MEGALOR Injection 10ml

Liver Diseases Rx required
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Best Price*  ₹ 232.00
MRP ₹290.00
(Inclusive of all taxes) * Mkt: Signova Pharma Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

MEGALOR contains l-ornithine-l-aspartate which belongs to the group of medicines called hepatoprotective agent. It is used in the treatment of hepatic encephalopathy. Hepatic encephalopathy is defined as a series of neuropsychiatric abnormalities in patients with liver dysfunction, after exclusion of brain disease. It is characterized by intellectual impairment, personality changes and a depressed level of consciousness. MEGALOR can also be used to treat hyperammonemia as a result of acute and chronic liver diseases such as liver cirrhosis, fatty liver or hepatitis.

L-ornithine-l-aspartate is made up of two amino acids called ornithine and aspartic acid. They stimulate ammonia detoxification by increasing the synthesis of urea in the liver. Before taking this medicine, inform your doctor if you have severe liver disease, because your doctor might adjust the infusion rate on an individual basis to avoid nausea and vomiting.

This medicine must only be administered by a physician or nurse. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results. This medicine is well tolerated with minimal side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor. Do not take this medicine if you have severe renal impairment. Ask your doctor for advice. If high doses of MEGALOR is used, it is important to monitor the levels of urea both in the serum and urine to avoid toxicity. Ask your doctor for advice before taking this medicine, if you are pregnant or breastfeeding.

USES OF MEGALOR

  • Treats hepatic encephalopathy
  • Treat hyperammonemia (elevated level of ammonia in blood) due to acute and chronic liver diseases

HOW MEGALOR WORKS

L-ornithine converts the toxic ammonia into non-toxic urea which is eliminated via kidneys. By doing this, it lowers the elevated level of ammonia in blood (hyperammonemia) and also helps the diseased liver to carry out its normal function smoothly (Detoxification). L-Aspartate is an important component of citric acid cycle which liberates energy in the form of ATP, which helps in regeneration of damaged liver cells.

DIRECTIONS FOR USE

MEGALOR should only be administered under careful supervision of a doctor or nurse into a vein (intravenous drip). Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF MEGALOR

MEGALOR is generally safe and does not cause any side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor.

WARNING & PRECAUTIONS

PREGNANCY

MEGALOR should be used with caution in pregnant women. Consult your doctor before taking this medicine.

BREASTFEEDING

MEGALOR should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.

DRIVING AND USING MACHINES

Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL

Avoid consumption of alcohol while taking this medicine, because alcohol can reduce the chances of healing and worsens the liver damage.

KIDNEY

Do not take MEGALOR, if you suffer from renal insufficiency (severely impaired kidney function). Consult your doctor for advice.

LIVER

MEGALOR should be taken with caution in patients with severe liver disease. Consult your doctor for advice. Dose adjustments has to be made on individual basis to avoid nausea and vomiting.

ALLERGY

Do not take this medicine if you are allergic (hypersensitive) to l-ornithine-l-aspartate.

INTERACTIONS

Tell your doctor about all the medicines you use, including prescription and non-prescription medicines, and herbal supplements.

SYNOPSIS

Drug :   L-ornithine-L-aspartate
Pharmacological Category :   Hepatoprotective agent
Therapeutic Indication :   Liver DiseaseHepatic Encephalopathy, Hyperammonemia
Dosage Forms :   Tablet, Granules, Infusion, Syrup

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT MEGALOR

How [GBNKYWORD] is given?

This medicine should be given by a doctor or nurse into a vein as an intravenous drip.

Can MEGALOR be given to children?

No. This medicine is not recommended for use in children below 6 years of age. Always consult your doctor/pediatrician for advice before using any medicine in children.

Can we consume alcohol while taking MEGALOR?

No. Avoid consumption of alcohol while taking this medicine, because alcohol can reduce the chances of healing and worsens the liver damage.

REFERENCES

1. James M. Ritter, Lionel D. Lewis, Timothy GK Mant & Albert Ferro. The Alimentary system. Alimentary system and liver. A Textbook of Clinical Pharmacology and Therapeutics. Fifth edition. Hodder Arnold, an imprint of Hodden Education, part of Hachette Livre UK 2008. Page 260-264.

2. Dayanand Medical College and Hospital. L-ornithine L-aspartate in Overt Hepatic Encephalopathy (HEAL). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on February 2017] [Accessed 25th November 2020] https://clinicaltrials.gov/ct2/show/NCT01722578

3. Centro Regional para el Estudio de las Enfermedades Digestivas. Efficacy of L-Ornithine L-Aspartate in Acute Hepatic Encephalopathy. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on September 2014] [Accessed 25th November 2020] https://clinicaltrials.gov/ct2/show/NCT01041755

4. All India Institute of Medical Sciences, New Delhi. Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients with Acute Liver Failure. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on January 2008] [Accessed 25th November 2020] https://clinicaltrials.gov/ct2/show/NCT00470314

5. Sandeep S. Sidhu. l-Ornithine l-Aspartate is Effective and Safe for the Treatment of Hepatic Encephalopathy in Cirrhosis. NCBI; PMC US National Library of Medicine, National Institute of Health. September 2018. [Accessed 25th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175754/

6. Gerald Kircheis and Stefan Lüth. Pharmacokinetic and Pharmacodynamic Properties of l-Ornithine l-Aspartate (LOLA) in Hepatic Encephalopathy. NCBI; PMC US National Library of Medicine, National Institute of Health. January 2019. [Accessed 25th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416235/

7. Merz Pharma GmbH & Co. KGaA. liverandbrain.com. [Revised on December 2008] [Accessed 25th November 2020] https://www.liverandbrain.com/wp-content/uploads/2019/06/HM-Patient-Information_Infusion-Concentrate_en-1.pdf

USEFUL DIAGNOSTIC TESTS

  • Magnetic Resonance Imaging (MRI) scan
  • Computerized Tomography (CT) scans
  • Electroencephalogram (EEG)
  • Urine analysis

PRODUCT DETAILS

    Net Qty
    1
    Item Weight
    20
    Ingredient
    L ORNITHINE L ASPARTATE 5 gm
    Hsn Code
    30049099
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