LENZEST 5MG CAPSULE contains Lenalidomide, which belongs to the group of medicines called Immunomodulatory agents. It is used in the treatment of multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma and follicular lymphoma. Cancer is a disease in which abnormal cells divide uncontrollably in the body and destroy body tissue.
Multiple myeloma is a type of cancer that affects a type of white blood cell (plasma cell) that collects in the bone marrow and divides uncontrollably, leading to kidney and bone damage. Myelodysplastic syndromes are a group of disorders that occur due to the abnormal functioning of blood cells.
Mantle cell lymphoma is a cancer of the lymph tissue where the B-cells or B lymphocytes (white blood cells) grow in an uncontrolled manner and build up in the lymph tissue, blood or bone marrow. Follicular lymphoma is slow-growing cancer that affects B lymphocytes that help fight infection.
Before taking LENZEST 5MG CAPSULE, inform your doctor if you have ever had blood clots, hepatitis B infection, varicella-zoster, HIV, kidney problems or a heart attack. LENZEST 5MG CAPSULE is not recommended for use among pregnant or breastfeeding women. Consult your doctor before taking it.
The most common side effects of taking LENZEST 5MG CAPSULE are rashes, itching, muscle cramps, muscle weakness, muscle pain, muscle aches, bone pain, joint pain, back pain, pain in the extremities, weakness, tiredness, constipation, diarrhoea, nausea, vomiting, stomach pain and heartburn. Consult your doctor if any of the symptoms worsen.
It is used to treat:
LENZEST 5MG CAPSULE works by enhancing the immune system that indirectly attacks the cancer cells. It stops the growth of new blood vessels within the tumour. It also limits the production of chemical messengers (cytokine and growth factor) which are responsible for the growth of cancer cells.
Take LENZEST 5MG CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Stop taking LENZEST 5MG CAPSULE and contact your doctor immediately if you experience any of the following side effects;
Nausea or vomiting:
Take this medicine with meals or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if your symptom gets worse or persist.
Flatulence:
Eat smaller and more frequent meals. Eat and drink slowly and exercise regularly. If the symptom does not improve, contact your doctor.
Constipation:
Eat plenty of fiber-rich foods, such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly. Consult your doctor if your symptom gets worse or persist.
Diarrhoea:
Drink lots of fluids, such as water or fruit juice, to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. Consult your doctor if your symptom gets worse or persist.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.
LENZEST 5MG CAPSULE is generally not recommended for use in pregnant women unless considered necessary. Consult your doctor before taking it.
LENZEST 5MG CAPSULE is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your doctor before taking it.
Do not drive or operate any machines if you feel dizzy, tired, sleepy or have vertigo or blurred vision after taking LENZEST 5MG CAPSULE.
Avoid consumption of alcohol while taking LENZEST 5MG CAPSULE.
LENZEST 5MG CAPSULE should be used with caution in patients with kidney problems. Consult your doctor before taking it.
LENZEST 5MG CAPSULE should be used with caution in patients with liver problems. Consult your doctor before taking it.
Do not take LENZEST 5MG CAPSULE if you are allergic to lenalidomide or any of the other ingredients of the medicines.
LENZEST 5MG CAPSULE should be used with caution in patients with heart problems. Consult your doctor before taking it.
Before taking LENZEST 5MG CAPSULE, inform your doctor if you:
Use in pediatrics:
LENZEST 5MG CAPSULE is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking it.
Use in geriatrics:
LENZEST 5MG CAPSULE should be used with caution in elderly patients (aged 75 years and above). Consult your doctor before taking it.
A. Drug-Drug interactions:
Before taking LENZEST 5MG CAPSULE, inform your doctor if you are taking any of the following medicine:
Overdosage:
If you or anyone else accidentally take too much of LENZEST 5MG CAPSULE, consult your doctor immediately or visit the nearby hospital.
Drug | : | Lenalidomide |
Pharmacological Category | : | Immunomodulatory agents |
Therapeutic Indication | : | Multiple myeloma, Myelodysplastic syndromes, Mantle cell lymphoma and Follicular lymphoma |
Dosage Forms | : | Capsule, Tablet |
How does LENZEST 5MG CAPSULE work?
LENZEST 5MG CAPSULE works by enhancing the immune system, which indirectly attacks cancer cells. It stops the growth of new blood vessels within the tumour. It also limits the production of chemical messengers (cytokines and growth factors), which are responsible for the growth of cancer cells.
Is it safe to use LENZEST 5MG CAPSULE on the elderly?
In elderly patients (75 years and older), LENZEST 5MG CAPSULE should be used with caution. Consult your doctor before taking LENZEST 5MG CAPSULE.
For what is LENZEST 5MG CAPSULE used?
LENZEST 5MG CAPSULE is an immunomodulatory agent used in the treatment of multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma and follicular lymphoma.
Are there any dietary restrictions when taking LENZEST 5MG CAPSULE?
LENZEST 5MG CAPSULE can be taken with or without food; there is no food restriction as such. Consult your doctor before taking LENZEST 5MG CAPSULE.
Is LENZEST 5MG CAPSULE safe in patients with kidney problems?
LENZEST 5MG CAPSULE should be used with caution in patients with kidney problems. Consult your doctor before taking LENZEST 5MG CAPSULE.
Can I stop taking LENZEST 5MG CAPSULE on my own?
Do not stop taking LENZEST 5MG CAPSULE on your own. You are advised to take LENZEST 5MG CAPSULE for as long as your doctor has prescribed it for you, depending on your medical condition. Do not hesitate to talk to your doctor if you experience any difficulty while taking LENZEST 5MG CAPSULE.
How do I take LENZEST 5MG CAPSULE?
Take LENZEST 5MG CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will determine the correct dose and duration for you depending on your age, body weight and disease condition.
1. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins and Edward A. Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors and Various Small Molecules. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical, 2018. Page – 1203-1236.
2. Sarah A. Holstein, Vera J. Suman and Philip L. McCarthy. Update on the role of lenalidomide in patients with multiple myeloma. Journal of Therapeutic Advances in Hematology. May 2018 [Accessed on 2nd June 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041862/
3. Shu-Kai Qiao, Xiao-Nan Guo, Jin-Hai Ren and Han-Yun Ren. Efficacy and Safety of Lenalidomide in the Treatment of Multiple Myeloma: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Chinese Medical Journal. May 2015. [Accessed on 2nd June] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831550/
4. Cirino Botta, Enrica Antonia Martino, Concetta Conticello, Francesco Mendicino, Ernesto Vigna, Alessandra Romano, Giuseppe Antonio Palumbo, Claudio Cerchione, Giovanni Martinelli, Fortunato Morabito, Francesco Di Raimondo and Massimo Gentile. Treatment of Lenalidomide Exposed or Refractory Multiple Myeloma: Network Meta-Analysis of Lenalidomide-Sparing Regimens. Frontiers in Oncology. April 2021. [Accessed on 2nd June] https://www.frontiersin.org/articles/10.3389/fonc.2021.643490/full
5. Myers Pharma limited. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 2nd June 2022] https://www.medicines.org.uk/emc/files/pil.347.pdf
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