Lupibrin Eye Drops 5ml

Glaucoma Rx required
NOT AVAILABLE

Best Price*  ₹ 254.40
MRP ₹318.00
(Inclusive of all taxes) * Mfr: Lupin Ltd * Country of Origin: NA



INTRODUCTION

LUPIBRIN contains Brinzolamide which belongs to the group of medicines called ophthalmic carbonic anhydrase inhibitor. It is used in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Glaucoma (elevated intraocular pressure) is a medical condition of eye that damage the optic nerve. This damage is usually caused by an abnormally high pressure in the eyes. Brinzolamide inhibits the formation of aqueous humor by inhibiting the activity of an enzyme called carbonic anhydrase and reduces elevated intraocular pressure.

The recommended daily dosage is 1 drop in the affected eye, twice a day. Continue to use this medicine, as long as your doctor tells you to do so, to obtain better results. The most common side effect of using this medicine are blurred vision and eye irritation. Avoid traveling or driving if your vision is abnormal or blurred. Do not use this medicine if you are pregnant or breastfeeding. Discuss the risk and benefits with your doctor. This medicine is generally not recommended for use in children or adolescents under 18 years of age unless prescribed by a physician. The most common side effects are blurred vision, eye irritation, itching or pain and dry eye.

USES OF LUPIBRIN

  • Treat glaucoma (elevated intraocular pressure)

HOW LUPIBRIN WORKS

Following ocular administration, brinzolamide is absorbed into the systemic circulation and inhibits an enzyme called carbonic anhydrase present in ciliary processes of the eye. Inhibition of carbonic anhydrase significantly decreases the secretion of aqueous humor in the eye, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. This in turn results in the reduction of intraocular pressure (IOP).

DIRECTIONS FOR USE

Apply this medicine as directed by your physician. It is intended for use only in the eyes. Do not swallow or inject the medicine. The recommended daily dosage is 1 drop in the affected eye, twice a day. Wash your hands before application. Tilt your head backwards and pull your eyelids with a clean finger. Gently press the bottle and apply a drop of medicine in your eye. Repeat the process in another eye if required. Do not touch the tip of the dropper. Continue to use this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF LUPIBRIN

COMMON

  • blurred vision
  • eye irritation, itching or pain
  • discharge from eye
  • dry eye

RARE

  • swelling in the eye
  • memory impairment
  • drowsiness
  • chest pain
  • nasal congestion
  • dry nose
  • ringing in the ears
  • hair loss
  • irregular heartbeat
  • difficulty in sleeping

HOW TO MANAGE SIDE EFFECTS

Blurred vision:

Try to rest and relax. Avoid traveling or driving if your vision is abnormal or blurred. If the symptom feels uncomfortable contact your doctor.

WARNING & PRECAUTIONS

PREGNANCY

LUPIBRIN is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

LUPIBRIN is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL

Avoid consumption of alcohol while taking this medicine.

KIDNEY

Do not use LUPIBRIN if you have any serious kidney disease. Consult your doctor for advice.

LIVER

LUPIBRIN should be used with caution in patients with severe liver disease. Consult your doctor for advice.

OTHERS

Do not take this medicine, if you have:

  • hyperchloremic acidosis (acidity in your blood)
  • dry eyes or corneal problems

INTERACTIONS

Talk to your doctor, if you are taking,

  • other carbonic anhydrous inhibitors (acetazolamide or dorzolamide)

SYNOPSIS

Drug :  

Brinzolamide

Pharmacological Category :   Carbonic anhydrase inhibitor
Therapeutic Indication :   Glaucoma
Dosage Forms :   Eye drops

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT LUPIBRIN

Can LUPIBRIN be used during pregnancy?

This medicine is not recommended for use during pregnancy unless considered necessary by your doctor. Consult your doctor for advice.

What happens when excess of LUPIBRIN is used?

Do not apply more than directed by your doctor. If used accidently contact your doctor for advice.

REFERENCES

1. KD. Tripathi. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Drugs for Glaucoma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 155.

2. Jeffrey D. Henderer and Christopher J. Rapuano. Ocular Pharmacology. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1787.

3. David Robertson and Italo Biaggioni. Basic and Clinical Pharmacology. 14th Edition. New York McGarw Hill Education 2018.  Page – 166.

4. Alcon Research. Efficacy and Safety of Brinzolamide/Brimonidine Fixed Combination BID Compared to Brinzolamide BID Plus Brimonidine BID in Subjects with Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on July 2018] [Accessed 27th November 2020] https://clinicaltrials.gov/ct2/show/NCT02339584

5. Michele Iester. Brinzolamide ophthalmic suspension: a review of its pharmacology and use in the treatment of open angle glaucoma and ocular hypertension. NCBI; PMC US National Library of Medicine, National Institute of Health. September 2008. [Accessed 27th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694021/

6. Pharmathen SA, Famar S.A. or BalkanPharma-Razgrad AD. Electronic Medicines Compendium (EMC); [Revised on February 2015] [Accessed 27th November 2020] https://www.medicines.org.uk/emc/files/pil.8054.pdf

7. Alcon Laboratories, Inc. U.S. Food & Drug Administration. 2006. [Accessed 27th November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/020816s009lbl.pdf

USEFUL DIAGNOSTIC TESTS

  • Tonometry
  • Ophthalmoscopy
  • Perimetry
  • Gonioscopy
  • Pachymetry

Manufacturer/Marketer Details

    Net Qty
    1
    Shelf Life
    NA
    Item Weight
    NA
    No. of Units in a Kit
    NA
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