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INTRODUCTION
L OSON 500MG TABLET contains Levofloxacin which belongs to the group of medicines called Antibiotics. L OSON 500MG TABLET is used to treat infections of acute sinusitis, lungs (such as long-term breathing problems/pneumonia), urinary tract (including kidney and bladder), prostate gland and skin & soft tissue (including muscles) in affected individuals.
It is also used to reduce the chances of getting anthrax (pulmonary disease) or worsening of the disease after getting exposed to anthrax causing bacteria.
L OSON 500MG TABLET is not recommended for use in patients allergic to levofloxacin and/or other quinolone antibiotics (such as moxifloxacin, ciprofloxacin, ofloxacin). It is also not recommended for use in patients suffering from epilepsy (seizure) and/or tendinitis (inflammation/irritation of tendon).
Before taking L OSON 500MG TABLET, inform your doctor if you have/had brain damage (due to stroke/other brain injury), diabetes, myasthenia gravis (long term neuromuscular junction disease), aneurysm (condition that occurs due to bulge or enlargement of large blood vessel), organ transplantation, heart problems (such as very slow heart rhythm, weak heart, myocardial infarction), kidney problems and/or liver problems.
L OSON 500MG TABLET is not recommended for use during pregnancy and in women planning for pregnancy. It is also not recommended for use in breastfeeding women.
L OSON 500MG TABLET is not recommended for use in children and adolescents (aged below 18 years). The medicine can be used with caution in elderly patients (aged above 60 years) after consulting the doctor.
The most common side effects after taking L OSON 500MG TABLET are sleeping problems, headache, dizziness, nausea, vomiting and/or diarrhoea. Consult your doctor if any of these symptoms worsens.
USES OF L OSON 500MG TABLET
- Treats infections of acute sinusitis, lungs (such as long-term breathing problems/pneumonia), urinary tract (including kidney and bladder), prostate gland and skin & soft tissue (including muscles) in affected individuals.
- Reduces the risk of getting anthrax (pulmonary disease) or worsening of the disease after getting exposed to anthrax causing bacteria.
HOW L OSON 500MG TABLET WORKS
L OSON 500MG TABLET works by inhibiting DNA gyrase (enzyme responsible for DNA synthesis) in bacteria which results in destruction of bacterial cell structure thus preventing the occurrence of bacterial infection in affected individuals.
DIRECTIONS FOR USE
Take L OSON 500MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF L OSON 500MG TABLET
COMMON
- sleeping problems
- headache, dizziness
- nausea, vomiting, diarrhoea
UNCOMMON
- candidiasis (a fungal infection)
- anxiety, confusion, nervousness, sleepiness, trembling and spinning sensation
- shortness of breath
- altered taste, loss of appetite, stomach upset, indigestion, stomach-ache, flatulence, constipation
- itching, skin rash, red itchy welts, hyperhidrosis (increased sweating)
- joint and muscle pain
- general weakness
RARE
- signs of low blood sugar such as shakiness, sweating, headache, hunger and/or nausea
- depression, mental problems, agitation, abnormal dreams/nightmares
- tingling sensation in hands and feet
- hearing impairment (tinnitus), blurred vision
- fever, racing heartbeat, low blood pressure, muscle weakness
- interstitial nephritis (allergic kidney reaction associated with altered kidney function and occasional kidney failure)
- sharply demarcated, erythematous patches with/without blisters.
Stop taking L OSON 500MG TABLET and consult your doctor immediately in case you experience:
- signs of allergic reaction such as rash, swallowing/breathing problems, swelling of lips/face/throat/tongue
- fits
- signs of DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) such as widespread rash, high fever, liver enzyme elevations, white blood cell abnormalities and/or enlarged lymph nodes
- signs of SIADH (syndrome associated with impaired water excretion and low levels of sodium) such as nausea, vomiting, cramps and/or irritability
- bruising and bleeding due to thrombocytopenia (condition that occurs due to a lowering of blood platelet count)
- neutropenia (low white blood cell count)
- signs of hypersensitivity reaction (exaggerated immune response) such as skin rash, red itchy welts, fever, shortness of breath
- change in psychotic reactions such as hallucinations, paranoia
- serious skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis (associated with signs such as reddish macules/circular patches with central blisters on the trunk, skin peeling, ulcers of mouth/throat/nose/genitals/eyes preceded by fever and flu-like symptoms)
- signs of liver problems such as loss of appetite, skin and eyes becoming yellow in colour, dark-coloured urine, itching and/or abdomen
- signs of neuropathy (nerve damage) such as burning, tingling, pain and/or numbness
- signs of severe bowel problem such as watery diarrhoea, stomach cramps, fever
- pain and inflammation in tendons/ligaments
- signs of agranulocytosis (condition that occurs due to lowering of white blood cells) such as fever, sore throat and/or general feeling of being unwell
- loss of circulation due to anaphylactic shock (severe allergic reaction)
- temporary loss of consciousness/posture (syncope)
- temporary loss of vision
- signs of prolongation of QT interval such as abnormal fast heart rhythm, cardiac arrest, alteration of the heart rhythm
- signs of aortic aneurysm (large bulge in aortic artery) and dissection (a tear in inner layer of aortic artery) such as sudden, severe pain in your abdomen, chest/back
- rapid onset of shortness of breath (especially when you lie down flat in your bed), swelling of ankles/feet/abdomen and/or new onset of heart palpitations
- inflammation of pancreas
- inflammation of liver
- pain/inflammation of tendon in ankle, wrist, elbow, shoulder and/or knee
- rhabdomyolysis (condition marked by muscle rupture and muscle destruction)
- suicidal thoughts/actions
- porphyria (very rare metabolic disease)
- impaired eyesight or other eye disturbances.
HOW TO MANAGE SIDE EFFECTS
Headache:
If L OSON 500MG TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking L OSON 500MG TABLET. If it lasts more than a week or severe, inform your doctor.
Dizziness:
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
Nausea/vomiting:
Take L OSON 500MG TABLET with or just after a meal. Stick to simple meals. Avoid eating oil rich or spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Talk with your doctor if the condition worsens.
Diarrhea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult your doctor and inform them if the symptom gets worse.
Itchy Skin:
Try to pat or tap your skin instead of scratching it. Hold a damp towel to cool your skin. Wear loose clothing and avoid tight clothes or clothes made from wool or synthetic fabrics. Avoid using perfumed soaps, deodorants or moisturizers and use a skin softener regularly.
WARNING & PRECAUTIONS
PREGNANCY
L OSON 500MG TABLET is not recommended for use during pregnancy and in women planning for pregnancy. Consult your doctor before taking L OSON 500MG TABLET.
BREASTFEEDING
L OSON 500MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking L OSON 500MG TABLET.
DRIVING AND USING MACHINES
Do not drive or operate machines if you feel dizzy, sleepy, spinning sensation and/or changes in eyesight after taking L OSON 500MG TABLET.
KIDNEY
L OSON 500MG TABLET should be taken with caution in patients with kidney problems. Consult your doctor before taking L OSON 500MG TABLET.
LIVER
L OSON 500MG TABLET should be taken with caution in patients with liver problems. Consult your doctor before taking L OSON 500MG TABLET.
ALLERGY
Do not take L OSON 500MG TABLET if you are allergic to levofloxacin, other quinolone antibiotics (such as moxifloxacin, ciprofloxacin, ofloxacin) and/or any other ingredients of this medicine.
HEART DISEASE
L OSON 500MG TABLET should be taken with caution in patients with heart problems such as prolonged QT interval, very slow heart rhythm, weak heart, myocardial infarction, heart valve regurgitation, aortic aneurysm/ dissection, endocarditis, congenital heart valve disease. Consult your doctor before taking L OSON 500MG TABLET.
OTHERS
L OSON 500MG TABLET is not recommended for use if you:
- have/ever had epilepsy (seizure)
- have/ever had tendinitis (inflammation/irritation of tendon) after treatment with quinolone antibiotics.
Before taking L OSON 500MG TABLET inform your doctor if you:
- have had damage to your brain due to a stroke/other brain injury
- are suffering from glucose – 6 – phosphate dehydrogenase deficiency (genetic disorder of red blood cells)
- have ever had mental health problems
- are diabetic
- suffer from myasthenia gravis (long term neuromuscular junction disease)
- have a history of aneurysm (bulge or enlargement of large blood vessel)
- suffer from connective tissue disorders such as Marfan syndrome, vascular Ehlers-Danlos syndrome, Turner syndrome, Sjogren’s syndrome
- have salt imbalance in the blood
- suffer from vascular disorders such as Takayasu arteritis, giant cell arteritis, Behçet´s disease, high blood pressure or known atherosclerosis, rheumatoid arthritis
- have ever developed a severe skin rash/peeling, blistering and/or mouth sores after taking the medicine
- have received an organ transplant.
Use in Paediatrics:
L OSON 500MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before taking the medicine.
Use in Geriatrics:
L OSON 500MG TABLET should be taken with caution in elderly patients (aged above 60 years). Consult your doctor before taking the medicine.
INTERACTIONS
A. Drug-Drug interactions:
Before taking L OSON 500MG TABLET, inform your doctor if you are taking any of the following medicine:
- corticosteroids (medicines used to reduce inflammation and supress the immune system) Ex. cortisone, hydrocortisone
- other quinolone antibiotics (medicines used to treat bacterial infections) Ex. moxifloxacin, ciprofloxacin or ofloxacin
- vitamin K antagonists (medicines used to thin blood) Ex. warfarin
- theophylline (used for breathing problems)
- non-steroidal anti-inflammatory drugs (medicines used for pain and inflammation) Ex. aspirin, ibuprofen, fenbufen, ketoprofen, indomethacin
- ciclosporin (used to prevent rejection of transplanted organ)
- antiarrhythmics (medicine used for abnormal heart rhythm) Ex. quinidine, hydroquinidine, disopyramide, sotalol, dofetilide, ibutilide, amiodarone
- tricyclic antidepressants (medicines used to treat depression) Ex. amitriptyline, imipramine
- antipsychotics (medicines used to treat bipolar disorder and schizophrenia) Ex. olanzapine, risperidone, clozapine
- erythromycin, clarithromycin, azithromycin (medicines used to treat bacterial infections)
- probenecid (a medicine used for treatment of gout)
- cimetidine (used for ulcers and heartburn)
- iron tablets (used for anaemia)
- zinc supplements, magnesium/aluminium-containing antacids (used for acid/heart burn)
- didanosine/sucralfate (used for stomach ulcers).
Overdosage:
If you or anyone else accidentally take too much of L OSON 500MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are seizures, confusion, dizziness, less conscious, tremor, heart problems (associated with signs such as uneven heartbeats, nausea) and/or stomach burning.
SYNOPSIS
| Drug | : | Levofloxacin |
| Pharmacological Category | : | Antibiotics |
| Therapeutic Indication | : | Bacterial infections, Reduces risk of anthrax occurrence |
| Dosage Forms | : | Tablet, Syrup, Oral Suspension, Oral Solution, Injection, Infusion, Eye drops, Eardrops |
MORE INFORMATION
- Keep L OSON 500MG TABLET out of reach of children.
- Store L OSON 500MG TABLET at room temperature.
FAQs ABOUT L OSON 500MG TABLET
What is L OSON 500MG TABLET used for?
L OSON 500MG TABLET is used to treat infections of acute sinusitis, lungs (such as long-term breathing problems/pneumonia), urinary tract (including kidney and bladder), prostate gland and skin & soft tissue (including muscles) in affected individuals. It is also used to reduce the risk of getting anthrax (pulmonary disease) or worsening of the disease after getting exposed to anthrax causing bacteria.
What are the side effects of L OSON 500MG TABLET?
The most common side effects after taking L OSON 500MG TABLET are sleeping problems, headache, dizziness, nausea, vomiting and/or diarrhoea. Consult your doctor if any of these symptoms worsens.
What happens if you take more L OSON 500MG TABLET than your required dose?
If you or anyone else accidentally take too much of L OSON 500MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are seizures, confusion, dizziness, less conscious, tremor, heart problems (associated with signs such as uneven heartbeats, nausea) and/or stomach burning.
How L OSON 500MG TABLET works?
L OSON 500MG TABLET works by inhibiting DNA gyrase (enzyme responsible for DNA synthesis) in bacteria which results in destruction of bacterial cell structure thus preventing the occurrence of bacterial infection in affected individuals.
How to take L OSON 500MG TABLET?
Take L OSON 500MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
REFERENCES
1. KD Tripathi. Sulfonamides, Cotrimoxazole and Quinolones. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 713.
2. Vivek Podder, Nazia M. Sadiq. Levofloxacin. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. September 2022. [Accessed on 8th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK545180/
3. Actavis Ltd. Electronic Medicines Compendium (EMC). [Revised in March 2022]. [Accessed on 8th October 2022] https://www.medicines.org.uk/emc/files/pil.4625.pdf
4. Leeford Healthcare Limited. LEVELFOX 750. [Accessed on 8th October 2022] https://www.leeford.in/product/1021/levelfox-750
USEFUL DIAGNOSTIC TESTS
- Bacterial culture test
- Blood and Urine tests
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