inform to your doctor, if you are taking any of these medicines:
If you or anyone else take too much of NIRORAB D TABLET, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of NIRORAB D TABLET might include altered consciousness, agitation, convulsions, disorientation, sleepiness, and extrapyramidal reactions (such as rigidity, tremor, drooling etc.).
|Pharmacological Category||:||Dopamine antagonist, Proton pump inhibitor|
|Therapeutic Indication||:||Peptic ulcer, GERD|
|Dosage Forms||:||Tablet, Capsule|
Can NIRORAB D TABLET cause diarrhea?
Yes. NIRORAB D TABLET can cause diarrhea in some individuals. Keep yourself hydrated by drinking plenty of fluids, oral electrolytes and juices. Do not self-treat diarrhea if it persists for a longer period. Contact your doctor for advice.
Can NIRORAB D TABLET cause acid reflux?
No. NIRORAB D TABLET is used to treat Gastro-Esophageal Reflux Disease (GERD) and does not cause acid reflux. If you experience any unusual symptoms after taking NIRORAB D TABLET, kindly consult your doctor.
Can NIRORAB D TABLET cause kidney damage?
NIRORAB D TABLET may rarely cause damage to your kidneys (Ex. interstitial nephritis). However, inform your doctor immediately if you experience any signs of kidney damage such as dark urine, blood in urine, painful urination or lower abdominal discomfort during treatment with NIRORAB D TABLET. Your doctor might reduce the dose or suggest an alternative therapy.
When and how should I take NIRORAB D TABLET?
Take NIRORAB D TABLET on an empty stomach or as advised by your physician. Swallow the medicine as a whole and do not crush or chew the medicine. Your doctor will decide the correct dose of NIRORAB D TABLET and duration of therapy for you, depending upon your age, body weight and health condition.
Can NIRORAB D TABLET be used in children?
No. NIRORAB D TABLET is not recommended for use in children and adolescents (below 18 years) due to lack of safety and effectiveness. Kindly consult child’s doctor if your child experiences any symptoms of gastro-esophageal reflux disease or peptic ulcer (such as nausea, vomiting, discomfort in upper stomach, stomach pain, heartburn, burping, etc.).
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2. Keith A. Sharkey and John L. Wallace. Treatment of disorders of bowel motility and water flux; Antiemetics; Agents used in biliary and pancreatic disease and Pharmacotherapy of gastric acidity, peptic ulcer and gastroesophageal reflux disease. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1326 & 1317-1320
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4. Janssen Research & Development, LLC. A Pharmacokinetics, Pharmacodynamics and Safety Study of Rabeprazole in Newborn Infants with Gastroesophageal Reflux Disease (GERD). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in April 2013] [Accessed on 1st October 2021] https://clinicaltrials.gov/ct2/show/NCT00855361
5. Savita Shahani, Prabha Sawant, Pareen Dabholkar. Rabeprazole plus domperidone: the answer for gastro-esophageal reflux disease. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. April 2008. [Accessed on 1st October 2021] https://pubmed.ncbi.nlm.nih.gov/18828350/
6. K Semmanaselvan, Qayum I Mukaddam, Manoj Naik. An Open Label, Prospective, Single Centre Study to Evaluate the Efficacy and Safety of Fixed Dose Combination of Rabeprazole (Enteric-Coated, EC) 20 mg + Domperidone (Sustained Release, SR) 30 mg Capsule in Treatment of Patients with Laryngopharyngeal Reflux Disease. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. July 2015. [Accessed on 1st October 2021] https://pubmed.ncbi.nlm.nih.gov/26731824/
7. Cipla Ltd. Rabicip D Capsules (Rabeprazole sodium + Domperidone). Ciplamed.com. [Revised in January 2020] [Accessed on 1st October 2021] https://www.ciplamed.com/content/rabicip-d-capsules
Domperidone+Rabeprazole Tablet : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
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