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INTRODUCTION
LESUBOW 25 TABLET contains Levosulpiride which belongs to the group of medicines called Prokinetic agents. It is used to treat nausea, vomiting and indigestion. It can also be used to treat diabetic gastroparesis.
Diabetic gastroparesis is a stomach condition caused due to poorly controlled diabetes. It prevents the stomach muscles from emptying its digested contents into the intestines. This creates a feeling of fullness even after eating only a little amount of food along with nausea and lack of appetite.
Before taking LESUBOW 25 TABLET inform your doctor if you have any kidney or heart problems. You must also inform your doctor if you have epilepsy, mania or any other mental illness as a precaution.
LESUBOW 25 TABLET is not recommended for use in patients having bleeding or any blockage or tear in the gut. It is also not suitable for use in patients having cancer or tumours in the body. Do not take LESUBOW 25 TABLET without consulting your doctor if you are pregnant or breastfeeding.
The most common side effects of taking LESUBOW 25 TABLET are headache, drowsiness, tiredness, breast enlargement and discharge and decrease in sex drive. Consult your doctor if any of these side effect bothers you.
USES OF LESUBOW 25 TABLET
It is used to treat:
- nausea and vomiting
- indigestion
- diabetic gastroparesis (causing sensation of fullness or lack of appetite)
HOW LESUBOW 25 TABLET WORKS
LESUBOW 25 TABLET is a prokinetic medicine with anti-emetic and anti-dyspeptic properties. It acts by blocking the actions of certain chemical messengers (dopamine) in the brain that controls the movement of stomach muscles. This action improves muscle movement in the stomach (gastric motility) and reduces the unpleasant symptoms of GI tract (such as nausea, vomiting, indigestion, sensation of fullness and lack of appetite).
DIRECTIONS FOR USE
Take LESUBOW 25 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking LESUBOW 25 TABLET unless your doctor advice you to stop.
SIDE EFFECTS OF LESUBOW 25 TABLET
COMMON
- headache
- drowsiness, tiredness
- weight gain
- lack of sleep
- increased salivation, tremor
- breast enlargement and discharge
- decrease in sex drive, problems in erection
RARE
Stop taking LESUBOW 25 TABLET and inform your doctor immediately if you experience any of the following side effects such as:
- signs of Neuroleptic malignant syndrome (such as high fever, rigid muscles, mood swings, fast or irregular heartbeat, changes in blood pressure, increased sweating)
- feeling dizzy or faint while standing up
- severe skin reactions (such as redness, blistering, peeling of skin and bleeding in the lips, eyes, mouth, nose and genitals with fever)
- chest pain, fast or irregular heartbeat, difficulty in breathing, feeling faint
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Drowsiness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling drowsy. Do not consume excessive alcohol, as it could aggravate your drowsiness. Consult your doctor if your drowsiness worsens.
WARNING & PRECAUTIONS
PREGNANCY
LESUBOW 25 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
BREASTFEEDING
LESUBOW 25 TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you feel drowsy after taking LESUBOW 25 TABLET.
ALCOHOL
Avoid consumption of alcohol while taking LESUBOW 25 TABLET, as it could make you feel drowsier.
KIDNEY
LESUBOW 25 TABLET should be used with caution in patients with kidney problems. Therefore, consult with your doctor before taking it.
ALLERGY
Do not take LESUBOW 25 TABLET if you are allergic to Levosulpiride.
HEART DISEASE
LESUBOW 25 TABLET should be used with caution in patients with heart problems (such as cardiac insufficiency, prolong QT interval). Therefore, consult with your doctor before taking it.
OTHERS
LESUBOW 25 TABLET is not recommended for use if you:
- have pheochromocytoma (tumours of the adrenal gland)
- have epilepsy (fits)
- have prolactinoma (a non-cancerous tumour of pituitary gland)
- have breast cancer
- have mania (elevated mood)
- have manic depression (alternative episodes of excitement and sadness)
- have bloody stools or bleeding in the gut
- have blockage or tear in the intestines
Before taking LESUBOW 25 TABLET, inform your doctor if you:
- have or had a previous history of stroke or problems in blood circulation
Use in pediatrics:
LESUBOW 25 TABLET should be used in children and adolescents (aged 14 years or above) only if prescribed by the physician. It is not recommended for use in children aged below 14 years due to lack of safety data. Therefore, consult your doctor for advice.
Use in geriatrics:
LESUBOW 25 TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug – Drug Interactions:
Before taking LESUBOW 25 TABLET inform your doctor if you are taking any of the following medicines such as:
- levodopa, ropinirole (medicines used to treat Parkinsonism)
- medicines used to treat high blood pressure (such as propranolol, atenolol, amlodipine, diltiazem, clonidine, ramipril, azilsartan)
- medicines used to treat irregular heartbeat (such as digitalis, quinidine, disopyramide, amiodarone, sotalol)
- medicines that can remove potassium from the body such as diuretics (Ex. furosemide, hydrochlorothiazide)
- amphotericin B (a medicine used to treat fungal infection)
- laxatives (used to treat constipation) Ex. lactulose, calcium dobesilate
- corticosteroids (used to treat pain and inflammation) Ex. prednisolone, dexamethasone, hydrocortisone
- tetracosectides (a diagnostic agent used for screening problems of adrenal gland)
- medicines used to treat severe tics (such as pimozide)
- medicine used to treat mental illness or depression (such as haloperidol, lithium, imipramine, thioridazine, sulpiride)
- methadone (a medicine used to treat drug addiction)
- other medicines used to treat stomach disorders (such as cisapride, aluminium hydroxide, sucralfate)
- erythromycin (a medicine used to treat bacterial infections)
- halofantrine (a medicine used to treat malaria)
- pentamidine (a medicine used to treat pneumonia)
- medicines used to treat anxiety (such as diazepam, clonazepam, pentobarbital, phenobarbital)
- narcotic analgesics (used for pain relief) Ex. morphine, fentanyl, pethidine
- medicines used to treat allergic reactions (Ex. cetirizine, levocetirizine)
Overdosage:
If you or anyone else accidentally took more LESUBOW 25 TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Levosulpiride |
| Pharmacological Category | : | Dopamine (D2) Receptor Antagonists |
| Therapeutic Indication | : | Indigestion, Nausea, Vomiting, Diabetic gastroparesis |
| Dosage Forms | : | Tablet, Capsule, Injection |
MORE INFORMATION
- Keep LESUBOW 25 TABLET out of the sight and reach of children
- Store LESUBOW 25 TABLET at room temperature
FAQs ABOUT LESUBOW 25 TABLET
What is LESUBOW 25 TABLET used for?
LESUBOW 25 TABLET is used to treat nausea, vomiting and indigestion. It can also be used to treat diabetic gastroparesis.
How and when to take LESUBOW 25 TABLET?
Take LESUBOW 25 TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
How long should I take LESUBOW 25 TABLET?
You need to take LESUBOW 25 TABLET for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
What to do if I forgot to take a dose of LESUBOW 25 TABLET?
If you forgot to take a dose of LESUBOW 25 TABLET, take it as soon as you remember. However, if it is time for the next dose of LESUBOW 25 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of LESUBOW 25 TABLET to compensate the missed ones.
What are the most common side effects of taking LESUBOW 25 TABLET?
The most common side effects of taking LESUBOW 25 TABLET are headache, drowsiness, tiredness, breast enlargement and discharge and decrease in sex drive. Consult your doctor if any of these side effect bothers you.
Can I stop taking LESUBOW 25 TABLET without consulting your doctor?
No. You should not stop taking LESUBOW 25 TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using LESUBOW 25 TABLET, consult your doctor for advice.
Will taking a higher dose of LESUBOW 25 TABLET be more effective?
No, taking a higher dose of LESUBOW 25 TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
What precautions do I need to follow while taking LESUBOW 25 TABLET?
Before taking LESUBOW 25 TABLET inform your doctor if you have any kidney or heart problems. You must also inform your doctor if you have epilepsy, mania or any other mental illness as a precaution. LESUBOW 25 TABLET is not recommended for use in patients having bleeding or any blockage or tear in the gut. It is also not suitable for use in patients having cancer or tumours in the body. Do not take LESUBOW 25 TABLET without consulting your doctor if you are pregnant or breastfeeding.
Can I take medication for high blood pressure along with LESUBOW 25 TABLET?
It is not advisable to take medicines to control blood pressure along with LESUBOW 25 TABLET without consulting your doctor as they may further reduce your blood pressure and make you feel dizzier.
Can LESUBOW 25 TABLET be used in pregnant women?
LESUBOW 25 TABLET is not recommended for use in pregnant women. Therefore, consult your doctor before taking it.
Can LESUBOW 25 TABLET make me feel drowsy?
Yes. Drowsiness is one of the common side effects of taking LESUBOW 25 TABLET. Avoid driving or operating any tools or machines completely while you are feeling drowsy. Do not consume excessive alcohol, as it could aggravate your drowsiness. Consult your doctor if your drowsiness worsens.
Can the use of LESUBOW 25 TABLET affect my sexual life?
LESUBOW 25 TABLET may cause decrease in sex drive and problems in erection in some individuals, although not everybody gets them. These side effects are usually temporary and disappears once the therapy is stopped. However, consult your doctor if it bothers you.
REFERENCES
1. Laurence Brunton, John Lazo, Keith Parker. Drugs Affecting Gastrointestinal Function. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. Eleventh Edition. 2005. Page – 986.
2. Chi-Wook Song, Hoon-Jae Chun, Chang-Duck Kim, Ho-Sang Ryu, Jae-Gol Choe, Jin-Hai Hyun. Effects of Levosulpiride in Patients with Functional Dyspepsia Accompanied by Delayed Gastric Emptying. NIH National Library of Medicine, National Centre for biotechnology information. PMC. PubMed Central. February 1998. [Accessed on 8th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531935/
3. Torrent Pharmaceuticals Ltd. Levazo 25. [Accessed on 8th November 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1398.pdf
4. Torrent Pharmaceuticals Ltd. Levazo SR 75. [Accessed on 8th November 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2483.pdf
5. Central Drugs Standard Control Organization. Levosulpiride Tablet (25mg). May 2007. Levosulpiride 75/150/200mg (add strength). December 2014. [Accessed on 8th November 2022] https://cdscoonline.gov.in/CDSCO/Drugs
USEFUL DIAGNOSTIC TESTS
- Abdomen - Ultrasound
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