NICOMALOM 1 Tablet 30's

INTRODUCTION

NICOMALOM 1 contains Nicoumalone (Acenocoumarol) which belongs to a group of medicines called anticoagulants (blood thinning medicines). Blood clots are clumps that occur when blood hardens from a liquid to a solid. A blood clot that forms inside one of your veins or arteries is called a thrombus. It acts as anticoagulant by reducing the effects of vitamin k (a vitamin your body uses to make blood-clotting factors) and reducing the blood concentration of prothrombin. It works by preventing the formation of blood clots. This medicine is used to treat and prevent blood clots. It does not dissolve the existing blood clots, but it inhibits them from growing larger and causing serious problems.

Take this medicine according to the dose and frequency as advised by your doctor. Swallow it as a whole. Before taking this medicine, tell your doctor if you are suffering from kidney or liver disease and about all the other medications that you are taking regularly, pregnant or breastfeeding. Consumption of alcohol is not recommended during treatment with NICOMALOM 1. The common side effects of this medicine are bleeding, dizziness or weakness.

USES OF NICOMALOM 1

• Treat and prevent blood clots

HOW NICOMALOM 1 WORKS

NICOMALOM 1 acts as anticoagulant by reducing the effects of vitamin k (a vitamin your body uses to make blood-clotting factors) and reducing the blood concentration of prothrombin.

DIRECTIONS FOR USE

Take this medicine according to the dose and frequency as advised by your doctor. Swallow it as a whole. Do not chew, crush or break the medicine. It may be taken with or without food.

SIDE EFFECTS OF NICOMALOM 1

HOW TO MANAGE SIDE EFFECTS

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Drowsiness or dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:

• warfarin, phenprocoumon
• heparin
• clindamycin, erythromycin, tetracycline, neomycin, chloramphenicol
• acetyl salicylic acid, aminosalicylic acid, diflunisal
• dipyridamole, clopidogrel, ticlopidine
• sulfinpyrazone
• cimetidine
• dextrothyroxine
• oral contraceptives
• celecoxib, methylprednisolone
• glibenclamide or glimepiride
• phenytoin
• amiodarone, quinidine

SYNOPSIS

MORE INFORMATION

Store at room temperature 15-25°C and keep out of reach of children.

FAQs ABOUT NICOMALOM 1

How long do I need to take NICOMALOM 1?

You should continue taking this medicine as long as recommended by your doctor.

What monitoring is required while taking NICOMALOM 1?

The bleeding times should be carefully monitored.

How long does it take for NICOMALOM 1 to start working?

It takes a little longer for to start working. On an average, it may take 3-4 days for this medicine to show its blood thinning effect.

REFERENCES

1. Weitz JI. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 865-871.

2. KD Tripathi MD. Drugs affecting blood and blood formation. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page - 622.

3. Norgine Pharmaceuticals Limited, Electronic Medicines Compendium (EMC); [Revised July 2020] [Accessed Oct 12, 2020] https://www.medicines.org.uk/emc/files/pil.2058.pdf

4. Paladin Labs Inc. May 22, 2009 [Accessed Oct 12, 2020] https://www.paladin-labs.com/our_products/Sintrom_en.pdf

5. Abbott Healthcare Pvt. Ltd. July 30, 2018; [Accessed Oct 12, 2020] https://www.acitrom.com/api.html

6. Fiore R. Rullo, Carl C. Bartels and James A. Evans. Clinical evaluation of Acenocoumarol (sintrom), an anticoagulant of intermediate range, Oct 11, 1958 [Accessed Oct 12, 2020] https://jamanetwork.com/journals/jama/article-abstract/324706