INTRODUCTION

NEBIVIE 2.5MG contains a medicine called nebivolol which belongs to the group of medicines called selective beta-1 adrenergic blocker. It is used to treat hypertension (raised blood pressure) and mild to moderate chronic heart failure in patients aged 70 or over, in addition to other therapies. Nebivolol controls heart pumping strength and prevents increase in heart rate. It also exerts vasodilating effects on blood vessels, which also contributes to reduce blood pressure.

Along with the treatment, certain lifestyle change plays an important role in treating your high blood pressure. Avoid smoking or alcohol consumption while you are on this therapy. Always eat a healthy balanced diet and reduce your salt intake. Try to exercise regularly, when advised by your doctor and manage your stress levels.

The most common side effects of taking this medicine are headache, dizziness, tiredness, nausea, diarrhea or constipation. Do not take this medicine, if you are pregnant, think you may be pregnant or breastfeeding. Consult your doctor for advice. Before taking this medicine, inform your doctor if you have serious heart, liver or kidney problems.

USES OF NEBIVIE 2.5MG

• Treats hypertension
• Treats mild and moderate chronic heart failure in patients aged 70 or over in addition to other therapies

HOW NEBIVIE 2.5MG WORKS

Nebivolol binds to and blocks the activity of beta-1 adrenergic receptors in the heart, and decreases cardiac contractility and heart rate, which reduces cardiac output resulting in low blood pressure. It also suppresses the activity of renin in the kidneys and prevents the activity of aldosterone which promotes vasodilation, decrease in peripheral vascular resistance, increase in stroke volume, ejection fraction and cardiac output that may lead to benefits in heart failure patients.

DIRECTIONS FOR USE

Take this medicine as directed by your physician. It can be taken either with food or on an empty stomach. Your doctor will decide the correct dose for you depending upon your condition. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF NEBIVIE 2.5MG

HOW TO MANAGE SIDE EFFECTS

Feeling sick (nausea):

Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.

Constipation: 

Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.

Diarrhea:

Drink lots of fluids to avoid dehydration. Avoid taking any medicines to treat diarrhea without speaking to a doctor.

Headache:  

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking,

• medicines used to treat high blood pressure or any heart problems (such as amiodarone)
• Anti-psychotic medicines (e.g. barbiturates, phenothiazine and thioridazine)
• medicines used to treat depression (e.g. amitriptyline, paroxetine, fluoxetine)
• medicines used to treat asthma or blocked nose (e.g. fluticasone, mometasone)
• medicines used to treat certain eye disorders such as glaucoma (e.g. latanoprost)
• Anti-ulcer drugs (e.g. cimetidine)
• baclofen (used to treat muscle pain)
• amifostine (used to treat cancer)
• mefloquine (used to treat malaria)

SYNOPSIS

MORE INFORMATION

Store at room temperature and keep out of reach of children.

FAQs ABOUT NEBIVIE 2.5MG

Can NEBIVIE 2.5MG cause diabetes?

No. This medicine has no effect on blood sugar levels and does not cause diabetes. If you experience any unusual side effects after taking this medicine, consult your doctor.

Can NEBIVIE 2.5MG cause shortness of breath?

Yes. This medicine may cause shortness of breath in some individuals. Try to rest and relax. If the symptom worsens, contact your doctor immediately.

How NEBIVIE 2.5MG works?

It is used to treat hypertension (raised blood pressure) and mild to moderate chronic heart failure in patients aged 70 or over, in addition to other therapies. This medicine controls heart pumping strength and prevents increase in heart rate. It also exerts vasodilating effects on blood vessels, which also contributes to reduce blood pressure.

REFERENCES

1. KD Tripathi. Antihypertensive drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 564.

2. Thomas Michel and Brian B. Hoffman. Treatment of myocardial ischemia and hypertension. Goodman & Gilman’s: The pharmacological basics of therapeutics. 12th Edition. New York Mc Graw Hill Medical: 2011. Page 771-772.

3. Forest Laboratories. Nebivolol in Patients with Systolic Stage 2 Hypertension (NEB-MD-20). NIH U.S. National library of medicine Clinical trials.gov. January 2012. [Accessed 27th October 2020] https://clinicaltrials.gov/ct2/show/NCT01057251

4. Justin Fongemie & Erika Felix-Getzik. A Review of Nebivolol Pharmacology and Clinical Evidence. Springer Nature Switzerland AG. July 2015. [Accessed 27th October 2020] https://link.springer.com/article/10.1007/s40265-015-0435-5

5. Glenmark Pharmaceuticals Europe Limited, Glenmark Pharmaceuticals s.r.o., Tillomed Laboratories Limited. Electronic Medicines Compendium (EMC) [Revised on December 2018] [Accessed 27th October 2020] https://www.medicines.org.uk/emc/files/pil.9967.pdf

6. Corden Pharma, Delorbis Pharmaceuticals Ltd; Electronic Medicines Compendium (EMC) [Revised on September 2018] [Accessed 27th October 2020] https://www.medicines.org.uk/emc/files/pil.3313.pdf

7. Balkan pharma. Electronic Medicines Compendium (EMC); [Revised on February 2019] [Accessed 27th October 2020] https://www.medicines.org.uk/emc/files/pil.5828.pdf

USEFUL DIAGNOSTIC TESTS

• Activated Partial Thromboplastin Time
• Complete Blood Count
• Kidney Function Test
• Prothrombin Time