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Maclar 500mg Tablet 10'S
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INTRODUCTION
MACLAR 500MG TABLET contains Clarithromycin which belongs to the group of medicines called Macrolide Antibiotics. It is used to treat infections like upper respiratory tract infections (pharyngitis, and sinusitis), lower tract respiratory infections (bronchitis and pneumonia), middle ear infections (acute otitis media), skin and soft tissue infections (impetigo, folliculitis, cellulitis and abscesses), tooth and mouth infections (periapical abscess, periodontitis) as well as in patients with duodenal ulceration and helicobacter pylori infection.
MACLAR 500MG TABLET is also used to treat mycobacterial infections (disseminated or localized) in adults, children and adolescents above 12 years of age.
Before prescribing MACLAR 500MG TABLET, your doctor may want you to undergo a few diagnostic tests to determine the exact cause of your infection before starting with MACLAR 500MG TABLET.
Before taking MACLAR 500MG TABLET, inform your doctor if you have liver, kidney disorder or have been diagnosed with coronary artery disease, severe heart failure or slowed heart rate.
MACLAR 500MG TABLET is not recommended in patients with a history of heart rhythm disorders (such as ventricular cardiac arrhythmia, and fast heart rhythm) and patients with long QT syndrome (abnormality in electrocardiogram).
If you are pregnant or breastfeeding, consult your doctor for advice before taking. The most common side effect of taking this medicine is stomach pain, headache, diarrhoea and sleeplessness. Contact your doctor immediately if any of the above symptoms worsen with time.
USES OF MACLAR 500MG TABLET
Used to treat:
- upper respiratory tract infections
- lower tract respiratory infections
- middle ear infections
- skin and soft tissue infections
- tooth and mouth infections
- duodenal ulceration
- helicobacter pylori infections
- mycobacterial infections
HOW MACLAR 500MG TABLET WORKS
MACLAR 500MG TABLET prevents the growth of bacteria by interfering with its protein synthesis and binds specific proteins present in the bacterial ribosomes, thus stopping the growth of the bacteria inside the body, which helps to reduce the infection and its symptoms.
DIRECTIONS FOR USE
Take MACLAR 500MG TABLET as advised by your physician.
For Tablet: Swallow MACLAR 500MG TABLET with a glass of water. Do not crush or chew the medicine.
For Dispersible Tablet: Disperse MACLAR 500MG TABLET in the specified quantity of water as mentioned in the label. Consume the mixture immediately after reconstitution.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Continue to take MACLAR 500MG TABLET for the stipulated duration prescribed by your doctor to achieve better results.
SIDE EFFECTS OF MACLAR 500MG TABLET
COMMON
- insomnia (difficult to fall asleep)
- taste disturbances
- headache
- diarrhoea
- vomiting, nausea
- indigestion
- stomach pain
- abnormal liver function results
- excessive sweating
UNCOMMON
- fungal infection (candidiasis)
- vaginal infection
- decrease in white blood cells and neutrophils (neutropenia)
- increase in eosinophils (eosinophilia)
- anorexia, loss of appetite
- restlessness, shaking
- dizziness, sleepiness
- balance disorder
- hearing disorder
- ringing in the ears
- palpitations (fast beating of the heart)
- ECG trace changes
- inflammation of the stomach, mouth, and tongue
- bloating, constipation, dry mouth
- burping, wind
- increased liver enzymes activity (alanine transferase)
- malaise (feeling unwell, discomfort)
- asthenia (weakness, lack of energy)
- chest pain
- chills, fatigue
RARE
Stop taking MACLAR 500MG TABLET and consult your doctor immediately if you experience any of the following side effects:
- severe or prolonged diarrhoea, with blood or mucus
- skin rash and irritation
- difficulty breathing, fainting
- swelling of the face, tongue, lips, eyes, and throat
- yellowing of the skin (jaundice)
- tender abdomen, loss of appetite
- pale stools, dark urine
- severe skin reactions with painful blistering of the skin, mouth, lips, eyes, and genitals (Stevens-Johnson syndrome/toxic epidermal necrolysis)
- red, scaly rash with bumps under the skin and blisters
- muscle pain or weakness (rhabdomyolysis)
- severe ulceration of the mouth, lips, and skin associated with illness
- inflammation of the internal organs
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhoea. Consult your doctor if the symptom did not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much alcohol. Consult your doctor if the symptom did not improve.
Nausea or Vomiting:
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily-rich or spicy foods.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.
WARNING & PRECAUTIONS
PREGNANCY
MACLAR 500MG TABLET is generally not recommended in pregnant women unless the potential benefits justify the potential risk to the fetus. Consult your doctor before taking the medicine.
BREASTFEEDING
MACLAR 500MG TABLET is not recommended in breastfeeding mothers as it may pass into the breast milk. Consult your doctor before taking the medicine.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizziness, vertigo, confusion, and disorientation after taking MACLAR 500MG TABLET.
KIDNEY
MACLAR 500MG TABLET is generally not recommended in patients with severe concurrent kidney failure. Consult a doctor before taking MACLAR 500MG TABLET.
LIVER
MACLAR 500MG TABLET is generally not recommended for patients with severe liver failure. Consult a doctor before taking MACLAR 500MG TABLET.
ALLERGY
Do not take MACLAR 500MG TABLET if you are allergic (hypersensitive) to Clarithromycin and other macrolide antibiotics or to any other constituents of MACLAR 500MG TABLET.
HEART DISEASE
MACLAR 500MG TABLET is not recommended for patients with heart rhythm disorders such as ventricular cardiac arrhythmia, including the type of ventricular tachycardia (torsades de pointes) and if you have long QT syndrome (showing abnormality in electrocardiogram). However MACLAR 500MG TABLET should be taken with caution in patients diagnosed with coronary artery disease, severe heart failure or slowed heart rate. Consult a doctor before taking.
OTHERS
MACLAR 500MG TABLET is not recommended to be taken if you:
- have abnormal levels of potassium and magnesium in the blood (hypokalemia, hypomagnesemia)
Use in pediatrics:
MACLAR 500MG TABLET is generally not recommended for use in children and adolescents under 12 years of age. Consult your doctor before taking MACLAR 500MG TABLET.
Use in geriatrics:
MACLAR 500MG TABLET should be taken with caution in elderly patients as they are prone to develop torsades de pointes arrhythmias (fast ventricular rhythm). Consult a doctor before taking MACLAR 500MG TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking MACLAR 500MG TABLET, inform your doctor if you are taking any of the following medicine:
- ergotamine and dihydroergotamine (medicine to treat migraine)
- astemizole or terfenadine (medicine to treat allergy)
- cisapride or domperidone (medicine to treat gastrointestinal disorder)
- pimozide, quetiapine (medicine to treat mental disorder)
- ticagrelor, ranolazine (medicine to treat heart and circulatory disease)
- colchicine (medicine to treat gout)
- lovastatin, and simvastatin (medicine to lower blood cholesterol)
- midazolam, alprazolam, triazolam (medicine to treat anxiety and insomnia)
- rifampicin, rifapentine, rifabutin (used to treat tuberculosis)
- fluconazole, itraconazole (used to treat fungal infection)
- atazanavir, efavirenz, etravirine, nevirapine, ritonavir, saquinavir, zidovudine (medicine to treat HIV)
- digoxin, quinidine, disopyramide, verapamil, amlodipine, diltiazem (medicine to treat heart disturbances and arterial hypertension)
- dabigatran, rivaroxaban, apixaban, warfarin (medicine use to thin blood)
- carbamazepine, valproate, phenytoin, phenobarbital (medicine to treat epilepsy)
- methylprednisolone (medicine to treat inflammation)
- omeprazole (medicine to reduce gastric acid secretion)
- cyclosporine, tacrolimus, sirolimus (medicine used for organ transplant)
- sildenafil, tadalafil, vardenafil (medicine to treat male erectile dysfunction)
- ibrutinib or vinblastine (medicines to treat cancer)
- tolterodine (medicine to treat urinary incontinence)
- sulfonylurea, nateglinide, repaglinide, insulin (medicines to treat diabetes)
- theophylline (medicine to treat asthma)
- St. John’s wort (herbal medicine to treat mild depression)
- gentamicin, amikacin, erythromycin, fidaxomicin (used to treat bacterial infections)
- cilostazol (medicine to treat muscle pain in the lower body)
Overdosage:
If you or anyone else accidentally took more of MACLAR 500MG TABLET. consult your doctor immediately. Symptoms of overdose are vomiting and stomach pain.
SYNOPSIS
| Drug | : | Clarithromycin |
| Pharmacological Category | : | Macrolide Antibiotics |
| Therapeutic Indication | : | Treat Bacterial infections |
| Dosage Forms | : | Tablet, Injection, Dry syrup, Oral suspensions, Gel, Granules, Lotion, Solution |
MORE INFORMATION
- Keep out of reach of children
- Store at room temperature
FAQs ABOUT MACLAR 500MG TABLET
What is MACLAR 500MG TABLET used for?
MACLAR 500MG TABLET is used to treat infections like upper respiratory tract infections (pharyngitis, and sinusitis), lower tract respiratory infections (bronchitis and pneumonia), middle ear infections (acute otitis media), skin and soft tissue infections (impetigo, folliculitis, cellulitis and abscesses), tooth and mouth infections (periapical abscess, periodontitis) as well as in patients with duodenal ulceration and helicobacter pylori infection.
If I start feeling well, can I skip the dose of MACLAR 500MG TABLET?
No. You should complete the full course of MACLAR 500MG TABLET as prescribed by your doctor. It is important that MACLAR 500MG TABLET be taken at the right dose and for the right duration given. Otherwise, the symptoms can prevail and sometimes worsen.
Will taking MACLAR 500MG TABLET more than the given dose provide a faster cure?
No, self-medication will always harm and result in an adverse reaction. Upon taking MACLAR 500MG TABLET more than the given dose, you may suffer from serious vomiting and stomach pain, in such cases consult a doctor immediately and go to the nearby hospital.
Who cannot take MACLAR 500MG TABLET?
MACLAR 500MG TABLET is not recommended for patients who have allergic reactions, fast, pounding, or irregular heartbeat, abnormal low levels of potassium or magnesium in the blood. Consult a doctor before taking MACLAR 500MG TABLET.
Can MACLAR 500MG TABLET be given to pregnant women?
MACLAR 500MG TABLET does not have adequate data, hence the medicine is not advised unless the potential benefit justifies the potential risk. Consult a doctor for advice before taking MACLAR 500MG TABLET.
Can MACLAR 500MG TABLET cause diarrhoea?
Yes, MACLAR 500MG TABLET can cause serious diarrhoea during or after antibiotic use. Usually, discontinuation of medicine can subside diarrhoea. However, if diarrhoea persists or if there is blood in the stool then immediately consult a doctor for advice.
REFERENCES
1. KD Tripathi. Clarithromycin. Essentials of Medical Pharmacology. Seventh Edition,2013. Page - 803.
2. Zhou Q, Zhu LL, Yan XF, Pan WS, Zeng S. Drug utilization of clarithromycin for gastrointestinal disease treatment. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2008. [Accessed on 10th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760198/
3. Aurobindo Pharma Limited. Dailymed. [Revised in February 2022] [Accessed on 10th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9aaffb41-408c-4372-8fd5-1d649450c0e9
4. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (emc) [Revised in October 2021] [Accessed on 10th June 2022] https://www.medicines.org.uk/emc/files/pil.4358.pdf
5. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (emc) [Revised in October 2021] [Accessed on 10th June 2022] https://www.medicines.org.uk/emc/files/pil.4357.pdf
6. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (emc) [Revised in February 2022] [Accessed on 10th June 2022] https://www.medicines.org.uk/emc/files/pil.12806.
7. Abbott Laboratories. [Accessed on 10th June 2022]. U.S. Food & Drug Administration. [Revised in 2012] [Accessed 10th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050662s044s050,50698s026s030,050775s015s019lbl.pdf
8. P.T. Abbott Indonesia. [Accessed on 10th June 2022] https://www.medicine.abbott/content/dam/bss/divisionalsites/epd/productpdf/Klaricid%20250mg%20and%20500mg%20Tablet%20Insert.pdf
9. Getz Pharma. Pvt. Limited. [Revised in August 2009] [Accessed on 10th June 2022] https://getzpharma.com/wp-content/uploads/2021/08/Claritek-Insert.pdf
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
- Blood Culture tests
AUTHOR DETAILS
Written By Dr. Janet.C, Pharm.D
Last updated on 12 Oct 2022 | 07:30 PM(IST)
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