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Drug Information

What is Gemfibrozil used for?

Gemfibrozil is a lipid-lowering agent used for the treatment of high serum triglyceride and cholesterol levels in the blood. It is usually prescribed for the treatment of conditions such as heart diseases and pancreatitis.

Gemfibrozil may also be prescribed for other conditions as determined by the doctor.

How does Gemfibrozil work?

Gemfibrozil belongs to the class of drugs called fibric acid derivatives or broad-spectrum lipid-lowering agents. The drug acts by limiting the substance availability for triglyceride production in the liver and stimulating the reverse cholesterol transport. Thus, it results in the decrease of triglycerides and cholesterol levels in the blood.

How to take Gemfibrozil?

The dosage and the drug form depends on the age, weight and medical condition of an individual. Take Gemfibrozil as prescribed by your doctor.

Swallow the capsule whole, but do not open or chew the capsule. Take Gemfibrozil with or without food.

If you miss a dose of Gemfibrozil, take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

What are the drugs that interact with Gemfibrozil?

The drugs that interact with Gemfibrozil are:

  • Amlodipine
  • Atorvastatin
  • Colchicine
  • Dicoumarol
  • Fluvastatin
  • Loperamide
  • Metformin
  • Niacin
  • Ritonavir
  • Warfarin

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Gemfibrozil?

The following are the most common side effects of Gemfibrozil:

  • Abdominal pain
  • Diarrhoea
  • Dizziness
  • Heartburn
  • Nausea
  • Unpleasant taste
  • Vomiting

The following are the severe side effects and you may require immediate medical attention:

  • Blood in urine
  • Persistent cough
  • Painful urination

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions Gemfibrozil?

  • Seek doctor’s advice before taking any other drug or herbal products while on Gemfibrozil
  • Avoid Gemfibrozil during pregnancy or breastfeeding because the safe use of the drug is not yet established.
  • Avoid grapefruit juice while taking Gemfibrozil.
  • Do not drive or operate heavy machinery if Gemfibrozil causes dizziness.
  • Do not exceed the dose more than what is prescribed.
  • Avoid consumption of alcohol as it may cause excessive dizziness when taken with Gemfibrozil.

You are advised not to take Gemfibrozil if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Gemfibrozil?

  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • Inform your doctor if you are pregnant or breastfeeding.
  • Tell your doctor if you are allergic to Gemfibrozil.
  • Tell the doctor if you have undergone any surgical procedure.
  • Inform your doctor about the pre-existing liver or kidney diseases.

Frequently Asked Questions about Gemfibrozil

  1. What is the usual dose of Gemfibrozil?
  2. The typical adult dose of Gemfibrozil is 600 mg twice a day. You must consult the doctor before taking the drug.

  3. How should Gemfibrozil be stored?
  4. Gemfibrozil is stored at controlled room temperature (20 – 25OC). Keep the medicine away from direct sunlight.

    1. Is it safe to alter the dose of Gemfibrozil?
    2. No, Gemfibrozil dose is prescribed depending on the severity of the condition. Therefore, altering the dose is not advised.

    3. Do I need to be monitored for any laboratory parameters while taking Gemfibrozil?
    4. Yes, serum triglyceride and cholesterol levels should be monitored when you are on Gemfibrozil medication.

    5. How long can I take Gemfibrozil?
    6. Gemfibrozil should be used only for the prescribed period.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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