INTRODUCTION

LUPILA 10MG TABLET contains Ilaprazole which belongs to the group of medicines called Proton pump inhibitors. LUPILA 10MG TABLET is used in the treatment of dyspepsia (also known as indigestion which occurs due to discomfort or pain in the upper abdomen), peptic and duodenal ulcer (sore on the lining of the stomach or the first part of the small intestine), and gastroesophageal reflux disease (condition in which the stomach acid repeatedly flows back into the tube connecting your mouth and stomach (esophagus).

Before taking LUPILA 10MG TABLET, inform your doctor if you have or had the habit of smoking tobacco, have persistent watery diarrhoea, fever or stomach pain, advanced liver disease or chronic kidney disease. LUPILA 10MG TABLET should be used with caution in pregnant and breast-feeding women only if clearly advised by the doctor.

LUPILA 10MG TABLET should be used with caution in elderly patients (aged above 65 years).  The most common side effects of taking LUPILA 10MG TABLET are nausea, headache, flatulence, and diarrhoea. Consult your doctor if any of your symptoms gets worsen.

USES OF LUPILA 10MG TABLET

Treats:

• dyspepsia
• peptic and duodenal ulcer
• gastroesophageal reflux disease

HOW LUPILA 10MG TABLET WORKS

LUPILA 10MG TABLET works by inhibiting the action of hydrogen-potassium adenosine triphosphatase (an enzyme responsible for acid secretion in the stomach) which leads to the reduced acid formation in the stomach thus providing relief from dyspepsia, gastric and duodenal ulcer, and gastroesophageal reflux disease.

DIRECTIONS FOR USE

Take LUPILA 10MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF LUPILA 10MG TABLET

HOW TO MANAGE SIDE EFFECTS

Bloating

Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. Do not or limit the intake of carbonated drinks. Avoid eating foods which causes bloating such as beans, lentils and others. Consult your doctor if your symptom gets worse.

Diarrhea

Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high fat or spicy foods. Do not take any medicine on your own to treat diarrhoea without consulting your doctor. Consult your doctor if the symptom gets worse.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.

Nausea And Vomiting

Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

Monitoring required

LUPILA 10MG TABLET should be used with caution in pregnant women only if considered clearly necessary. Consult your doctor before taking LUPILA 10MG TABLET.

BREASTFEEDING

Monitoring required

LUPILA 10MG TABLET should be used with caution in breastfeeding women only if considered clearly necessary. Consult your doctor before taking taking LUPILA 10MG TABLET.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol while taking LUPILA 10MG TABLET as it may increase the acid production in the stomach and may worsen your existing condition.

KIDNEY

Use with Caution

LUPILA 10MG TABLET should be used with caution in patients with kidney problems such as chronic kidney disorders. Consult your doctor before taking LUPILA 10MG TABLET.

LIVER

Use with Caution

LUPILA 10MG TABLET should be used with caution in patients with advanced liver disease. Consult your doctor before taking LUPILA 10MG TABLET.

ALLERGY

Contraindicated

Do not take LUPILA 10MG TABLET if you are allergic to ilaprazole, benzimidazole (such as albendazole), other proton pump inhibitors (such as omeprazole, pantoprazole) or any other ingredients of this medicine.

USE IN GERIATRICS

Use with Caution

LUPILA 10MG TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking LUPILA 10MG TABLET.

INTERACTIONS

A. Drug-Drug interactions:

Before taking LUPILA 10MG TABLET, inform your doctor if you are taking any of the following medicines:

• clarithromycin, amoxicillin (used to treat bacterial infection)
• midazolam (used to treat anxiety and to produce sedation before surgery)
• ketoconazole (used to treat fungal infection)

B. Drug-Food interaction:

Avoid excessive intake of soft drinks, citrus juices, carbonated drinks, fried food, caffeinated beverages (such as tea or coffee) while taking LUPILA 10MG TABLET as it may cause undesirable effects to occur due to interaction with this medicine.

Overdosage:

If you or anyone else accidentally take too much of LUPILA 10MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of LUPILA 10MG TABLET are weak bones, signs of low magnesium level in blood (such as tiredness, confusion, shakiness or dizziness), muscle twitches, irregular heartbeat, signs of vitamin B12 deficiency (such as feeling tired, weak, and pale due to anaemia), pounding heartbeat, shortness of breath, light-headedness, indigestion, flatulence, nerve problems (such as numbness, tingling and problems in walking) and loss of appetite.

SYNOPSIS

MORE INFORMATION

• Keep LUPILA 10MG TABLET out of reach of children
• Store at room temperature

FAQs ABOUT LUPILA 10MG TABLET

Q: What are the long-term effects of taking LUPILA 10MG TABLET?

A: Long-term effects of LUPILA 10MG TABLET are weak bones, signs of low magnesium level in blood (such as tiredness, confusion), muscle twitches, irregular heartbeat, signs of vitamin B12 deficiency (such as feeling tired, weak, and pale due to anaemia), pounding heartbeat, shortness of breath, light-headedness, indigestion, flatulence, nerve problems (such as numbness) and loss of appetite. Consult your doctor immediately if you experience any of these side effect.

Q: Can I stop taking LUPILA 10MG TABLET if I feel better?

A: Your doctor will decide and advice when to reduce the dosage and to stop the treatment. If you stop taking LUPILA 10MG TABLET abruptly, your symptoms might appear again and making the condition getting worse. Consult your doctor before you stop taking LUPILA 10MG TABLET.

Q: What are the common side effects of taking LUPILA 10MG TABLET?

A: The most common side effects of taking LUPILA 10MG TABLET are nausea, headache, flatulence, and diarrhoea. Consult your doctor if any of these symptoms worsen or needs immediate care.

Q: Does LUPILA 10MG TABLET cause weight gain?

A: Yes, LUPILA 10MG TABLET may cause weight gain due to reflux symptoms which could increase your food consumption. Consult your doctor before taking LUPILA 10MG TABLET to discuss on the side effect if you have any further queries.

Q: Is LUPILA 10MG TABLET safe to use during pregnancy?

A: LUPILA 10MG TABLET should be used with caution in pregnant women only if clearly advised by your doctor. Consult your doctor before taking LUPILA 10MG TABLET if you are pregnant or planning to get pregnant.

REFERENCES

1. Nayoung Kim. Pharmacokinetics and Pharmacodynamics of Gastrointestinal Drugs.Sex/gender-specific Medicine in the Gastrointestinal Diseases. Edition. 2022. Page – 442.

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3. Xin-Xing Tantai, Long-Bao Yang, Zhong-Cao Wei, Cai-Lan Xiao, Li-Rong Chen, Jin-Hai Wang, and Na Liu. Association of proton pump inhibitors with risk of hepatic encephalopathy in advanced liver disease: A meta-analysis. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. [Revised in June 2019] [Accessed on 29th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558434/

4. Hee Jeong Lee, Haekyung Lee, Song Hee Oh, Joonbyung Park, Suyeon Park, Jin Seok Jeon, HyunJin Noh, Dong Cheol Han, Soon Hyo Kwon. Chronic kidney disease (CKD) patients are exposed to more proton pump inhibitor (PPI)s compared to non-CKD patients. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. [Revised in September 2018] [Accessed on 29th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136773/

5. Alejandro A. Nava-Ocampo, Elvia Y. Velazquez-Armenta, Jung-Yeol Han, and Gideon Koren. Use of proton pump inhibitors during pregnancy and breastfeeding. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. [Revised in July 2006] [Accessed on 29th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781096/

6. Robert M. Ward, and Gregory L. Kearns. Proton Pump Inhibitors in Pediatrics. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. [Revised in March 2013] [Accessed on 29th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616221/

7. Yu–Xiao Yang, David C. Metz. Safety of Proton Pump Inhibitor Exposure. Reviews in basic and clinical gastroenterology and hepatology. Gastroenterology – American Gastroenterological Association. [Revised in August 2010] [Accessed on 29th August 2022] https://www.gastrojournal.org/article/S0016-5085(10)01241-2/fulltext

8. Central Drugs Standard Control Organisation (CDSCO). Ilaprazole. [Accessed on 29th August 2022] https://cdscoonline.gov.in/CDSCO/Drugs

9. Livzon. Ilaprazole (Enteric-coated Tablets). [Accessed on 29th August 2022] https://en.livzon.com.cn/product/8.html

10. Taj Pharma. Ilaprazole (Digicool). [Accessed on 29th August 2022] https://meds.tajpharma.com/portfolio-item/ilaprazole-10mg-tablets-digicool/

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USEFUL DIAGNOSTIC TESTS

• Gastroscopy
• Manometry

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 06 Mar 2023 | 09:07 AM(IST)