INTRODUCTION

NE 400MG CAPSULE contains Tocopherol Acetate (Vitamin E) which belongs to the group of medicines called Vitamins. NE 400MG CAPSULE is used as a dietary supplement to prevent Vitamin E deficiency and to treat haemolytic anaemia (red blood disorder that occurs due to Vitamin E deficiency), cardiovascular disease & heavy metal poisoning in affected individuals.

The medicine is also used as a dietary supplement to act as an antioxidant (to reduce oxidative stress) and to provide betterment for hair and skin in affected individuals.

NE 400MG CAPSULE is not recommended for use in patients allergic to Vitamin E.

Before taking NE 400MG CAPSULE, inform your doctor if you have bleeding condition/blood clotting disorder, thrombosis (clot inside a blood vessel), gastrointestinal problems (such as pancreatic dysfunction/bile duct disorders), diabetes, kidney, and/or liver problems.

NE 400MG CAPSULE is not recommended for use during pregnancy when used at higher doses. It should be used with caution in pregnant women when indicated for use at recommended doses. It is also not recommended for use in breastfeeding women when used at higher doses and advised to be used with caution in breastfeeding mothers when used at recommended doses.

NE 400MG CAPSULE is generally not recommended for use in children and adolescents (aged below 18 years) unless it is clearly necessary. It is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.

The most common side effects of taking NE 400MG CAPSULE are nausea, headache, changes in vision, and/or gastrointestinal upset. Consult your doctor if any of these symptoms worsens.

USES OF NE 400MG CAPSULE

• As a dietary supplement to prevent Vitamin E deficiency
• Treats haemolytic anaemia, cardiovascular disease, and heavy metal poisoning in affected individuals
• Act as an antioxidant (to reduce oxidative stress) and provides betterment for hair and skin in affected individuals

HOW NE 400MG CAPSULE WORKS

NE 400MG CAPSULE acts as an antioxidant and protect cells from free radicals (compounds that cause damage to the cells resulting in illness & aging process) which initiates antioxidation process in the cells thus treating disease such as cardiovascular disorders in affected individuals.

DIRECTIONS FOR USE

Take NE 400MG CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF NE 400MG CAPSULE

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take NE 400MG CAPSULE with/just after a meal. Stick to simple meals. Avoid eating oil rich/spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, and drink slowly in between meals. Consult your doctor if the condition worsens.

Headache:

If NE 400MG CAPSULE causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking NE 400MG CAPSULE. If it lasts more than a week or becomes severe, then consult and inform your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking NE 400MG CAPSULE, inform your doctor if you are taking any of the following medicine:

• oral contraceptives (used for prevention of pregnancy)
• Vitamin supplement such as Vitamin A (used for vision, growth, reproduction and immunity), Vitamin K (helps in blood clotting to prevent excessive bleeding)
• anticoagulants (medicines used to prevent blood clot) Ex. warfarin

Overdosage:

If you or anyone else accidentally take too much of NE 400MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are hypertension (high blood pressure), fatigue, diarrhoea, and/or myopathy (neuromuscular disorder that cause muscle weakness).

SYNOPSIS

MORE INFORMATION

• Keep NE 400MG CAPSULE out of reach of children
• Do not store NE 400MG CAPSULE above 30ºC

FAQs ABOUT NE 400MG CAPSULE

What is NE 400MG CAPSULE used for?

NE 400MG CAPSULE is used as a dietary supplement to prevent Vitamin E deficiency and to treat haemolytic anaemia (blood disorder), cardiovascular disease & heavy metal poisoning, which is also used (as a dietary supplement) to act as an antioxidant to reduce oxidative stress and to provide betterment for hair and skin in affected individuals.

What are the common side effects of taking NE 400MG CAPSULE?

The most common side effects of taking NE 400MG CAPSULE are nausea, headache, changes in vision, and/or gastrointestinal upset. Consult your doctor if any of these symptoms worsens.

How NE 400MG CAPSULE works?

NE 400MG CAPSULE acts as an antioxidant and protect cells from free radicals (compounds that cause damage to the cells resulting in illness & aging process) which initiates antioxidation process in the cells thus treating disease such as cardiovascular disorders in affected individuals.

How NE 400MG CAPSULE should be taken?

Take NE 400MG CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Can NE 400MG CAPSULE be used in pregnant women?

No, NE 400MG CAPSULE is not recommended for use during pregnancy when used at higher doses. It should be used with caution in pregnant women when indicated for use at recommended doses. Consult your doctor before taking the medicine.

REFERENCES

1. K.D Tripathi. Vitamins. Essentials of Medical Pharmacology, 7th edition 2013. Page- 911.

2. Jacquelyn Medina; Vikas Gupta. Vitamin E. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. May 2022. [Accessed on 16th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK557737/

3. Simin Nikbin Meydani, Erin Diane Lewis, Dayong Wu. Perspective: Should Vitamin E Recommendations for Older Adults Be Increased? NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. August 2018. [Accessed on 10th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140432/

4. Mereck Limited. Evion 400. [Accessed on 16th September 2022] https://www.evion.in/prescribing-information

5. Square Pharmaceuticals Ltd. Evit Soft. [Accessed on 16th September 2022] http://www.squarepharma.com.bd/downloads/1609736158_pdoc_Evit%20soft%20DS%20web.pdf

USEFUL DIAGNOSTIC TESTS

• Serum alpha-tocopherol test
• Lipid profile test