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MYHEP DVIR 60/400 Tablet 28's
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INTRODUCTION
MYHEP DVIR 60/400 TABLET is a combination of Sofosbuvir and Daclatasvir which belongs to the group of medicines called Antiviral agents. It is used to treat chronic (long-term) Hepatitis C infection.
Hepatitis C infection is a viral infection caused due to hepatitis C virus. It predominantly affects the liver and causes severe liver damage. It spreads mostly through contact with blood from an infected person (such as through sharing needles).
MYHEP DVIR 60/400 TABLET is suitable for use both in adults and in children (aged 3 years or above). Before taking MYHEP DVIR 60/400 TABLET inform your doctor if you have diabetes, kidney problems or any other liver problems apart from hepatitis C infection (such as liver transplant or hepatitis B infection).
Do not take MYHEP DVIR 60/400 TABLET without consulting your doctor if you are pregnant or breastfeeding. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy during treatment with this medicine and until 5 weeks after stopping the treatment.
The most common side effects of taking MYHEP DVIR 60/400 TABLET are fever, flu-like symptoms, migraine headache, dizziness, hair thinning, dry skin, muscle pain, back pain, tiredness, weakness, lack of sleep, stomach discomfort and loss of appetite. Consult your doctor if they trouble you.
USES OF MYHEP DVIR 60/400 TABLET
- Treats chronic Hepatitis C infection
HOW MYHEP DVIR 60/400 TABLET WORKS
MYHEP DVIR 60/400 TABLET is an antiviral agent. It acts by blocking the actions of certain viral proteins that is required for the viral cell to grow and multiply. As a result, it controls the multiplication of harmful viral cells within the body which reduces the severity of the infection.
DIRECTIONS FOR USE
Take MYHEP DVIR 60/400 TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. MYHEP DVIR 60/400 TABLET can be taken with or without meals.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the infection. Do not stop taking MYHEP DVIR 60/400 TABLET without consulting your doctor as it may reduce its effectiveness.
SIDE EFFECTS OF MYHEP DVIR 60/400 TABLET
COMMON
- fever, chills, cold, flu-like symptoms
- nausea, vomiting, diarrhoea, loss of appetite
- lack of sleep (insomnia)
- tiredness, weakness, irritability
- headache, migraine, dizziness
- skin rash or itching
- muscle aches and pains, joint pain
- low RBC, WBC and platelet count in blood
- mouth ulcers
- mood changes, depression, anxiety, agitation
- blurred vision
- loss of memory or concentration
- weight loss
- stomach discomfort, constipation, dry mouth, indigestion, acid reflux
- hair loss and thinning hair, dry skin
- back pain
RARE
Stop taking MYHEP DVIR 60/400 TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, nose, throat which causes difficulty in breathing or swallowing)
- severe skin reactions causing widespread skin rashes with severe itching, blistering and peeling of skin, accompanied with fever, flu-like symptoms and ulcers in the mouth, eyes and/or genitals)
- shortness of breath, slow or irregular heartbeat or problems in heart rhythm problems
HOW TO MANAGE SIDE EFFECTS
Nausea and Vomiting:
Take MYHEP DVIR 60/400 TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
WARNING & PRECAUTIONS
PREGNANCY
MYHEP DVIR 60/400 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it. Women undergoing therapy with medicine, must use a suitable contraceptive method to avoid pregnancy during and until 5 weeks after stopping the therapy.
BREASTFEEDING
MYHEP DVIR 60/400 TABLET may pass through the breast milk. Therefore, it is not recommended for use in breastfeeding women. Consult your doctor for advice before taking it.
DRIVING AND USING MACHINES
Do not drive or handle any machines if your ability is affected by MYHEP DVIR 60/400 TABLET.
KIDNEY
MYHEP DVIR 60/400 TABLET should be used with caution in patients with kidney problems (such as dialysis). Therefore, consult your doctor before taking it.
LIVER
MYHEP DVIR 60/400 TABLET should be used with caution in patients with other liver problems apart from hepatitis C infection such as awaiting a liver transplant or hepatitis B infection. Therefore, consult your doctor before taking it.
ALLERGY
Do not take MYHEP DVIR 60/400 TABLET if you are allergic to Daclatasvir or Sofosbuvir.
HEART DISEASE
MYHEP DVIR 60/400 TABLET should be used with caution if you have heart problems. Consult your doctor for advice.
OTHERS
Before taking MYHEP DVIR 60/400 TABLET, inform your doctor if you:
- are taking medicines for any on-going viral infections
- have diabetes
Use in Paediatrics:
MYHEP DVIR 60/400 TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use in Geriatrics:
MYHEP DVIR 60/400 TABLET should be used with caution in elderly people. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking MYHEP DVIR 60/400 TABLET inform your doctor if you are taking any of the following medicines such as:
- rifampicin, rifabutin, rifapentine (used to treat tuberculosis)
- St. John’s wort (a medicine used to treat depression)
- medicines used to treat epilepsy (such as carbamazepine, phenobarbital, phenytoin, oxcarbazepine)
- rosuvastatin (a medicine used to treat high blood cholesterol levels)
- amiodarone, digoxin (used to treat irregular heart rate)
- modafinil (a medicine used to treat narcolepsy)
- warfarin, dabigatran, vitamin k antagonists (used for blood thinning)
- medicines used to suppress your immune system (such as tacrolimus, cyclosporine)
- medicines used to treat HIV infection (such as atazanavir/ritonavir, atazanavir/cobicistat, elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate combination tablet, etravirine, nevirapine or efavirenz)
- medicines used to treat bacterial infection (such as clarithromycin, telithromycin or erythromycin)
- medicines used to treat fungal infection (such as ketoconazole, itraconazole, posaconazole or voriconazole)
- medicines used to treat heart problems (such as verapamil, diltiazem, nifedipine or amlodipine)
- medicines used to control blood cholesterol levels (such as rosuvastatin, atorvastatin, fluvastatin, simvastatin, pitavastatin or pravastatin)
- oral contraceptives (birth control pills) Ex. ethinylestradiol, drospirenone
- medicines used to treat stomach ulcers or heartburn (such as aluminium hydroxide, omeprazole, lansoprazole, rabeprazole, pantoprazole, esomeprazole, famotidine, cimetidine, nizatidine or ranitidine)
- dexamethasone (a steroid medicine used to treat allergic or autoimmune reactions)
Overdosage:
If you or anyone else accidentally took more MYHEP DVIR 60/400 TABLET, consult your doctor immediately.
SYNOPSIS
| Drug | : | Daclatasvir, Sofosbuvir |
| Pharmacological Category | : | HCV NS5A inhibitors, Nucleotide polymerase inhibitors |
| Therapeutic Indication | : | Hepatitis C infection |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep MYHEP DVIR 60/400 TABLET out of reach of children
- Store MYHEP DVIR 60/400 TABLET at room temperature
FAQs ABOUT MYHEP DVIR 60/400 TABLET
Q: What is MYHEP DVIR 60/400 TABLET?
A: MYHEP DVIR 60/400 TABLET is an antiviral medicine used to treat Hepatitis C infection.
Q: Is MYHEP DVIR 60/400 TABLET safe?
A: MYHEP DVIR 60/400 TABLET is safe at doses prescribed by the physician.
Q: How does MYHEP DVIR 60/400 TABLET work in our body?
A: MYHEP DVIR 60/400 TABLET acts by blocking the actions of certain viral proteins that is required for the viral cell to grow and multiply. This reduces multiplication of viral cells and prevents the spread of infection.
Q: Can I stop taking MYHEP DVIR 60/400 TABLET if I feel unwell?
A: No. Do not stop taking MYHEP DVIR 60/400 TABLET without consulting your doctor. Take MYHEP DVIR 60/400 TABLET regularly, because if you miss a dose of MYHEP DVIR 60/400 TABLET or take it at irregular intervals, you may experience some unpleasant reactions.
Q: What to do if I forget to take a dose of MYHEP DVIR 60/400 TABLET?
A: If you miss a dose of MYHEP DVIR 60/400 TABLET take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular time. Do not take a double dose of MYHEP DVIR 60/400 TABLET to compensate the missed dose.
Q: Can MYHEP DVIR 60/400 TABLET cure Hepatitis C completely?
A: Yes. MYHEP DVIR 60/400 TABLET acts by reducing the number of viral cells within the body. Eventually, it can eliminate the virus from the body and can cure hepatitis C completely.
Q: What are the precautions to be followed while taking MYHEP DVIR 60/400 TABLET?
A: Before taking MYHEP DVIR 60/400 TABLET inform your doctor if you have diabetes, kidney problems or any other liver problems apart from hepatitis C infection (such as liver transplant or hepatitis B infection). Do not take MYHEP DVIR 60/400 TABLET without consulting your doctor if you are pregnant or breastfeeding. Regularly visit your doctor and take all the blood tests recommended for you. Do not stop taking MYHEP DVIR 60/400 TABLET without consulting your doctor.
Q: Can MYHEP DVIR 60/400 TABLET be used in children?
A: MYHEP DVIR 60/400 TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Q: How to take MYHEP DVIR 60/400 TABLET?
A:Take MYHEP DVIR 60/400 TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. MYHEP DVIR 60/400 TABLET can be taken with or without meals. Continue to take MYHEP DVIR 60/400 TABLET regularly as advised by your physician for maximum benefits.
REFERENCES
1. Harsh Mohan. Viral Hepatitis. The Liver, Biliary Tract and 592 Exocrine Pancreas. Textbook of Pathology. 6th Edition. Page – 605.
2. Seyed Ali, Dehghan Manshadi, Shahin Merat, Minoo Mohraz, Mehrnaz Rasoolinejad, Shanaz Sali, Masoud Mardani, Payam Tabarsi, Mohammad-Hossein Somi, Roya Sedghi, Katayoun Tayeri, Mehri Nikbin, Jalal Karimi, Amir-Houshang Sharifi, Saeed Kalantari, Alireza Norouzi, Dorsa Merat, Zeinab Malekzadeh, Babak Mirminachi, Hossein Poustchi, Reza Malekzadeh. Single pill sofosbuvir and daclatasvir for treating hepatis C in patients co-infected with human immunodeficiency virus. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. August 2021. [Accessed on 5th January 2023] https://pubmed.ncbi.nlm.nih.gov/33930223/
3. Gilead Sciences Ireland UC. Sovaldi 400 mg film-coated tablets sofosbuvir. Electronic Medicines Compendium (EMC) [Revised in June 2021] [Accessed on 4th January 2023] https://www.medicines.org.uk/emc/files/pil.12361.pdf
4. Bristol-Myers Squibb S.r.l. Daklinza 30 mg and 60 mg film-coated tablets. European Medicines Agency. [Accessed on 5th January 2023] https://www.ema.europa.eu/en/documents/product-information/daklinza-epar-product-information_en.pdf
5. Central Drugs Standard Control Organization. Each film coated tablet contains : Daclatasvir Dihydrochloride Eq to Daclatasvir………..60 mg Sofosbuvir……………....400 mg. June 2018. [Accessed on 5th January 2023] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
- Bilirubin Total
- Hepatitis B s (Surface) Antigen
- Hepatitis C Virus Total Antibody
- Liver Function Test
AUTHOR DETAILS
Written By Srilekha. R, B.Pharm
Last updated on 06 Jan 2023 | 01:56 PM(IST)
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