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Mahaflox 400mg Tablet 5'S
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INTRODUCTION
MAHAFLOX 400MG TABLET contains Moxifloxacin which belongs to the group of medicines called Antibiotics. It is used to treat acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, community acquired pneumonia, skin and soft tissue infections, uncomplicated urinary tract infection and pelvic inflammatory disease.
MAHAFLOX 400MG TABLET is not recommended for use in patients having liver and heart problems. MAHAFLOX 400MG TABLET is not recommended for use in pregnant or breastfeeding mothers. Consult your doctor before taking.
Before taking MAHAFLOX 400MG TABLET inform your doctor if you have or had myasthenia gravis, diabetes, epilepsy or any mental disorders.
MAHAFLOX 400MG TABLET is not recommended for use in children and adolescents below 18 years of age. MAHAFLOX 400MG TABLET should be used with caution in elderly patients with renal impairment. Consult your doctor before taking the medicine.
The common side effects of MAHAFLOX 400MG TABLET are headache, dizziness, nausea, vomiting and stomach pain. Consult your doctor if the above symptoms does not improve.
USES OF MAHAFLOX 400MG TABLET
It is used to treat:
- acute bacterial sinusitis
- acute bacterial exacerbation of chronic bronchitis
- community acquired pneumonia
- skin and soft tissue infections
- uncomplicated urinary tract infection
- pelvic inflammatory disease
HOW MAHAFLOX 400MG TABLET WORKS
MAHAFLOX 400MG TABLET works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV which are required for DNA replication and transcription resulting in cell death. This prevents the bacterial cells from dividing and repairing and destroys them.
DIRECTIONS FOR USE
Always take this medicine as directed by your physician. Swallow the medicine as whole with a glass of water. Do not crush or chew the medicine. Your doctor will give the correct dose depends on your age, body weight and severity of the infection.
SIDE EFFECTS OF MAHAFLOX 400MG TABLET
COMMON
- headache
- dizziness
- nausea
- vomiting
- stomach pain
- diarrhea
- increase in liver enzyme like yellowing of skin and eyes
- low blood potassium level such as irregular heartbeat
UNCOMMON
- sleep problems
- signs of low number of white blood cells like fever, infections, mouths sores
- constipation
- decreased appetite and food intake
- aches and pains such as back, chest, pelvic and extremities pains, joint pain
- signs of increase or decrease in blood cells necessary for blood clotting (Ex. weakness, bleeding, tingling in the hands and feet)
- sweating, anxiety, restlessness, agitation, confusion, disorientation, shaking
- palpitations, signs of angina pectoris like pressing, squeezing, or crushing pain
- difficulty in breathing (asthma)
- increase of a special digestive enzyme in the blood (amylase)
- visual disturbances like double and blurred vision
- weight gain
- muscle pain
- signs of increase of bilirubin abdominal pain or swelling, chills, fever
- dehydration or dry skin
RARE
- hallucination, abnormal dreams, disturbed concentration, balance disorder and poor co-ordination
- high or low blood pressure
- inflammation of the mouth
- ringing/noise in the ears
- impairment of skin sensation
- changes in smell
- serious skin rashes including Stevens-Johnson syndrome and toxic epidermal necrolysis characterized by reddish target-like macules or circular patch, skin peeling, ulcers of mouth, throat, nose, genitals, and eyes and can be preceded by fever and flu-like symptoms
- red, scaly widespread rash with bumps under the skin and blisters accompanied by fever at the initiation of treatment (acute generalized exanthematous pustulosis)
- syndrome associated with impaired water excretion and low levels of sodium (SIADH)
Stop taking MAHAFLOX 400MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of inflammation of blood vessels such as red spots on your skin, usually on your lower legs or effects like joint pain
- pain and swelling of the tendons (tendonitis), rupture of tendons
- muscle weakness, tenderness, or pain
- severe diarrhea containing blood and/or mucus
- signs of inflammation of liver like feeling of unwell or yellowing of the whites of the eyes, dark urine, itching of the skin, a tendency to bleed or disturbances of thought
- severe, sudden allergic reaction
- convulsions (fits)
- pain, burning, tingling, numbness and/or weakness in extremities
- depression
- abnormal heart rhythms, life-threatening irregular heartbeat
- worsening of the symptoms of myasthenia gravis (abnormal muscle fatigue leading to weakness and in serious cases paralysis)
- signs of kidney problems such as decrease in urine output, swelling in legs, ankles or feet, fatigue, nausea, drowsiness, shortness of breath or confusion
- feeling mentally unwell (potentially leading to self-harm, such as suicidal ideations/thoughts, or suicide attempts)
HOW TO MANAGE SIDE EFFECTS
Nausea or Vomiting:
Take this medicine with, or just after meals. Stick to simple meals. Try to avoid oil rich or spicy foods, sugary snacks, and drinks. Try to drink liquid slowly along with your meals, or in between meals. Consult your doctor if your symptom is not improving.
Constipation:
Eat fibre rich foods like fresh fruit, vegetables, and cereals. Drink plenty of water. Exercise more regularly.
Dizziness:
Lie, or sit down immediately when you feel dizzy. Try to avoid vehicle driving. Discuss with your doctor if the symptom worsens.
Headache:
Apply hot or cold-water bag on your head. Try to take rest in a quiet and dark room. Drink tea or coffee. Massage on scalp or head with mild pressure. Consult your doctor for advice.
Stomach pain:
Try to rest and relax. Have smaller and frequent meals. Keep a heat pad on your stomach. Consult your doctor for advice.
WARNING & PRECAUTIONS
PREGNANCY
MAHAFLOX 400MG TABLET is not recommended for use in pregnant women or if you think you might become pregnant. Discuss the risks and benefits with your doctor.
BREASTFEEDING
MAHAFLOX 400MG TABLET is not recommended for use in breastfeeding women. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or handle any machines while taking MAHAFLOX 400MG TABLET, since it may cause dizziness, light-headedness, or transient loss of vision.
KIDNEY
Dosage adjustment is not required in patients with mild to severely impaired renal function or in patients on chronic dialysis. Consult your doctor before taking MAHAFLOX 400MG TABLET.
LIVER
MAHAFLOX 400MG TABLET is not recommended in patients with severe liver disease or increased liver enzymes or any active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic (hypersensitive) to Moxifloxacin or any other ingredients of this medicine.
HEART DISEASE
MAHAFLOX 400MG TABLET is not recommended in patients with abnormal or slow heart rhythm or abnormal heart rhythms. MAHAFLOX 400MG TABLET should be used with caution in patients having heart valve heart disease, aortic aneurysm or aortic dissection or congenital heart valve disease, enlargement, or bulge of a large blood vessel or any other active heart disease. Consult your doctor before taking this medicine.
OTHERS
MAHAFLOX 400MG TABLET is not recommended for use if you:
- have a history of tendon disease/disorder
- have electrolyte disturbances (uncorrected hypokalaemia)
- have diabetes (elderly)
Before taking MAHAFLOX 400MG TABLET, inform your doctor if you:
- have epilepsy
- have mental health problems
- have glucose- 6-phosphate dehydrogenase deficiency
- have myasthenia gravis (abnormal muscle fatigue leading to weakness and in serious cases paralysis)
- have a complicated infection of the female upper genital tract (associated with an abscess of the fallopian tubes and ovaries or of the pelvis)
Use in pediatrics:
MAHAFLOX 400MG TABLET is not recommended for use in children and adolescents below 18 years of age, since efficacy and safety have not been established. Consult your doctor for taking.
Use in geriatrics:
Elderly patients with renal disorders should use MAHAFLOX 400MG TABLET with caution if they are unable to maintain adequate fluid intake, because dehydration may increase the risk of renal failure. Consult your doctor before taking the medicine.
INTERACTIONS
A. Drug-Drug interactions:
Before taking MAHAFLOX 400MG TABLET, inform your doctor if you are taking the following medicine:
- quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, dofetilide, ibutilide (medicines used to treat heart problems)
- phenothiazines, pimozide, sertindole, haloperidol, sultopride and tricyclic antidepressant (medicines used to treat psychotic problems)
- saquinavir, sparfloxacin, intravenous erythromycin, pentamidine (medicine used to treat infection)
- halofantrine (medicine used to treat malaria)
- terfenadine, astemizole, mizolastine (medicine used to treat allergies)
- intravenous vincamine, bepridil (medicines used to lower blood pressure)
- diphemanil, cisapride, iron, zinc, didanosine (medicine used to treat stomach problems)
- medicines that lower the blood potassium levels (Ex. spironolactone)
- laxatives like methylcellulose, wheat bran (medicines used to treat constipation)
- prednisolone, betamethasone, dexamethasone, hydrocortisone
- amphotericin B (medicine used to treat fungal infections)
- antacids magnesium or aluminium hydroxide (used to treat heart burn and indigestion)
- warfarin (medicine used as blood thinner)
- charcoal containing medicines (used to treat certain types of poisoning)
Overdosage:
If you or anyone else accidentally takes too much of MAHAFLOX 400MG TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Moxifloxacin |
| Pharmacological Category | : | Fluoroquinolones |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Tablet, Injection, Infusion, Eye Drops, Ophthalmic solution, Eye Gel, Gel, Eye Ointment, Ointment |
MORE INFORMATION
- Keep out of reach of children
- Store at room temperature
FAQs ABOUT MAHAFLOX 400MG TABLET
What are the uses of MAHAFLOX 400MG TABLET?
MAHAFLOX 400MG TABLET is used to treat acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, community acquired pneumonia, skin and soft tissue infections, uncomplicated urinary tract infection and pelvic inflammatory disease.
How does MAHAFLOX 400MG TABLET works?
MAHAFLOX 400MG TABLET works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV which are required for DNA replication and transcription resulting in cell death. This prevents the bacterial cells from dividing and repairing and destroys them.
Can MAHAFLOX 400MG TABLET be used in pregnant and breast-feeding woman?
MAHAFLOX 400MG TABLET is not recommended for use in pregnant women or if you think you might become pregnant and in breast feeding woman. Discuss the risks and benefits with your doctor.
Can MAHAFLOX 400MG TABLET be given to children?
MAHAFLOX 400MG TABLET is not recommended for use in children and adolescents aged below 18 years as the efficacy and safety have not been established for this age group. Consult your doctor for advice.
Does MAHAFLOX 400MG TABLET cause headache?
Yes, it may cause headache in some patients. Apply hot or cold-water bag on your head. Try to take rest in a quiet and dark room. Drink tea or coffee. Massage on scalp or head with mild pressure. Consult your doctor for advice.
REFERENCES
1. KD. Tripathi. Sulfonamides, Cotrimoxazole and Quinolones. Essentials of medical pharmacology. Eighth edition. 2013. Page – 764.
2. Ilija Kuzman, Alexandr Bezlepko, Irena Kondova Topuzovska, László Rókusz, Liudmyla Iudina, Hans-Peter Marschall and Thomas Petri. Efficacy and safety of moxifloxacin in community acquired pneumonia: a prospective, multicenter, observational study. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. June 2014. [Accessed on 27th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105837
3. Paul M. Tulkens, Pierre Arvis, and Frank Kruesmann. Moxifloxacin Safety. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. December 2012. [Accessed on 27th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3585838/
4. Laboratoires BTT. Electronic Medicines Compendium (EMC). [Revised in May 2021]. [Accessed on 27th June 2022] https://www.medicines.org.uk/emc/files/pil.2358.pdf
5. Accord Healthcare Limited. Pharmathen S.A. Electronic Medicines Compendium (EMC). [Revised in November 2020] [Accessed on 27th June 2022] https://www.medicines.org.uk/emc/files/pil.3273.pdf
USEFUL DIAGNOSTIC TESTS
- Complete blood count
AUTHOR DETAILS
Written By Dr. Janet.C, Pharm.D
Last updated on 21 Oct 2022 | 10:21 AM(IST)
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