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INTRODUCTION
MESAHENZ 400MG contains Mesalamine which is an Anti-inflammatory agent. It is used to treat and prevent mild-to-moderate Ulcerative colitis. Ulcerative colitis is an inflammatory bowel disease in which the lining of the bowel, colon and rectum becomes swollen and inflamed. Symptoms include, but not limited to, rectal bleeding, stomach pain and bloody diarrhea.
MESAHENZ 400MG act locally in the colon and rectum and reduce inflammation. It can also prevent further episodes (flares) of ulcerative colitis. Along with this treatment, your doctor might recommend you to avoid smoking and alcohol consumption, to stick to simple meals and to drink plenty of water. Prior to the treatment, your doctor might take blood and urine test to access the function of your kidneys.
Take MESAHENZ 400MG preferably after meals. On the course of treatment, regular monitoring of your liver, kidney and blood are required, to avoid any unwanted or toxic effects. Before taking MESAHENZ 400MG, inform your doctor, if you are pregnant or breastfeeding. While taking MESAHENZ 400MG, drink plenty of fluids to avoid dehydration, especially if you had severe or prolonged episodes of vomiting and/or diarrhea, high fever, or heavy sweating. The most common side effects of MESAHENZ 400MG are abdominal pain, nausea, vomiting, bloating and headache.
USES OF MESAHENZ 400MG
- Treats and prevents mild-to-moderate Ulcerative colitis
HOW MESAHENZ 400MG WORKS
MESAHENZ 400MG is an anti-inflammatory medicine. It locally acts in the colon and rectum and reduces pain and inflammation by directly blocking the production of certain chemicals and enzymes (i.e., cyclooxygenase) that are responsible for it. As a result, it improves the symptoms of ulcerative colitis.
DIRECTIONS FOR USE
MESAHENZ 400MG must be taken with food and preferably at the same time each day. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of MESAHENZ 400MG for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF MESAHENZ 400MG
COMMON
- headache
- changes in blood pressure
- nausea, vomiting, stomach pain, flatulence diarrhea, indigestion
- skin rash, itching
- joint pain, back pain
- weakness or tiredness
- fever
UNCOMMON
- increased risk of bleeding and bruising
- dizziness, sleepiness
- shaking or trembling
- painful ears
- fast heartbeat
- throat pain
- signs of an inflamed pancreas (such as pain in upper abdomen and
back and feeling sick) - sign of a rectal polyp (a non-cancerous growth in the rectum causing constipation with bleeding)
- acne
- hair loss
- muscle pain
- swollen face
RARE
- kidney failure
- increased infection due to decrease in WBC count
- increased photosensitivity
Stop taking MESAHENZ 400MG and contact your doctor immediately if you experience any of the following side effects:
- sign of Acute Intolerance Syndrome (such as severe stomach pain, cramping, bloody diarrhea, fever, headache, or skin rash)
- unexplained bruising (without injury), skin rash, signs of anemia (such as looking pale, feeling tired or weak) with fever, sore throat, or unusual bleeding (Ex. nose bleeds)
- signs of serious skin reactions (such as skin rash, reddish non-elevated, target-like, or circular patches on the trunk, often with central blisters, skin peeling, ulcers of mouth, throat, nose, genitals, and eyes accompanied by fever and flu-like symptoms)
- allergic reactions (swelling of tongue, lips and around eyes)
- signs of increased pressure in the brain (such as headache which may originate behind your eyes and worsen with eye movements, blurred vision, double vision, seeing light flashes, difficulty in seeing to the side, and brief or permanent vision loss associated with nausea, vomiting, dizziness, and ringing in ears)
HOW TO MANAGE SIDE EFFECTS
Nausea or vomiting:
Try taking MESAHENZ 400MG with, or just after meal and stick to simple meals. Do not eat rich or spicy food.
Diarrhea:
Drink lots of fluids, to avoid dehydration. Avoid taking any medicines for diarrhea without consulting a doctor.
Stomach pain:
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.
Headache:
Rest and drink plenty of fluids. Do not drink alcohol. Ask your doctor to recommend a painkiller.
Flatulence:
Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptom worsens, contact your doctor straight away.
WARNING & PRECAUTIONS
PREGNANCY
MESAHENZ 400MG should not be used in pregnant women unless clearly necessary. Consult your doctor before taking.
BREASTFEEDING
MESAHENZ 400MG should not be used in breastfeeding mothers unless clearly necessary. Consult your doctor before taking.
DRIVING AND USING MACHINES
Do not drive or operate any machines if your ability is affected by MESAHENZ 400MG.
ALCOHOL
Avoid consumption of alcohol while taking MESAHENZ 400MG.
KIDNEY
Do not take MESAHENZ 400MG if you have a severe kidney impairment. Consult your doctor for advice.
LIVER
MESAHENZ 400MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
ALLERGY
Talk to your doctor if you are allergic to Mesalamine, Sulphasalazine, Aspirin or other salicylates.
LUNGS
MESAHENZ 400MG should be taken with caution in patients with lung disease. Consult your doctor for advice.
HEART DISEASE
MESAHENZ 400MG should be taken with caution among patients who have already had inflammation of heart. Consult your doctor before taking.
OTHERS
Before taking MESAHENZ 400MG, inform your doctor if you:
- have narrowing or blockage of the stomach or gut
- are going to have urine test
- have or had any bleeding disorders in the past
Use in Pediatrics:
MESAHENZ 400MG is not recommended for use in children and adolescents (below 18 years). Consult your doctor before taking
Use in Geriatrics:
MESAHENZ 400MG should be taken with caution among elderly patients. Consult your doctor before taking.
INTERACTIONS
Talk to your doctor, if you are taking any of the following medicine along with MESAHENZ 400MG,
- antibiotics (used to treat bacterial infections) such as amoxicillin, metronidazole, or sulfamethoxazole
- other medicines used to treat ulcerative colitis such as sulfasalazine
- azathioprine (used to treat severe rheumatoid arthritis)
- 6-mercaptopurine (used to treat cancer)
- warfarin, acenocoumarol and phenprocoumon (used for blood thinning)
Overdosage:
If you or anyone else accidentally take too much of MESAHENZ 400MG, consult your doctor immediately or go to the nearby hospital straight away. Symptoms of overdose might include headache, dizziness, sensation of ringing in the ears, confusion, drowsiness, shortness of breath, excessive loss of water due to vomiting, diarrhea or excessive sweating, lightheadedness, rapid breathing, and increased body temperature.
SYNOPSIS
| Drug | : | Mesalazine (mesalamine/5-amino salicylic acid) |
| Pharmacological Category | : | Anti-inflammatory agent |
| Therapeutic Indication | : | Ulcerative colitis |
| Dosage Forms | : | Tablet, Powder, Enema, Pellet |
MORE INFORMATION
- Keep MESAHENZ 400MG out of reach of children
- Store at room temperature
FAQs ABOUT MESAHENZ 400MG
Can MESAHENZ 400MG cause pancreatitis?
MESAHENZ 400MG may rarely cause inflammation of pancreas (pancreatitis) in some individuals. Signs of pancreatitis might include upper abdominal pain, stomach pain that radiates to your back region, nausea, vomiting, rapid heart rate and fever. Contact your doctor immediately if you experience any of the above symptoms.
Can I stop taking MESAHENZ 400MG by my own?
No. Do not stop taking MESAHENZ 400MG unless your doctor tells you to do so. Continue to take this medicine as instructed by your physician to obtain better results.
Can I take prednisolone along with MESAHENZ 400MG?
Avoid concomitant use of steroidal medicine like prednisolone while taking MESAHENZ 400MG as it can potentiate the risk of side effects. Consult your doctor for an alternative therapy.
Can MESAHENZ 400MG be used in children?
MESAHENZ 400MG is generally not recommended for use in children due to lack of safety data. Consult your doctor for advice.
Can MESAHENZ 400MG cause hair loss?
MESAHENZ 400MG can cause hair loss in some individuals. However, the exact reason behind hair fall is unknown. Usually, this side effect is resolved after discontinuation of the medicine. However, if it bothers you, contact your doctor for advice.
REFERENCES
1. KD Tripathi. Drugs for Constipation and Diarrhoea. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 684.
2. Tilo Grosser, Emer Smyth and Garret A. Fitzgerald. Anti-inflammatory, Antipyretic, and analgesic agents; Pharmacotherapy of gout. Goodman & Gilman’s: The Pharmacological Basics of Therapeutics. 12 Edition. New York Mc Graw Hill Medical 2011. Page – 979.
3. Gerald G. Briggs, Roger K. Freeman. B. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 375-376.
4. Maggie Ham and Alan C Moss. Mesalamine in the treatment and maintenance of remission of ulcerative colitis. NCBI. PMC. US National Library of Medicine. National Institute of Health. January 2013. [Accessed 18th March 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314328/
5. Cosmo SpA. Electronic Medicines Compendium (EMC) [Revised in June 2021] [Accessed 18th March 2022] https://www.medicines.org.uk/emc/files/pil.6154.pdf
6. Shire Development, Inc. U. S. Food and Administration. [Revised in June 2014]. [Accessed 18th March 2022] https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/022000Orig1s005.pdf
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- Anti Neutrophilic Cytoplasmic Antibody - P
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- Anti Saccharomyces Cerevisiae (ASCA), IgG
- C- Reactive Protein Quantitative
- Erythrocyte Sedimentation Rate
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