INTRODUCTION

LINANEXT 5 contains Linagliptin which is an oral anti-diabetic agent. It is used to treat type 2 diabetes mellitus in adults when treatment with first line oral anti-diabetic medicine (such as metformin) or diet and exercise does not give adequate response. It is generally used in combination with other anti-diabetic medicines (such as metformin, glimepiride, glipizide, empagliflozin, or insulin) for better results. Type 2 diabetes is a chronic medical condition in which the body does not make enough insulin, or the produced insulin does not work well. Symptoms includes excessive urination, excessive thirst, hunger, fatigue, and blurred vision.

Linagliptin is a DPP-4 inhibitor. It helps pancreas to secrete more insulin (a hormone that digests glucose/sugar) by inhibiting an enzyme called Dipeptidyl peptidase 4, which ultimately leads to decrease in blood glucose level. Along with the treatment, follow regular exercise and diet plan as advised by your doctor to achieve better results.

LINANEXT 5 is strictly not recommended for use in children and adolescents under 18 years of age. Your doctor will monitor your blood sugar levels through periodic blood/urine tests. Before taking LINANEXT 5 inform your doctor if you have or ever had kidney disease, heart disease, or pancreas problems. LINANEXT 5 should be used with caution in pregnant and breast-feeding women. The most common side effects of LINANEXT 5 are fast heartbeat, anxiety, increased sweating, and tiredness.

USES OF LINANEXT 5

• Treat type 2 diabetes mellitus in adults

HOW LINANEXT 5 WORKS

LINANEXT 5 effectively reduces blood glucose levels, where linagliptin acts by increasing the release of insulin (a hormone secreted by pancreas that helps in digestion) by inhibiting the activity of an enzyme called Dipeptidyl peptidase 4. As a result, the sugars present in the blood are digested by insulin, leading to a marked decrease in blood glucose level.

DIRECTIONS FOR USE

Take LINANEXT 5 with or without food. Swallow LINANEXT 5 as whole and do not crush or chew it. Your doctor will decide the dose and duration of the therapy depending upon your age, body weight and disease condition.

SIDE EFFECTS OF LINANEXT 5

HOW TO MANAGE SIDE EFFECTS

Low blood sugar:

Try to take sugary snack or drink (in small glass) like fruit juices or sugar candy and test your sugar level after 10 minutes, if there is no change in blood sugar to the required level again try taking juices or snack. Consult your doctor if your symptoms do not improve.

WARNING & PRECAUTIONS

INTERACTIONS

Before taking LINANEXT 5, inform your doctor if you are taking any of the following medicines:

• carbamazepine, phenobarbital, or phenytoin (used to treat fits (seizures) or chronic pain)
• antibiotic such as rifampicin (used to treat infections such as tuberculosis)

Overdosage:

If you or anyone else accidentally take too much of LINANEXT 5, consult your doctor immediately. Overdosage can increase the risk of side effects.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store below 15-30°C

FAQs ABOUT LINANEXT 5

What is the use of LINANEXT 5?

LINANEXT 5 is used to treat type 2 diabetes mellitus in adults, it is a condition in which the body does not make enough insulin or the insulin produced does not work properly. While taking this medicine follow proper diet regimen and exercise schedule to reduce high blood sugar levels.

Does LINANEXT 5 cause hypoglycaemia (low blood sugar)?

When LINANEXT 5 taken in combination with medicines called sulphonylureas and/or insulin, it can cause decrease in your blood sugar levels which may affect your consciousness. Your doctor may recommend frequent blood test to monitor your glucose level to minimise the risk of hypoglycaemia, especially combined with sulphonylurea and/or insulin.

How does LINANEXT 5 works?

LINANEXT 5 increases the release of insulin from the pancreas and thus decreases the hormones that raise blood sugar levels. This reduces the fasting and post meal sugar level.

Is LINANEXT 5 safe to use in kidney disease patients?

Yes, LINANEXT 5 is safe to use in patients with kidney disease and no dose adjustment is recommended for these patients.

REFERENCES

1. KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. seventh edition.2013. Page-275

2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page 2247-2248.

3. Rachael Aletti 1, Angela Cheng-Lai. Linagliptin: the newest dipeptidyl peptidase-4 inhibitor for type 2 diabetes mellitus. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Jan-Feb 2012. [Accessed 24th March 2022] https://pubmed.ncbi.nlm.nih.gov/22143285/

4. Boehringer Ingelheim Pharma GmbH & Co. KG; Electronic Medicines Compendium (EMC) [Revised on June2020] [Accessed 24th March 2022] https://www.medicines.org.uk/emc/files/pil.4762.pdf

5. Boehringer Ingelheim Pharmaceuticals, Inc 2011; U.S. Food & Drug Administration; [Revised on may2011] [Accessed 24th March 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/201280lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose - Fasting Blood
• Glucose - Postprandial Blood
• Glycosylated Hemoglobin