Availability & Expiry
INTRODUCTION
MYAZA 100MG INJECTION contains Azacitidine which belongs to the group of medicines called Anticancer agents. It is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukaemia (CMML) and acute myeloid leukaemia (AML).
In CMML, the bone marrow releases excess amount of monocytes (a type of blood cells) into the blood stream whereas, in the AML the bone marrow releases excess amount of immature white blood cells. Both are characterised by recurrent infections, fever, tiredness and increased bleeding or bruising.
MYAZA 100MG INJECTION is typically used in adults who cannot undergo stem cell transplantation. Before receiving MYAZA 100MG INJECTION inform your doctor if you have any lung, liver, kidney or heart problems.
MYAZA 100MG INJECTION is not recommended for use in pregnant or breastfeeding women. Both men and women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with this medicine. Men may seek advice on sperm preservation, if necessary, prior to the therapy with this medicine.
The most common side effects of receiving MYAZA 100MG INJECTION are increased bleeding, increased infections, tiredness, nausea, vomiting, diarrhea, constipation, loss of appetite, stomach pain, weakness, pain and redness at the site of injection, sore nose and throat, cold sores, headache, dizziness, trouble sleeping, weight loss, ulcers of mouth or tongue and hair loss. Consult your doctor if any of these side effects trouble you.
USES OF MYAZA 100MG INJECTION
It is used in adults to treat:
- all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow)
- Chronic myelomonocytic leukaemia (CMML; blood cancer of monocytes)
- acute myeloid leukaemia (AML; blood cancer of WBC)
HOW MYAZA 100MG INJECTION WORKS
MYAZA 100MG INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.
DIRECTIONS FOR USE
MYAZA 100MG INJECTION will be given to you only by a doctor or a nurse beneath the skin (subcutaneously) of thighs, arms or abdomen.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF MYAZA 100MG INJECTION
COMMON
- low RBC count causing anemia, tiredness and pale skin
- increased infections, lung infections (pneumonia), fever and chills
- increased bleeding tendency due to low blood platelet counts
- nausea, vomiting
- diarrhea, constipation, loss of appetite, stomach pain
- tiredness, weakness
- injection site reactions (such as pain, redness and swelling or lump formation)
- Joint pain, muscle pain, skin rashes with redness and itching
- sore nose and throat, cold sores, sinnusitis
- headache, dizziness
- trouble sleeping (insomnia)
- nosebleeds, bleeding gums
- weight loss
- urinary tract infections
- ulcers of mouth or tongue
- high or low blood pressure
- anxiety, confusion
- hair loss, dehydration
- oral fungal infection
- sleepiness
- fluid around the lungs or heart
UNCOMMON
- painful skin ulceration
RARE
- dry cough
- painless swelling in the fingertips
Consult your doctor immediately if you experience any of the following side effects after receiving MYAZA 100MG INJECTION:
- signs of liver problems (such as yellowing of skin and whites of the eye, drowsiness, shakiness, bloating and easy bruising)
- signs of kidney problems (such as low urine output, swollen feet and legs, back pain, rapid heart rate, dizziness, nausea, vomiting, tiredness, reduced appetite confusion and restlessness)
- signs of increased infections such as fever
- lung infections causing fever, chest pain and shortness of breath
- bleeding within the head or bleeding within the stomach causing bloody stools, bloody urine, or bleeding under the skin causing red pin points dots to appear on the skin
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing, fainting)
- blood infections (sepsis)
HOW TO MANAGE SIDE EFFECTS
Mouth Ulcers
Avoid eating spicy foods. Drink plenty of water. Apply a pain-relieving gel on the affected areas of the mouth if required. Consult your doctor if the symptom did not improve.
Constipation
Try to eat more high-fibre foods such as fresh fruits, vegetables, cereals, and drink plenty of water. Exercise regularly. If this does not help, inform your doctor for receiving alternate treatments for constipation.
Injection Site Reactions
Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedMYAZA 100MG INJECTION is not recommended for use in pregnant women as it may harm the growing baby. Therefore, inform your doctor before receiving it. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with MYAZA 100MG INJECTION and until 6 months after stopping the therapy. If you accidentally became pregnant while receiving MYAZA 100MG INJECTION, inform your doctor immediately.
BREASTFEEDING
ContraindicatedMYAZA 100MG INJECTION is not recommended for use in breastfeeding women. Therefore, inform your doctor before receiving it.
DRIVING AND USING MACHINES
Use with CautionMYAZA 100MG INJECTION may cause tiredness. Therefore, do not drive or operate any machines if your ability is affected by MYAZA 100MG INJECTION.
KIDNEY
Use with CautionMYAZA 100MG INJECTION should be used with caution in patients with kidney diseases. Therefore, inform your doctor before receiving it.
LIVER
Consult your doctorMYAZA 100MG INJECTION is not recommended for use in patients with advanced liver cancer. It should be used with caution in patients with other liver diseases. Therefore, inform your doctor before receiving it.
ALLERGY
ContraindicatedTalk to your doctor before receiving MYAZA 100MG INJECTION if you are allergic to Azacitidine.
LUNGS
Use with CautionMYAZA 100MG INJECTION should be used with caution in patients with a previous history of lung diseases. Therefore, inform your doctor before receiving it.
HEART DISEASE
Use with CautionMYAZA 100MG INJECTION should be used with caution in patients with a previous history of heart attack or any other heart conditions. Therefore, inform your doctor before receiving it.
USE IN PEDIATRICS
ContraindicatedMYAZA 100MG INJECTION is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor for advice.
USE IN GERIATRICS
Use with CautionMYAZA 100MG INJECTION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.
OTHERS
Inform your doctor, before receiving MYAZA 100MG INJECTION, if you:
- have low RBC, WBC or platelet count in blood
INTERACTIONS
A. Drug - Drug interactions:
Before receiving MYAZA 100MG INJECTION, inform your doctor about all the prescription medicines, non-prescription medicines and over-the counter health or herbal supplements taken by you as a precaution.
Overdosage:
If you or anyone else accidentally took more MYAZA 100MG INJECTION, consult your doctor immediately or visit the nearby hospital straight away.
SYNOPSIS
| Drug | : | Azacitidine |
| Pharmacological Category | : | Cytidine Analogs |
| Therapeutic Indication | : | Blood cancer, Myelodysplastic syndromes |
| Dosage Forms | : | Injection, Tablet |
MORE INFORMATION
- Keep MYAZA 100MG INJECTION out of reach of children
- Before opening: Store MYAZA 100MG INJECTION at room temperature
- After opening: Store MYAZA 100MG INJECTION in refrigerator between 2-8°C
FAQs ABOUT MYAZA 100MG INJECTION
Q: What is the use of MYAZA 100MG INJECTION?
A: MYAZA 100MG INJECTION is used in adults to treat all sub-types of myelodysplastic syndromes (MDS; group of cancers associated with blood and bone marrow) and certain types of blood cancers known as Chronic myelomonocytic leukaemia (CMML) and acute myeloid leukaemia (AML).
Q: How does MYAZA 100MG INJECTION works?
A: MYAZA 100MG INJECTION is an anticancer medication. It works by blocking the actions of certain enzymes (DNA/RNA methyltransferase) within the cancer cells that is required for the cells to grow and multiply. It also reduces the production of new genetic material (RNA and DNA) within the cells. As a result, it prevents abnormal cell division within the body, slows down the growth of cancer cells and helps the bone marrow to produce normal blood cells.
Q: Can I take MYAZA 100MG INJECTION during breastfeeding?
A: No. MYAZA 100MG INJECTION is not recommended for use in breast-feeding women. Therefore, inform your doctor before receiving it.
Q: Can MYAZA 100MG INJECTION increase the risk of infections?
A: MYAZA 100MG INJECTION may cause a drop in the number of white blood cells in the body and may weaken your immune system. As a result, you may be at a greater risk of getting infected while receiving MYAZA 100MG INJECTION. To avoid this, your doctor will regular monitor your blood counts as a precaution. However, inform your doctor if you experience any signs of infection such as fever.
Q: Can the use of MYAZA 100MG INJECTION make me feel tired?
A: Yes. MYAZA 100MG INJECTION may make you feel tired easily. This is because, it reduces the levels of red blood cells in your blood and may make you anaemic. Consult your doctor if you experience tiredness after receiving MYAZA 100MG INJECTION. Tiredness can also occur if you have any pre-existing disease conditions such as liver or kidney impairment while receiving this medicine.
Q: Can I drive a car after receiving MYAZA 100MG INJECTION?
A: MYAZA 100MG INJECTION may make you feel tired or weak. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by MYAZA 100MG INJECTION.
Q: How MYAZA 100MG INJECTION is administered?
A: MYAZA 100MG INJECTION will be given to you only by a doctor or a nurse beneath the skin (subcutaneously) of thighs, arms or abdomen.
Q: How to control nausea caused due to MYAZA 100MG INJECTION?
A: Generally, anticancer medicines are associated with uncontrollable nausea and vomiting. To avoid this, your doctor would prescribe a suitable medicine to control them along with MYAZA 100MG INJECTION. If not, consult your doctor for a suitable anti-emetic medicine. Do not self-treat nausea.
REFERENCES
1. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. Cytotoxic agents. Chemotherapy of Neoplastic Diseases. 12th Edition. Page – 1700.
2. Cyrus Khan, Neeta Pathe, Salman Fazal, John Lister, and James M. Rossetti. Azacitidine in the management of patients with myelodysplastic syndromes. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2012. [Accessed on 21st March 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627328/
3. Zentiva Pharma UK Limited. Azacitidine 25 mg/ml powder for suspension for injection azacitidine. European Medicines Compendium. [Revised in September 2022]. [Accessed on 21st March 2023] https://www.medicines.org.uk/emc/files/pil.12470.pdf
4. American Society of Health-System Pharmacists. Azacitidine Injection. Medlineplus.gov. [Accessed on 21st March 2023] https://medlineplus.gov/druginfo/meds/a607068.html
5. Central Drugs Standard Control Organization. Azacitidine for injection 100 mg/vial. April 2014. Azacitidine Injection 100mg/vial. September 2015. [Accessed on 21st March 2023] https://cdscoonline.gov.in/CDSCO/Drugs
USEFUL DIAGNOSTIC TESTS
- Bone marrow smear microscopy examination
- Complete Blood Count
- Peripheral Smear Examination
PRODUCT DETAILS
ALTERNATE BRANDS
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