LIOTON GEL contains Heparin which belongs to the group of medicines called Anticoagulants. It is used to treat varicose syndromes and their complications, phlebothrombosis (blood clot in veins), thrombophlebitis (inflammation of a vein due to blood clot), superficial periphlebitis (inflammation of the superficial veins), varicose ulcers, post-surgical varicose veins, after saphenectomy (removal of a damaged vein).
LIOTON GEL can also be used in traumas and injuries, localized oedemas, subcutaneous hematoma (collection of blood under the skin) alone or in combination with systemic therapy.
A blood clot or thrombus is a gel-like collection of blood that form in arteries or veins when blood changes from liquid to partially solid form. Your doctor might want you to take certain blood tests prior to the treatment.
Before applying LIOTON GEL inform your doctor if you have bleeding, open wounds or mucosae, sites of infection, or hemorrhagic phenomena (excessive bleeding). There is a lack of data on the use of LIOTON GEL in pregnant and breastfeeding women. Consult with your doctor before using.
LIOTON GEL is not recommended for use in children and adolescents below 18 years of age. The most common side effects of applying LIOTON GEL are burning, redness, itching and irritation at application site. Consult your doctor if symptoms do not show improvement.
Treats,
LIOTON GEL binds to the antithrombin (an enzyme present in the clotting system) which in turn inhibits several clotting factors such as factor Xa, factor IIa. This inactivation of thrombin prevents the formation of clots and prolongs the clotting time of blood.
Apply LIOTON GEL as advised by your physician. It is for external use only. Apply the medicine to the affected area and massage gently. Wash your hands before and after the application of the medicine. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
Stop applying LIOTON GEL and contact your doctor immediately if you experience any of the following side effects:
Itchy skin:
Hot water makes your skin irritated, so avoid taking hot showers. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. To soothe and hydrate irritated skin, apply moisturizers. Contact your doctor if the itching worsens.
There is a lack of data on the use of LIOTON GEL in pregnant women. Consult with your doctor before using.
There is a lack of data on the use of LIOTON GEL in breastfeeding women. Consult with your doctor before using.
LIOTON GEL does not affect your ability to drive or use machines.
Do not apply LIOTON GEL if you are allergic to Heparin or any other ingredients of this medicine.
LIOTON GEL is not recommended for use if you:
Before applying LIOTON GEL, inform your doctor if you have:
Use in pediatrics:
LIOTON GELis not recommended for use in children and adolescents below 18 years of age as safety and effectiveness have not been established yet. Consult with your child’s doctor before using LIOTON GEL for your child.
Use in geriatrics:
There is no information the use of LIOTON GEL in elderly patients. Ask for your doctor’s advice before using.
A. Drug - Drug interactions:
Before applying LIOTON GEL, inform your doctor if you are taking any of the following medicine:
Overdosage:
If you or anyone else accidentally ingests or applies too much of LIOTON GEL, consult your doctor immediately or visit the nearby hospital.
Drug | : | Heparin |
Pharmacological Category | : | Anticoagulant |
Therapeutic Indication | : | Blood clots |
Dosage Forms | : | Gel, Injection, Solution, Topical solution |
Can LIOTON GEL be used in children?
LIOTON GELis not recommended for use in children and adolescents below 18 years of age as safety and effectiveness have not been established yet. Consult your child’s doctor before using LIOTON GEL for your child.
What is LIOTON GEL used for?
LIOTON GEL is used to treat varicose syndromes and their complications, blood clots in veins of the leg, inflammation of veins in the leg, varicose ulcers, post-surgical varicose veins, after removal of the damaged vein, traumas and injuries, localized oedemas, subcutaneous hematoma
Can LIOTON GEL be used in pregnant women?
Inform your doctor if you are pregnant or planning to have a baby before applying LIOTON GELas safety and effectiveness has not been established yet. Consult your doctor before applying it.
Can LIOTON GEL cause any side effects?
LIOTON GEL can cause itching, burning, redness and irritation at the application site in certain patients. Consult your doctor if the symptoms worsen
How does LIOTON GEL work?
LIOTON GEL binds to the antithrombin which in turn inhibits several clotting factors (factor Xa, factor IIa). Thus, by inactivating the thrombin it prevents the formation of clots and prolongs the clotting time of blood.
1. KD Tripathi. Drugs Affecting Coagulation, Bleeding and Thrombosis. Essentials of medical pharmacology. Eighth Edition. 2019. Page –663-664.
2. Vikas Saini, Tanvir Samra, Nitin Ahuja, Sameer Sethi. A prospective randomized study to evaluate safety and efficacy of heparin topical solution (1000 IU/ml) compared to heparin topical gel (200 IU/g) in prevention of infusion-associated phlebitis. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed Central. November 2018. [Accessed on 11th August 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364337/
3. Cesare Vecchio, Anna Frisinghelli. Topically applied heparins for the treatment of vascular disorders: a comprehensive review. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed.govl.. [Accessed on 11th August 2022]. https://pubmed.ncbi.nlm.nih.gov/18783299/
4. A.Menarini Manufacturing Logistics and Services s. r.l. Heparin. [Revised in April 2022] [Accessed on 11th August 2022] https://myhealthbox.eu/en/view/1713833/12bf9dc32c5347af6f251ea29579737d/leaflet
5. Prevago Healthcare. Thrombohep Gel (Heparin). [Accessed on 11th August 2022]. https://www.prevegohealthcare.com/product-page/thrombohep-gel
6. Leeford Healthcare. Aparin (Heparin). [Accessed on 11th August 2022]. https://www.leeford.in/product/1244/aparin
7. Heparin. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 11th August 2022] https://cdscoonline.gov.in/CDSCO/Drugs
Drug bank. Heparin. [Accessed on 11th August 2022]. https://go.drugbank.com/drugs/DB01109
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