INTRODUCTION

MIOL FORTE INJECTION contains Mecobalamin which belongs to the group of medicines called Vitamins. MIOL FORTE INJECTION is used to treat diabetic neuropathy (nerve damage caused by diabetes), peripheral neuropathy (peripheral nerve damage that affects hands, feet and arms) and megaloblastic anaemia (blood disorder) caused by vitamin B12 deficiency in affected individuals.

MIOL FORTE INJECTION is also used to treat sciatica pain (leg pain), back pain and general weakness in affected individuals.

MIOL FORTE INJECTION is not recommended for use in patients allergic to mecobalamin and/or other B12 containing medicines.

Before receiving MIOL FORTE INJECTION, inform your doctor if you have Leber's disease (inherited form of vision loss) and/or suffering from low potassium level (with associated signs such as muscle twitches/cramps, low blood pressure), optic nerve disease (swelling and nerve damage to the eyes), kidney and/or liver problems.

MIOL FORTE INJECTION is not recommended for use during pregnancy and in breastfeeding women. It should be used with caution in children & adolescents (aged 6 months to 18 years) and in elderly patients (aged above 65 years) after consulting the doctor.

The most common side effects of receiving MIOL FORTE INJECTION are headache, nausea, vomiting, diarrhoea, loss of appetite, skin rash and/or hot flushes. Consult your doctor if any of these side effects worsens.

USES OF MIOL FORTE INJECTION

• Treats diabetic and peripheral neuropathies
• Treats megaloblastic anaemia (caused by vitamin B12 deficiency)
• Treats sciatica pain (leg pain), back pain and general weakness in affected individuals.

HOW MIOL FORTE INJECTION WORKS

MIOL FORTE INJECTION works by aiding in the synthesis of myelin (lipid rich material that covers nerve fibres) which helps in protecting the nerve fibres and thereby providing relief from diabetic & peripheral neuropathy, sciatica pain and back pain in affected individuals. It also promotes nucleic acid synthesis in the bone marrow which helps in the maturation and division of erythroblasts thus preventing poor production of red blood cells and thereby improving megaloblastic anaemia in affected individuals.

DIRECTIONS FOR USE

MIOL FORTE INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection or into the muscle as an intramuscular injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF MIOL FORTE INJECTION

HOW TO MANAGE SIDE EFFECTS

Headache:

If MIOL FORTE INJECTION causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving MIOL FORTE INJECTION. If it lasts more than a week or severe, inform your doctor.

Nausea and vomiting:

Receive MIOL FORTE INJECTION with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Talk with your doctor if the condition worsens.

Diarrhea:

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult your doctor and inform them if the symptom gets worse.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before receiving MIOL FORTE INJECTION, inform your doctor if you are receiving any of the following medicine:

• neomycin (used to prevent/treat bacterial skin infections)
• amino salicylic acid (used to treat tuberculosis)
• histamine H2-antagonists (used to treat and prevent recurrence of duodenal ulcers) Ex. ranitidine, famotidine 
• colchicine (used in the treatment of gout)
• oral contraceptives (used to prevent pregnancy) Ex. ethinyl estradiol and norethindrone
• chloramphenicol (used to treat bacterial infections)
• cimetidine (used to treat ulcers of stomach and intestines)

Overdosage:

MIOL FORTE INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

SYNOPSIS

MORE INFORMATION

• Keep MIOL FORTE INJECTION out of reach of children
• Store MIOL FORTE INJECTION below 30°C

FAQs ABOUT MIOL FORTE INJECTION

What is MIOL FORTE INJECTION used for?

MIOL FORTE INJECTION is used to treat diabetic neuropathy (nerve damage caused by diabetes), peripheral neuropathy (peripheral nerve damage that affects hands, feet and arms) and megaloblastic anaemia (blood disorder) caused by vitamin B12 deficiency. It is also used to treat sciatica pain (leg pain), back pain and general weakness in affected individuals.

How MIOL FORTE INJECTION is received?

MIOL FORTE INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection or into the muscle as an intramuscular injection. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

What are the side effects of MIOL FORTE INJECTION?

The most common side effects of receiving MIOL FORTE INJECTION are headache, nausea, vomiting, diarrhoea, loss of appetite, skin rash and/or hot flushes. Consult your doctor if any of these side effects worsens.

How MIOL FORTE INJECTION works?

MIOL FORTE INJECTION works by aiding in the synthesis of myelin (lipid rich material that covers nerve fibres) which helps in protecting the nerve fibres and thereby providing relief from diabetic & peripheral neuropathy, sciatica pain and back pain in affected individuals.   It also promotes nucleic acid synthesis in the bone marrow which helps in the maturation and division of erythroblasts thus preventing poor production of red blood cells and thereby improving megaloblastic anaemia in affected individuals.

Does MIOL FORTE INJECTION cause headache?

Yes, MIOL FORTE INJECTION causes headache as it is the commonest side effect associated with the use of MIOL FORTE INJECTION. If such side effect experienced after receiving the medicine, then try to take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of receiving MIOL FORTE INJECTION. If it lasts more than a week or severe, then inform your doctor.

REFERENCES

1. KD. Tripathi. Drugs affecting blood and blood formation, Vitamins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 606.

2. Rabia G Sezer, Abdulkadir Bozaykut, Handan A Akoglu, Gül N Özdemir. The Efficacy of Oral Vitamin B12 Replacement for Nutritional Vitamin B12 Deficiency.  NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. March 2018. [Accessed on 4th November 2022] https://pubmed.ncbi.nlm.nih.gov/29189512/

3. Emmanuel Andrès, Thomas Vogel, Laure Federici, Jacques Zimmer, Ecaterina Ciobanu and Georges Kaltenbach. Cobalamin Deficiency in Elderly Patients: A Personal View. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. May 2008. [Accessed on 4th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672039/

4. Getz Pharma (Pvt) Ltd. Nervon. [Accessed on 4th November 2022] https://getzpharma.com/wp-content/uploads/2016/08/Nervon-Range-Leaflet-Export-GA.pdf

5. Cradle Life Science Pvt. Ltd. MUST Injection. [Accessed on 4th November 2022] https://cradlelifesciences.com/product.php

6. KINESIS BIOCARE. Vitkin-1500 INJECTION. [Accessed on 4th November 2022] https://www.kinesisbiocare.in/vitkin-1500-injection-methylcobalamin-1500mcg-injection--4429240.html

7. KINESIS BIOCARE. Vitkin-1500 INJECTION. [Accessed on 4th November 2022] https://www.kinesisbiocare.in/vitkin-1500-injection-methylcobalamin-1500mcg-injection--4429240.html

8. Integrated Laboratories Pvt Ltd. Methylcobalamin Injection. [Accessed on 4th November 2022] https://integratedlaboratories.in/methylcobalamin-injection-intebion-2500/#

USEFUL DIAGNOSTIC TESTS

• Nerve conduction test
• Complete blood count