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INTRODUCTION
LURASTAR 80MG contain Lurasidone which belongs to a group of medicine called antipsychotics. It is used to treat symptoms of schizophrenia in adults (aged 18 years and over) and adolescents aged 13-17 years. Schizophrenia is a mental disorder with distortions in thinking, perception and emotions that includes hallucinations (hearing voices or seeing things that are not there) and delusions (fixed, false beliefs). This medicine helps in improving these symptoms of schizophrenia. It works by blocking receptors for neurotransmitters, dopamine and serotonin. By blocking their receptors, this medicine helps to normalise the activity of the brain, reducing the symptoms of schizophrenia.
Always take LURASTAR 80MG exactly as your doctor has told you. This medicine must be taken with or without food. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Do not drive or operate any machine while taking this medicine since it may cause sleepiness, dizziness, and vision problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine. The most common side effects are restlessness, sleepiness, parkinsonism, nausea, vomiting, indigestion, dry mouth or excess saliva, abdominal pain, insomnia, agitation, anxiety, weight gain. This medicine strictly not recommended for use in children below 13 years of age.
USES OF LURASTAR 80MG
- Treat symptoms of schizophrenia in adults (aged 18 years and over) and adolescents aged 13-17 years
HOW LURASTAR 80MG WORKS
LURASTAR 80MG works by blocking receptors for neurotransmitters, dopamine and serotonin. By blocking their receptors, this medicine helps to normalise the activity of the brain, reducing the symptoms of schizophrenia.
DIRECTIONS FOR USE
Always take LURASTAR 80MG exactly as your doctor has told you. This medicine must be taken with or without food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.
SIDE EFFECTS OF LURASTAR 80MG
SERIOUS
- severe allergic reaction seen as fever, swollen mouth, face, lip or tongue, shortness of breath, itching, skin rash and sometimes a drop in blood pressure
- serious blistering rash affecting the skin, mouth, eyes and genitals (Stevens-Johnson syndrome)
- fever, sweating, muscle stiffness, and reduced consciousness (neuroleptic malignant syndrome)
- blood clots in the veins especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing
COMMON
- restlessness and inability to sit still
- sleepiness
- parkinsonism
- speech problems, unusual muscle movements (extrapyramidal symptoms (EPS))
- dizziness
- muscle spasms and stiffness
- nausea, vomiting
- rash and itching
- indigestion
- dry mouth or excess saliva
- abdominal pain
- insomnia, agitation, and anxiety
- weight gain
- increase in creatine phosphokinase (an enzyme in muscles), increase in creatinine (a marker of kidney function)
RARE
- rhabdomyolysis which is the breakdown of muscle fibres that leads to the release of muscle fibre contents (myoglobin) into the bloodstream, seen as muscle pain, being sick, being confused, an abnormal heart rate and rhythm, and possibly dark urine
- increase in eosinophils (a type of white blood cell)
HOW TO MANAGE SIDE EFFECTS
Sleepiness:
Get up and move around to feel awake. Take a nap to take the edge off the sleepiness. Give your eyes a break to avoid weakness.
Dizziness:
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
Nausea and vomiting:
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Dry mouth:
Chew sugar-free gum or suck on sugar-free hard candies. control your caffeine intake. Do not use mouthwashes. Sip water regularly.
Abdominal pain:
Keep try to rest and relax. Eat and drink slowly and smaller and frequent meals. Applying a heat pad or covered hot water bottle on your stomach. If still pain persists, speak to your doctor.
WARNING & PRECAUTIONS
PREGNANCY
LURASTAR 80MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
LURASTAR 80MG should be used with caution in breast feeding women. Consult your doctor before taking this medicine.
DRIVING AND USING MACHINES
Do not drive or operate any machine while taking this medicine it may cause sleepiness, dizziness, and vision problems.
ALCOHOL
Consumption of alcohol is not recommended during treatment with LURASTAR 80MG.
KIDNEY
LURASTAR 80MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
LURASTAR 80MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take LURASTAR 80MG if you are allergic (hypersensitive) to Lurasidone or any other ingredients in this medicine.
HEART DISEASE
LURASTAR 80MG should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.
OTHERS
Tell your doctor if you have or had a condition such as,
- suicidal thoughts or behaviour
- parkinson’s disease or dementia
- ever been diagnosed with a condition whose symptoms include high temperature and muscle stiffness (also known as neuroleptic malignant syndrome) or if you have ever experienced rigidity, tremors or problems moving (extrapyramidal symptoms) or abnormal movements of the tongue or face (tardive dyskinesia)
- history of seizures (fits) or epilepsy
- history of blood clots
- enlarged breasts in male (gynecomastia), milky nipple discharge (galactorrhea), absence of menstruation (amenorrhea) or erectile dysfunction
- diabetes or are prone to diabetes
- an increase in your weight
- blood pressure dropping upon your standing up which may cause fainting
INTERACTIONS
Talk to your doctor if you are taking,
- levodopa (used to treat parkinson’s disease and restless legs syndrome)
- ergot alkaloid derivatives (used to treat migraine)
- terfenadine and astemizole (used to treat hay fever and other allergic conditions)
- cisapride (used to treat digestive problems)
- pimozide (used to treat psychiatric illnesses)
- quinidine (used to treat heart conditions)
- bepridil (used to treat chest pain)
- buprenorphine (used to treat opioid dependence)
- opioids (used to treat sever pain)
- anti-depressants such as moclobemide, tranylcypromine, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, doxepin, or trimipramine (used to treat depression)
- diltiazem and bosentan, verapamil (used to treat high blood pressure)
- erythromycin, nafcillin (used to treat infections)
- fluconazole (used to treat fungal infections)
- amprenavir, efavirenz, etravirine (used to treat HIV infection)
- aprepitant (used to treat nausea and vomiting)
- armodafinil, modafinil (used to treat sleepiness)
- prednisone (used to treat inflammatory disease)
- rufinamide (used to treat seizures)
SYNOPSIS
| Drug | : | Lurasidone |
| Pharmacological Category | : | Second Generation (Atypical) Antipsychotic |
| Therapeutic Indication | : | Schizophrenia |
| Dosage Forms | : | Tablet |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT LURASTAR 80MG
Can I take LURASTAR 80MG during pregnancy?
LURASTAR 80MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
What should be avoided while taking LURASTAR 80MG?
Alcohol should be avoided while taking this medicine since taking both together may cause severe side effects. In addition to that, you should not drink grapefruit juice while take this medicine since it affects the way it works.
Can LURASTAR 80MG cause dizziness?
Yes, this medicine may cause dizziness in some individuals. Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
REFERENCES
1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page -2322 - 2323.
2. Frank I Tarazi 1, Marco A Riva. The preclinical profile of lurasidone: clinical relevance for the treatment of schizophrenia. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Oct 2013. [Accessed 30 Nov 2020] https://pubmed.ncbi.nlm.nih.gov/23837554/
3. Philip D Harvey. The clinical utility of lurasidone in schizophrenia: patient considerations. US National Library of Medicines, National Institutes of Health. 28 Apr 2015. [Accessed 30 Nov 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425313/
4. AndersonBrecon (UK) Ltd; Electronic Medicines Compendium (EMC); [Revised on July 2020] [Accessed 30 Nov 2020] https://www.medicines.org.uk/emc/files/pil.7549.pdf
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