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INTRODUCTION
MESAHENZ 400MG contains mesalamine (mesalazine) which belongs to the group of medicines called salicylates. It is an anti-inflammatory drug used to treat and prevent mild-to-moderate Ulcerative colitis. Ulcerative colitis is an inflammatory bowel disease in which the lining of the bowel, colon and rectum are inflamed.
MESAHENZ 400MG act locally in the colon and rectum and reduce inflammation. It can also prevent further episodes (flares) of ulcerative colitis. Along with this treatment, your doctor might recommend you, to avoid smoking and alcohol consumption, stick to simple meals and to drink plenty of water. Prior to the treatment, your doctor might take blood and urine test to access the function of your kidneys.
Take this medicine as directed by your physician. Swallow the medicine as a whole with a glass of water. Avoid concomitant use of MESAHENZ 400MG with lactulose and other anti-inflammatory disease, because it can increase the risk of side effects. On the course of treatment, regular monitoring of your liver, kidney and blood is required, to avoid any unwanted or toxic effects. If you are pregnant or think you may be pregnant, or breastfeeding inform your doctor before taking this medicine. The most common side effect of taking this medicine are abdominal pain, nausea, vomiting, bloating and headache.
USES OF MESAHENZ 400MG
- Treats and prevents mild-to-moderate Ulcerative colitis
HOW MESAHENZ 400MG WORKS
Mesalamine inhibits the production of prostaglandins (lipid compounds which produces tissue damage and inflammation) by blocking the activity of cyclooxygenase and lipoxygenase. Decreased production of prostaglandins reduces the inflammation in the colon and rectum, which in turn reduces the symptoms associated with ulcerative colitis.
DIRECTIONS FOR USE
Take this medicine as directed by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
SIDE EFFECTS OF MESAHENZ 400MG
SERIOUS
- allergic reactions (such as skin rash, itching, shortness of breath, swelling of the face, lips or throat, increased heartbeat or chest pain)
- fever, sore throat
- mouth or lip ulcers
- spots underneath your skin anywhere on your body
- pale skin
- swollen ankles
- unusual bleeding (e.g. unexpected nosebleeds or bleeding gums)
- change in color or amount of urine produced
COMMON
- diarrhea
- abdominal pain
- nausea or vomiting
- wind (bloating)
- headache
- muscle pain
- indigestion
- rectal disorder
RARE
- inflammation of pancreas
- numbness and tingling of fingers and toes
- hair loss
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Try taking this medicine with, or just after meal and stick to simple meals. Do not eat rich or spicy food.
Diarrhea:
Drink lots of fluids, to avoid dehydration. Avoid taking any medicines for diarrhoea without speaking to a doctor.
Stomach pain:
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Bloating or wind:
Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptoms get worse, contact your doctor straight away.
WARNING & PRECAUTIONS
PREGNANCY
MESAHENZ 400MG should not be used in pregnant women unless clearly necessary. Consult your doctor before taking.
BREASTFEEDING
MESAHENZ 400MG should not be used in breastfeeding mothers unless clearly necessary. Consult your doctor before taking.
DRIVING AND USING MACHINES
Do not drive or operate any machines if your ability is affected by this medicine.
ALCOHOL
Avoid consumption of alcohol while taking this medicine.
KIDNEY
Do not take MESAHENZ 400MG if you have a severe kidney impairment. Consult your doctor for advice.
LIVER
MESAHENZ 400MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
ALLERGY
Do not take this medicine if you are allergic to mesalazine (mesalamine), aspirin or other salicylates.
LUNGS
MESAHENZ 400MG should be taken with caution in patients with lung disease. Consult your doctor for advice.
OTHERS
Do not take this medicine, if you:
- have stomach ulcers with or without bleeding in the gut
INTERACTIONS
Talk to your doctor, if you are taking,
- lactulose (used to treat constipation)
- non-steroidal anti-inflammatory drugs (such as ibuprofen, aspirin, celecoxib)
- azathioprine (used to treat severe rheumatoid arthritis)
- 6-mercaptopurine or thioguanine (used to treat cancer)
- Medicines that stops blood clotting (e.g. warfarin)
SYNOPSIS
| Drug | : | Mesalazine (mesalamine/5-amino salicylic acid) |
| Pharmacological Category | : | Salicylates, 5-Amino salicylic acid derivative |
| Therapeutic Indication | : | Ulcerative colitis |
| Dosage Forms | : | Tablet, Powder, Enema, Pellet |
MORE INFORMATION
Store at room temperature and keep out of reach of children.
FAQs ABOUT MESAHENZ 400MG
Can MESAHENZ 400MG cause pancreatitis?
This medicine may rarely cause inflammation of pancreas (pancreatitis) in some individuals. Contact your doctor for advice.
Can MESAHENZ 400MG cause hair loss?
This medicine may rarely cause hair loss in some individuals. Contact your doctor for advice.
Can MESAHENZ 400MG be crushed?
No. Swallow the medicine as a whole with a drink of water. Do not crush or chew the medicine.
REFERENCES
1. KD Tripathi. Drugs for Constipation and Diarrhoea. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 684.
2. Tilo Grosser, Emer Smyth and Garret A. Fitzgerald. Anti-inflammatory, Antipyretic, and analgesic agents; Pharmacotherapy of gout. Goodman & Gilman’s: The Pharmacological Basics of Therapeutics. 12 Edition. New York Mc Graw Hill Medical 2011. Page – 979.
3. Gerald G. Briggs, Roger K. Freeman. B. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 375-376.
4. Bausch Health Americas, Inc. Mesalamine Pellet to Maintain Remission of Mild to Moderate Ulcerative Colitis. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on November 2019] [Accessed 29th October 2020] https://clinicaltrials.gov/ct2/show/NCT00767728
5. Bausch Health Americas, Inc. Long-Term Safety and Tolerability of Mesalamine Pellets in Participants With Ulcerative Colitis in Remission. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on November 2019] [Accessed 29th October 2020] https://clinicaltrials.gov/ct2/show/NCT00326209
6. Simone Cristina Déo1, Itamar Francisco Andreazza , João Carlos Possamai. Development of mesalazine pellets coated with methacrylic-derived polymer. Brazilian Journal of Pharmaceutical Sciences. August 2010 [Accessed 29th October 2020] https://www.scielo.br/pdf/bjps/v47n1/a12v47n1.pdfs
7. Ferring GmbH. Electronic Medicines Compendium (EMC); [Revised on October 2019] [Accessed 29th October 2020] https://www.medicines.org.uk/emc/files/pil.913.pdf
8. Warner Chilcott or Allergan Pharmaceuticals International Limited. Electronic Medicines Compendium (EMC); [Revised on September 2018] [Accessed 29th October 2020] https://www.medicines.org.uk/emc/files/pil.6167.pdf
9. Shire Pharmaceuticals Limited. Electronic Medicines Compendium (EMC); [Revised on March 2020] [Accessed 29th October 2020] https://www.medicines.org.uk/emc/medicine/20347#gref
10. Warner Chilcott or Allergan Pharmaceuticals International Limited. Electronic Medicines Compendium (EMC); [Revised on September 2018] [Accessed 29th October 2020] https://www.medicines.org.uk/emc/files/pil.2217.pdf
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