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Myhep 400mg Tablet 28'S
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INTRODUCTION
MYHEP 400MG TABLET contains Sofosbuvir which belongs to the group of medicines called Antiviral agents. MYHEP 400MG TABLET is used with Ribavirin/ Peginterferon alfa and ribavirin (antiviral medicines) to treat hepatitis C viral infection in adults and children (aged 3 years/above), which is a type of viral infection that infects the liver.
MYHEP 400MG TABLET is not recommended for use in patients allergic to Sofosbuvir.
Before taking MYHEP 400MG TABLET, inform your doctor if you have a history of hepatitis B virus infection, and/or suffer from diabetes, heart problems, kidney problems, and/or other liver problems.
MYHEP 400MG TABLET is not recommended for use during pregnancy and in women planning for pregnancy since Ribavirin (antiviral medicine used with Sofosbuvir) may cause harm to the unborn baby. Women of childbearing potential should use effective contraceptive measures to avoid getting pregnant and undergo a routine pregnancy test during and after treatment (for 9 months). If accidental pregnancy occurs, then it should be informed to the doctor immediately. The medicine is also not recommended for use in breastfeeding women since it is not known whether the medicine may pass through breast milk.
MYHEP 400MG TABLET is not recommended for use in children (aged below 3 years) and is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.
The most common side effects of taking MYHEP 400MG TABLET are fever, chills, diarrhoea, nausea, vomiting, dizziness, feeling depressed/anxious/agitated, and/or headache. Consult with your doctor if any of these symptoms worsen.
USES OF MYHEP 400MG TABLET
- Treats Hepatitis C viral infection in adults and children (aged 3 years/above) when used with Ribavirin/ Peginterferon alfa and ribavirin (antiviral medicines)
HOW MYHEP 400MG TABLET WORKS
Sofosbuvir works by lowering the load of hepatitis C virus in the body by binding to hepatitis C virus RNA and interfering with its life cycle thus preventing the viral replication in the body and treating the infection in affected individuals.
DIRECTIONS FOR USE
Take MYHEP 400MG TABLET as advised by your doctor. Swallow the medicine along with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF MYHEP 400MG TABLET
COMMON
- fever, chills, flu-like symptoms
- diarrhoea, nausea, vomiting
- trouble sleeping, feeling tired, irritability, dizziness, changes in mood, feeling depressed/anxious/agitated
- headache, blurred vision
- memory loss, loss of concentration
- rash, itchy skin
- loss of appetite, decreased appetite
- muscle aches, joint pain
- shortness of breath, cough
- signs of anaemia such as feeling tired, headaches, shortness of breath
- signs of low white blood cells such as getting more prone to infections, fever, chills, sore throat, mouth ulcers
- signs of low blood platelet count such as excessive bruising, prolonged bleeding from cuts, blood in urine/stools
- weight loss
- shortness of breath (while exercising)
- stomach discomfort, constipation, dry mouth, indigestion, acid reflux
- hair loss and thinning hair
- dry skin
- back pain, muscle spasms
- chest pain, weakness
- common cold
RARE
Stop taking MYHEP 400MG TABLET, if you experience any of the following symptoms:
- signs of heart problems (in patients who had/currently taking medicines for heart problems like amiodarone) such as slow/irregular heartbeat, heart rhythm problems, shortness of breath/worsening of the existing condition, chest pain, light-headedness, palpitations, and/or fainting
HOW TO MANAGE SIDE EFFECTS
Headache:
Try using a hot or cold-water bag on your head. Take some rest in a quiet and dark room. Drink tea or coffee. Consult your doctor if your symptom worsens.
Diarrhoea:
Drink plenty of fluids such as water, fruit juices or electrolytes (ORS) to avoid dehydration in your body. Consult your doctor if your symptom does not improve.
Constipation:
Take fibre-rich foods in your diets such as fresh fruits, vegetables and whole grain cereals, and drink plenty of fluids. Exercise more regularly and stay active. Consult your doctor if your symptom worsens.
Nausea and vomiting:
Take medicine with or just after a meal and stick to simple meals and avoid taking oil rich food or spicy food. Consult your doctor if your symptom gets worse or does not improve.
WARNING & PRECAUTIONS
PREGNANCY
MYHEP 400MG TABLET is not recommended for use during pregnancy and in women planning for pregnancy since Ribavirin (antiviral medicine used with Sofosbuvir) may cause harm to the unborn baby. Women of childbearing potential should use effective contraceptive measures to avoid getting pregnant and undergo a routine pregnancy test during and after treatment (for 9 months). If accidental pregnancy occurs, then it should be informed to the doctor immediately. Consult your doctor before taking the medicine.
BREASTFEEDING
MYHEP 400MG TABLET is not recommended for use in breastfeeding women since it is not known whether the medicine may pass through breast milk. Consult your doctor before taking the medicine.
DRIVING AND USING MACHINES
Do not drive/operate machines if you feel tired, dizzy, and experience blurred vision/reduced attention after taking MYHEP 400MG TABLET along with other medicines.
KIDNEY
MYHEP 400MG TABLET should be used with caution in patients with kidney problems and in patients who undergo dialysis. Consult with your doctor before taking the medicine.
LIVER
MYHEP 400MG TABLET should be used with caution in patients suffering from liver problems other than Hepatitis C infection. Consult your doctor before taking before taking the medicine.
ALLERGY
Do not take MYHEP 400MG TABLET if you are allergic to Sofosbuvir, and/or any other ingredients of this medicine.
HEART DISEASE
MYHEP 400MG TABLET should be used with caution in patients with heart problems. Consult your doctor before taking the medicine.
OTHERS
Before taking MYHEP 400MG TABLET, inform your doctor if you have:
- diabetes
- history of hepatitis B virus infection.
Use in Pediatrics:
MYHEP 400MG TABLET is not recommended for use in children (aged below 3 years). Consult your doctor before taking the medicine.
Use in Geriatrics:
MYHEP 400MG TABLET should be used with caution in elderly patients (aged 65 years/above). Consult your doctor before taking the medicine.
INTERACTIONS
A. Drug-Drug interactions:
- other antiviral medicines (used to treat Hepatitis C infection) Ex. Ribavirin, Peginterferon alfa
- amiodarone (used in the treatment of irregular heartbeat)
- warfarin and vitamin k antagonist (used as blood thinning agent)
- carbamazepine, phenobarbital, phenytoin, oxcarbazepine (used to treat epilepsy and prevent seizure)
- modafinil (used in the treatment of narcolepsy)
- rifapentine, rifampicin (used in the treatment of tuberculosis)
- St. John’s wort (herbal medicine used to treat depression).
Overdosage:
If you or anyone else accidentally take too much of MYHEP 400MG TABLET, consult your doctor immediately or visit the nearby hospital to manage overdose symptoms.
SYNOPSIS
| Drug | : | Sofosbuvir |
| Pharmacological Category | : | Pyrimidine nucleosides |
| Therapeutic Indication | : | Hepatitis C viral infection |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep MYHEP 400MG TABLET out of reach from children
- Store MYHEP 400MG TABLET at room temperature
FAQs ABOUT MYHEP 400MG TABLET
What is MYHEP 400MG TABLET used for?
MYHEP 400MG TABLET is used with Ribavirin/ Peginterferon alfa and ribavirin (antiviral medicines) to treat hepatitis C viral infection in adults and children (aged 3 years/above), which is a type of viral infection that infects the liver.
What are the side effects of MYHEP 400MG TABLET?
The most common side effects of taking MYHEP 400MG TABLET are fever, chills, diarrhoea, nausea, vomiting, dizziness, feeling depressed/anxious/agitated, and/or headache. Consult with your doctor if any of these symptoms worsen.
How MYHEP 400MG TABLET work?
Sofosbuvir works by lowering the load of hepatitis C virus in the body by binding to hepatitis C virus RNA and interfering with its life cycle thus preventing the viral replication in the body and treating the infection in affected individuals.
How MYHEP 400MG TABLET should be taken?
Take MYHEP 400MG TABLET as advised by your doctor. Swallow the medicine along with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
What happens if you take MYHEP 400MG TABLET more than its required dosage?
If you or anyone else accidentally take too much of MYHEP 400MG TABLET, consult your doctor immediately or visit the nearby hospital to manage the overdose symptoms.
REFERENCES
1. Thomas M. Schmidt. Pathogenesis and Immunology: Antiviral Agents. Encyclopaedia of Microbiology: Volume 1. Fourth edition. 2019. Page – 200.
2. Harmeet Kaur Bhatia, Harmanjit Singh, Nipunjot Grewal,Navreet Kaur Natt. Sofosbuvir: A novel treatment option for chronic hepatitis C infection. NIH National Library of Medicine. National centre for biotechnology information. PMC PubMed Central. October 2014. [Accessed on 25th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231565/
3. Hideyuki Tamai, Naoki Shingaki, Yoshiyuki Ida, Ryo Shimizu, Shuya Maeshima, Junpei Okamura, Akira Kawashima, Taisei Nakao, Takeshi Hara, Hiroyoshi Matsutani, Izumi Nishikawa, Katsuhiko Higashi. Sofosbuvir plus ribavirin is tolerable and effective even in elderly patients 75-years-old and over. NIH National Library of Medicine. National centre for biotechnology information. PMC PubMed Central. September 2020. [Accessed on 25th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522558/
4. Gilead Sciences Ireland UC. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 25th May 2022] https://www.medicines.org.uk/emc/files/pil.12361.pdf
USEFUL DIAGNOSTIC TESTS
- HCV antibody test
- Magnetic resonance elastography
AUTHOR DETAILS
Written By Dr. K .AZEEM HUSSAIN, B.D.S
Last updated on 09 Dec 2022 | 05:30 PM(IST)
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