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INTRODUCTION
MYTRET C AQUEOUS is a combination of Clindamycin and Tretinoin which belongs to the group of medicines called Topical Antibiotics and Retinoids respectively. It is used on the skin to treat acne in adults and in adolescents (aged 12 years or older).
Clindamycin is a topical antibiotic. It acts by stopping the growth and multiplication of the acne-causing bacteria on the skin. Tretinoin is a synthetic derivative of vitamin A. It controls acne breakouts by preventing the skin pores from getting clogged with sebum (oil produced in the skin) and dead skin cells. It also removes the dead skin cells that clogs the hair follicles in areas affected with acne and helps your skin renew itself more quickly.
MYTRET C AQUEOUS is for topical use only. Avoid using MYTRET C AQUEOUS on inflamed, irritated, or sensitive skin areas. Do not use any cosmetics or make-up products before applying MYTRET C AQUEOUS.
MYTRET C AQUEOUS may make your skin more sensitive to sunlight. Therefore, use sunscreen and wear protective clothing while going outdoors.
Before using MYTRET C AQUEOUS inform your doctor if you have any other skin conditions (such as rosacea, eczema) apart from acne. You must also inform your doctor if you have any problems in your gut (ulcerative colitis) or have a family history of skin cancer.
MYTRET C AQUEOUS is not recommended for use in pregnant or breastfeeding women. Women of childbearing age must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with MYTRET C AQUEOUS.
MYTRET C AQUEOUS may cause skin redness, dryness, itching, stinging, or burning sensation and peeling at the site of application. If you experience them, stop using MYTRET C AQUEOUS for a while until your skin recovers. Consult your doctor if they worsen.
USES OF MYTRET C AQUEOUS
- Treats acne in adults and in adolescents (aged 12 years or older)
HOW MYTRET C AQUEOUS WORKS
MYTRET C AQUEOUS effectively controls acne breakouts. It contains two medicines namely, clindamycin and tretinoin. Clindamycin prevents the growth and multiplication of acne-causing bacteria on the skin. Tretinoin controls acne breakouts by preventing the skin pores from getting clogged with sebum (oil) and dead skin cells. It regulates the growth of skin cells and sheds the excessive dead skin cells that clogs the hair follicles in areas affected with acne and helps your skin renew itself more quickly.
DIRECTIONS FOR USE
Always use MYTRET C AQUEOUS as directed by your physician. It is for external use only. Wash the affected area of the skin with warm water before application. Pat it dry. Apply a thin layer of MYTRET C AQUEOUS on the affected area. Let the medicine completely dry on your skin before applying any make-up products or cosmetics.
Do not use any cosmetics or make-up products before applying MYTRET C AQUEOUS. Check the label of the medicine or consult your doctor regarding the quantity of the medicine that needs to be applied.
Avoid contact of MYTRET C AQUEOUS with eyes, ears, mouth, or vagina. Your doctor will decide the duration of therapy for you depending upon your skin condition.
SIDE EFFECTS OF MYTRET C AQUEOUS
COMMON
- skin redness, irritation, itching, burning or stinging sensation at the site of application
- skin dryness, peeling of the skin, sensitivity to sunlight
UNCOMMON
- increased sebum production
- skin rash, scaling, sunburn
- skin discoloration
RARE
- stomach pain, nausea
- headache, eye irritation
- skin infections (cold sore)
- loss of skin pigmentation
Stop using MYTRET C AQUEOUS and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as swelling of your face, eyes, lips, tongue, or throat, trouble breathing, nettle rash, severe dizziness, collapse)
- severe or prolonged diarrhea with stomach cramps
- severe itching, or burning or peeling of the skin
HOW TO MANAGE SIDE EFFECTS
Skin rash:
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing while going outdoors. Consult your doctor for a suitable moisturizer that suits your skin. Consult your doctor if your skin condition worsens.
Sensitivity to sunlight:
Do not expose the affected part of the skin to the direct sunlight. Use protective clothing while going outdoors. Consult your doctor if you require any sunscreen to protect your skin while going outdoors. Consult your doctor if your skin condition worsens.
WARNING & PRECAUTIONS
PREGNANCY
MYTRET C AQUEOUS is not recommended for use in pregnant women. Therefore, inform your doctor before using MYTRET C AQUEOUS if you are pregnant or think you may be pregnant. Women of childbearing age must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with MYTRET C AQUEOUS.
BREASTFEEDING
MYTRET C AQUEOUS is not recommended for use in breast feeding women. Therefore, consult your doctor before using it.
ALLERGY
Do not use MYTRET C AQUEOUS if you are allergic to Tretinoin, Clindamycin or Lincomycin.
OTHERS
MYTRET C AQUEOUS is not recommended for use if you:
- have a chronic inflammatory bowel disease (Ex. Ulcerative colitis, Crohn’s disease)
- have a previous history of colitis while taking any antibiotics (signs include prolonged diarrhea with stomach cramps)
- have a family history of skin cancer
- have acute eczema (allergic skin reaction causing skin inflammation, redness, dryness, and scaly skin)
- have rosacea (skin redness, peeling and warmth with pimples)
- have folliculitis (a type of skin inflammation)
- have perioral dermatitis (skin rash surrounding the mouth)
- have severe forms of acne such as nodular acne (deep cystic nodular acne lesions with pimples)
Before using MYTRET C AQUEOUS inform your doctor if you:
- have any skin inflammation, irritation, or photosensitivity
- have an upcoming surgery
Use in pediatrics:
MYTRET C AQUEOUS should be used in children and in adolescents (aged 12 years or older) only if prescribed by the physician. It is not recommended for use in children aged below12 years due to lack of safety data. Therefore, consult your doctor before using it.
Use in geriatrics:
MYTRET C AQUEOUS should be used with caution in elderly patients. Therefore, consult your doctor before using it.
INTERACTIONS
A. Drug-Drug Interaction:
Before using MYTRET C AQUEOUS inform your doctor if you are using any:
- skin care preparations that contain sulfur, salicylic acid, benzoyl peroxide, high amount of alcohol, astringents, spices, or lime
- chemical abrasives (used for chemical peeling of skin) Ex. glycolic acid, salicylic acid, alpha hydroxy acids, beta-hydroxy acids
- medicated soaps, cleansers or scrubbing solutions
- anti-infectives (used to treat infections) Ex. erythromycin, metronidazole, streptomycin, gentamicin, kanamycin
- corticosteroids (used to treat inflammation) Ex. betamethasone, beclomethasone
- muscle relaxants (used for relaxing muscles prior to surgeries) Ex. vecuronium, rocuronium
- warfarin (a medicine used for blood thinning)
Overdosage:
Excessive application of MYTRET C AQUEOUS may cause skin irritation, redness, and dryness. If this happened, rinse your skin with warm water. If irritation persists, stop using MYTRET C AQUEOUS for a few days or until irritation subsides or consult your doctor if necessary. Sometimes, excessive use may also cause stomach pain, diarrhea, nausea or vomiting. If this happens, contact your doctor immediately.
SYNOPSIS
| Drug | : | Clindamycin, Tretinoin |
| Pharmacological Category | : | Lincosamide Antibiotics, Synthetic Retinoids |
| Therapeutic Indication | : | Acne |
| Dosage Forms | : | Gel, Gel (Topical), Oinment |
MORE INFORMATION
- Keep MYTRET C AQUEOUS out of reach of children
- Store MYTRET C AQUEOUS at room temperature
- Avoid contact of MYTRET C AQUEOUS with eyes, ears, nose, or mouth. If contact happens accidentally, rinse it off with warm water
FAQs ABOUT MYTRET C AQUEOUS
How long does it take for MYTRET C AQUEOUS to show the results?
It may take up to 12 weeks for MYTRET C AQUEOUS to show the results. However, this period may vary from patient-to-patient depending upon the severity of acne. Therefore, regularly use MYTRET C AQUEOUS for the stipulated duration mentioned by your doctor.
Will MYTRET C AQUEOUS be more effective if I overuse it?
Do not overuse MYTRET C AQUEOUS. Excessive application of MYTRET C AQUEOUS may cause skin irritation and dryness. Therefore, use MYTRET C AQUEOUS only directed by your physician.
What precautions do I need to follow while using MYTRET C AQUEOUS?
Use MYTRET C AQUEOUS as directed by the physician. Avoid using MYTRET C AQUEOUS on inflamed, irritated, or sensitive skin areas. Do not use any cosmetics or make-up products before applying MYTRET C AQUEOUS. Use sunscreen and wear protective clothing while going outdoors. Before using MYTRET C AQUEOUS inform your doctor if you have any other skin problems apart from acne. Consult your doctor before using MYTRET C AQUEOUS if you are pregnant or breastfeeding as a precaution. Contact your doctor if your skin condition worsens.
Can the use of MYTRET C AQUEOUS make my skin sensitive to sunlight?
Yes. MYTRET C AQUEOUS may make your skin more sensitive to sunlight. Therefore, use protective clothing while going outdoors. Do not exposure the affected part of the skin to the direct sunlight. Consult your doctor if you require any sunscreen to protect your skin while going outdoors. Consult your doctor if your skin condition worsens.
What are the common side effects of using MYTRET C AQUEOUS?
MYTRET C AQUEOUS may cause skin redness, dryness, itching, stinging, or burning sensation and peeling at the site of application. If you experience them, stop using MYTRET C AQUEOUS for a while until your skin recovers. Consult your doctor if they worsen.
Can MYTRET C AQUEOUS be used in children?
MYTRET C AQUEOUS should be used in children and in adolescents (aged 12 years or older) only if prescribed by the physician. It is not recommended for use in children aged below12 years due to lack of safety data. Therefore, consult your doctor before using it.
How does MYTRET C AQUEOUS works?
MYTRET C AQUEOUS acts by preventing the growth and multiplication of acne-causing bacteria. It can also open the skin pores and removes the accumulated dead skin cells and excess oil that triggers acne breakouts.
Can I use MYTRET C AQUEOUS to treat acne during pregnancy?
No. MYTRET C AQUEOUS should not be used to treat acne in pregnant women. Therefore, inform your doctor before using MYTRET C AQUEOUS if you are pregnant or think you may be pregnant. Women of childbearing age must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with MYTRET C AQUEOUS.
REFERENCES
1. KD. Tripathi. Macrolide, Lincosamide, Glycopeptide and Other Antibacterial Antibiotics; Urinary Antiseptics & Anticancer Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 756 & 869.
2. Nicholas Schmidt, PhD corresponding author and Eugene H. Gans, PhD. Clindamycin 1.2% Tretinoin 0.025% Gel versus Clindamycin Gel Treatment in Acne Patients. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Jun 2011. [Accessed on 22nd March 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140902/
3. Meda Pharma GmbH & Co. KG; Electronic Medicines Compendium (EMC) [Revised in October 2019] [Accessed on 15th July 2022] https://www.medicines.org.uk/emc/files/pil.5371.pdf
4. DPT Laboratories. Tretinoin Gel (microspheres 0.1 and 0.04%). [Revised in April 2012]. [Accessed on 15th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/202567Orig1s000lbl.pdf
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