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Mega CV 300mg Injection 1'S
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INTRODUCTION
MEGA CV 300MG INJECTION contains Amoxicillin and Clavulanic acid, which belong to the group of medicines called Penicillins and Beta-Lactamase Inhibitors. It is used in children for the treatment and prophylaxis of various bacterial infections (such as respiratory tract infections, which include pneumonia), acute exacerbation of chronic bronchitis, urinary tract infections (cystitis, urethritis, pyelonephritis), bone and joint infections (osteomyelitis), middle ear infections (otitis media), tonsillitis, sinusitis, skin, and soft tissue infections such as cellulitis, boils, wound infections, intra-abdominal sepsis, dental infections, infections of genital organs in females.
Along with treatment with MEGA CV 300MG INJECTION, your doctor might order bacterial culture tests to enhance the outcomes of the treatment and in cases of prolonged treatment with MEGA CV 300MG INJECTION, your doctor might conduct a complete blood count, and liver or kidney function test.
MEGA CV 300MG INJECTION is not recommended for use in patients with severe kidney impairment, a history of liver problems or jaundice after taking penicillin antibiotics. MEGA CV 300MG INJECTION should be used with caution in patients suffering from glandular fever (a viral infection causing sore throat, high fever, swelling of salivary glands etc), liver disease, kidney disease, who are not passing urine daily, convulsions (fits) or large intestine inflammation.
MEGA CV 300MG INJECTION is not recommended for use in pregnant women unless necessary. MEGA CV 300MG INJECTION should be used with caution in breastfeeding women as it may pass through breast milk. MEGA CV 300MG INJECTION should be used with caution in neonates, and infants (less than 12 weeks of age). The most common side effects after receiving MEGA CV 300MG INJECTION are diarrhoea, thrush (fungal infection), etc. Consult your doctor immediately in case any of the side effects worsen.
USES OF MEGA CV 300MG INJECTION
- Treatment and prophylactic management of various bacterial infection
HOW MEGA CV 300MG INJECTION WORKS
MEGA CV 300MG INJECTION helps in treating bacterial infection where Amoxicillin works by inhibiting penicillin-binding proteins (which are involved in the synthesis of the bacterial cell wall) leading to the activation of autolytic enzymes in the bacterial cell wall. Therefore, leading to lysis of the cell wall and death of the bacterial cell and Clavulanic acid inhibits the activity of bacterial enzymes known as beta-lactamases and hence enhances the antibacterial activity of amoxicillin.
DIRECTIONS FOR USE
MEGA CV 300MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion or intravenous injection. Your doctor will decide the exact dose and duration of treatment for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF MEGA CV 300MG INJECTION
COMMON
- diarrhoea
- thrush (candida fungal infection)
UNCOMMON
- rashes, itching, hives (raised itch rashes)
- urticaria
- nausea and vomiting
- dizziness, headache
- indigestion
- abnormal liver enzymes
RARE
- erythema multiforme (skin rashes, blisters, small target rashes)
- low number of platelets (cells that help in clotting)
- decreased white blood cells
- swelling and inflammation at the site of injection
Stop receiving MEGA CV 300MG INJECTION and consult your doctor immediately in case you experience:
- severe allergic reaction which includes rashes, collapsing or fainting, swelling of face, throat which may cause difficulty in breathing, fever, joint pain, swollen lymph nodes of neck, armpits, groin, red or purple raised spots on skin due to inflammation of blood vessels
- swelling and tenderness of vein which is very painful on touching
- watery diarrhoea with blood or mucus, fever, and abdominal pain which occurs due to inflammation of the large intestine
- inflammation of the liver (hepatitis), jaundice (yellowing of white part of eyes, nails, skin paleness)
- inflammation of kidney tubes
- delayed blood clotting
- convulsions (fits) most commonly experienced by patients suffering from kidney disease
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drink plenty of water or fruit juices to keep you hydrated. Don’t take any medicine on your own to treat diarrhoea. Consult your doctor if your symptoms get worse or persist.
Headache
Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving balm on the head if required. Consult your doctor if your symptoms get worse or persist.
Nausea And Vomiting
Receive the medicine, before meals. Stick to simple meals. Avoid eating oily or spicy food. Consult your doctor if your symptoms get worse or persist.
Skin Rash Or Itching
Avoid hot showers because hot water can irritate the skin and does not scratch the affected area. Apply moisturizing cream, Sunscreen and use protective clothing. Consult your doctor if your symptoms get worse or persist.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredMEGA CV 300MG INJECTION is not recommended for use in pregnant women unless necessary. Consult your doctor before receiving MEGA CV 300MG INJECTION.
BREASTFEEDING
Use with CautionMEGA CV 300MG INJECTION should be used with caution in breastfeeding women as it may pass through breast milk. Consult your doctor before receiving MEGA CV 300MG INJECTION.
DRIVING AND USING MACHINES
ContraindicatedDo not drive or operate machinery after receiving MEGA CV 300MG INJECTION.
KIDNEY
Consult your doctorMEGA CV 300MG INJECTION is not recommended for use in patients with severe kidney impairment. Consult your doctor before receiving MEGA CV 300MG INJECTION.
MEGA CV 300MG INJECTION should be used with caution in patients suffering from kidney problems. Consult your doctor before receiving MEGA CV 300MG INJECTION.
LIVER
Consult your doctorMEGA CV 300MG INJECTION is not recommended for use in patients who had a history of liver problems or jaundice after taking penicillin antibiotics. Consult your doctor before receiving MEGA CV 300MG INJECTION.
MEGA CV 300MG INJECTION should be used with caution in patients suffering from, liver disease. consult your doctor before receiving MEGA CV 300MG INJECTION.
ALLERGY
ContraindicatedDo not receive MEGA CV 300MG INJECTION if you are allergic to Amoxicillin, Clavulanic acid, Cephalosporins or any other ingredients in this medicine.
OTHERS
Before receiving MEGA CV 300MG INJECTION inform your doctor if you have:
- glandular fever (viral infection causing sore throat, high fever, swelling of salivary glands etc)
- not been urinating regularly
- convulsions (fits)
- large intestine inflammation
- urine and blood tests
Use in Paediatrics:
MEGA CV 300MG INJECTION should be used with caution in children (less than 12 weeks of age). Consult your doctor for advice.
Use in Geriatric:
MEGA CV 300MG INJECTION should be used with caution in the elderly. Consult your doctor for advice.
INTERACTIONS
A. Drug-Drug interactions:
Before receiving MEGA CV 300MG INJECTION, inform your doctor if you are taking any of the following medicine:
- medicines used to treat gout (Ex. allopurinol, probenecid)
- medicines used to treat blood clots (Ex. warfarin)
- methotrexate (used for the treatment of cancer, and severe psoriasis)
- medicine used to prevent organ transplant rejection (Ex. mycophenolate mofetil)
- medicines used for the prevention of pregnancy (oral contraceptives)
Overdosage:
MEGA CV 300MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to receive an overdose. However, consult your doctor or nurse immediately if you experience any unusual symptoms. Symptoms of an overdose of MEGA CV 300MG INJECTION are nausea, diarrhoea, fits, and upset stomach.
SYNOPSIS
| Drug | : | Amoxicillin, Clavulanic Acid |
| Pharmacological Category | : | Penicillins and Beta-Lactamase Inhibitors |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Tablets, Syrup, Oral Drops, Eye Drops, Ear Drops, Oral Suspension, Infusion, Dispersible Tablet, Dry Suspension, Dry Syrup, Granules |
MORE INFORMATION
- Keep MEGA CV 300MG INJECTION out of reach from children
- Store MEGA CV 300MG INJECTION below 25°C
FAQs ABOUT MEGA CV 300MG INJECTION
Q: What are uses of MEGA CV 300MG INJECTION?
A: MEGA CV 300MG INJECTION is used in adults and children for the treatment of various bacterial infections such as respiratory tract infections which includes pneumonia, Acute exacerbation of chronic Bronchitis, urinary tract infections (cystitis, urethritis, pyelonephritis), bone and joint infections (osteomyelitis), middle ear infections (otitis media), Tonsillitis, sinusitis, skin, and soft tissue infections such as cellulitis, boils, wound infections, intra-abdominal sepsis, dental infections, infections of genital organs in females. MEGA CV 300MG INJECTION is also used as prophylaxis against various bacterial infections associated with major surgeries of the heart, joints, kidney, head and neck, stomach, biliary tract, intestine, and pelvic region.
Q: What are side effects of MEGA CV 300MG INJECTION?
A: The most common side effects after receiving MEGA CV 300MG INJECTION are vomiting, diarrhoea, thrush (fungal infection), etc. Consult your doctor immediately in case any of the side effects worsen.
Q: How MEGA CV 300MG INJECTION works?
A: MEGA CV 300MG INJECTION helps in treating bacterial infection where Amoxicillin works by inhibiting penicillin-binding proteins (which are involved in the synthesis of the bacterial cell wall) leading to the activation of autolytic enzymes in the bacterial cell wall. Therefore, leading to lysis of the cell wall and death of the bacterial cell and Clavulanic acid inhibits the activity of bacterial enzymes known as beta-lactamases and hence enhances the antibacterial activity of amoxicillin.
Q: Is MEGA CV 300MG INJECTION safe for use in pregnant and breastfeeding women?
A: No, MEGA CV 300MG INJECTION is not recommended for use in pregnant women unless necessary and MEGA CV 300MG INJECTION should be used with caution in breastfeeding women as it may pass through breastmilk. Consult your doctor before receiving MEGA CV 300MG INJECTION.
Q: Is MEGA CV 300MG INJECTION safe for use in children?
A: Yes, MEGA CV 300MG INJECTION is safe for use in children but it should be used with caution in children less than 3 months of age. Consult your doctor for advice.
REFERENCES
1. KD Tripathi. Antimicrobial Drugs. Essentials of Medical Pharmacology, 7th edition. 2013. Page-723, 724.
2. Justin Evans, Maryam Hannoodee, Micah Wittler. Amoxicillin Clavulanate. National Centre for Biotechnology. NLM. National Institute of Health. Statpearls. December 2021. [Accessed on 22nd October 2022] https://www.ncbi.nlm.nih.gov/books/NBK538164/#article-17475.s5
3. GlaxoSmithKline Pharmaceuticals Limited. Amoxicillin + Clavulanic acid. [Revised in July 2022] [Accessed on 22nd October 2022] https://india-pharma.gsk.com/media/6337/augmentin-i-v.pdf
4. Cipla Limited. Amoxicillin + Clavulanic acid. [Revised in September 2019] [Accessed on 22nd October 2022] https://www.ciplamed.com/content/advent-iv-injection , https://www.ciplamed.com/print-product-pdf/24188
5. Augpen Injection (Amoxicillin + Clavulanic acid). Zuventus Healthcare Limited. [Accessed on 22nd October 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=65
USEFUL DIAGNOSTIC TESTS
- Bacterial culture tests
- Complete blood count
- Liver and kidney function test
AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS
Last updated on 04 Feb 2023 | 12:34 PM(IST)
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