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Nifutin Tablet 10'S
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INTRODUCTION
NIFUTIN TABLET contains Nitrofurantoin which belongs to the group of medicines called Antibiotics. It is used in the treatment and prevention of urinary tract infections. It is an infection that occurs in any part of the urinary system including bladder, kidneys, ureters and urethra. It causes symptoms such as strong, continuous urge to urinate, burning sensation while urinating, decreased flow in urine, cloudy appearance of urine, blood in urine and pain in pelvic region, especially seen among women.
Your doctor will regularly test to know how your lungs and liver are working. NIFUTIN TABLET may also interfere with urine tests for sugar, resulting in a false positive result.
NIFUTIN TABLET should be taken with caution in patients with lung or liver disease, anaemia, diabetes (high blood sugar), any illness causing severe weakness, electrolyte imbalance and vitamin B deficiency and recommended for use in patients with severe kidney disease.
NIFUTIN TABLET is not recommended for use in pregnant women at the stage of labour or delivery because of the possibility that use at this stage may harm the baby and should be used with caution in breast-feeding women.
This medicine is avoided for use in infants below 3 months of age. NIFUTIN TABLET should be used with caution in elderly patients.
The most common side effects of taking NIFUTIN TABLET are nausea, vomiting, loss of appetite and diarrhoea. Talk to your doctor if any of the side effects gets worsen.
USES OF NIFUTIN TABLET
- Prevents and treat infections of the bladder, kidney and other parts of the urinary tract
HOW NIFUTIN TABLET WORKS
NIFUTIN TABLET effectively treats and prevents urinary tract infection by killing bacteria present in the urethra, bladder, and/or kidneys. It mainly acts through disrupting the production of genetic material present in the bacterial cell.
DIRECTIONS FOR USE
Take NIFUTIN TABLET as advised by your physician. Swallow NIFUTIN TABLET with a glass of water and do not crush or chew it. Your doctor will decide the correct dose for you depending upon your age, body weight and the severity of infection. NIFUTIN TABLET should always be taken with food or milk for effective working and to avoid stomach upset.
SIDE EFFECTS OF NIFUTIN TABLET
COMMON
- nausea
- vomiting
- loss of appetite
- diarrhoea
UNCOMMON
- acute pulmonary reaction syndrome (sudden onset of fever, chills, cough, body pain, and shortness of breath)
- sub-acute pulmonary reactions (persistent dry cough, shortness of breath and fever)
- chronic pulmonary reaction (gradual onset of persistent dry cough and shortness of breath)
RARE
- loss of consciousness (collapse)
- anemia (fatigue, skin pallor, shortness of breath, dizziness or fast heartbeat due to damage to bone marrow causing deficiency of the red blood cells)
- signs of liver failure which may be fatal (yellow coloured skin and eyes along with stomach pain and swelling)
Stop taking NIFUTIN TABLET and consult your doctor immediately if you experience any of the following side effects:
- any sudden wheeziness, difficulty in breathing, swelling of the eyelids, face or lips, rash or itching that affects your whole body
- fever, chills, cough and shortness of breath (reaction of lung with the medicine within a week or very slowly, mainly in elderly patients)
- yellowing of the skin or whites of the eyes (inflammation of the liver causing jaundice)
- changes in the sense of feeling and using muscles along with headache, extreme mood changes, confusion, weakness, blurred vision (due to affected nerves outside the spinal cord), which may be severe and permanent in some cases
- severe headaches (raised pressure in the skull)
- severe reduction in blood cells which results in weakness, bruising or more instance of infections
- blue or purple coloration of the skin (cyanosis causing low oxygen levels in the blood)
- signs of cutaneous vasculitis (fever, flu, abdominal pain, diarrhoea, blood in your stool, skin lesions and weakness)
- signs of autoimmune hepatitis (jaundice, fatigue, abdominal pain, joint pain and swelling)
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drink lots of fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If the symptom does not improve, contact your doctor.
Loss Of Appetite
Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only when you're hungry. Eat a nutritious snack which is rich in calories and protein such as dried fruit and nuts.
Nausea And Vomiting
Take NIFUTIN TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. If the symptom does not improve, contact your doctor.
WARNING & PRECAUTIONS
PREGNANCY
Consult your doctorNIFUTIN TABLET is not recommended for use during labour or delivery because of the possibility that use at this stage may harm the baby. It can be used with caution in pregnant women or are planning to have a baby. However, consult your doctor before taking NIFUTIN TABLET.
BREASTFEEDING
Consult your doctorNIFUTIN TABLET should be used with caution for breastfeeding women and should be avoided particularly for infant with known or suspected with erythrocyte enzyme deficiency (including G6PD deficiency) as it may pass through the breast milk. Consult your doctor before taking NIFUTIN TABLET.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel dizzy or drowsy after taking NIFUTIN TABLET.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking NIFUTIN TABLET because it might make you dizzier.
KIDNEY
Consult your doctorNIFUTIN TABLET is not recommended for use in patients with kidney disease that severely affects the function of kidneys. It should be used with caution in patients with kidney problems. Consult your doctor before taking NIFUTIN TABLET.
LIVER
Use with CautionNIFUTIN TABLET should be taken with caution in patients with liver disease. Consult your doctor before taking NIFUTIN TABLET.
ALLERGY
ContraindicatedDo not take NIFUTIN TABLET if you are allergic to nitrofurantoin.
LUNGS
Use with CautionNIFUTIN TABLET should be taken with caution in patients with lung disease. Consult your doctor before taking NIFUTIN TABLET.
USE IN PEDIATRICS
Consult your doctorNIFUTIN TABLET should be used with caution in children (under 6 years of age) and infants above 3 months of age. It is not recommended for infants below three months of age. However, consult your child’s doctor for advice.
USE IN GERIATRICS
Use with CautionNIFUTIN TABLET should be used with caution in elderly patients. Consult your doctor before taking NIFUTIN TABLET.
OTHERS
NIFUTIN TABLET is not recommended for use if you:
- are suffering from a blood disorder called porphyria (build-up of certain chemicals related to red blood cell that affects skin and nerve function)
- are deficient in an enzyme called g6pd (glucose-6-phosphate dehydrogenase) that causes in abdomen or back pain, fatigue, dark urine, pallor, or yellow skin and eyes
Before taking NIFUTIN TABLET, inform your doctor if you:
- have diabetes (high blood sugar)
- have anaemia (a decrease in red blood cells that causes pale skin, weakness and breathlessness)
- are suffering from any illness causing severe weakness
- lack of vitamin B (especially that results in fatigue, mouth sores, diarrhoea, and depression)
- have abnormal electrolyte levels in your blood
INTERACTIONS
A. Drug-Drug interactions:
Before taking NIFUTIN TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used in the treatment of indigestion (such as antacids like magnesium trisilicate)
- medicines used to treat gout (Ex. probenecid or sulfinpyrazone)
- medicines which slow the passage of food through the stomach (Ex. atropine, hyoscine)
- medicines used to treat raised pressure in the eye known as glaucoma (such as carbonic anhydrase inhibitors Ex. acetazolamide)
- medicines which makes the urine less acidic (Ex. potassium citrate mixture)
- medicines used in the treatment of bacterial infections (Ex. ciprofloxacin, levofloxacin, moxifloxacin, gemifloxacin, besifloxacin)
- oral contraceptive such as ethinyl estradiol (medicine used in the prevention of pregnancy)
- typhoid vaccine (medicine given for the prevention of typhoid)
Overdosage:
If you or anyone else accidentally takes too much of NIFUTIN TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastric irritation, nausea and vomiting.
SYNOPSIS
| Drug | : | Nitrofurantoin |
| Pharmacological Category | : | Antibiotic |
| Therapeutic Indication | : | Urinary tract infections |
| Dosage Forms | : | Capsule, Tablet |
MORE INFORMATION
- Keep NIFUTIN TABLET out of reach of children
- Store at room temperature
FAQs ABOUT NIFUTIN TABLET
Q: What happens if you don't take NIFUTIN TABLET with food?
A: You should always take NIFUTIN TABLET along with food or milk. Taking this medicine along with food or milk makes it work more effectively against urinary tract infections. This will also prevent stomach upset and help the absorption.
Q: What to do if I forget to take NIFUTIN TABLET?
A: If you forget to take NIFUTIN TABLET, don’t panic. If you remember later, take that day’s dose as usual. If you miss a whole day’s dose, then take normal dose on the next day. Do not ever take a double dose to make up for the forgotten dose. If you are not sure, consult your doctor immediately.
Q: Does NIFUTIN TABLET work for other infections?
A: No, NIFUTIN TABLET belongs to a class of medication called antibiotics, which works by killing bacteria. This medicine is mainly used in the treatment of urinary tract infections. It does not work for cold, flu and other viral infections.
Q: How long does it take for NIFUTIN TABLET to work?
A: NIFUTIN TABLET should start working within three to five days, although it may take up to a week for symptoms of urinary tract infections to clear. Be sure to complete the full course of medication. That is the only way to ensure the infection is completely gone.
Q: Can NIFUTIN TABLET be used in infants?
A: Yes, NIFUTIN TABLET is generally used in children (under 6 years) and infants above 3 months of age. It is not recommended for infants below three months. Your child’s doctor will decide the correct dose or select a suitable alternative therapy for your child.
REFERENCES
1. KD. Tripathi. Antibiotics. Essentials of medical pharmacology. Eighth edition. 2019. Page – 735,736.
2. Squadrito FJ, del Portal D. Nitrofurantoin. NIH National Library of Medicine, National center for biotechnology information. July 2021 [Accessed on 10th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK470526/
3. Angela Huttner, Els M. Verhaegh, Stephan Harbarth, Anouk E. Muller, Ursula Theuretzbacher, Johan W. Mouton, Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials, Journal of Antimicrobial Chemotherapy. [Accessed on 10th May 2022] https://doi.org/10.1093/jac/dkv147
4. Meiji Pharma Spain. Health Products Regulatory Authority (HPRA) [Revised in May 2021] [Accessed on 10th May 2022] https://www.hpra.ie/img/uploaded/swedocuments/3a92db31-ada9-46ed-abc6-f4c67161c564.pdf
5. Asis Pharmaceuticals. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 10th May 2022] https://www.medicines.org.uk/emc/files/pil.13236.pdf
USEFUL DIAGNOSTIC TESTS
- Urine analysis
- Urine culture test
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 16 Mar 2023 | 10:53 AM(IST)
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