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INTRODUCTION
LINID INFUSION contain linezolid which belongs to a group of medicine called oxazolidinones. It is used to treat pneumonia and some infections in the skin or under the skin. Pneumonia is an infection in one or both lung which causes inflammation in the air sacs (alveoli) in your lungs. The alveoli fill with fluids or pus, making it difficult to breathe.
LINID INFUSION prevents the synthesis of essential proteins required by bacteria to carry out vital functions and thus stops their growth. The most common side effects are headache, nausea, vomiting, diarrhoea, changes in numbers of certain cells in the blood. This medicine may react with a substance called tyramine which is naturally present in some foods such as large amount of mature cheese, yeast extracts, or soya bean extracts such as soy sauce, and drinking alcohol, especially draught beers and wine. This interaction may cause an increase in your blood pressure, so avoid consumption of these foods.
LINID INFUSION will be given to you through a drip (by infusion into a vein) by a doctor or nurse. It is strictly not recommended for use in children and adolescents under 18 years. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF LINID INFUSION
- Treat pneumonia and some infections of the skin
HOW LINID INFUSION WORKS
LINID INFUSION stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions.
DIRECTIONS FOR USE
LINID INFUSION will be given to you through a drip (by infusion into a vein) by a doctor or nurse. Your doctor will decide the dose and frequency depending on your condition.
SIDE EFFECTS OF LINID INFUSION
SERIOUS
- skin reaction such as red sore skin and flaking (dermatitis)
- allergic reaction symptoms such as severe skin disorder, swelling particularly around the face and neck, wheezing and/or difficulty breathing
- problem with your visions such as blurred vision, change in colour vision, numbness, difficulty in seeing detail or if your field of vision becomes restricted
- severe diarrhoea containing blood and/or mucus (antibiotics associated colitis including pseudomembranous colitis)
- agitation, confusion, delirium, rigidity, tremor, incoordination and seizures
- inflammation of the pancreas
- convulsions
- transient ischaemic attack (temporary disturbance of blood flow to the brain causing short term symptom such as loss of vision, leg and arm weakness, slurring of speech and loss of consciousness)
- ringing in the ears (tinnitus)
COMMON
- fungal infections especially vaginal or oral thrush
- headache, fever
- metallic taste in the mouth
- diarrhoea, nausea or vomiting, constipation
- change in some blood test result including those measuring your kidney or liver function or blood sugar level
- unexplained bleeding or bruising, which may be due to changes in specific cells in the blood which may affect blood clotting or lead to anaemia
- difficulty in sleeping
- increased blood pressure
- anaemia (low red blood cell)
- changes in numbers of certain cells in the blood which may affect your ability to fight infection (symptoms such as sore throat, mouth ulcers, tiredness)
- skin rash, itching skin
- dizziness
- localised or general abdominal pain
RARE
- superficial tooth discolouration, removable with professional dental cleaning (manual descaling)
HOW TO MANAGE SIDE EFFECTS
Headache:
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Diarrhoea:
Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without talking to a doctor.
Nausea or vomiting:
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Dizziness:
Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.
Abdominal pain:
Try to rest and relax. Eat and drink slowly or have smaller and frequent meal. Apply heat pad or covered hot water bottle on your stomach. If still pain persists, speak to your doctor.
Constipation:
Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.
Fever:
Drink plenty of fluids and water. Avoid taking cold bath or showers.
WARNING & PRECAUTIONS
PREGNANCY
LINID INFUSION is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
LINID INFUSION is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
Do not drive or operate any machine while taking this medicine as it may cause dizziness or vision problems and unwell.
ALCOHOL
Consumption of alcohol is not recommended during treatment with LINID INFUSION.
KIDNEY
LINID INFUSION should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
LINID INFUSION should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take LINID INFUSION if you are allergic (hypersensitive) to linezolid or any other ingredients in this medicine.
LUNGS
LINID INFUSION should be used with caution in patients suffering from active lung diseases (rapid breathing). Consult your doctor for advice.
OTHERS
Tell your doctor if you have or had a condition such as,
- overactive thyroid
- a tumour of the adrenal glands (phaeochromocytoma) or carcinoid syndrome (caused by tumours of the hormone system with symptoms of diarrhoea, flushing of the skin, wheezing)
- manic depression, schizoaffective disorder, mental confusion or other mental problems
- bruise and bleed easily
- anaemic (have low red blood cells)
- prone to getting infections
- a history of seizures
INTERACTIONS
Talk to your doctor if you are taking,
- monoamine oxidase inhibitors (MAOIs) such as phenelzine, isocarboxazid, selegiline, moclobemide (used to treat depression or Parkinson’s disease)
- decongestant cold and flu remedies containing pseudoephedrine or phenylpropanolamine
- some medicines such as salbutamol, terbutaline, fenoterol (used to treat asthma)
- antidepressants such as tricyclics or SSRIs (selective serotonin re-uptake inhibitors) including amitriptyline, cipramil, clomipramine, dosulepin, doxepin, fluoxetine, fluvoxamine, imipramine, lofepramine, paroxetine, sertraline
- medicines such as sumatriptan, zolmitriptan (used to treat migraine)
- medicines such as adrenaline (epinephrine) (used to treat sudden, severe allergic reactions)
- medicines such as noradrenaline (norepinephrine), dopamine and dobutamine
- medicines such as pethidine (used to treat moderate to severe pain)
- medicines such as buspirone (used to treat anxiety disorders)
- medicine such as warfarin (stops blood clotting)
- antibiotic such as rifampicin (used to treat infections)
SYNOPSIS
| Drug | : | Linezolid |
| Pharmacological Category | : | Antibiotic, Oxazolidinone |
| Therapeutic Indication | : | Pneumonia and some infections of the skin |
| Dosage Forms | : | Tablet, Injection, Infusion, Syrup |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT LINID INFUSION
Can LINID INFUSION cause diarrhoea?
Yes, this medicine may cause diarrhoea in some individuals. Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without talking to a doctor.
Can I take LINID INFUSION during Pregnancy?
No, it is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
Can I take LINID INFUSION during breast-feeding?
No, it is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
REFERENCES
1. KD Tripathi. Macrolide, Lincosamide, Glycopeptide and Other Antibacterial Antibiotics; Urinary Antiseptics. Essentials of Medical Pharmacology. Seventh Edition,2013. Page - 758.
2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 2254-2255.
3. Yan Licorresponding author and Wei Xu. Efficacy and safety of linezolid compared with other treatments for skin and soft tissue infections: a meta-analysis. US National Library of Medicines, National Institutes of Health. 28 Feb 2018. [Accessed 29 Dec 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809614/
4. Infomed Fluids S.R.L; Electronic Medicines Compendium (EMC); [Revised on Jun 2015] [Accessed 29 Dec 2020] https://www.medicines.org.uk/emc/files/pil.7300.pdf
5. Fresenius Kabi Norge AS; Electronic Medicines Compendium (EMC); [Revised on Jan 2017] [Accessed 29 Dec 2020] https://www.hpra.ie/img/uploaded/swedocuments/PIL-2175859-10032017165215-636247615417938750.pdf
USEFUL DIAGNOSTIC TESTS
- Complete Blood Count
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