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INTRODUCTION
MAMOFEN contains Tamoxifen which belongs to the group of medicines called antioestrogens. It is used to treat breast cancer and also reduces the risk of developing breast cancer in pre- and postmenopausal women and helps to slow down the growth and multiplication of cancer cells. This medicine is also used for infertility in women caused by a failure to produce and release eggs (ovulate) properly. Your doctor will prescribe the right dose and duration according to your health condition
Oestrogen is a natural substance in body and some breast cancers need oestrogen to grow. Tamoxifen blocks the activity of estrogen and these oestrogens cannot stimulate the cells to divide and grow.
Always take MAMOFEN as directed by your physician. Before taking, tell your doctor if you have liver, kidney, heart problems, blood clot disorders or if you are on infertility treatment. This medicine is not advisable for use if you are pregnant or breastfeeding. It is not recommended for use in children and adolescents under 18 years of age. The most common side effects are hot flushes, nausea, tiredness, weakness or lack of energy (fatigue) and skin rashes.
USES OF MAMOFEN
- Treats Breast cancer
- Reduces the risk of developing breast cancer in pre- and postmenopausal women
- Treats infertility in women
HOW MAMOFEN WORKS
MAMOFEN blocks the activity of estrogen (a female hormone) in the breast and stops the growth of some breast tumors that need estrogen to grow.
DIRECTIONS FOR USE
Always take MAMOFEN as directed by your physician. Swallow the medicine as whole with a glass of water and do not crush or chew the medicine.
SIDE EFFECTS OF MAMOFEN
SERIOUS
- swelling of the face, throat or tongue, fever, breathing difficulty or dizziness
- unusual bleeding or a discharge from vagina
- irregular periods
- discomfort, pain or pressure in the lower tummy
COMMON
- hot flushes
- nausea
- tiredness, weakness or lack of energy (fatigue)
- fluid retention
- skin rashes
- damage to the retina
- tingling or numbness
- abnormal sense of taste
- increase in risk of blood clots
- leg cramp and muscle pain
- increased level of fats
- looking pale and feeling tired (anaemia)
- headache and feeling lightheaded
- itching around the vagina
- hair loss (alopecia)
- vomiting
- diarrhoea
- constipation
- changes in liver enzyme levels
RARE
- changes to the cornea
- reduction in white blood cells (neutropenia)
- blurring, blind spots, distorted vision, reduced colour vision and pain when moving the eyes (inflammation of the optic nerve)
- increase in the size of tumours
- inflammation of the liver
- inflammation of the blood vessels
- painful periods, persistent pain in the pelvic area and infertility
- swelling of ovarian cysts
- small, soft growths on the vagina
- decrease in white blood cells
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and drink plenty of fluids. Apply a wet or cold cloth to forehead and rest in a quiet, comfortable, dark room.
Nausea:
Take normal regular meals and do not eat spicy foods.
Diarrhoea:
Drink plenty of fluids to avoid dehydration.
Vomiting:
Drink clear or ice-cold drinks and eat light, bland foods, avoid sweets.
Constipation:
Eat fruits, vegetables whole grains and fiber rich foods.
WARNING & PRECAUTIONS
PREGNANCY
MAMOFEN is not recommended for use during pregnancy. Consult your doctor for advice.
BREASTFEEDING
MAMOFEN is not recommended if you are breastfeeding, as it may pass into breast milk. Consult your doctor for advice.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel tiredness, weakness or lack energy (fatigue) while taking this medicine.
ALCOHOL
Consumption of alcohol is not recommended while taking this MAMOFEN.
LIVER
MAMOFEN should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Inform your physician if you are allergic (hypersensitive) to Tamoxifen.
OTHERS
Before taking this medicine, talk to your doctor if you have or had,
- history of blood clots
- are being treated for infertility
- risk of developing blood clots, particularly in relation to delayed breast reconstruction surgery (weeks to years after the operation)
- hereditary angioedema
INTERACTIONS
Tell your doctor if you’re taking,
- anastrozole, letrozole, exemestane (treats breast cancer)
- paroxetine, fluoxetine, bupropion (treat depression)
- quinidine (treats abnormal heart rhythms)
- cincalet/cinacalcet (treats parathyroid gland disorders)
- warfarin (used to thin the blood)
- rifampicin (used to treat bacterial infections)
- oral contraceptives
- hormone replacement therapy
SYNOPSIS
| Drug | : | Tamoxifen |
| Pharmacological Category | : | Antineoplastic Agent, Estrogen Receptor Antagonist, Selective Estrogen Receptor Modulator (SERM) |
| Therapeutic Indication | : | Selective Estrogen Receptor Modulator (SERM) |
| Dosage Forms | : | Tablet |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT MAMOFEN
Is MAMOFEN an estrogen blocker?
Yes, it is an anti-cancer medication used to treat breast cancer in post-menopausal women.
How long can use MAMOFEN?
It depends on your condition as advised by your doctor.
How long is it safe to take MAMOFEN?
It is safe to take this medicine as long when it is prescribed by your doctor. Do not stop taking without consulting to your physician.
Is MAMOFEN effective?
Yes it is effective if used in the correct dose and duration advised by your doctor.
REFERENCES
1. KD. Tripathi. Estrogens, progestins and contraceptives. Essentials of medical pharmacology. Seventh edition. 2013. Page – 313-315.
2. Moy B, Lee RJ, Smith M. Natural Products in Cancer Chemotherapy: Hormones and Related Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. Page - 1756-1759.
3. Chrousos GP. The Gonadal Hormones & Inhibitors. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page - 716.
4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 1311-1314.
5. Tillomed Laboratories Ltd. [Revised on July, 2021] [Accessed on Sep 07, 2021] https://www.medicines.org.uk/emc/files/pil.11607.pdf
6. AstraZeneca. 1995. [Revised on March 08, 2021] [Accessed on Sep 07, 2021] https://www.astrazeneca.ca/content/dam/az-ca/downloads/productinformation/nolvadex-d-product-monograph-en.pdf
7. Drugs.com. Tamoxifen. [Revised on May 24, 2020] [Accessed on Sep 07, 2021] https://www.drugs.com/ppa/tamoxifen.html
8. Cancer research UK. Tamoxifen. [Accessed on Sep 07, 2021] https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/tamoxifen
USEFUL DIAGNOSTIC TESTS
- Breast Cancer (CA 15.3/ ER/ PR)
PRODUCT DETAILS
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
