Minirin Melt 120mcg Tablet 10'S

INTRODUCTION

MINIRIN MELT 120MCG contains desmopressin which belongs to the group of medicines called synthetic antidiuretic peptide. It is used to treat diabetes insipidus (a condition with extreme thirst and continuous production of large volumes of dilute urine). It can also be used to treat primary nocturnal enuresis (bed wetting from the age of 5) and nocturia in adults up to 65 years (night-time urine production exceeding bladder capacity).

Desmopressin works by reducing the amount of water that is eliminated in the urine. It enhances the reabsorption of water in the kidneys. Avoid drinking large amounts of water or fluid during this medication that leads to a build-up of water resulting in dilution of the salt in the body and may cause a serious problems or convulsions.

The most common side effect of taking this medicine are headache, stomach pain swelling of ankles. Before taking this medicine, inform your doctor if you are dehydrated due to vomiting, diarrhea or systemic infections. There is an increased risk of pre-eclampsia during this medication, so inform your doctor if you are pregnant or planning to become pregnant. MINIRIN MELT 120MCG should be used with caution in breastfeeding women. Consult your doctor for advice.

USES OF MINIRIN MELT 120MCG

• Diabetes insipidus (a condition with extreme thirst and continuous production of large volumes of dilute urine)
• Primary nocturnal enuresis (bed wetting from the age of 5)
• Nocturia in adults up to 65 years (urine production at night exceeding bladder capacity)

HOW MINIRIN MELT 120MCG WORKS

Desmopressin mimics the action of endogenous anti-diuretic hormone. After administration, desmopressin works by reducing the amount of water that is eliminated in the urine. It enhances the reabsorption of water in the kidneys.

DIRECTIONS FOR USE

Always take this medicine as directed by your doctor. Swallow the medicine as whole with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results. Avoid drinking large amounts of water while taking MINIRIN MELT 120MCG since it could lead to a build-up of water leading to serious problems or convulsions.

SIDE EFFECTS OF MINIRIN MELT 120MCG

HOW TO MANAGE SIDE EFFECTS

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

Weight gain:

Exercise more regularly. e.g. walking or running. 

Headache:  

Rest and drink plenty of fluids. Do not drink too much alcohol.

Constipation: 

Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking,

• medicine used to treat depression or epilepsy (fluoxetine, phenytoin)
• medicine used for pain and/or inflammation e.g. indomethacin, aspirin
• other diuretic medicine (e.g. furosemide)
• loperamide (used to treat diarrhea)

SYNOPSIS

MORE INFORMATION

Store at room temperature 15-25°C and keep out of reach of children.

FAQs ABOUT MINIRIN MELT 120MCG

Can MINIRIN MELT 120MCG cause weight gain?

Yes. This medicine may cause weight gain in some individuals. Exercise more regularly. e.g. walking or running. 

Can MINIRIN MELT 120MCG be used in pregnancy?

Consult your doctor before taking this medicine, if you are pregnant, as blood pressure monitoring is recommended due to the increased risk of pre-eclampsia.

Can we drink alcohol while taking MINIRIN MELT 120MCG?

No. Avoid alcohol consumption while taking this medicine. This could lead to serious problems.

REFERENCES

1. KD. Tripathi. Antidiuretics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 596-597.

2. Robert F. Reilly and Edwin K. Jackson. Regulation of renal function and vascular volume. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 708-714.

3. Roger K. Long & Hakan Cakmak. Hypothalamic & Pituitary Hormones. Basic and Clinical Pharmacology. 14th Edition. New York McGarw Hill Education 2018.  Page – 681-682.

4. Gerald G. Briggs and Roger K. Freeman. D. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 1085-1086.

5. Teva Pharmaceuticals USA. Desmopressin Acetate 0.2 mg Tablets, Fasting. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on September 2009] [Accessed 26th November 2020] https://clinicaltrials.gov/ct2/show/NCT00835211

6. Ferring Pharmaceuticals. Efficacy and Safety of Desmopressin Melt for the Treatment of Nocturia. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on November 2015] [Accessed 26th November 2020] https://clinicaltrials.gov/ct2/show/NCT00477490

7. Fara M. Friedman and Jeffrey P. Weiss. Desmopressin in the treatment of nocturia: clinical evidence and experience. NCBI; PMC US National Library of Medicine, National Institute of Health. December 2013. [Accessed 26th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825109/

8. Ferring GmbH. Electronic Medicines Compendium (EMC); [Revised on October 2011] [Accessed 26th November 2020] https://www.medicines.org.uk/emc/files/pil.1285.pdf

9. Ferring GmbH. Health Products Regulatory Authorities (HPRA); [Revised on April 2015] [Accessed 26th November 2020] https://www.hpra.ie/img/uploaded/swedocuments/PA1009-1-3%20PIL-2162024-08052015145558-635666937589703750.pdf

USEFUL DIAGNOSTIC TESTS

• Urine analysis
• Oral glucose tolerance test
• Kidney function test