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INTRODUCTION
LECEREIN GM TABLET is a combination of Diacerein, Glucosamine, and Methyl Sulfonyl Methane which belongs to the group of medicines called proteoglycan synthesis stimulators and nutritional supplements respectively. It is used in the treatment of osteoarthritis. Osteoarthritis is a condition that causes pain, swelling, and stiffness in the joints of the hands, knees, hips, and spine.
In osteoarthritis, the cartilage between the bones in the joint breaks down, which in turn causes the affected bones to slowly get bigger. The joint cartilage often breaks down because of mechanical stress or biochemical changes within the body, causing the bone underneath to fail.
LECEREIN GM TABLET is not recommended for use in patients with liver problems. Before taking LECEREIN GM TABLET, inform your doctor if you have suffered from impaired glucose tolerance, kidney problems, heart disease, or asthma. LECEREIN GM TABLET is generally not recommended for use among women who are pregnant or breastfeeding.
LECEREIN GM TABLET is not recommended for use in children and adolescents (18 years and below). LECEREIN GM TABLET is to be taken with caution by elderly patients. The most common side effects of taking LECEREIN GM TABLET are nausea, diarrhoea, constipation, indigestion, heartburn, and urine discoloration. Ask your doctor for advice if any of these side effects worsen or don’t improve.
USES OF LECEREIN GM TABLET
- Treats osteoarthritis
HOW LECEREIN GM TABLET WORKS
LECEREIN GM TABLET is a combination of Diacerein, Glucosamine and Methyl Sulfonyl Methane. Diacerein and Glucosamine are proteoglycan synthesis stimulators that facilitate the formation of cartilage, which is an important structural component of the body. Methyl Sulfonyl Methane is a nutritional supplement that functions by lessening pain and swelling by reducing inflammation.
DIRECTIONS FOR USE
Take LECEREIN GM TABLET as advised by your physician. Swallow the medicine with enough water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration of LECEREIN GM TABLET for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF LECEREIN GM TABLET
COMMON
- nausea
- diarrhoea
- constipation
- indigestion
- heartburn
- urine discoloration
UNCOMMON
- rash
- itching
- flushing
RARE
Stop taking LECEREIN GM TABLET and contact your physician immediately if you experience any of the following side effects:
- angioedema (signs include a swollen face, tongue and/or pharynx and/or difficulty swallowing or hives together with difficulties breathing)
HOW TO MANAGE SIDE EFFECTS
Constipation
Eat more fiber-rich foods such as fresh fruits, vegetables and cereals and drink more water. Exercise more regularly.
Diarrhea
Drink more fluids like water, squash or fruit juice to keep yourself hydrated. Do not consume any medicine for diarrhoea by yourself without consulting your doctor. If the symptom doesn’t improve consult with your doctor.
Nausea And Vomiting
Take this medicine with or just after meals. Stick to simple meals. Avoid eating rich or spicy food. If the symptom doesn’t improve consult with your doctor.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredLECEREIN GM TABLET is not recommended for use by pregnant women unless considered necessary. Consult your physician before taking it.
BREASTFEEDING
ContraindicatedLECEREIN GM TABLET is not recommended for use in breastfeeding women as small traces may pass through the mother’s milk. Consult your physician before taking it.
DRIVING AND USING MACHINES
Use with CautionDizziness has been reported during treatment with LECEREIN GM TABLET and may affect the ability to drive and use machines. Consult your physician before taking LECEREIN GM TABLET.
ALCOHOL
Use with CautionLECEREIN GM TABLET should be used with caution if drinking any alcoholic beverage.
KIDNEY
Use with CautionLECEREIN GM TABLET should be taken with caution in patients with kidney problems. Consult your doctor for advice
LIVER
Use with CautionLECEREIN GM TABLET should be taken with caution in patients with liver problems. Consult your doctor for advice
ALLERGY
ContraindicatedDo not take LECEREIN GM TABLET if you are allergic to Diacerein, Glucosamine, Methyl Sulfonyl Methane or any of the other ingredients of this medicine.
HEART DISEASE
Use with CautionLECEREIN GM TABLET should be taken with caution in patients with heart problems. Consult your doctor for advice.
USE IN PEDIATRICS
ContraindicatedLECEREIN GM TABLET is not recommended for use in children and adolescents (18 years and below). Consult your physician for advice before taking LECEREIN GM TABLET.
USE IN GERIATRICS
Use with CautionLECEREIN GM TABLET should be taken with caution in elderly patients. Consult your doctor for advice before taking LECEREIN GM TABLET.
INTERACTIONS
A. Drug-Drug Interactions:
Inform your physician if you are taking any of the following drugs before taking LECEREIN GM TABLET:
- medicine used to thin the blood (Ex. warfarin)
- medicine used to treat diabetes (Ex. metformin, insulin)
- medicine used to treat bacterial infections (Ex. tetracyclines)
Overdosage:
If you or anyone else accidentally take too much of LECEREIN GM TABLET, consult your doctor immediately or visit the nearby hospital. The symptoms of overdosage may include headache, dizziness, disorientation, joint pain, feeling sick (nausea) or being sick (vomiting), diarrhoea or constipation.
SYNOPSIS
| Drug | : | Diacerein, Glucosamine, Methyl Sulfonyl Methane |
| Pharmacological Category | : | Proteoglycan synthesis stimulators and Nutritional supplements respectively |
| Therapeutic Indication | : | Osteoarthritis |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep LECEREIN GM TABLET out of reach from children
- Store at room temperature in a cool and dry place
FAQs ABOUT LECEREIN GM TABLET
Q: What precautions are to be taken if I take too much LECEREIN GM TABLET?
A: If you or anyone else accidentally takes too much LECEREIN GM TABLET, consult your doctor immediately or visit the nearby hospital. The symptoms of an overdose of LECEREIN GM TABLET may include headache, dizziness, disorientation, joint pain, feeling sick (nausea) or being sick (vomiting), diarrhoea or constipation.
Q: Is LECEREIN GM TABLET safe to use in children and the elderly?
A: LECEREIN GM TABLET is not recommended for use in children (age 18 years and below) and it should be used with caution in elderly patients. Before taking LECEREIN GM TABLET, please consult your physician for advice.
Q: Can LECEREIN GM TABLET be given to pregnant and breastfeeding women?
A: LECEREIN GM TABLET should not be used in pregnant or breastfeeding women unless necessary. Consult your physician before taking it.
Q: How does LECEREIN GM TABLET act?
A: LECEREIN GM TABLET is a diacerein, glucosamine and methyl sulfonyl methane combination. Diacerein and glucosamine are proteoglycan synthesis stimulators that facilitate the formation of cartilage, which is an important structural component of the body. Methyl Sulfonyl Methane is a nutritional supplement that functions by lessening pain and swelling by reducing inflammation.
Q: What are the common side effects of LECEREIN GM TABLET?
A: The most common side effects of taking LECEREIN GM TABLET are nausea, diarrhoea, constipation, indigestion, heartburn and urine discoloration. Ask your doctor for advice if any of these side effects worsen or don’t improve.
REFERENCES
1. Karel Pavelka, Olivier Bruyère, Cyrus Cooper, John A. Kanis, Burkhard F. Leeb, Emmanuel Maheu, Johanne Martel-Pelletier, Jordi Monfort, Jean-Pierre Pelletier, René Rizzoli and Jean-Yves Reginster. Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO. Journal of Drugs and Aging. February 2016. [Accessed on 12th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756045/
2. Toru Ogata, Yuki Ideno, Masami Akai, Atsushi Seichi, Hiroshi Hagino, Tsutomu Iwaya, Toru Doi, Keiko Yamada, Ai-Zhen Chen, Yingzi Li and Kunihiko Hayashi. Effects of glucosamine in patients with osteoarthritis of the knee: a systematic review and meta-analysis. Journal of Clinical Rheumatology. April 2018. [Accessed on 12th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097075/
3. Mariè van der Merwe and Richard J. Bloomer. The Influence of Methylsulfonylmethane on Inflammation-Associated Cytokine Release before and following Strenuous Exercise. Journal of Sports Medicine. October 2016. [Accessed on 12th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097813/
4. Leeford. Diacerein, Glucosamine and Methyl Sulfonyl Methane. [Accessed on 12th July 2022] https://www.leeford.in/product/941/dincerin-plus
5. Green Cross Remedies. Diacerein, Glucosamine and Methyl Sulfonyl Methane. [Accessed on 12th July 2022] https://greencrossindia.com/p/flixcart-tablets.html
6. Saturn Formulations Pvt. Ltd. Diacerein, Glucosamine and Methyl Sulfonyl Methane. [Accessed on 12th July 2022] https://saturnformulations.in/product/diacerein-glucosamine-sulphate-potassium/
7. Alpha Drugs. Diacerein, Glucosamine and Methyl Sulfonyl Methane. [Accessed on 12th July 2022] https://www.alphadrug.in/product/walksafe
8. FMC Pharma Ltd. [Revised on May 2016] [Accessed on 12th July 2022] https://www.hpra.ie/img/uploaded/swedocuments/2171814.PA1521_003_002.cb4ba0a2-1887-4c40-afe6-e19cea656342.000001750mg%20PIL%20.160824.pdf
USEFUL DIAGNOSTIC TESTS
- Calcium
- Rheumatoid Factor IgG Antibody
AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS
Last updated on 16 Feb 2023 | 05:00 PM(IST)
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