LIGNOCIN Injection 30ml

Anaesthesia - Local Rx required

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INTRODUCTION

LIGNOCIN contains Lignocaine which belongs to the group of medicines called Local Anesthetic agents. It is used to cause numbness (loss of sensation) of body parts at regions where it has been administered (local anesthesia). It is generally used prior to spinal anesthesia or before surgical procedures to cause temporary loss of sensation. It also helps to control heartbeat in patients having arrythmia (irregular heartbeat).

LIGNOCIN will be given to you only by a trained anesthesiologist around the areas (such as hands, legs, abdomen, pelvis, spine) locally where loss of sensation (numbness) is required.

Before receiving LIGNOCIN, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any breathing disorders, blood problems, epilepsy, glaucoma, stroke, dehydration, low blood potassium levels or muscle weakness.

LIGNOCIN should be used in pregnant or breastfeeding women only if considered necessary by the physician. The most common side effects of receiving LIGNOCIN are nausea, slow heart rate, dizziness, lower back pain, difficulty in walking and inability to control urine or bowel movements. Inform your doctor if any of these side effects worsen.

USES OF LIGNOCIN

  • Causes numbness of body parts when used prior to spinal anesthesia or surgical procedures
  • Treats arrythmia (irregular heartbeat)

HOW LIGNOCIN WORKS

LIGNOCIN is an anesthetic agent. It reduces pain sensation and causes numbness of body parts by blocking the flow of certain ions (sodium ions) through the nerves that causes pain sensation. As a result, it limits the transfer of pain signals from the peripheral part of the body (i.e., face, hands, legs, abdomen, pelvis) to the brain which leads to loss of sensation. It also normalizes heart rate by blocking the generation of abnormal electrical signals in the heart.

DIRECTIONS FOR USE

LIGNOCIN will be given to you only by a doctor or by a trained anesthesiologist. Your doctor/ anesthesiologist will decide the correct dose and site of administration for you depending upon your age, body weight, health condition and type of nerve block which is required to provide anesthesia or pain relief.

It can be administered locally to the region where loss of sensation (numbness) is required or can be administered in a vein, around the spinal cord or a nerve to causes numbness during surgeries (caesarean section or other major surgeries) to stop pain sensation.

SIDE EFFECTS OF LIGNOCIN

COMMON

  • pain at site of injection
  • low blood pressure causing dizziness, drowsiness, or lightheadedness
  • nausea, vomiting
  • tingling or pricking sensation (pins and needles)
  • slow heartbeat, feeling faint
  • changes in vision, blurred vision
  • difficulty in passing urine
  • pain or numbness in the legs or back
  • unable to walk properly
  • problems in controlling bowels and bladder

RARE

Consult your doctor immediately if you experience any of the following side effects after receiving LIGNOCIN:

  • signs of severe allergic reactions (such as skin rash, severe itching of the skin with raised lumps, blisters in the skin, swelling of the face, lips, tongue and/or throat with difficulty in breathing or swallowing)
  • blood problems (causing bluish discoloration of the skin, headache, tiredness, weakness and shortness of breath)
  • fits or convulsions

 

HOW TO MANAGE SIDE EFFECTS

Pain at injection site:

Place an ice pack on the injected site. Do not move the affected area frequently. If the symptom worsens, consult your doctor.

Dizziness:

Avoid standing or walking after surgery. Try to rest and relax. Get enough sleep. Consult your doctor if you continue to feel dizzy for a prolonged period.

WARNING & PRECAUTIONS

PREGNANCY

LIGNOCIN should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor if you are pregnant or think you may be pregnant before receiving LIGNOCIN.

BREASTFEEDING

LIGNOCIN should be used in breastfeeding women only if it is considered necessary by the physician. Therefore, inform your doctor before receiving LIGNOCIN if you are breastfeeding.

DRIVING AND USING MACHINES

LIGNOCIN may make you feel dizzy or drowsy for some time after administration. Therefore, do not drive or operate any heavy tools or machines if your ability is affected by LIGNOCIN.

ALCOHOL

Avoid consumption of alcohol before receiving LIGNOCIN.

KIDNEY

LIGNOCIN should be used with caution in patients with kidney problems. Therefore, consult your doctor before receiving it.

LIVER

LIGNOCIN should be used with caution in patients with liver problems. Therefore, consult your doctor before receiving it.

ALLERGY

Do not receive LIGNOCIN if you are allergic to Lignocaine or any other local anesthetics (such as bupivacaine).

LUNGS

LIGNOCIN should be used with caution in patients with breathing disorders (such as asthma or COPD). Therefore, consult your doctor before receiving it.

HEART DISEASE

LIGNOCIN is not recommended for use in patients with heart diseases (such as heart block or abnormal or a very slow heartbeat). It should be used with caution in patients with other heart disorders. Therefore, consult your doctor before receiving it.

OTHERS

LIGNOCIN is not recommended for use if you:

  • have low blood volume
  • have porphyria (an inherited blood disorder)

Before receiving LIGNOCIN inform your physician if you:

  • are feeling sick or tired for no reason
  • have epilepsy (fits)
  • have glaucoma
  • have low potassium levels in blood causing muscle cramps and constipation
  • recently had vomiting, diarrhea or excessive blood loss
  • are not drinking enough amount of water
  • have too much acidity in the blood
  • have any skin infection (with pus) in and around the areas where the medicine is planned to be administered
  • have problems in thinking or reasoning
  • have myasthenia gravis (severe muscle weakness or tenderness)
  • are in stroke
  • have imbalance in the constituents of the blood
  • have a blood disorder

Use in pediatrics:

LIGNOCIN should be used in children and adolescents (aged below 18 years) only if it is considered necessary by the physician. It is not recommended for use in neonates aged less than 1 month. Therefore, consult your doctor for advice before administration.

Use in geriatrics:

LIGNOCIN should be used with caution in the elderly patients. Therefore, consult your doctor for advice before receiving it.

INTERACTIONS

A. Drug-Drug interactions:

Before receiving LIGNOCIN inform your doctor if you are receiving any of the following medicines:

  • halothane (used to cause unconsciousness before a surgical procedure)
  • medicines used to treat heart problems such as hypertension, angina, or abnormal heart rate (Ex. atenolol, propranolol, verapamil, amlodipine, nifedipine, amiodarone, mexiletine)
  • diuretics (used to reduce edema and blood pressure) Ex. furosemide, spironolactone, hydrochlorothiazide
  • medicines used to treat HIV infection (Ex. ritonavir, nelfinavir)
  • medicines used to treat psychotic disorders (such as chlorpromazine, pimozide, sertindole, olanzapine, quetiapine, zotepine)
  • suxamethonium (used to relax muscles)
  • opioid analgesics (used for pain relief) Ex. morphine, pethidine, fentanyl
  • dolasetron (used to treat nausea and vomiting)
  • cimetidine (used to treat heartburn, and stomach ulcers)
  • acetazolamide (used to treat increased eye pressure)
  • quinupristin and dalfopristin (used to treat bacterial infection)
  • oral contraceptives (birth control pills) Ex. drospirenone, ethinyl estradiol

Overdosage:

LIGNOCIN will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of overdosage might include lightheadedness, numbness of tongue or ringing sound in the ears.

SYNOPSIS

Drug :  

Lignocaine

Pharmacological Category :  

Voltage Gated Sodium Channel Blockers

Therapeutic Indication :   Local anesthesia, Arrythmia
Dosage Forms :  

Injection, Gel, Cream, Ointment, Jelly, Topical Solution, Spray, Oral solution, Plaster

MORE INFORMATION

  • Keep LIGNOCIN out of reach of children
  • Store LIGNOCIN at room temperature

FAQs ABOUT LIGNOCIN

How long will it take for LIGNOCIN to induce numbness?

It may take around 2-5 minutes for LIGNOCIN to create numbness of body parts. However, this period may vary from person-to-person based on the dose and amount of the LIGNOCIN that is administered to you.

Is LIGNOCIN a narcotic medicine?

No. LIGNOCIN is not a narcotic. It is a local anesthetic agent which is used to create loss of sensation (numbness) in certain body parts following administration.

Can LIGNOCIN affect blood pressure?

Yes. LIGNOCIN may cause changes in blood pressure (high or low blood pressure) and so if you experience any unusual symptoms like feeling extremely dizzy or lightheaded after receiving LIGNOCIN consult your doctor.

What are the common side effects of LIGNOCIN?

The most common side effects of receiving LIGNOCIN are nausea, slow heart rate, dizziness, lower back pain, difficulty in walking and inability to control urine or bowel movements. Inform your doctor if any of these side effects worsen.

What are the symptoms that could appear if I received excessive amount of LIGNOCIN?

LIGNOCIN will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of overdosage might include lightheadedness, numbness of tongue or ringing sound in the ears.

Can LIGNOCIN be used in children?

Yes. LIGNOCIN is used in children and in adolescents (aged between 18 years) only if it is considered necessary by the physician. It is not recommended for use in neonates aged below 1 month due to lack of safety data.

Can LIGNOCIN cause nerve damage?

Yes. LIGNOCIN may cause nerve damage when administered in excess amount. Therefore, inform your doctor if you experience signs of nerve damage (such as tingling in the hands and feet) while receiving LIGNOCIN.

Is LIGNOCIN safe for use in pregnant women?

LIGNOCIN should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor if you are pregnant or think you may be pregnant before receiving LIGNOCIN.

How long does the effects of LIGNOCIN lasts long in the body?

The effects of LIGNOCIN may last about 10-20 minutes after intravenous administration and for about 60-90 minutes after intramuscular administration. However, the recovery period may vary from person-to-person based on the dose and amount of the LIGNOCIN that is administered to you.

REFERENCES

1. KD. Tripathi. Drugs acting on peripheral (somatic) nervous system. Essentials of medical pharmacology. 8th Edition. 2019. Page – 392.

2. Weinberg L, Peake B, Tan C and Nikfarjam M. Pharmacokinetics and pharmacodynamics of lignocaine: A review. World Journal of Anesthesiology. July 2015. [Accessed on 8th September 2022] https://www.wjgnet.com/2218-6182/full/v4/i2/17.htm

3. JOSE E. USUBIAGA, WILLIAM GUSTAFSON, FRANK MOYA AND BURTON GOLDSTEIN Departments of Anesthesiology and Psychiatry, University of Miami, School of Medicine and Jackson Memorial Hospital, Miami, Florida, US.A. The Effect of Intravenous Lignocaine on Cardiac Arrhythmias During Electroconvulsive Therapy. British Journal of Anesthesia. [Accessed on 8th September 2022] https://www.bjanaesthesia.org.uk/article/S0007-0912(17)51889-9/pdf

4. Mercury Pharmaceuticals Limited. Electronic Medicines Compendium (EMC). [Revised in May 2021] [Accessed on 8th September 2022] https://www.medicines.org.uk/emc/files/pil.4781.pdf

5. Hameln pharma ltd. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 8th September 2022] https://www.medicines.org.uk/emc/files/pil.6277.pdf

6. Mercury Pharmaceuticals (Ireland) Ltd. Electronic Medicines Compendium (EMC). [Revised in
April 2016] [Accessed on 8th September 2022] https://www.hpra.ie/img/uploaded/swedocuments/2143491.PA0073_112_006.8f88df24-b092-4c3b-bf3f-294aa775a103.000001Lidocaine%20Hydrochloride%202%20PIL.170524.pdf

7. Innovative Pharmaceuticals Pvt Ltd. LIGNOCIN Injection 30ml. [Accessed on 8th September 2022] https://www.innovativepharma.in/product/lignocin-injection/

PRODUCT DETAILS

    Country Of Origin
    India
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LIGNOCIN Injection 30ml

LIGNOCIN Injection 30ml Mkt: Innovative Pharmaceuticals Pvt Ltd

M.R.P.: Rs.36.96
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