NEOVEC COMBIPACK Injection 5's

Muscle Cramps/Spasticity Rx required
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Best Price* ₹ 450.90 MRP ₹ 501.00
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INTRODUCTION

NEOVEC COMBIPACK contains Vecuronium which belongs to the group of medicines called Skeletal muscle relaxants. It relaxes your muscles and keeps your body still during a surgery. It can also be used during endotracheal intubation (a tube is placed into the windpipe to open airways) and during an operation as part of general anesthesia. NEOVEC COMBIPACK can be used both in adults and in children (including newborns).

Before receiving NEOVEC COMBIPACK inform your doctor if you have any lung, liver, kidney, or heart problems. You must also inform your doctor if you have any nerve or muscle disorders, electrolyte imbalance or if you are severely dehydrated.

NEOVEC COMBIPACK should be used in pregnant or breastfeeding women only if it is considered necessary by the physician. However, it may be used during a caesarean section in pregnant women under close supervision.

NEOVEC COMBIPACK may cause difficulty in breathing which is due to relaxation of muscle involved in breathing. In such cases, your doctor might provide you with additional ventilation support until the effect of NEOVEC COMBIPACK wears off.

Other most common side effects of receiving NEOVEC COMBIPACK are pain or irritation at the site of injection, muscle weakness, dizziness, and low blood pressure. Inform your doctor if any of these symptoms worsen.

USES OF NEOVEC COMBIPACK

It is used in adults and in children (aged 0-18 years including newborns) to:

  • relax muscles prior to a surgical procedure
  • easily fix flexible plastic tube into the trachea during endotracheal intubation

HOW NEOVEC COMBIPACK WORKS

NEOVEC COMBIPACK is a muscle relaxant. It works by blocking the transmission of nerve signals from the nerve fibers to the muscles. As a result, it causes muscle relaxation and help you stay still during surgeries. NEOVEC COMBIPACK can also relax the muscles involved in breathing which facilitates easy fix of flexible plastic tube into the trachea during endotracheal intubation.

DIRECTIONS FOR USE

NEOVEC COMBIPACK will be given to you only by a doctor or a nurse into the vein (intravenously).  under close monitoring. Your doctor will decide the correct dose for you depending upon your age, body weight and health condition.

SIDE EFFECTS OF NEOVEC COMBIPACK

COMMON

  • difficulty in breathing
  • muscle weakness or paralysis
  • dizziness
  • flushing
  • pain or irritation at the site of injection
  • redness or itchy rashes of the skin

UNCOMMON

  • altered effects (too effective or not effective enough)
  • low blood pressure
  • increased heart rate
  • delay in recovery from the anesthetic effect

RARE

  • bronchospasm (tightness of airway muscles)

Contact your doctor immediately if you experience any of the following side effects after receiving NEOVEC COMBIPACK:

  • severe allergic reactions (such as skin rash, severe itching of the skin with raised lumps, blisters in the skin, swelling of the face, lips, tongue and/or throat with difficulty in breathing or swallowing)
  • high fever, rigid muscle, rapid heart rate
  • muscle weakness or paralysis
  • dizziness, light-headedness or low blood pressure, fainting
  • breathing difficulty, wheezing, or coughing

HOW TO MANAGE SIDE EFFECTS

Pain and Irritation at the site of injection:

Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor.

Dizziness:

Avoid standing or walking after surgery. Try to rest and relax. Get enough sleep. Consult your doctor if you continue to feel dizzy for a prolonged period.

WARNING & PRECAUTIONS

PREGNANCY

NEOVEC COMBIPACK should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor if you are pregnant or think you may be pregnant before receiving NEOVEC COMBIPACK. However, NEOVEC COMBIPACK can be used during a caesarean section in pregnant women under close medical supervision.

BREASTFEEDING

NEOVEC COMBIPACK should be used in breastfeeding women only if it is considered necessary by the physician. Therefore, inform your doctor before receiving it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel tired, weak, or dizzy after receiving NEOVEC COMBIPACK.

KIDNEY

NEOVEC COMBIPACK should be used with caution in patients with kidney problems. Therefore, inform your doctor before receiving it.

LIVER

NEOVEC COMBIPACK should be used with caution in patients having problems with their liver or gall bladder. Therefore, inform your doctor before receiving it.

ALLERGY

Do not receive NEOVEC COMBIPACK if you are allergic to Vecuronium or any other muscle relaxants (such as pancuronium).

LUNGS

NEOVEC COMBIPACK should be used with caution in patients with lung or respiratory problems. Therefore, inform your doctor before receiving it.

HEART DISEASE

NEOVEC COMBIPACK should be used with caution in patients with heart problems. Therefore, inform your doctor before receiving it.

OTHERS

Before receiving NEOVEC COMBIPACK inform your physician if you:

  • have problems in blood circulation
  • have edema (swelling of body parts)
  • have nerve or muscle disorder (such as myasthenia gravis, poliomyelitis, Eaton-Lambert syndrome etc.)
  • have low potassium or calcium levels in the blood
  • have high magnesium levels in the blood
  • are dehydrated (due to vomiting or diarrhea)
  • have increased carbon dioxide in the blood (alkalosis)
  • have increased acid level in the blood (acidosis)
  • are obese or overweight
  • have cachexia (muscle loss from the body)
  • have drop in body temperature during anesthesia
  • have burns

Use in pediatrics:

NEOVEC COMBIPACK should be used in infants, children, and in adolescents (aged between 0-18 years) under close medical supervision.

Use in geriatrics:

NEOVEC COMBIPACK should be used with caution in elderly patients. Therefore, consult your doctor for advice before receiving it.

INTERACTIONS

A. Drug-Drug interactions:

Before receiving NEOVEC COMBIPACK inform your doctor if you are taking any of the following medicines:

  • lithium (a medicine used to treat bipolar disorder)
  • quinidine (a medicine used to treat irregular heartbeat)
  • quinine (a medicine used to treat malaria)
  • betamethasone, prednisone, prednisolone, triamcinolone, methylprednisolone (used to treat inflammation in the body)
  • thiopental (a medicine used to treat convulsion)
  • magnesium salts (used to treat low magnesium levels in the blood)
  • lignocaine (a medicine used to cause temporary numbness of a confined area)
  • succinylcholine, suxamethonium, pancuronium, d-tubocurarine, metocurine, and gallamine (used to relax muscles)
  • neomycin, streptomycin, kanamycin, gentamicin, lincosamide and polypeptide antibiotics, acylamino-penicillin antibiotics, and dihydrostreptomycin (used to treat bacterial infection)
  • phenytoin, carbamazepine and thiopental (used to treat fits and seizures)
  • cimetidine (a medicine used to reduce stomach acid production)
  • diuretics (used to improve urine output) Ex. furosemide, chlorothiazide
  • medicines used to treat heart problems (such as atenolol propranolol, amlodipine, nifedipine)
  • calcium chloride and potassium chloride

Overdosage:

NEOVEC COMBIPACK will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

SYNOPSIS

Drug :  

Vecuronium

Pharmacological Category :  

Neuromuscular Blocking Agents

Therapeutic Indication :  

Muscle relaxant

Dosage Forms :  

Injection

MORE INFORMATION

  • Keep NEOVEC COMBIPACK out of reach of children
  • Store NEOVEC COMBIPACK at room temperature

FAQs ABOUT NEOVEC COMBIPACK

What is the use of NEOVEC COMBIPACK?

NEOVEC COMBIPACK is a muscle relaxant used to relax your muscles and keeps your body still during a surgery. It can also be used during endotracheal intubation (a tube is placed into the windpipe) and during an operation as part of general anesthesia. NEOVEC COMBIPACK can be used in adults and in children (including newborns).

What NEOVEC COMBIPACK does to my body?

NEOVEC COMBIPACK is a muscle relaxant. It works by blocking the transmission of nerve signals from the nerve fibers to the muscles. As a result, it causes muscle relaxation and help you stay still during surgeries. NEOVEC COMBIPACK can also relax the muscles involved in breathing which facilitates easy fix of flexible plastic tube into the trachea during endotracheal intubation.

How long does the effects of NEOVEC COMBIPACK lasts long?

NEOVEC COMBIPACK is intermediate acting muscle relaxant with relatively short duration of action. The effects of NEOVEC COMBIPACK may begin to wear off after 10-15 minutes of administration. However, this period may also vary (from 25 min-45 min) depending upon the amount of the medicine that has been administrated to you.

What type of drug is NEOVEC COMBIPACK?

NEOVEC COMBIPACK is a muscle relaxant. It belongs to neuromuscular blocking agents, where it blocks the transmission of nerve signals from the nerve fibers to the muscles.

Why is NEOVEC COMBIPACK used before surgeries?

NEOVEC COMBIPACK is used prior to surgeries to relax your muscles and to make you immobile.

Why is NEOVEC COMBIPACK used along with anesthesia?

NEOVEC COMBIPACK is used along with anesthesia prior to the surgeries to relax your muscles and to make you immobile. It can also relax the muscles involved in breathing which facilitates easy fix of flexible plastic tube into the trachea during endotracheal intubation.

What are the side effects of NEOVEC COMBIPACK?

The most common side effects of receiving NEOVEC COMBIPACK are pain and irritation at the site of injection, muscle weakness, dizziness, low blood pressure and difficulty in breathing. Inform your doctor if any of these symptoms worsen.

Can NEOVEC COMBIPACK be reversed?

Yes. The effect of NEOVEC COMBIPACK reverses on its own and 25% of recovery is expected to occur in 25 to 45 min and 95% of recovery is expected to occur in 45 to 65 min.

Is NEOVEC COMBIPACK an anesthetic drug?

NEOVEC COMBIPACK is a muscle relaxant, used as an adjuvant with anesthetic medicine before undergoing a surgical procedure. It is not an anesthetic.

Will I be staying awake after using NEOVEC COMBIPACK?

NEOVEC COMBIPACK only relaxes your skeletal muscles and does not affect your consciousness. However, it might make you feel dizzy or faint. Moreover, NEOVEC COMBIPACK is used along with anesthetic medication to create numbness before surgery. The anesthesia used along with NEOVEC COMBIPACK might reduce your consciousness.

Is NEOVEC COMBIPACK safe for use in pregnant women?

NEOVEC COMBIPACK should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor if you are pregnant or planning to become pregnant before receiving NEOVEC COMBIPACK. Your doctor will decide the risks and benefits before administrating NEOVEC COMBIPACK to you. However, NEOVEC COMBIPACK can be used during a caesarean section in pregnant women under close supervision.

REFERENCES

1. KD. Tripathi. Drugs act on the peripheral nervous system. Skeletal Muscle Relaxants. Essentials of medical pharmacology. 8th edition. 2019. Page – 379.

2. LS Chaudhari, AN Shetty, M Buddhi, G Krishnan. A comparison of continuous infusion of vecuronium and atracurium in midline and paramedian laparotomies. JPGM. Journal of Postgraduate Medicine. 1999. [Accessed on 6th September 2022] https://jpgmonline.com/article.asp?issn=0022-3859;year=1999;volume=45;issue=1;spage=5;epage=9;aulast=Chaudhari

3. Ranbaxy (UK) Limited a Sun Pharmaceutical Company. Electronic Medicines Compendium (EMC). [Revised in June 2019] [Accessed on 6th September 2022] https://www.medicines.org.uk/emc/files/pil.2619.pdf

4. Merck Sharp & Dohme (Australia) Pty Limited. National Prescribing Service (NPS) Limited. [Revised in September 2014] [Accessed on 6th September 2022] https://www.nps.org.au/assets/medicines/79cf9035-34dc-4e0e-8591-a53300feee8e-reduced.pdf

5. Hospira, Inc. U.S. Food and Drug Administration (FDA). Vecuronium Bromide. [Revised in August 2018] [Accessed on 6th September 2022] https://labeling.pfizer.com/ShowLabeling.aspx?id=4648

6. Ben Venue Laboratories, Inc. U.S. Food and Drug Administration (FDA). Vecuronium Bromide. [Revised in July 2018] [Accessed on 6th September 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/075549s013lbl.pdf

PRODUCT DETAILS

    Net Qty
    1 N
    Ingredient
    VECURONIUM BROMIDE 4 mg
    Hsn Code
    30049099
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