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INTRODUCTION
NIMEGESIC IR contain Nimesulide which belongs to a group of medicine called non-steroidal anti-inflammatory drug (NSAID). It is used to treat acute pain and period pains. It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).
NIMEGESIC IR can be taken after food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine. This medicine is strictly not recommended for use in children under 12 years. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine. The common side effects are ulcers of the stomach and upper part of the small bowels (peptic/gastroduodenal ulcers), hole in the wall of the bowels (perforation) or bleeding of the digestive tract, diarrhoea, sickness, vomiting, minor changes in blood tests for liver function.
USES OF NIMEGESIC IR
- Treat acute pain and period pains
HOW NIMEGESIC IR WORKS
NIMEGESIC IR works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).
DIRECTIONS FOR USE
Always take NIMEGESIC IR exactly as your doctor has told you. It can be taken after food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.
SIDE EFFECTS OF NIMEGESIC IR
SERIOUS
- stomach discomfort or pain, loss of appetite, nausea, bleeding from your stomach or bowel or passing black motions
- skin disorders such as rash or redness
- wheezing or shortness of breath
- yellowing of your skin or the whites of your eyes (jaundice)
- unexpected change in the amount or colour of urine
- swelling of your face, feet, or legs
- persistent tiredness
COMMON
- ulcers of the stomach and upper part of the small bowels (peptic/gastroduodenal ulcers)
- hole in the wall of the bowels (perforation) or bleeding of the digestive tract
- diarrhoea, sickness, vomiting, minor changes in blood tests for liver function
RARE
- anaemia
- decrease in white cells in the blood, increase in certain white cells (eosinophils) in the blood
- changes in blood pressure
- bleeding
- discomfort passing urine or stoppage of urine, blood in the urine
- increase in potassium in the blood
- feelings of anxiety or nervousness
- nightmares
- blurring of vision
- increased pulse rate
- skin flushing
- redness of the skin
- skin inflammation (dermatitis)
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without talking to a doctor.
Nausea and vomiting:
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Stomach pain:
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Applying heat pad or covered hot water bottle on your stomach. If still pain persists, speak to your doctor.
WARNING & PRECAUTIONS
PREGNANCY
NIMEGESIC IR is not recommended for use in pregnant women unless necessary (last 3 months of pregnancy). Discuss the risks and benefits with your doctor.
BREASTFEEDING
NIMEGESIC IR is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate any machine while taking this medicine as it may cause dizziness or sleepiness.
ALCOHOL
Consumption of alcohol is not recommended during treatment with NIMEGESIC IR.
KIDNEY
NIMEGESIC IR is not recommended in patients with active kidney diseases. Before taking, discuss the risks and benefits with your doctor.
LIVER
NIMEGESIC IR is not recommended in patients with active liver diseases. Before taking, discuss the risks and benefits with your doctor.
ALLERGY
Do not take NIMEGESIC IR if you are allergic (hypersensitive) to nimesulide or any other ingredients in this medicine.
LUNGS
NIMEGESIC IR is not recommended in patients with active lung diseases (wheezing, chest tightness, breathlessness (asthma). Before taking, discuss the risks and benefits with your doctor.
HEART DISEASE
NIMEGESIC IR is not recommended in patients with active heart diseases. Before taking, discuss the risks and benefits with your doctor.
OTHERS
Tell your doctor if you have or had a condition such as,
- have had nasal blockage due to swellings in the lining in your nose (nasal polyps)
- have had skin rashes / nettles rash (urticaria)
- have had sudden skin or mucosal swelling, such as swelling around the eyes, face, lips, mouth, or throat, possibly making breathing difficult (angioneurotic oedema)
- recent or history of stomach or intestinal ulcers or bleeding (ulceration or bleeding occurring at least twice), holes (perforations) in your stomach or intestines
- have had bleeding into the brain (a stroke)
- have any other problem with bleeding or any problems due to your blood not clotting
- are taking drugs of addiction, or have developed a habit that makes you dependent on drugs or other substances
- are suffering from fever or flu (feeling generally achy, unwell, chills or shivering or have a temperature)
- have high blood pressure, diabetes, or high cholesterol or are a smoker
- bleeding (causing tar-coloured stools) or ulceration of your digestive tract (causing abdominal pain)
- have ever suffered from peptic ulcers
- bleeding from the stomach or bowel, or from inflammatory conditions of the bowel such as ulcerative colitis or Crohn’s disease
- are elderly
- have an intolerance to some sugars
INTERACTIONS
Talk to your doctor if you are taking,
- corticosteroids (used in the treatment of inflammatory conditions)
- anti-coagulants such as warfarin, or antiplatelet agents, aspirin, or other salicylates (used for thin the blood)
- antihypertensives or diuretics (used to control blood pressure or heart conditions)
- lithium, selective serotonin reuptake inhibitors (used to treat depression and similar conditions)
- methotrexate (used for the treatment of rheumatoid arthritis and cancer)
- cyclosporin (used after transplantation or for the treatment of immune system disorders)
SYNOPSIS
| Drug | : | Nimesulide |
| Pharmacological Category | : | Non-steroidal anti-inflammatory drugs |
| Therapeutic Indication | : | Acute pain and period pains |
| Dosage Forms | : | Tablet, capsule, Injection, Oral drops, Gel, Suspension |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT NIMEGESIC IR
Is NIMEGESIC IR an antibiotic?
No, it is not an antibiotic. It belongs to a group of medicine called non-steroidal anti-inflammatory drug (NSAID).
Can I take NIMEGESIC IR for headache?
It can be taken for a headache only when advised by your doctor.
Does NIMEGESIC IR contain sulphur?
No, it does not contain sulphur.
REFERENCES
1. KD Tripathi. Nonsteroidal Antiinflammatory Drugs and Antipyretic-Analgesics. Essentials of Medical Pharmacology. Seventh Edition, 2013. Page - 203-204.
2. H G Kress 1, A Baltov 2, A Basinski 3, F Berghea 4, J Castellsague 5, C Codreanu 6, E Copaciu 7, M A Giamberardino 8, M Hakl 9, L Hrazdira 10, M Kokavec 11, J Lejcko 12, L Nachtnebl 13, R Stancík 14, A Švec 15, T Tóth 16, M V Vlaskovska 17, J Woron 18. Acute pain: a multifaceted challenge - the role of nimesulide. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. 2016. [Accessed 27 Jan 2021] https://pubmed.ncbi.nlm.nih.gov/26414386/
3. Helsinn Birex Pharmaceuticals Ltd; Electronic Medicines Compendium (EMC); [Revised on Dec 2017] [Accessed 27 Jan 2021] https://mri.cts-mrp.eu/human/downloads/IT_H_0150_001_FinalPI.pdf
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
PRODUCT DETAILS
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