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INTRODUCTION
MINOPRIDE 50MG CAPSULE contains Minocycline, which belongs to the group of medicines called Antibiotics. It is used to treat certain forms of bacterial infections that affect the ears, eyes, throat, nose, and respiratory system (chest infections), gonorrhoea or pelvic, skin infections (acne), urinary tract infections and prostate infections. It also helps in the treatment of meningitis carriers. It is also used in the prevention of infections before and after an operation.
Before taking MINOPRIDE 50MG CAPSULE, inform your doctor if you have or ever had liver or kidney problems. Avoid consumption of alcohol, milk or milk products while taking MINOPRIDE 50MG CAPSULE, as it may lead to unwanted side effects.
MINOPRIDE 50MG CAPSULE should be used with caution among women who are pregnant or breastfeeding as it can affect the development of the unborn baby. MINOPRIDE 50MG CAPSULE should be used with caution by adults and adolescents but not recommended for use under the age of 12 years. The most common side effects of taking MINOPRIDE 50MG CAPSULE are dizziness and fever. Consult your doctor if any of the symptoms worsen.
USES OF MINOPRIDE 50MG CAPSULE
- Treats varied types of infections, such as bacterial infections that affect ears, eyes, throat, nose and respiratory system (chest infections), gonorrhoea or pelvic, skin infections (acne), urinary tract infections and prostate infections
- Treats meningitis carriers
- Prevention of infection before and after an operation
HOW MINOPRIDE 50MG CAPSULE WORKS
MINOPRIDE 50MG CAPSULE has properties of immunomodulatory, anti-inflammatory and neuroprotective effects. It can work by any of the following mechanism such as inhibitory effect on activities of enzymes such as MMPs or iNOS; reduction in protein tyrosine nitration because of scavenging properties; inhibition of activation of caspase-1 and caspase 3; enhancement of Bcl-2-derived effects which protects the cells against apoptosis; inhibition of the activity of PARP-1; reduction in the amount of p38 MAPK phosphorylation. All these activities of minocycline help in fighting against various bacterial infections.
DIRECTIONS FOR USE
Take MINOPRIDE 50MG CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew. You can take MINOPRIDE 50MG CAPSULE while sitting down or standing.
Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF MINOPRIDE 50MG CAPSULE
COMMON
- dizziness
UNCOMMON
- fever
RARE
- vertigo (spinning sensation)
- tinnitus (ringing in ears) and other hearing problems
- loss of appetite
- headache
- diarrhoea
- feeling or being sick
- hair loss
- abnormal and unexplained bruising and bleeding for a longer period. This might indicate low platelet levels in the blood
- discolouration of teeth
- cough
- reduced sense of touch
- feeling of pins and needles in the hands or feet
- muscle and joint pain
- skin problems such as itching, skin rashes, nettle rashes, the appearance of the same skin reaction in the same area after taking medicine, and the occurrence of red round lumps under the skin below the knee
- redness, pain, or tenderness, swelling around a vein (vasculitis)
- increased levels of liver enzymes or urea observed in blood test
- increase in a specific type of WBCs seen in blood test
Stop taking MINOPRIDE 50MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:
- severe headaches
- eye problems such as blurred or double vision, loss of vision
- urine problems such as little or no urine production, discomfort, or pain during the passing of urine, and the production of dark or cloudy urine with lower back pain. These are indications of serious kidney problems
- skin problems such as the occurrence of purple painful lumps on the skin (erythema nodosum), patches of dark skin colour, burning, tingling or redness of the skin after exposure to direct or artificial sunlight
- inflammation is seen in various parts such as the liver, blood vessels, tongue, vagina or mouth, and intestines which causes severe nausea and vomiting, stomach cramps or diarrhoea and itching of the anus. These are indicative of the growth of tetracycline-resistance bacteria
- recurrent and frequent infections causing fever, chest infections, severe chills, or mouth ulcers. These are signs of low WBCs levels in the blood
- dark urine, pale stools, loss of appetite, yellowing of skin or whites of eyes, and stomach pain. These are indications of serious liver problems.
- fatigue, chest pain or pressure and shortness of breath during exercise are signs of inflamed heart muscles (myocarditis)
- sudden sharp chest pain which aggravates by deep breathing or coughing. These are signs of inflammation of the membrane surrounding the heart (pericarditis)
- muscle pain
- inflammation, pain, swelling or stiffness of joints with fever
- allergic reaction is seen as red itchy swollen skin, severe skin rashes, and swelling seen on the face, mouth, lips, tongue, or throat which results in breathing difficulties
- tiredness, weakness, or pale skin
- breathing problems such as wheezing, shortness of breath at rest, coughing with chest tightness or worsening of asthma
- stomach cramps, watery diarrhoea might be with blood, loss of appetite, and feeling sick (nausea or being sick). This may be a sign of pancreas inflammation
- severe skin reactions, blistering of skin, mouth, genitals, and eyes, peeling, or flaking of skin
- hair loss, weight loss, fever, rash (especially on the face), generalized feeling of being unwell and pain in joints. These are signs of Systemic Lupus Erythematous
- fits
- changes in the level of blood cells (drug reaction with eosinophilia and systemic symptoms – DRESS)
HOW TO MANAGE SIDE EFFECTS
Vomiting:
Take MINOPRIDE 50MG CAPSULE with or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if the symptom worsens.
Dizziness:
If your feel dizzy, lie down, close your eyes and relax. Once you start feeling better, get up slowly and not with a jerk. Sit like that for 5-10 minutes and then you can continue working. Consult your doctor if the symptom worsens.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much alcohol. Consult your doctor if the symptom worsens.
Diarrhoea:
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Consult your doctor if the symptom worsens.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. Consult your doctor if the symptom worsens.
WARNING & PRECAUTIONS
PREGNANCY
MINOPRIDE 50MG CAPSULE is generally not recommended for use by pregnant women or women who are planning to conceive, as it can affect the development of the foetus. Consult your doctor before taking it.
BREASTFEEDING
MINOPRIDE 50MG CAPSULE is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizziness, spinning sensation while standing, headaches, eyesight problems, light-headedness, ringing in the ears or hearing problems after taking MINOPRIDE 50MG CAPSULE.
ALCOHOL
Avoid consumption of alcohol while taking MINOPRIDE 50MG CAPSULE. The absorption of MINOPRIDE 50MG CAPSULE can be affected by food, milk or milk products.
KIDNEY
MINOPRIDE 50MG CAPSULE should be taken with caution in patients with severe kidney disease. Consult your doctor before taking it.
LIVER
MINOPRIDE 50MG CAPSULE should be taken with caution in patients with liver disease. Consult your doctor before taking it.
ALLERGY
Do not take MINOPRIDE 50MG CAPSULE if you are allergic to minocycline.
OTHERS
MINOPRIDE 50MG CAPSULE is not recommended for use if you:
- have systemic lupus erythematosus (an autoimmune disorder where the immune system of the body attacks its tissue causing damage and inflammation of various parts of the body)
- have a need for dialysis treatment
Before taking MINOPRIDE 50MG CAPSULE, inform your doctor if you:
- have myasthenia gravis (a condition which causes muscle weakening)
Use in paediatrics:
MINOPRIDE 50MG CAPSULE is generally not recommended for under 12 years of age as it can affect growing bones and teeth and cause staining of teeth along with reduced enamel content in teeth. Consult your doctor before taking it.
Use in geriatrics:
MINOPRIDE 50MG CAPSULE should be used with caution in elderly patients. Consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking MINOPRIDE 50MG CAPSULE, inform your doctor if you are taking any of the following medicine:
- anticoagulants (used to thin blood) Ex. warfarin
- antacids (used to treat indigestion) Ex. – magnesium hydroxide and calcium carbonate
- hepatotoxic medicine (medicines that might affect the working of the liver)
- sucralfate and bismuth salts (used to treat ulcers)
- kaolin (used to treat diarrhoea)
- quinapril (ACE inhibitor, used to treat high blood pressure)
- antibiotic (a medicine used to treat infections) Ex. – penicillin
- diuretics Ex. bumetanide and furosemide
- retinoids (used to treat acne) Ex. isotretinoin or retinol
- ergotamine (used to treat migraines)
- ergometrine (used to induce labour or abortion)
- medicines containing zinc salts, calcium, iron, magnesium, or aluminium
B. Drug–Food Interactions:
Avoid drinking alcohol while taking MINOPRIDE 50MG CAPSULE as it may increase the risk of side effects. The absorption of MINOPRIDE 50MG CAPSULE can be reduced by food, milk or milk products.
Overdosage:
If you or anyone else accidentally take too much of MINOPRIDE 50MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are dizziness and feeling sick or nauseous.
SYNOPSIS
| Drug | : | Minocycline |
| Pharmacological Category | : | Antibiotics |
| Therapeutic Indication | : | Acne |
| Dosage Forms | : | Tablet, Capsules, Injection |
MORE INFORMATION
- Keep MINOPRIDE 50MG CAPSULE out of reach from children
- Store MINOPRIDE 50MG CAPSULE at room temperature
FAQs ABOUT MINOPRIDE 50MG CAPSULE
Can MINOPRIDE 50MG CAPSULE be used in pregnant women?
No, it is not recommended to use MINOPRIDE 50MG CAPSULE in pregnant women or if you are planning to get pregnant as it can affect the growth and development of the unborn baby. Consult your doctor before taking it.
How to take MINOPRIDE 50MG CAPSULE?
The dosage of MINOPRIDE 50MG CAPSULE will be decided by your doctor or pharmacist. But remember to not take MINOPRIDE 50MG CAPSULE with food, milk, or other milk products as this can reduce the absorption of the medicine. Do not immediately take this medicine after dinner just before bed, rather take it standing or sitting upright.
Can children under the age of 12 years take MINOPRIDE 50MG CAPSULE?
No, it is not safe for children under the age of 12 years to take MINOPRIDE 50MG CAPSULE as this medicine can affect the development of bone and cause staining of teeth and reduced amount of enamel content in teeth.
Will taking a higher dose of MINOPRIDE 50MG CAPSULE be more effective?
No, taking a higher dose of MINOPRIDE 50MG CAPSULE will not be effective, rather you might suffer from symptoms of overdose such as nausea, vomiting or dizziness. Consult your doctor immediately if you have accidentally taken a higher dose of MINOPRIDE 50MG CAPSULE.
What are the medicines that I should avoid while taking MINOPRIDE 50MG CAPSULE?
There are multiple medicines that one should avoid while taking MINOPRIDE 50MG CAPSULE such as anticoagulants like warfarin, antacids like magnesium hydroxide, ergotamine for migraines and ergometrine for inducing labour or abortion.
Can someone with lactose intolerance take MINOPRIDE 50MG CAPSULE?
No, if you know that you or someone you know, have lactose intolerance or intolerance to some other sugars, consult your doctor before taking MINOPRIDE 50MG CAPSULE.
Can we consume alcohol while taking MINOPRIDE 50MG CAPSULE?
Avoid alcohol consumption while taking MINOPRIDE 50MG CAPSULE as the absorption of the medicine will be reduced. Also, avoid taking milk or milk products or food while taking MINOPRIDE 50MG CAPSULE because of reduce absorption.
What should be done if I have missed a dose of MINOPRIDE 50MG CAPSULE?
If you miss your dose of MINOPRIDE 50MG CAPSULE do not take the missed dose even if you remember it later and follow the scheduled regime for your medicine.
Can we take MINOPRIDE 50MG CAPSULE after meals?
No, avoid taking MINOPRIDE 50MG CAPSULE after meals or with milk or milk products, as this can lead to reduced absorption of MINOPRIDE 50MG CAPSULE and the medicine will not work efficiently.
Is driving safe after taking MINOPRIDE 50MG CAPSULE?
No, driving is not safe after taking MINOPRIDE 50MG CAPSULE as you may feel dizziness, headaches, lightheadedness, spinning sensation while standing, ringing in the ears, or other hearing problems and eyesight problems. You should avoid driving or using machines after taking MINOPRIDE 50MG CAPSULE.
REFERENCES
1. K.D Tripathi. Tetracyclines and Chloramphenicol (Broad-Spectrum Antibiotics). Essentials of medical pharmacology. Seventh edition. 2013. Page – 733.
2. N Garrido-Mesa, A Zarzuelo, and J Gálvez. Minocycline: far beyond an antibiotic. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. May 2013. [Accessed on 1st June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651660/
3. Linda Stein Gold Sunil Dhawan, Jonathan Weiss, Zoe Diana Draelos, Herman Ellman, Iain A Stuart. A novel topical minocycline foam for the treatment of moderate-to-severe acne vulgaris: Results of 2 randomized, double-blind, phase 3 studies. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. January 2019. [Accessed on 1st June 2022] https://pubmed.ncbi.nlm.nih.gov/30165171/
4. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed 1st June 2022] https://www.medicines.org.uk/emc/files/pil.8478.pdf
5. Accord. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed 1st June 2022] https://www.medicines.org.uk/emc/files/pil.5915.pdf
6. Mylan Products Ltd. Electronic Medicines Compendium (EMC). [Revised in April 2018] [Accessed 1st June 2022] https://www.medicines.org.uk/emc/files/pil.9519.pdf
7. Dexcel Pharma Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2014] [Accessed 1st June 2022] https://www.medicines.org.uk/emc/files/pil.654.pdf
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