Lefno 10mg Tablet 10'S

Arthritis Rx required

Best Price*  ₹ 100.60
MRP ₹111.78
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mfr: Ipca Laboratories Ltd * Country of Origin: India
TOTAL AMOUNT ₹ 111.78

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INTRODUCTION

LEFNO 10MG contains Leflunomide which belongs to the group of medicines called anti-rheumatic drug. It is used to treat active rheumatoid arthritis or psoriatic arthritis in adult patients. Rheumatoid arthritis is a chronic auto-immune inflammatory disorder characterized by inflammation of joints, swelling, difficulty in moving and pain. Psoriatic arthritis is an inflammatory arthritis that affects people with psoriasis. Symptoms includes inflammation of joints, swelling, difficulty in moving, pain and patches of red, scaly skin (skin lesions). It acts by inhibiting the release of T-cells and B cells, that are responsible for inflammation, swelling and redness in arthritis.

While taking this medicine, avoid consumption of alcohol because it can increase the chance of liver damage. Your doctor will carry out several blood tests, before and during treatment with LEFNO 10MG, to monitor the functions of your liver and blood cells. This medicine may take about 4 weeks or longer to feel an improvement in your condition. So, continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

Take this medicine as directed by your physician. It can be taken with or without food. Swallow the medicine with a glass of water. The most common side effects of taking this medicine are headache, dizziness, skin rash and neuropathy. Contact your doctor if these symptom bothers you. Talk to your doctor before taking this medicine, if you are a male who wish to father a child, because leflunomide can pass into semen. Before taking this medicine, inform your doctor if you are pregnant or breastfeeding. This medicine is strictly not recommended for use in children and adolescents below 18 years of age.

USES OF LEFNO 10MG

  • Treats active rheumatoid arthritis in adults
  • Treats psoriatic arthritis in adults

HOW LEFNO 10MG WORKS

LEFNO 10MG acts by inhibiting the proliferation of activated autoimmune lymphocytes by interfering with cell cycle progression. It blocks the release of autoimmune T-cells and production of autoantibodies by B cells, that are responsible for inflammation, swelling and redness in arthritis.

DIRECTIONS FOR USE

Take LEFNO 10MG as directed by your physician. It can be taken with or without food. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, weight and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF LEFNO 10MG

SERIOUS

  • serious allergic reaction (such as skin rash, weakness, dizziness and difficulty in breathing)
  • pale skin, tiredness or bruising
  • jaundice
  • fever, sore throat or cough
  • tingling sensation or pain in your hands or feet

COMMON

  • mild allergic reactions
  • loss of appetite, tiredness
  • headache, dizziness
  • paraesthesia (abnormal skin sensations like tingling)
  • mild increase in blood pressure
  • colitis, diarrhea, abdominal pain, nausea or vomiting
  • mouth ulcers
  • hair loss
  • eczema, dry skin, rash or itching
  • tendonitis (pain caused by inflammation of tendons)
  • peripheral neuropathy (pain in nerves of arms or legs)

RARE

  • severe increase in blood pressure

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

WARNING & PRECAUTIONS

PREGNANCY

LEFNO 10MG should be used with caution in pregnant women. Consult your doctor before taking this medicine.

BREASTFEEDING

LEFNO 10MG should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.

DRIVING AND USING MACHINES

Do not drive or operate any machines while taking this medicine, because it may cause dizziness.

ALCOHOL

Avoid consumption of alcohol while taking this medicine, because it can increase the chance of liver damage.

KIDNEY

Do not take LEFNO 10MG if you have moderate to severe kidney problems. Consult your doctor for advice.

LIVER

Do not take LEFNO 10MG if you have severe liver problems. Consult your doctor for advice.

ALLERGY

Do not take this medicine if you are allergic to leflunomide or teriflunomide (used to treat multiple sclerosis).

LUNGS

LEFNO 10MG should be used with caution in patients who had ever suffered from inflammation of lung (interstitial lung disease) or tuberculosis. Consult your doctor for advice.

OTHERS

Do not take this medicine, if you:

  • have severe hypoproteinemia (decreased proteins levels in blood), any serious infections, bone marrow problems, low numbers of red blood cells, white blood cells or platelets in blood
  • suffering from any problem that affects immune system (e.g. AIDS)

INTERACTIONS

Talk to your doctor, if you are taking,

  • other medicines used to treat rheumatoid arthritis such as antimalarials (e.g. chloroquine or hydroxychloroquine), azathioprine, intramuscular or oral gold, D-penicillamine and other immunosuppressive medicines (e.g. methotrexate)
  • medicines used to treat diabetes (e.g. repaglinide, pioglitazone, nateglinide, or rosiglitazone)
  • medicines used to treat cancer (e.g. daunorubicin, doxorubicin, paclitaxel or topotecan)
  • certain medicines used to treat infections (e.g. cefaclor, benzylpenicillin (penicillin G), ciprofloxacin)
  • medicines used to treat high cholesterol levels (e.g. rosuvastatin, simvastatin, atorvastatin, pravastatin and colestyramine)
  • oral contraceptives (birth control pills) e.g. ethinylestradiol and levonorgestrel
  • warfarin (used to thin the blood)
  • teriflunomide (used to treat multiple sclerosis)
  • duloxetine (used to treat depression)
  • alosetron (used in the management of severe diarrhea)
  • theophylline (used to treat asthma)
  • tizanidine (a muscle relaxant)
  • indomethacin and ketoprofen (used to treat pain or inflammation)
  • furosemide (a diuretic used for heart disease)
  • zidovudine (used for HIV infection)
  • activated charcoal
  • vaccinations

SYNOPSIS

Drug :   Leflunomide
Pharmacological Category :   Anti-rheumatic drug
Therapeutic Indication :  

Rheumatoid arthritis, Psoriatic arthritis

Dosage Forms :   Tablet

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT LEFNO 10MG

Can LEFNO 10MG cause mouth ulcers?

Yes. This medicine might cause mouth ulcers in some individuals. Consult your doctor if this side effect bothers you.

Can LEFNO 10MG cause liver damage?

Yes. This medicine might rarely induce liver damage in some individuals. If you experience any symptoms like tiredness, abdominal pain, or jaundice (yellow color of eyes or skin), please contact your doctor immediately, as these may indicate liver failure.

After how long one can see improvement after using LEFNO 10MG?

It may take about 4 weeks or longer to show improvement in your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

REFERENCES

1. KD. Tripathi. Autacoids and related drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 212.

2. Gerald G. Briggs and Roger K. Freeman. L. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page - 2196 – 2201.

3. Sanofi. Efficacy of Leflunomide on Joint Inflammation and Destruction of Joint Integrity in Active Rheumatoid Arthritis (RA) Patients. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on January 2011] [Accessed 3rd November 2020] https://clinicaltrials.gov/ct2/show/NCT00280644

4. M H Schiff, V Strand, C Oed, I Loew-Friedrich. Leflunomide: efficacy and safety in clinical trials for the treatment of rheumatoid arthritis. NIH National Library of Medicine, National Center for Biotechnology Information. June 2000. [Accessed 3rd November 2020] https://pubmed.ncbi.nlm.nih.gov/12861359/

5. Sanofi Winthrop Industrie. Electronic Medicines Compendium (EMC); [Revised on February 2020] [Accessed 3rd November 2020] https://www.medicines.org.uk/emc/files/pil.4054.pdf

6. Sanofi Winthrop Industrie. Electronic Medicines Compendium (EMC); [Revised on September 2014] [Accessed 3rd November 2020] https://www.medicines.org.uk/emc/files/pil.4193.pdf

7. Sanofi Winthrop Industrie. Electronic Medicines Compendium (EMC); [Revised on February 2020] [Accessed 3rd November 2020] https://www.medicines.org.uk/emc/files/pil.4055.pdf

USEFUL DIAGNOSTIC TESTS

  • Rheumatoid Factor - Agglutination
  • Rheumatoid Factor - Turbidometry
  • Rheumatoid Factor IgG Antibody

Manufacturer/Marketer Details

    Net Qty
    1
    Shelf Life
    NA
    Item Weight
    17.5
    No. of Units in a Kit
    NA
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Lefno 10mg Tablet 10'S

Lefno 10mg Tablet 10'S Mfr: Ipca Laboratories Ltd

M.R.P.: Rs.111.78
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