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INTRODUCTION
NEPATOP contains Nepafenac which belongs to a group of medicines known as nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to prevent and relieve eye pain and inflammation and reduces the risk of macular oedema following cataract surgery on the eye in diabetic patients.
Use this medicine exactly as prescribed by your doctor. The dose you use will depend on your age, other medications you are taking and whether you have any kidney or liver problems. This medicine is not recommended for use in children and adolescents below 18 years of age and pregnant women. The common side effects are nausea, vomiting, headache and dizziness. Consult your doctor for advice. Avoid driving or handling of machines while using this medicine, since it may cause blurred vision. Avoid sunlight during using this medicine.
USES OF NEPATOP
- Treat pain and inflammation associated with cataract surgery
- Reduces risk of macular oedema following cataract surgery
HOW NEPATOP WORKS
NEPATOP is a non-steroidal anti-inflammatory and analgesic prodrug. After instillation, it penetrates the cornea and is converted by ocular tissue hydrolases to amfenac, a nonsteroidal anti- inflammatory drug. Amfenac inhibit the synthesis of prostaglandins in the iris, ciliary body, and conjunctiva and thus, prevent ocular inflammation and reduce pain.
DIRECTIONS FOR USE
Use this medicine according to the dose and frequency as advised by your doctor. It is for external use only. Check the label for directions before use. Only use this medicine for your eyes. Do not swallow or inject.
SIDE EFFECTS OF NEPATOP
SERIOUS
- inflammation on the eye surface and coloured part of the eye (iritis)
RARE
- iris inflammation, eye pain,
- eye discomfort, dry eye, eyelid swelling, irritation, discharge
- allergic conjunctivitis (eye allergy)
- increases tear production, deposits on the eye surface, fluid or swelling at the back of the eye
- dizziness, headache
- nausea
- skin inflammation
HOW TO MANAGE SIDE EFFECTS
Redness of eye:
Place a cool compress over the eyes, by soaking clean cloth in warm or cold water and then squeezing it out.
Headache:
Rest and drink plenty of fluids. Ask your doctor to recommend a painkiller.
Nausea:
Stick to simple normal meals and do not eat rich or spicy foods.
Eye irritation:
Wash your eyes with preservative-free saline water or apply a cold, wet washcloth. Don't rub your eyes often.
WARNING & PRECAUTIONS
PREGNANCY
NEPATOP is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
NEPATOP is safe to use during breastfeeding. Consult your doctor before using this medicine.
DRIVING AND USING MACHINES
Do not drive or handle any machines while using this medicine as it may cause blurred vision.
ALLERGY
Do not use if you are allergic (hypersensitive) to Nepafenac.
OTHERS
Inform your doctor, if you have or had:
- asthma
- skin allergy
- inflammation in nose when using other NSAIDs
- bleeding problems
- diabetes
- rheumatoid arthritis
- eye disorders or surgery
- wear contact lens
INTERACTIONS
Inform your doctor if you are using or have recently taken any other medicines, including medicines obtained without a prescription.
- warfarin (used to reduce blood clotting)
- other NSAIDs medicines
SYNOPSIS
| Drug | : | Nepafenac |
| Pharmacological Category | : | Nonsteroidal Anti-inflammatory Drug (NSAID) |
| Therapeutic Indication | : | Ocular pain and inflammation associated with cataract surgery |
| Dosage Forms | : | Eye drops |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT NEPATOP
What is NEPATOP used for?
It is used to prevent and treat redness, pain and swelling that occurs after cataract surgery and to reduce the risk of postoperative macular edema (swelling of a layer present at the back of the eye) associated with cataract surgery in diabetic patients.
How long can I use NEPATOP?
It is usually used for up to 14 days after eye surgery or as directed by your doctor. Do not start using this medication without consulting doctor.
Do NEPATOP cause blurred vision?
Yes, it may cause blurred vision which may impair the ability to drive or use machinery. Avoid driving or using machines until this symptom have been subsided.
REFERENCES
1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 970.
2. Jeffrey D. Henderer and Christopher J Rapuno. Ocular pharmacology. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 1789.
3. M Nardi, C Lobo, A Bereczki, J Cano, E Zagato, S Potts, G Sullins, and R Notivol. Analgesic and anti-inflammatory effectiveness of nepafenac 0.1% for cataract surgery: Clinical ophthalmology, Dec 2007; [Accessed Nov 23, 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704522/
4. Novartis Pharmaceuticals UK Ltd. Electronic Medicines Compendium (EMC); [Revised on Aug 2020] [Accessed Nov 23, 2020] https://www.medicines.org.uk/emc/files/pil.6549.pdf
5. Alcon laboratories, Inc. 2005, U.S. Food & Drug Administration, [Revised on June 2011] [Accessed Nov 23, 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021862s008lbl.pdf
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