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INTRODUCTION
LARI Q 300 TABLET contains Quinine which belongs to the group of medicines called Antimalarials. It is used to treat malaria. It can also be used to treat and prevent night cramps when sleep is regularly disrupted.
Malaria is a serious parasite infectious disease spread by certain mosquitoes. Symptoms such as chills, fever, and an enlarged spleen.
LARI Q 300 TABLET is not recommended for use in patients with blood in urine, ringing in ears, suffer from muscle weakness (myasthenia gravis), have problems with eyes or difficulty seeing, have a disorder affecting the red blood cells. Consult your doctor before taking it.
LARI Q 300 TABLET should be taken with caution in patients with irregular heartbeat or any other heart disease, or those who have or were born with any condition that causes an abnormal heart rhythm. Consult your doctor before taking it.
LARI Q 300 TABLET is not recommended for use in pregnant women unless considered clearly necessary. LARI Q 300 TABLET is not recommended for use in breastfeeding women unless considered clearly necessary. Consult your doctor before taking it.
Before taking LARI Q 300 TABLET inform your doctor if you have had malaria for a long time, suffer from severe glucose-6-phosphate dehydrogenase deficiency (G6PD).
LARI Q 300 TABLET is not recommended for use in children (under 10 years). Consult your doctor before taking it.
LARI Q 300 TABLET should be used with caution in elderly patients (aged 65 years and above). Proper dose adjustment and careful monitoring are required in such patients. Consult your doctor before taking it.
The most common side effects of taking LARI Q 300 TABLET headache, dizziness, nausea, ringing in ears. Contact your doctor if any of the side effects get worse.
USES OF LARI Q 300 TABLET
- Used to treat malaria
HOW LARI Q 300 TABLET WORKS
LARI Q 300 TABLET works by increasing the levels of heme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading.
DIRECTIONS FOR USE
Take LARI Q 300 TABLET as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you based upon your age, body weight and disease condition.
SIDE EFFECTS OF LARI Q 300 TABLET
COMMON
- headache
- sweating
- ringing in ears
- dizziness
- change in colour vision
- nausea
- flushing
- mild hearing loss
- blurred vision
RARE
Stop taking LARI Q 300 TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reactions symptoms such as itchy skin rash, swelling of the lips, face, throat or tongue, flushing, fever, asthma, or sensitivity to light
- sores in the mouth, nose, and eyes, skin rash, blistering (Stevens-Johnson syndrome)
- cinchonism symptoms such as abdominal pain, diarrhoea, disturbed vision (blurred vision, changes in colour perception or field of vision, total blindness)
- headache, feeling or being sick, ringing in the ears or impaired hearing, rashes, loss of consciousness, fits, shock due to heart problems, irregular heartbeats
- bruising or bleeding easily, frequent nose bleeds, or more sore throats and infections than usual
HOW TO MANAGE SIDE EFFECTS
Headache:
If LARI Q 300 TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headache should usually go away after the first week of taking LARI Q 300 TABLET. If headaches last more than a week or severe, inform your doctor.
Nausea or Vomiting:
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods.
Diarrhoea:
Drink lots of fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
LARI Q 300 TABLET is not recommended for use in pregnant women unless considered clearly necessary. LARI Q 300 TABLET should not be taken for cramps during pregnancy. Consult your doctor before taking it.
BREASTFEEDING
LARI Q 300 TABLET is not recommended for use in breastfeeding women unless considered clearly necessary. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel that your vision is affected or causes vertigo (dizziness or spinning sensation) after taking LARI Q 300 TABLET.
KIDNEY
Tell your doctor if you have any kidney disease, before taking LARI Q 300 TABLET.
LIVER
Tell your doctor if you have any liver disease, before taking LARI Q 300 TABLET.
ALLERGY
Do not take LARI Q 300 TABLET if you are allergic to Quinine or quinoline or any of the other ingredients of this medicine.
HEART DISEASE
LARI Q 300 TABLET should be taken with caution in patients with irregular heartbeat or any other heart disease, or those who have or were born with any condition that causes an abnormal heart rhythm. Consult your doctor before taking it.
OTHERS
LARI Q 300 TABLET is not recommended for use if you:
- have ringing in ears
- suffer from muscle weakness (myasthenia gravis)
- have problems with eyes or difficulty seeing
- have a disorder affecting the red blood cells (haemolysis)
Before taking LARI Q 300 TABLET inform your doctor if you:
- had malaria for a long time
- suffer from severe glucose-6-phosphate dehydrogenase deficiency (G6PD)
Use in pediatrics:
LARI Q 300 TABLET is not recommended for use in children (under 10 years). Your doctor will give the right dose depending on your child’s age, body weight and disease condition. Consult your doctor before taking it.
Use in geriatrics:
LARI Q 300 TABLET should be used with caution in elderly patients (aged above 65 years). Proper dose adjustment and careful monitoring are required in such patients. Consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking LARI Q 300 TABLET inform your doctor if you are taking any of the following medicines:
- dapsone (used to prevent malaria)
- anticoagulants (used to stop blood from clotting)
- digoxin (used to treat heart problems)
- chloroquine, mefloquine, artemether with lumefantrine, primaquine, halofantrine (used to treat malaria)
- cimetidine (used to treat stomach ulcers or acid reflux and indigestion)
- amantadine (used to treat Parkinsons Disease or some viral infections)
- ciclosporin (used to prevent transplant rejection)
- flecainide, quinidine, or amiodarone (used to treat irregular heartbeats)
- astemizole or terfenadine (used to treat allergic reactions)
- pimozide or thioridazine (used to treat some mental disorders)
- moxifloxacin, rifampicin, or antifungals (used to treat infections)
- medicines used to treat diabetes
- suxamethonium (used as a muscle relaxant)
- HIV medicines (used to treat HIV infection)
- barbiturates, carbamazepine, or phenytoin (used to treat epilepsy)
- levacetylmethadol (used as pain killer)
B. Drug - Food interactions:
Avoid foods like fava beans during treatment with LARI Q 300 TABLET if you suffer from severe glucose-6-phosphate dehydrogenase (G6PD) deficiency, as this can cause episodes of anaemia.
Overdosage:
If you or anyone else accidentally takes too much of LARI Q 300 TABLET consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are trouble breathing, changes in heartbeat, fits, ringing in the ears or loss of hearing, headache, vomiting, changes in eyesight, muscle twitching or weakness, low blood sugar.
SYNOPSIS
| Drug | : | Quinine |
| Pharmacological Category | : | Antimalarials |
| Therapeutic Indication | : | Malaria, Night cramps |
| Dosage Forms | : | Tablet, Injection, Syrup, Suspension |
MORE INFORMATION
- Keep LARI Q 300 TABLET out of reach of children
- Store below 25°C
FAQs ABOUT LARI Q 300 TABLET
Is LARI Q 300 TABLET safe in pregnancy?
LARI Q 300 TABLET is generally not recommended for use in pregnancy unless considered clearly necessary. It should not be taken for cramps during pregnancy. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking LARI Q 300 TABLET.
Can LARI Q 300 TABLET be given to children?
No. LARI Q 300 TABLET is not recommended for use in children below 10 years of age. Your doctor will select a suitable alternative treatment for your child.
What if I forget to take a dose of LARI Q 300 TABLET?
If you forget to take a dose of LARI Q 300 TABLET, take it as soon as you remember. However, omit the forgotten dose if it is almost time for the next one. Do not take LARI Q 300 TABLET two times to make up for the missed dose.
Can I stop taking LARI Q 300 TABLET on my own?
Continue taking LARI Q 300 TABLET until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition or any new symptoms. Contact your doctor in such case.
Does LARI Q 300 TABLET help leg cramps?
LARI Q 300 TABLET is widely used to treat night leg cramps in adults and the elderly, but it should not be used routinely (more than 4 weeks). Consult your doctor before taking it.
How should LARI Q 300 TABLET be taken? Can it be crushed?
No. Do not break, crush or chew LARI Q 300 TABLET. Take it as advised by your physician. Swallow it with a glass of water. Your doctor will decide the correct dose and duration for you based on your age, body weight and disease condition.
Can I take LARI Q 300 TABLET with other medications?
Before taking LARI Q 300 TABLET, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, over the counter or any herbal medicine, as these might interact with each other and cause serious side effects.
REFERENCES
1. KD. Tripathi. Drugs Acting on Peripheral (Somatic) Nervous System. Antimalarial Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 356, 825.
2. Achan, J., Talisuna, A. O. rhart, A., Yeka, A., Tibenderana, J. K., Baliraine, F. N., Rosenthal, P. J., & D'Alessandro, U. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. May 2011. [Accessed on 3rd August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121651/
3. Hogan D. B. Quinine: not a safe drug for treating nocturnal leg cramps. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. March 2015. [Accessed on 3rd August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347765/
4. Accord. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 3rd August 2022] https://www.medicines.org.uk/emc/files/pil.5866.pdf
5. Accord. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 3rd August 2022] https://www.medicines.org.uk/emc/files/pil.4554.pdf
USEFUL DIAGNOSTIC TESTS
- Malarial Falciparum & Vivax Antigen
- Malarial Parasite Identification
- Peripheral Smear Examination
- Peripheral Smear for Malaria
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