INTRODUCTION

MINIPRESS XL 5MG contains Prazosin hydrochloride which belongs to a group of medicines called alpha-blockers. It is used to treat high blood pressure, mild enlargement of prostate gland in men, Raynaud's disease (fingers become white and painful when cold) and certain types of heart failure. This medicine is often used in combination with other medicines. It reduces the resistance to blood flow by relaxing muscles in the walls of blood vessels and also increase the flow of urine in patients with prostate problems by relaxing muscles in the prostate gland.

Prazosin hydrochloride blocks sympathetically mediated vasoconstriction and produces fall in blood pressure. It inhibits the postsynaptic alpha-1 adrenoceptors which blocks the vasoconstricting (narrowing) effect of epinephrine and norepinephrine on the blood vessels, leading to peripheral blood vessel dilation. MINIPRESS XL 5MG lowers high blood pressure by relaxing the blood vessels which makes the blood passes through them more easily. In heart failure, it works by relaxing the main blood vessels of the heart, allowing the heart to pump blood more easily.

Always take this MINIPRESS XL 5MG exactly as directed by your doctor. Before taking this medicine, inform your doctor if you have liver, kidney or heart problems, are pregnant or breastfeeding. Consult your doctor if you do not feel better or if you feel worse while taking this medicine. It is not recommended for use in children under 12 years of age. The common side effects are headache, drowsiness and weakness.

USES OF MINIPRESS XL 5MG

• High blood pressure
• Mild enlargement of prostate gland
• Raynaud's disease

HOW MINIPRESS XL 5MG WORKS

MINIPRESS XL 5MG reduces the resistance to blood flow by relaxing muscles in the walls of blood vessels. They also increase the flow of urine in patients with prostate problems by relaxing muscles in the prostate gland.

DIRECTIONS FOR USE

Take this medicine according to the dose and frequency as advised by your doctor. Swallow it as a whole. Do not chew, crush or break the medicine. It can be taken with or without food.

SIDE EFFECTS OF MINIPRESS XL 5MG

HOW TO MANAGE SIDE EFFECTS

Drowsiness or dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Feeling sick (nausea) or indigestion:

Stick to simple normal meals and do not eat rich or spicy foods.

Constipation:

Add fruits, vegetables whole grains and other high-fiber foods to your normal diet.

Diarrhea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Nasal stuffiness:

Take long showers or breathe in steam from a pot of warm water. Place a warm, wet towel on your face.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:

• calcium antagonists
• ACE inhibitors or beta-blockers
• medicines for erectile dysfunction (impotence)

SYNOPSIS

MORE INFORMATION

Store below 30ºC and keep out of reach of children.

FAQs ABOUT MINIPRESS XL 5MG

How should MINIPRESS XL 5MG be taken?

Always take this medicine exactly as advised by your doctor. It should be taken by mouth and can be taken before or after meals.

How long do I need to take MINIPRESS XL 5MG?

Your doctor will decide the dose and duration of treatment based on your condition.

How does MINIPRESS XL 5MG work for nightmares?

It is an alpha 1 antagonist which can decrease the level of norephrine in the central nervous system thereby reducing the nightmares related to PTSD (Post-traumatic stress disorder).

REFERENCES

1. KD Tripathi MD.  Cardiovascular drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 564.

2. Westfall TC, WestfallIn DP. Adrenergic Agonists and Antagonists. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page 305-308.

3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 1145-46.

4. Robertson D, Biaggioni I. Adrenoreceptor Antagonists Drugs. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 152.

5. Pfizer Australia Pty Ltd. Nov 2019; [Accessed Oct 15, 2020] http://secure.healthlinks.net.au/content/pf/retriever.cfm?product=pfcminit10112

6. Pfizer Australia Pty Ltd. Jan 23, 2012; [Accessed Oct 15, 2020] https://gp2u.com.au/static/pdf/M/MINIPRESS-PI.pdf

7. Pfizer Limited. Electronic Medicines Compendium (EMC); [Revised on June 2018] [Accessed Oct 15, 2020] https://www.medicines.org.uk/emc/files/pil.1068.pdf

USEFUL DIAGNOSTIC TESTS

• Kidney function test