INTRODUCTION
MEPRIDE PM 1 TABLET is a combination of Glimepiride, Metformin and Pioglitazone which belongs to the group of medicines called Antidiabetic agents. It is used in adults to treat type II diabetes mellitus when diet, exercise and treatment with single agents does not result in adequate sugar control.
Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused due to inadequate production of a hormone called insulin (produced by pancreas to metabolize glucose) in the body or due to inadequate sensitivity of body cells to the actions of insulin.
Before taking MEPRIDE PM 1 TABLET, inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have any eye problems, hormonal imbalance, alcoholism, or if you are malnourished, starved, on an irregular diet as a precaution.
MEPRIDE PM 1 TABLET is strictly not recommended for use in patients with type I diabetes mellitus, bladder cancer, severe heart failure or lactic acidosis. It is also not suitable for use in pregnant or breastfeeding women.
Along with the treatment, follow the diet and lifestyle changes advised by your doctor to achieve better results. Avoid smoking and consumption of alcohol while taking MEPRIDE PM 1 TABLET as it may aggravate your existing condition.
The most common side effects of taking MEPRIDE PM 1 TABLET are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain. Consult your doctor if any of these side effect worsens.
USES OF MEPRIDE PM 1 TABLET
- Treats Type II diabetes mellitus
HOW MEPRIDE PM 1 TABLET WORKS
MEPRIDE PM 1 TABLET stimulates the pancreas to secrete more insulin (a hormone involved in glucose metabolism). It also makes our body more sensitive to insulin which helps in digesting the circulating sugars (glucose) in the blood, thereby reducing blood sugar levels. Additionally, it can also reduce the glucose produced by the liver and reduces its absoprtion in the body.
DIRECTIONS FOR USE
Take MEPRIDE PM 1 TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and disease condition.
Do not stop taking MEPRIDE PM 1 TABLET unless your doctor advice you to stop.
SIDE EFFECTS OF MEPRIDE PM 1 TABLET
COMMON
- hypoglycemia (low blood sugar levels)
- nausea, vomiting
- diarrhoea, stomach pain, loss of appetite, flatulence
- changes in taste, metallic taste
- headache, dizziness
- joint pain, back pain, muscle pain
- impotence
- respiratory infection, sinus infection, sore throat
- weight gain
UNCOMMON
- difficulty in sleeping (insomnia)
- proteins in urine
- spinning sensation (vertigo)
RARE
Stop taking MEPRIDE PM 1 TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of lactic acidosis (cold hands or feet, dizziness or light-headedness, slow or irregular heartbeat, weakness or tiredness, unusual muscle pain, trouble breathing, sleepiness or drowsiness, stomach pains, nausea or vomiting)
- symptoms of heart failure (such as unusual shortness of breath or trouble in breathing, rapid increase in weight or localised swelling (oedema), especially in the ankles or legs, unusual tiredness)
- signs and symptoms of bladder cancer (such as blood in your urine, pain while urinating or urgent need to pee)
- increased risk of fractures (especially in the bones of hand, upper arm, or foot in women)
- blurred vision due to swelling at the back of the eye or worsening of existing blurred vision
- serious allergic reaction (such as hives, swelling of the face, lips, tongue or throat causing difficulty in breathing or swallowing)
- signs of liver problems (such as nausea or vomiting, stomach pain, unusual or unexplained tiredness, loss of appetite, dark urine, yellowing of the skin or the whites of the eyes)
HOW TO MANAGE SIDE EFFECTS
Hypoglycemia:
Have foods rich in sugars such as fruit juices, glucose drinks, candies, honey or biscuits. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or a drink and check the blood sugar again. Consult your doctor if there is no improvement in your condition.
Diarrhoea:
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhoea becomes uncontrollable.
Nausea:
Take MEPRIDE PM 1 TABLET with or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol. Consult your doctor if your dizziness worsens.
WARNING & PRECAUTIONS
PREGNANCY
MEPRIDE PM 1 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
BREASTFEEDING
MEPRIDE PM 1 TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if your ability is affected by MEPRIDE PM 1 TABLET.
ALCOHOL
Avoid consumption of alcohol while taking MEPRIDE PM 1 TABLET as it may increase the risk of unwanted side effects.
KIDNEY
MEPRIDE PM 1 TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
LIVER
MEPRIDE PM 1 TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
ALLERGY
Do not take MEPRIDE PM 1 TABLET if you are allergic to Glimepiride, Metformin, Pioglitazone or to any other sulfonylureas (Ex. glyburide, gliclazide) or sulphonamides (Ex. sulfasalazine).
HEART DISEASE
MEPRIDE PM 1 TABLET is not recommended for use in patients with severe heart problems (such as heart failure). It should be used with caution in patients with other heart problems. Therefore, consult your doctor before taking it.
OTHERS
MEPRIDE PM 1 TABLET is not recommended for use if you:
- have type I diabetes mellitus (insulin-dependent diabetes)
- have lactic acidosis (build-up of lactic acid in the body)
- have diabetic ketoacidosis (a diabetic complication causing episodes of fatigue, nausea, frequent urination and muscular stiffness)
- have bladder cancer
- pass bloody urine
Before taking MEPRIDE PM 1 TABLET, inform your doctor if you:
- are recovering from any injury, operation, infection or from any form of stress
- have G6PD deficiency
- are on fasting or malnourished, starved, on an irregular diet, or feeling weak
- perform extreme physical exercises without proper carbohydrate intake
- are severely dehydrated
- have hormonal problems (Ex. disorders of the pituitary gland, adrenal cortex or thyroid gland)
- are an alcoholic
- have edema (swelling of body parts)
- smoke
- have a special type of diabetic eye disease called macular oedema (swelling of the back of the eye with worsening of your vision)
- have cysts on your ovaries (polycystic ovarian syndrome)
- previously had stroke
- have anaemia (low RBC in the blood)
- have any bone problems or are at risk of developing bone fractures
- are a premenopausal woman
- have thyroid problems
Use in pediatrics:
MEPRIDE PM 1 TABLET is not recommended for use in children and in adolescents (aged below 18 years). Therefore, consult your doctor before taking it.
Use in geriatrics:
MEPRIDE PM 1 TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.
INTERACTIONS
Before taking MEPRIDE PM 1 TABLET, inform your doctor if you are taking any of the following medicines:
- other medicines used to treat diabetes mellitus (such as teneligliptin, rosiglitazone, insulin, gliclazide)
- medicines used for treating pain and inflammation (Ex. aspirin, ibuprofen, celecoxib, phenylbutazone, azopropazone, oxyphenbutazone)
- medicines used to treat urinary infections (amikacin, nitrofurantoin, sulfamethoxazole)
- medicines used to treat bacterial infections (such as tetracyclines, chloramphenicol, ciprofloxacin, clarithromycin)
- medicines used to treat fungal infection (Ex. fluconazole, miconazole, isuvaconazole)
- medicines used to prevent blood clotting (Ex. warfarin)
- medicines used for male sex hormone replacement therapy (Ex. testosterone)
- medicines used to treat depression (such as moclobemide, isocarboxazid, phenelzine, tranylcypromine, fluoxetine)
- medicines used to treat high blood cholesterol levels (Ex. fenofibrate, nicotinic acid, colesevelam)
- medicines used to treat high blood pressure (Ex. enalapril, lisinopril, ramipril, atenolol, propranolol, telmisartan, olmesartan, clonidine, guanethidine and reserpine)
- disopyramide (a medicine used to treat abnormal heartbeat)
- medicines used to treat gout (Ex. allopurinol, probenecid, sulfinpyrazone)
- medicines used to treat cancer (Ex. cyclophosphamide, ifosfamide, trofosfamide, vandetanib, crizotinib and olaparib)
- fenfluramine (a medicine used to treat obesity)
- pentoxifylline (a medicine which can improve blood flow in the body)
- medicines used to treat allergic rhinitis (Ex. tritoqualine)
- alpha-blockers (medicines used to treat high blood pressure or prostate problems) Ex. prazosin, doxazosin
- hormonal replacement therapy (used to treat menstrual disorders in women) Ex. estradiol
- thiazide diuretics (used to treat edema and high blood pressure) Ex. hydrochlorothiazide
- levothyroxine (a medicine used to treat thyroid problems)
- medicines to treat mental illness (such as chlorpromazine, prochlorperazine, lithium)
- corticosteroids (used to treat pain and inflammation) Ex. prednisolone, betamethasone
- medicines used to treat asthma (Ex. salbutamol, terbutaline)
- adrenaline (a medicine used to treat emergency conditions)
- medicines used to treat constipation (Ex. lactulose, liquid paraffin)
- medicines used to treat epilepsy (Ex. phenytoin)
- barbiturates (used to induce sleep) Ex. phenobarbital
- medicines used to reduce increased pressure in the eye (Ex. acetazolamide)
- glucagon, diazoxide (medicines used to manage signs of low blood sugar levels)
- cimetidine (a medicine used to treat stomach ulcers)
- rifampicin (a medicine used to treat tuberculosis)
- dolutegravir (a medicine used to treat HIV infection)
- ranolazine (a medicine used to treat chest pain)
- trimethoprim (a medicine used to treat bacterial infection)
Overdosage:
If you or anyone else accidentally took more MEPRIDE PM 1 TABLET, you may experience the signs of hypoglycemia (such as increased hunger, sweating, headache, feeling clammy, restless or aggressive, shakiness, fast heartbeat and confusion). To manage this, consume any sugary food immediately. If the symptom did not improve or worsens contact your doctor immediately. Other symptoms of overdosage might include vomiting, stomach pain with muscle cramps, generally feeling unwell with severe tiredness and difficulty in breathing.
SYNOPSIS
| Drug | : | Glimepiride, Metformin, Pioglitazone |
| Pharmacological Category | : | Sulfonylureas, Biguanides, PPAR-gamma and PPAR-alpha agonists |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep MEPRIDE PM 1 TABLET out of reach of children
- Store MEPRIDE PM 1 TABLET at room temperature
FAQs ABOUT MEPRIDE PM 1 TABLET
Q: What is MEPRIDE PM 1 TABLET used for?
A: MEPRIDE PM 1 TABLET is an antidiabetic medicine used to treat Type II diabetes mellitus when diet, exercise and treatment with single agents does not result in adequate response.
Q: How and when to take MEPRIDE PM 1 TABLET?
A: Take MEPRIDE PM 1 TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and disease condition.
Q: How long should I take MEPRIDE PM 1 TABLET?
A: You need to take MEPRIDE PM 1 TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
Q: What is the best time to take MEPRIDE PM 1 TABLET?
A: MEPRIDE PM 1 TABLET must be taken with meals to avoid gastrointestinal side effects.
Q: What to do if I forgot to take a dose of MEPRIDE PM 1 TABLET?
A: If you forgot to take a dose of MEPRIDE PM 1 TABLET, take it as soon as you remember. However, if it is time for the next dose of MEPRIDE PM 1 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of MEPRIDE PM 1 TABLET to compensate the missed ones.
Q: Can I stop taking MEPRIDE PM 1 TABLET without consulting your doctor?
A: No. You should not stop taking MEPRIDE PM 1 TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using MEPRIDE PM 1 TABLET, consult your doctor for advice.
Q: Will taking a higher dose of MEPRIDE PM 1 TABLET be more effective?
A: No, taking a higher dose of MEPRIDE PM 1 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I take medication for high blood pressure along with MEPRIDE PM 1 TABLET?
A: It is not advisable to take medicines to control blood pressure while taking MEPRIDE PM 1 TABLET without consulting your doctor, as they have known interactions with MEPRIDE PM 1 TABLET.
Q: How to manage the side effects of MEPRIDE PM 1 TABLET?
A: Low blood sugar is a common side effect of taking MEPRIDE PM 1 TABLET. Try to have sugar rich food items such as fruit juice, glucose tablets or gel, soft drinks, honey or sugary candy. Check your blood sugar after 10 minutes. If not gained optimum level, take another sugary snack, or drink, and check the blood sugar levels once again. If your condition did not improve, consult your doctor immediately.
Q: Can MEPRIDE PM 1 TABLET be taken with insulin?
A: Co-administration of MEPRIDE PM 1 TABLET with insulin is considered risky as they can increase the chances of hypoglycemia (low blood sugar levels). Therefore, consult your doctor before taking it.
Q: Can MEPRIDE PM 1 TABLET be used in pregnant women?
A: MEPRIDE PM 1 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor for advice before taking it.
Q: Does MEPRIDE PM 1 TABLET cause bone fractures?
A: MEPRIDE PM 1 TABLET may cause bone fractures in some individuals. Therefore, it is important for you to inform your doctor before taking MEPRIDE PM 1 TABLET if you have any bone problems or are at risk of developing any bone fractures (such as menopause).
Q: Does MEPRIDE PM 1 TABLET cause weight gain?
A: Yes. MEPRIDE PM 1 TABLET may cause weight gain in some individuals. To avoid this, follow a healthy diet and regular physical activity as advised by your physician. However, if you experience any weight gain due to swelling of body parts (such as in face, legs, or hands), consult your doctor immediately.
Q: What are the side effects of taking MEPRIDE PM 1 TABLET?
A: The most common side effects of taking MEPRIDE PM 1 TABLET are low blood sugar levels, nausea, stomach upset, constipation, sore throat, muscle pain, headache, dizziness and weight gain. Consult your doctor if any of these side effect worsens.
REFERENCES
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 270, 275 & 277.
2. Jeong Mi Kim, Sang Soo Kim, Jong Ho Kim, Mi Kyung Kim, Tae Nyun Kim, Soon Hee Lee, Chang Won Lee, Ja Young Park, Eun Sook Kim, Kwang Jae Lee, Young Sik Choi, Duk Kyu Kim and In Joo Kim. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. July 2019. [Accessed on 9th January 2023]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043969/
3. Brown & Burk UK Limited. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 9th January 2023]. https://www.medicines.org.uk/emc/files/pil.10742.pdf
4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 9th January 2023]. https://www.medicines.org.uk/emc/files/pil.594.pdf
5. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 9th January 2023]. https://www.medicines.org.uk/emc/files/pil.11951.pdf
6. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2020] [Accessed on 9th January 2023] https://www.medicines.org.uk/emc/files/pil.8836.pdf
7. Cipla Ltd. TRIEXER ER Tablets (Glimepiride + Pioglitazone hydrochloride + Metformin hydrochloride). Ciplamed. [Revised in September 2020]. [Accessed on 9th January 2023] https://www.ciplamed.com/content/triexer-er-tablets
8. Central Drugs Standard Control Organization. FDC of Glimepiride (1mg/2mg) + Pioglitazone (15mg) + Metformin (500mg E.R) Tablet. August 2005. [Accessed on 9th January 2023] https://cdscoonline.gov.in/CDSCO/Drugs
USEFUL DIAGNOSTIC TESTS
- Glucose - Fasting Blood
- Glucose - Postprandial Blood
- Glycosylated Haemoglobin
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