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INTRODUCTION
MINIPRESS XL 5MG contains Prazosin which belongs to the group of medicines called Alpha-Blockers. It is mainly used to treat hypertension (condition in which force of the blood is high against the arterial walls), heart failure (a condition in which heart doesn’t pump blood well) and Raynaud’s disease (condition in which some areas of the body may feel numb and cold such as fingers and toes). MINIPRESS XL 5MG is also used to treat prostatic hyperplasia in men. Prostatic hyperplasia can be defined as an age-related mild prostate gland enlargement which is categorized by urinary difficulties or increased frequency of urination during night-time.
Prazosin works by reducing the blood pressure where it helps relax the walls of blood vessels and reduce the resistance to blood flow so that blood can pass smoothly without any obstruction. It reduces the chances of heart failure by acting on the main blood vessel, thus allowing the heart to pump blood effectively. It treats Raynaud’s disease (fingers become white and painful when cold) by relaxing the blood vessels so that blood can reach the fingers and promotes circulation thereby prevents fingers being cold and stiff. MINIPRESS XL 5MG also treats prostatic hyperplasia (mild enlargement of prostate gland) by relaxing the muscles of bladder and prostate gland and thus helps to pass urine easily.
Before taking MINIPRESS XL 5MG, inform your doctor if you have kidney or liver disease. You should inform your doctor if you have ever had a fainting after passing urine. MINIPRESS XL 5MG may cause complications during eye surgeries such as cataract, therefore inform your doctor if you are undergoing any eye operations. MINIPRESS XL 5MG is not recommended in children under (12 years of age) and also patients having allergy to prazosin or other quinazolines such as doxozosin and tetrazosin. MINIPRESS XL 5MG should be used with caution in pregnant women, breast feeding mothers and elderly people. Consult your doctor before taking it. Most common side effects of MINIPRESS XL 5MG are nausea, vomiting, drowsiness, fainting and dizziness etc. Consult your doctor if any of the symptoms bothers you.
USES OF MINIPRESS XL 5MG
- Treats hypertension (high blood pressure)
- Treats heart failure
- Treats Raynaud’s disease (painful cold fingers)
- Treats prostatic hyperplasia (mild enlargement of prostate gland) in men
HOW MINIPRESS XL 5MG WORKS
MINIPRESS XL 5MG reduces the blood pressure by relaxing the blood vessels so that blood that pass easily without any obstruction. It reduces the chances of heart failure by acting on the main blood vessel, thus allowing the heart to pump blood productively. It treats raynauds disease (painful cold fingers) by relaxing the blood vessels so that blood can reach the fingers and promotes circulation thereby prevents fingers being cold and stiff. MINIPRESS XL 5MG also treats prostatic hyperplasia (mild enlargement of prostate gland) by relaxing the muscles of bladder and prostate gland and thus promotes easy passage of urine.
DIRECTIONS FOR USE
Take MINIPRESS XL 5MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. You can take this medicine before or after food or drinks.
SIDE EFFECTS OF MINIPRESS XL 5MG
COMMON
- fainting and dizziness especially on standing up.
- headache, drowsiness, or weakness
- palpitations (irregular beating of heart)
- nausea and vomiting
- lack of energy
- depression or nervousness
- constipation and diarrhoea
- dry mouth
- nasal stuffiness
- blurred vision
- shortness of breath or rash (signs of allergic reaction)
- swelling of the feet, ankles or leg
- increased frequency of urination
UNCOMMON
- stomach discomfort or pain
- chest pain accompanied by increased heartbeat
- tingling sensation or numbness
- ringing or buzzing in the ear
- redness in the eyes or eye pain
- sleeping difficulties
- sweating
- itching of skin
- painful joints
- difficulty or inability in erection of penis
RARE
- infection and pain in pancreas
- abnormal slow beating of heart
- hallucinations (abnormal imagining about things which are not real)
- loss of hair
- decreased blood pressure
- flushing (redness)
- abnormal breast enlargement especially in men
- persistent erection of the penis
- sleeping disorder causing increased tendency to fall asleep (narcolepsy)
- urinary incontinence (leaking of urine)
- fever and pain
- swelling of blood vessels
Stop taking MINIPRESS XL 5MG and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as sudden wheeziness, difficulty in breathing, swelling of eyelids, face, lips, rash or itching which affects the whole body)
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Take this medicine with, or just after meals. Stick to simple and healthy meals. Avoid eating oily or spicy foods. Consult your doctor immediately if the symptoms are worsening.
Constipation:
Eat plenty of foods which contain fibre such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. If the symptom does not improve consult your physician.
Diarrhoea:
Drink plenty of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have frequent and small quantities of food Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.
Headache:
Use a cold pack or hot pads to reduce the pressure on your head. Reduce looking into bright light and try to get adequate sleep. Consult your doctor if symptom is not improving.
Dizziness:
Try to lie down or sit immediately if you feel dizzy. Drink enough water to get hydrated. Consult your doctor if symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
MINIPRESS XL 5MG should be used during pregnancy only if considered clearly necessary. Consult your doctor before taking it.
BREASTFEEDING
MINIPRESS XL 5MG is excreted in small amounts through breast milk, so it should be used with caution in breastfeeding mothers. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizziness, drowsiness, or weakness after taking MINIPRESS XL 5MG.
ALCOHOL
Avoid consumption of alcohol while taking MINIPRESS XL 5MG because it might cause dizziness, light-headedness, or fainting.
KIDNEY
MINIPRESS XL 5MG should be used with caution in patients with kidney disease. Consult your doctor before taking.
LIVER
MINIPRESS XL 5MG should be used with caution in patients with liver disease. Consult your doctor before taking.
ALLERGY
Do not take MINIPRESS XL 5MG if you are allergic to Prazosin or other quinazolines such as doxazosin and terazosin.
HEART DISEASE
MINIPRESS XL 5MG should be used with caution in patients having heart failure due to another heart conditions such as heart attack or valvular heart disease. This heart conditions can gradually make this medicine ineffective and can lead to oedema (fluid retention) in legs and ankles. Consult your doctor before taking it.
OTHERS
Before taking MINIPRESS XL 5MG, inform your doctor if you:
- have ever had a fainting after passing the urine
- are undergoing an eye operation due to cataract (cloudiness of lens)
- have prolonged erection of penis which lasts than 4 hours
Use in paediatrics:
- MINIPRESS XL 5MG is not recommended for use in children and adolescents (under 12 years of age). Consult your doctor before taking it.
Use in geriatrics:
- MINIPRESS XL 5MG should be used with caution in elderly patients usually initiating the treatment with the lowest possible dose. Consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug Interactions:
Before taking MINIPRESS XL 5MG, inform your doctor if you are taking any of the following medicine:
- calcium antagonists and ACE inhibitors (medicines used to treat high blood pressure) Ex. amlodipine, diltiazem, captopril enalapril
- beta blockers (medicines used to treat angina (chest pain) Ex. atenolol, metoprolol
- medicines used to treat erectile dysfunction (impotence) (Ex. sildenafil, tadalafil)
- diuretics (medicines used to treat oedema) Ex. hydrochlorothiazide, furosemide
Overdosage:
If you or anyone else accidentally take too much of MINIPRESS XL 5MG, consult your doctor immediately or visit the nearby hospital. Overdosage may lead to decrease in blood pressure.
SYNOPSIS
| Drug | : | Prazosin |
| Pharmacological Category | : | Alpha-Blockers |
| Therapeutic Indication | : | Hypertension, Heart failure, Raynauds disease, Prostatic hyperplasia |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep this medicine out of reach of children
- Store at room temperature
FAQs ABOUT MINIPRESS XL 5MG
How MINIPRESS XL 5MG works on my body?
MINIPRESS XL 5MG reduces the blood pressure by relaxing the blood vessels so that blood can pass smoothly without any obstruction. It reduces the chances of heart failure by acting on the main blood vessel, thus allowing the heart to pump blood productively. It treats Raynauds disease (painful cold fingers) by relaxing the blood vessels so that blood can reach the fingers and promotes circulation thereby prevents fingers being cold and stiff. MINIPRESS XL 5MG also treats prostatic hyperplasia (mild enlargement of prostate gland) by relaxing the muscles of bladder and prostate gland and thus enhance the urine passage easily.
Is MINIPRESS XL 5MG safe to use in children?
No, MINIPRESS XL 5MG is not recommended for use in children and adolescents (under 12 years of age) due to lack of safety and effectiveness. Consult your doctor for suggestion before taking MINIPRESS XL 5MG.
How to take MINIPRESS XL 5MG?
Take MINIPRESS XL 5MG as advised by your physician. Swallow MINIPRESS XL 5MG with a glass of water. Do not crush or chew the medicine. Your doctor will decide the exact dose and duration for you depending upon your age, body weight and state of your disease. You are advised to consume this medicine before or after food. This medicine in some cases can cause light-headedness, weakness especially when you are standing up and can occasionally cause fainting. You are advised to lie down till you feel better if you feel any of these symptoms.
Can I take MINIPRESS XL 5MG if I have any kidney problems?
MINIPRESS XL 5MG should be used with caution among patients having kidney problems. Your doctor may adjust the dose or choose another alternative medicine depending upon the kidney function. Consult your doctor before taking it.
Will the use of MINIPRESS XL 5MG affect my sex life?
Yes. MINIPRESS XL 5MG may affect the sexual life of men. It decreases the sexual desire in men and cause difficulty or inability in achieving erection of the penis. It can also cause breast enlargement in men. If you experience such problems, contact your doctor immediately.
Can I take a higher dose of MINIPRESS XL 5MG?
No. Do not take a higher dose of MINIPRESS XL 5MG than recommended by your doctor. Taking a higher dose of MINIPRESS XL 5MG without consulting a doctor can increase the risk of toxicity and can lead to side effects. If the prescribed dose is not effective for you, consult your doctor for a suitable higher dose. Never consume a higher dose MINIPRESS XL 5MG without proper medical supervision.
Is MINIPRESS XL 5MG a sleeping pill?
No, MINIPRESS XL 5MG is not used as a sleeping pill. But at the same time, it may cause uncommon and rare side effect such as sleeping difficulties and a sleeping disorder called narcolepsy causing increased tendency to fall asleep. Consult your doctor immediately if you are experiencing any sleeping problems.
Can MINIPRESS XL 5MG make me feel high?
No, MINIPRESS XL 5MG does not make you addictive or cause extreme feelings. Most common psychiatric symptoms caused by this medicine are nervousness and depression. Consult your doctor immediately if you feel these symptoms bothers you.
Is MINIPRESS XL 5MG safe to use in pregnancy?
MINIPRESS XL 5MG should be used with caution among pregnant women or women who are planning to become pregnant. Consult your doctor before taking it.
How long should I use MINIPRESS XL 5MG?
You are recommended to use MINIPRESS XL 5MG until your doctor suggests you stop the medication as per the suggested course and duration. Do not stop the medication without the instructions of the doctor as it may lead to serious problems.
REFERENCES
1. KD Tripathi MD. Cardiovascular drugs. Essentials of Medical Pharmacology. Eighth Edition, 2019. Page – 610.
2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 1145-1146.
3. Basquez R, Pippin MM. Prazosin. NIH National Library of Medicine, National centre for biotechnology information. [Revised in 10th May 2022] [Accessed on 28th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK555959/
4. Kung S, Espinel Z, Lapid MI. Treatment of nightmares with prazosin: a systematic review. [Revised in September 2012] [ Accessed on 28th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538493/
5. Pfizer Australia Pty Ltd. Minipress (prazosin) [Revised in January 2012] [Accessed on 28th May 2022] https://gp2u.com.au/static/pdf/M/MINIPRESS-PI.pdf
6. Pfizer Australia Pty Ltd. Minipress. [Revised in February 2022] [Accessed on 28th May 2022] http://secure.healthlinks.net.au/content/pf/retriever.cfm?product=pfcminit10112
7. Pfizer Limited. Electronic Medicines Compendium (EMC); [Revised in October 2020] [Accessed on 28th May 2022] https://www.medicines.org.uk/emc/files/pil.1068.pdf
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