Natrise 30mg Tablet 4'S

Hypertension Rx required

Best Price*  ₹ 804.00
MRP ₹1,005.00
(Inclusive of all taxes) *4 Tablet(s) in a Strip * Mkt: Sun Pharmaceutical Industries Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

NATRISE contains tolvaptan belongs to a group of medicines called vasopressin antagonists. This medicine is indicated in Autosomal dominant polycystic kidney disease” (ADPKD) and also clinically significant hypervolemic and euvolemic hyponatremia in adults with conditions such as heart failure, liver disease, and certain hormone imbalances. Vasopressin by reducing urine output causes fluid retention and prevent the loss of water from the body. Autosomal dominant polycystic kidney disease” (ADPKD) is a condition where fluid-filled cysts grow in the kidneys leading to increased pressure on the surrounding tissues that impairs the kidney function leading to kidney failure.

NATRISE prevents the vasopressin having effect on the water retention. This reduces the amount of water in the body which slows the growth of kidney cysts in patients with ADPKD, reduces symptoms of the disease and increases urine production. It also increases the sodium and salt levels in your blood by removing extra water content in the body as urine in patients with heart failure, liver disease, and certain hormone imbalances.

USES OF NATRISE

  • Treat a disease called “autosomal dominant polycystic kidney disease” (ADPKD)
  • Treat significant hypervolemic and euvolemic hyponatremia (low serum sodium levels in adults)

HOW NATRISE WORKS

NATRISE prevents the vasopressin having effect on the water retention. This reduces the amount of water in the body which slows the growth of kidney cysts in patients with ADPKD, reduces symptoms of the disease and increases urine production. It also increases the sodium and salt levels in your blood by removing extra water content in the body as urine in patients with heart failure, liver disease, and certain hormone imbalances.

DIRECTIONS FOR USE

Always take NATRISE exactly as prescribed by your doctor. Swallow the medicine whole with plenty of water.

SIDE EFFECTS OF NATRISE

SERIOUS

  • difficult to urinate
  • swelling of the face, lips or tongue, itching, generalized rash, or severe wheezing or breathlessness (symptoms of an allergic reaction)

COMMON

  • dizziness, drowsiness, headache
  • dehydration
  • high levels of sodium, potassium, creatinine, uric acid and blood sugar
  • decrease in level of blood sugar
  • decreased appetite
  • fainting
  • low blood pressure when standing up
  • constipation
  • diarrhea
  • dry mouth
  • feeling sick, thirst, rapid rise in level of sodium
  • patchy bleeding in the skin
  • itching
  • general feeling of being unwell
  • blood in urine
  • raised levels of liver enzymes in the blood

HOW TO MANAGE SIDE EFFECTS

Skin rash and itching:

Avoid bathing with hot water because hot water can irritate the skin. Moisturizers can be used regular basis to soothe and hydrate the affected area.

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Diarrhea:

Drink lot of fluid, such as water or squash, to avoid dehydration. Do not take any other medicines consulting your doctor.

WARNING & PRECAUTIONS

PREGNANCY

NATRISE is not recommended for use in pregnant women unless necessary. Consult your doctor for advice.

BREASTFEEDING

NATRISE is not recommended for use in breastfeeding women unless necessary. Consult your doctor for advice.

DRIVING AND USING MACHINES

Do not drive or operate any machinery while taking this medicine, it may make you feel dizziness.

ALCOHOL

Avoid drinking too much of alcohol while taking this medicine.

KIDNEY

This medicine should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.

LIVER

This medicine should be taken with caution in patients with severe liver disease. Consult your doctor for advice.

ALLERGY

If you are allergic (hypersensitive) to this medicine or any other ingredients in this medicine.

HEART DISEASE

This medicine should be taken with caution in patients with severe heart disease. Consult your doctor for advice.

INTERACTIONS

Talk to your doctor if you are taking:

  • ketoconazole
  • macrolide antibiotics
  • medicines to treat high blood pressure and chest pain
  • medicines used to treat epilepsy/seizures and some sleep disorders
  • rifampicin (used to treat tuberculosis)
  • digoxin (used for treatment of irregularities of heartbeat and heart failure)
  • desmopressin (used to increase blood clotting factors)

SYNOPSIS

Drug :  

Tolvaptan

Pharmacological Category :   Vasopressin antagonists
Therapeutic Indication :  

Autosomal dominant polycystic kidney disease (ADPKD), Significant hypervolemic and euvolemic hyponatremia

Dosage Forms :   Tablet

MORE INFORMATION

Store at room temperature 15-25°C and keep out of reach of children.

FAQs ABOUT NATRISE

What is NATRISE used to treat?

It is used to treat low levels of salt (sodium) in the blood, which can result from conditions such as heart failure and certain hormone imbalances.

Can NATRISE be used in pregnant women?

No. It is not recommended for use in the pregnant women. Consult your doctor before taking.

What causes low sodium?

A low sodium level has many causes, including consumption of too many fluids, kidney failure, heart failure, cirrhosis, and use of diuretics. Symptoms result from brain dysfunction.

REFERENCES

1. Eline A. Dubois, Robert Rissmann & Adam F. Cohen, New drug mechanisms: Tolvaptan, [Revised on Jan 2012] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248250/

2. Goodman and Gilman’s: The Pharmacological Basis of Therapeutics. Chapter 25 - Regulation of renal function and vascular volume, 12th edition 2011. Page: 739.

3. AndersonBrecon (UK) Limited; Electronic Medicines Compendium (EMC); [Revised on April 2020] [Accessed 26 Oct 2020] https://www.medicines.org.uk/emc/files/pil.6849.pdf

4. Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan; U.S. Food & Drug Administration; [Revised on Oct 2012] [Accessed 26 Oct 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022275s007lbl.pdf

5. Laia Sans-Atxer and Dominique Joly; Tolvaptan in the treatment of autosomal dominant polycystic kidney disease: patient selection and special considerations; [Published on 31 Jan 2018] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797468/

PRODUCT DETAILS

    Net Qty
    1
    Item Weight
    10
    Ingredient
    TOLVAPTAN 30MG
    Hsn Code
    30049099
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Natrise 30mg Tablet 4'S

Natrise 30mg Tablet 4'S Mkt: Sun Pharmaceutical Industries Ltd

M.R.P.: Rs.1,005.00
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