INTRODUCTION

MAGTAM NOVO 1000/500MG INJECTION is a combination of Cefoperazone and Sulbactam which belongs to the group of medicines called Antibiotics. It is used to treat various bacterial infections such as respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicemia (serious bloodstream infection), meningitis (inflammation of brain and spinal cord membranes, typically caused by an infection), skin and soft tissue infections.

It is also used to treat bone and joint infections, gonorrhea (sexually transmitted bacterial infection), endometritis (inflammation of the uterine lining due to infection), pelvic inflammatory disease (infection of the female reproductive organs) and other infections of the genital tract.

Bacterial infections are caused by multiplication of specific harmful strain of bacteria anywhere in the body. It is characterized by symptoms such as fever, nausea, vomiting, headache tiredness and swollen lymph nodes in the neck, armpits, groin or elsewhere.

Before receiving MAGTAM NOVO 1000/500MG INJECTION, inform your doctor if you have impaired kidney function, severe biliary obstruction (blockage of the bile ducts), severe liver disease, malabsorption conditions and have schedule for laboratory tests (such as measuring glucose in the urine).

MAGTAM NOVO 1000/500MG INJECTION should be used with caution in pregnant and breastfeeding women only if advised by the doctor. Also, it should be used with caution in children and elderly patients.

The most common side effects of receiving MAGTAM NOVO 1000/500MG INJECTION are diarrhea, nausea and vomiting. Inform your doctor if any of these side effects bothers you.

USES OF MAGTAM NOVO 1000/500MG INJECTION

Treats bacterial infections such as:

• respiratory tract infections
• urinary tract infections (upper and lower)
• intra-abdominal infections
• septicemia
• meningitis
• skin and soft tissue infections
• bone and joint infections
• pelvic inflammatory disease
• endometritis
• gonorrhea
• other infections of the genital tract

HOW MAGTAM NOVO 1000/500MG INJECTION WORKS

MAGTAM NOVO 1000/500MG INJECTION contains cefoperazone and sulbactam. Cefoperazone works by stopping the formation of bacterial cell coverings, which makes the bacteria susceptible for killing. Sulbactam works by reducing bacterial resistance and enhancing the activity of cefoperazone against the bacteria. Together, they helps to treat various bacterial infections.

DIRECTIONS FOR USE

MAGTAM NOVO 1000/500MG INJECTION will be given to you only by a doctor or a nurse, either into the vein (intravenously) or muscle (intramuscularly). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of the infection.

SIDE EFFECTS OF MAGTAM NOVO 1000/500MG INJECTION

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take regular sips of cold drink. Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. If nausea does not improve, inform your doctor.

Headache:

Apply hot or cold-water bag on your head. Drink plenty of fluids. Try taking rest in a quiet and dark room. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the headache does not reduce.

Diarrhea:

Keep yourself hydrated by drinking lot of fluids such as water or fruit juices. If the symptom does not improve, inform your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before receiving MAGTAM NOVO 1000/500MG INJECTION, inform your doctor if you are taking any of the following medicines:

• medicines used to treat bacterial infections such as aminoglycosides (Ex. gentamicin, tobramycin, amikacin and streptomycin)
• oral anti-coagulants (Ex. warfarin) (used to prevent or treat blood clots)

Overdosage:

MAGTAM NOVO 1000/500MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms such as neurologic effects (such as fits).

SYNOPSIS

MORE INFORMATION

• Store below 25°C and protect from light

FAQs ABOUT MAGTAM NOVO 1000/500MG INJECTION

What is MAGTAM NOVO 1000/500MG INJECTION used for?

MAGTAM NOVO 1000/500MG INJECTION is a combination of Cefoperazone and Sulbactam which belongs to the group of medicines called antibiotics. It is used to treat several bacterial infections such as respiratory tract infections, urinary tract infections (upper and lower), intra-abdominal infections, septicemia, meningitis, skin and soft tissue infections, bone and joint infections, gonorrhea, endometritis, pelvic inflammatory disease and other infections of the genital tract.

How does MAGTAM NOVO 1000/500MG INJECTION work?

MAGTAM NOVO 1000/500MG INJECTION contains cefoperazone and sulbactam. Cefoperazone works by stopping the formation of bacterial cell coverings, which makes the bacteria susceptible for killing. Sulbactam works by reducing bacterial resistance and enhancing the activity of cefoperazone against the bacteria. Together, they helps to treat various bacterial infections.

How MAGTAM NOVO 1000/500MG INJECTION is administered?

MAGTAM NOVO 1000/500MG INJECTION will be given to you only by a doctor or a nurse, either into the vein (intravenously) or muscle (intramuscularly). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and severity of the infection.

Is MAGTAM NOVO 1000/500MG INJECTION safe to use in patients with liver disease?

MAGTAM NOVO 1000/500MG INJECTION should be used with caution in patients with severe biliary obstruction (blockage of the bile ducts) and severe liver disease. Consult your doctor for advice before receiving MAGTAM NOVO 1000/500MG INJECTION.

What are the common side effects of MAGTAM NOVO 1000/500MG INJECTION?

The most common side effects of receiving MAGTAM NOVO 1000/500MG INJECTION are diarrhea, nausea, vomiting and coagulopathy (impairment in the blood's ability to clot). Inform your doctor if any of these side effects bothers you.

REFERENCES

1. Conan MacDougall. Penicillins, Cephalosporins and Other Beta-Lactam Antibiotics. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical, 2018. Page – 1023-1038.

2. Lan, Shao-Huan, Shen-Peng Chang, Chih-Cheng Lai, Li-Chin Lu and Hung-Jen Tang. Efficacy and safety of cefoperazone-sulbactam in empiric therapy for febrile neutropenia: A systemic review and meta-analysis. National Library of Medicine. February 2020. [Accessed on 4th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034635/

3. Chiang, Tsung-Ta, Hung-Jen Tang, Cheng-Hsun Chiu, Te-Li Chen, Mao-Wang Ho, Chen-Hsiang Lee, Wang-Huei Sheng and Ya-Sung Yang.Antimicrobial activities of cefoperazone-sulbactam in comparison to cefoperazone against clinical organisms from medical centers in Taiwan. Journal of Medical Sciences. December 2016. [Accessed on 4th June 2022] https://www.jmedscindmc.com/article.asp?issn=1011-4564;year=2016;volume=36;issue=6;spage=229;epage=233;aulast=Chiang;aid=JMedSci_2016_36_6_229_196365

4. Pfizer Limited. Electronic Medicines Compendium (EMC). [Revised in April 2020] [Accessed on 4th June 2022] https://labeling.pfizer.com/ShowLabeling.aspx?id=14800#:~:text=mEq)%20per%20gram.-,Sulbactam%20is%20an%20off%2Dwhite%20crystalline%20powder%20which%20is%20highly,(1.5%20mEq)%20per%20gram.

USEFUL DIAGNOSTIC TESTS

• Complete Blood Count
• Bacterial culture test