Miprogen 100 mg Pessaries 10'S

INTRODUCTION

MIPROGEN 100 MG contains Progesterone which belongs to the group of medicines called progestins. It is used to treat pre-menstrual syndrome and post-natal depression (depression after childbirth) in female patients. Premenstrual syndrome (PMS) is a combination of physical, emotional and psychological disturbances that occur during 7 to 10 days before their monthly period (after ovulation) and typically ends with the onset of menstrual flow. This medicine also prevents preterm delivery and miscarriage during the early stages of pregnancy.

Progesterone is a naturally produced female sex hormone that works by adjusting the hormonal balance within the body and provides relief from PMS and post-natal depression. Wash your hands thoroughly before and after inserting the pessary. Depending upon the condition, it can be either inserted into the vagina or the rectum (back passage). Place the pessary between the vagina or rectum and gently push it upwards.

The most common side effects of this medicine are drowsiness, stomach pain and breast pain. Contact your doctor if these symptom bothers you. Before using this medicine, inform your doctor if you have or ever had unexplained vaginal bleeding or previous miscarriage. Your doctor will suggest you a suitable alternative therapy. If you are pregnant or think you might be pregnant, consult your doctor before using this medicine, because the risks of congenital anomalies, from exposure to exogenous progesterone during pregnancy have not been fully established. This medicine is not recommended for use in lactating mothers and in children or adolescents. Consult your doctor before taking.

USES OF MIPROGEN 100 MG

• Treats pre-menstrual syndrome and post-natal depression
• Prevents preterm delivery and miscarriage during the early stages of pregnancy

HOW MIPROGEN 100 MG WORKS

MIPROGEN 100 MG maintains the balance of menstrual hormone levels, restores progesterone levels in case of deficiency. This effect reduces the symptoms associated with falling progesterone levels on the brain and blood such as tension, irritability, depression, headache and bloating.

DIRECTIONS FOR USE

Wash your hands thoroughly before and after inserting the pessary. Depending upon the condition, it can be either inserted into the vagina or the rectum (back passage). You may find it easier if you are lying down or squatting to insert into the vagina. Place the pessary between the lips of the vagina and push it upwards and backwards. To insert into the rectum, gently push the pessary into the rectum for about one inch. Squeeze your buttocks together for a few seconds and your muscles will hold the pessary in place when it is in far enough.  Do not swallow this medicine. To treat PMS, start using MIPROGEN 100 MG on day 12 or 14 of your menstrual cycle.

SIDE EFFECTS OF MIPROGEN 100 MG

HOW TO MANAGE SIDE EFFECTS

Drowsiness:

Try to rest and relax. Get enough sleep. Avoid travelling, driving or operating any machinery if you are feeling drowsy. Consult your doctor if this symptom bothers you.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking,

• carbamazepine (a medicine used to treat fits or certain type of pain or mood disorders)
• rifampicin (used to treat infections)
• phenytoin (used to treat and prevent seizures)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT MIPROGEN 100 MG

Can MIPROGEN 100 MG cause bleeding?

No. It does not cause any unnecessary vaginal bleeding. However, it should be taken with caution in people who have unexplained vaginal bleeding.

Can MIPROGEN 100 MG cause thrust?

Currently, there are not enough evidence about this medicine on the incidence of thrush. If you experience any unusual symptoms after using this medicine, contact your doctor.

Can MIPROGEN 100 MG cause stomach cramps?

Yes. This medicine may cause stomach cramps in some individuals. Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

REFERENCES

1. KD. Tripathi. Hormones and related drugs: Estrogens, Progestins and Contraceptives. Essentials of medical pharmacology. Seventh edition. 2013. Page – 316-319.

2. Ellis R. Levin and Stephen R. Hammes. Estrogens and Progestins. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1180-1184.

3. University of North Carolina. Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and Parturition. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on November 2017] [Accessed 9th November 2020] https://clinicaltrials.gov/ct2/show/NCT01762943

4. P J Magill. Investigation of the efficacy of progesterone pessaries in the relief of symptoms of premenstrual syndrome. progesterone Study Group. NCBI; PMC US National Library of Medicine, National Institute of Health. November 1995 [Accessed 9th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1239433/

5. Kimberly Ann Yonkers, Prof. P M Shaughn O’Brien and Prof. Elias Eriksson Premenstrual syndrome. NCBI; PMC US National Library of Medicine, National Institute of Health. June 2011 [Accessed 9th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118460/

6. Ford O, Lethaby A, Roberts H, Mol BWJ. Progesterone for premenstrual syndrome. Cochrane. March 2012. [Accessed 9th November 2020] https://www.cochrane.org/CD003415/MENSTR_progesterone-for-premenstrual-syndrome

7. Accord-UK Ltd. Electronic Medicines Compendium (EMC); [Revised on August 2019] [Accessed 9th November 2020] https://www.medicines.org.uk/emc/files/pil.5568.pdf

USEFUL DIAGNOSTIC TESTS

• Anti-Mullerian Hormone
• Glycosylated Hemoglobin
• Testosterone Total
• Thyroid Stimulating Hormone