INTRODUCTION
LOFECAM 8MG contains Lornoxicam which belongs to a group of medicines called Non-steroidal anti-inflammatory drug (NSAID) and Anti-rheumatic drug of the oxicam class. It is used for short term treatment of mild to moderate pain when oral administration is not possible (Ex. after dental surgery).
Lornoxicam is a non-steroidal anti-inflammatory drug with analgesic properties. It is related to inhibition of prostaglandin synthesis (inhibition of cyclooxygenase enzyme), leading to desensitisation of peripheral nociceptors and consequently inhibition of inflammation.
This medicine will be administered by your physician or nurse. Before receiving this LOFECAM 8MG inform your doctor if you have history of stomach ulcers, heart diseases, high blood pressure, diseases related to liver or kidney. It is not advisable for use during pregnancy and breastfeeding. The common side effects are headache, dizziness, nausea, vomiting and stomach pain. This medicine may impair fertility and is not recommended for women attempting to become pregnant.
USES OF LOFECAM 8MG
- Treats mild to moderate pain when oral administration is inappropriate (Ex. after dental surgery)
HOW LOFECAM 8MG WORKS
LOFECAM 8MG inhibits the activity of certain enzymes, which leads to reduced prostaglandin and thromboxane production and decreased pain and inflammation.
DIRECTIONS FOR USE
LOFECAM 8MG will be administered as intramuscularly (IM) or intravenously (IV) by your doctor or nurse.
SIDE EFFECTS OF LOFECAM 8MG
SERIOUS
- abdominal bleeding, skin rash, damage to the internal lining of the nostrils, mouth, eyelids, ears, genitals or anus
- shortness of breath, chest pains or swelling of ankle
- stomach pain and black stools
- yellowing of the skin and eyes
- ulcers; swelling of the face, lips, tongue, or throat causing breathing difficulty
- fever; blistering, inflammation on hands and feet or in the mouth area (Stevens-Johnson syndrome)
- infections of the skin (chickenpox)
COMMON
- mild, passing headache and dizziness
- nausea, abdominal pain, diarrhoea and vomiting
RARE
- sore throat
- anaemia, decrease in blood cell count, weakness
- confusion, nervousness, agitation, feeling sleepy (somnolence), paraesthesia (tingling sensations), abnormal sense of taste, tremor, migraine and visual disturbances
- increase in blood pressure, hot flush
- bleeding, haematoma (bruising), prolonged bleeding time
- difficulty in breathing, cough, bronchospasm
- perforated ulcer, blood vomit, gastrointestinal bleeding, black tarry stools, inflammation in the mouth, oesophagitis (inflammation of the gullet), gastro-oesophageal reflux, difficulty swallowing and inflammation of the tongue
- abnormal liver function
- eczema, rash
- bone pain, muscle cramp, muscle pain
- urinary problems
- increase in urea or creatinine
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink plenty of fluids to avoid dehydration.
Stomach pain:
Place a warm water bottle on your abdomen. Soak in a warm bath. Drink plenty of water.
Headache:
Rest and drink plenty of fluids. Apply a wet or cold cloth on forehead, rest in a quiet, comfortable and dark room.
Nausea:
Take regular routine meals and avoid spicy foods.
Vomiting:
Drink clear or ice-cold drinks, eat light and avoid sweets.
Dizziness:
Get up and move around and take small naps to edge off the sleepiness.
WARNING & PRECAUTIONS
PREGNANCY
LOFECAM 8MG is not recommended in the first six and last three months of pregnancy. Consult your doctor before taking it.
BREASTFEEDING
LOFECAM 8MG is not recommended in breastfeeding women. Consult your doctor before taking it.
DRIVING AND USING MACHINES
LOFECAM 8MG has negligible or no influence on the ability to drive or use machinery.
KIDNEY
LOFECAM 8MG is not recommended in patients with severe kidney impairment. Consult your doctor for advice.
LIVER
LOFECAM 8MG is not recommended in patients with severe liver impairment. Consult your doctor for advice.
ALLERGY
Tell your doctor if you are allergic (hypersensitive) to Lornoxicam.
HEART DISEASE
LOFECAM 8MG is recommended in patients with severe heart failure or any other heart problems. Consult your doctor for advice.
OTHERS
- Do not use this medicine, if you have thrombocytopenia (low blood platelet count), gastrointestinal bleeding, bleeding disorders and history of peptic ulcer.
- Before receiving this medicine, inform your doctor if you have history of high blood pressure, ulcerative colitis or Crohn’s disease, history of bleeding tendency, asthma, SLE, blood coagulation disorder or stroke.
Use in pediatrics:
- Due to lack of data, this medicine is not recommended for use in children and adolescents under 18 years of age due to lack of data.
Use in geriatrics:
- LOFECAM 8MG should be used with caution in elderly patients with renal and hepatic impairment (above 65 years of age). Consult your doctor before taking.
INTERACTIONS
A. Drug - Drug interactions:
Inform to your physician, if you are taking,
- acetylsalicylic acid, ibuprofen and COX-2 inhibitors (treats pain)
- cimetidine (treats ulcers)
- heparin, phenprocoumon (treats blood clot)
- corticosteroids
- methotrexate (treats cancer)
- lithium (treats mental disorders)
- ciclosporine or tacrolimus
- digoxin, ACE inhibitors, beta-adrenergic blockers (treats heart problems)
- diuretics
- quinolone antibiotics
- SSRI (used to treat depression)
- glibenclamide (treats diabetes)
- rifampicin and fluconazole (treats infections)
- angiotensin II receptor blocker (used to treat high blood pressure)
- pemetrexed (treats lung cancer)
Overdosage:
- This medicine will be administered by your doctor or nurse, in case of an overdose, consult your doctor immediately. Symptoms include nausea, vomiting, symptoms associated with central nervous system (such as dizziness or disturbances in vision).
SYNOPSIS
| Drug | : | Lornoxicam |
| Pharmacological Category | : | Non-steroidal anti-inflammatory drug |
| Therapeutic Indication | : | Treats Pain and Inflammation |
| Dosage Forms | : | Tablet, Injection |
MORE INFORMATION
- Keep out of reach of children
- Do not store above 25°C
FAQs ABOUT LOFECAM 8MG
Is LOFECAM 8MG safe?
It is a safe medicine and it will be administered by your doctor or nurse.
Does LOFECAM 8MG cause dizziness?
Yes, it may cause dizziness in some individuals, consult your doctor immediately if this persists for a long time.
Is LOFECAM 8MG safe to use in asthma patients?
NSAID’s are not recommended in asthmatic patients.
REFERENCES
1. Susanna Radhofer-Welte, Peter Dittrich, Marija Simin and Poul Erik Branebjer. Comparative Bioavailability of Lornoxicam as Single Doses of Quick-Release Tablet, Standard Tablet and Intramuscular Injection. Aug 24, 2012; [Accessed on Sep 29, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485324/
2. Central Drugs Standard Control Organisation. Lornoxicam; [Accessed on Sep 29, 2021] https://cdscoonline.gov.in/CDSCO/Drugs
3. Takeda UK Limited. Feb 26, 2010; [Revised on Jan 17, 2011] [Accessed on Sep 29, 2021] http://www.hpra.ie/img/uploaded/swedocuments/LicenseSPC_PA1547-005-003_11032015142107.pdf
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