POSANAT Injection 16.7ml

Fungal Infections Rx required
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Best Price* ₹ 6,080.00 MRP ₹ 7,600.00
(Inclusive of all taxes) * Mkt: Natco Pharma Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

POSANAT INJECTION contains Posaconazole which belongs to the group of medicines called Antifungals. It is used to treat fungal infections such as invasive aspergillosis (in adults and pediatrics aged 13 years and older) and used as prophylaxis to prevent fungal infections such as invasive aspergillus and candida infections in severely immunocompromised patients such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia (low count of a type of white blood cell (neutrophils) due to chemotherapy.    

Before receiving POSANAT INJECTION inform your doctor if you have liver, kidney or heart problems, problem with potassium, magnesium or calcium levels in the blood. Your doctor might want you to take certain blood tests prior to the treatment with POSANAT INJECTION to understand the existing condition.     

POSANAT INJECTION is not recommended for use in pregnant women unless advised by the doctor and it is not recommended for use in breastfeeding women. Safety and effectiveness of POSANAT INJECTION have not been established in pediatric patients younger than 2 years of age and it should be used with caution in elderly patients. Consult your doctor before receiving POSANAT INJECTION.

The most common side effects of receiving POSANAT INJECTION are headache, fever, rash, itching and constipation. Inform your doctor immediately if any of the side effect worsens.

USES OF POSANAT INJECTION

Treats or prevent fungal infections, such as:

  • Treats invasive aspergillosis (in adults and pediatrics aged 13 years and older)
  • Used as prophylaxis to prevent invasive aspergillus and candida infections (in severely immunocompromised patients)

HOW POSANAT INJECTION WORKS

POSANAT INJECTION works by blocking the synthesis of ergosterol, a key component of the fungal cell membrane, thus results in killing or stopping the growth of fungi causing infection.

DIRECTIONS FOR USE

POSANAT INJECTION will be given to you only by a doctor or a nurse into the vein as an intravenous infusion. Your doctor will decide the right dose and duration of POSANAT INJECTION for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF POSANAT INJECTION

COMMON

  • abnormal skin sensations (numbness, tingling, itching, creeping, pricking or burning)
  • swelling, redness and tenderness along the vein at the administration site
  • high blood pressure, headache
  • loss of appetite, stomach pain or upset stomach, passing wind, dry mouth, changes in taste
  • heartburn (burning sensation in the chest which rises up to throat)
  • fever, weakness
  • dizzy, tired or sleepy
  • rash, itching
  • constipation, rectal discomfort

UNCOMMON

  • anemia (headaches, feeling tired or dizzy, being short of breath or looking pale and a low level of hemoglobin)
  • inflammation of the blood vessels, fits
  • nerve damage (neuropathy)
  • abnormal heart rhythm, low blood pressure, palpitation, slow or fast heartbeat
  • inflammation of the pancreas (pancreatitis) (causes severe stomach pain)
  • oxygen supply to the spleen is interrupted characterized by severe stomach pain
  • severe kidney problems (passing more or less urine, that is a different colour than usual)
  • cough, hiccups, nose bleeds
  • severe sharp chest pain when breathing in (pleuritic pain)
  • swelling of lymph glands (lymphadenopathy)
  • reduced feeling of sensitivity especially on the skin
  • tremor
  • pain at the injection site
  • high or low blood sugar levels
  • blurred vision, sensitivity to light
  • hair loss, mouth ulcers
  • shivering, feeling generally unwell
  • pain, back or neck pain, in arms or legs
  • water retention (oedema)
  • menstrual problems (abnormal vaginal bleeding)
  • being completely or partially unable to talk, inability to sleep
  • swelling of the mouth
  • abnormal dreams or difficulty sleeping
  • problems with co-ordination or balance
  • mucosal inflammation, stuffy nose
  • difficulty breathing, chest discomfort
  • feeling bloated, mild to severe nausea, vomiting, cramps and diarrhea, belching
  • confusion, feeling jittery

RARE

  • pneumonia (feeling short of breath and producing discolored phlegm)
  • high blood pressure in the blood vessels in the lungs (pulmonary hypertension)
  • blood problems such as unusual blood clotting or prolonged bleeding
  • severe allergic reactions (widespread blistering rash and skin peeling)
  • mental problems such as hallucination
  • fainting
  • having problems thinking or talking, having jerking movements, in hands
  • stroke (signs include pain, weakness, numbness, or tingling in the limbs)
  • having a blind or dark spot in field of vision
  • hemolytic uremic syndrome (when red blood cells breakup)
  • heart failure or heart attack
  • blood clots in the legs (intense pain or swelling of the legs)
  • blood clots in the lungs (pain while breathing, shortness of breath)
  • bleeding into the stomach or gut (vomiting blood or passing blood in stool)
  • intestinal obstruction (feeling bloated, vomiting, severe constipation, loss of appetite, and cramps)
  • large purple discoloration on the skin
  • swelling of the face or tongue
  • depression, double vision
  • breast pain
  • adrenal glands not working properly (cause weakness, tiredness, loss of appetite, skin discoloration)
  • pituitary gland not working properly (may cause low blood levels of some hormones that affect the male or female sex organs)
  • pseudoaldosteronism (high blood pressure with a low potassium level)
  • hearing problems

Inform your doctor immediately if you experience any of the following side effects while receiving POSANAT INJECTION:

  • severe nausea or vomiting, diarrhea
  • signs of liver problems (jaundice, unusually dark urine or pale feces, feeling sick for no reason, stomach problems, loss of appetite or unusual tiredness or weakness, an increase in liver enzymes shown up in blood tests)
  • allergic reaction

HOW TO MANAGE SIDE EFFECTS

Headache:

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the symptom does not improve.

Dry mouth:

Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Inform your doctor if the symptom does not improve.

Stomach pain:

Try to take rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, inform your doctor. 

Loss of appetite:

Eat when you are hungry. Eat a nutritious snack rich in calories and protein, such as dried fruit and nuts. If the symptom does not show improvement, inform your doctor.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. If the symptom does not improve, inform your doctor.

WARNING & PRECAUTIONS

PREGNANCY

POSANAT INJECTION is not recommended for use in pregnant women unless advised by the doctor. If you are a woman of childbearing age, use effective contraception to avoid pregnancy during treatment with POSANAT INJECTION. Consult your doctor before receiving POSANAT INJECTION.  

BREASTFEEDING

POSANAT INJECTION is not recommended for use in breastfeeding women as small amount of this medicine is excreted in the breastmilk. Consult your doctor before receiving POSANAT INJECTION.

DRIVING AND USING MACHINES

Do not drive or use machines if you feel sleepy, dizzy or blurring of vision after receiving POSANAT INJECTION.

LIVER

POSANAT INJECTION should be used with caution in patients with liver problems. Consult your doctor before receiving POSANAT INJECTION.

ALLERGY

Do not receive POSANAT INJECTION if you are allergic to Posaconazole or any other ingredients of this medicine. POSANAT INJECTION should be used with caution if you are allergic to other antifungal medicines such as ketoconazole, fluconazole or itraconazole.

HEART DISEASE

POSANAT INJECTION should be used with caution in patients with abnormal heart rhythm, weakness of the heart muscle or heart failure and very slow heartbeat. Consult your doctor before receiving POSANAT INJECTION.

OTHERS

Before receiving POSANAT INJECTION, inform your doctor if you:

  • have any problem with potassium, magnesium or calcium levels in the blood

Use in pediatrics:

Safety and effectiveness of POSANAT INJECTION have not been established in pediatric patients younger than 2 years of age. Consult your child’s doctor for advice.

Use in geriatrics:

POSANAT INJECTION should be used with caution in elderly patients. Consult your doctor before receiving POSANAT INJECTION.

INTERACTIONS

A. Drug - Drug interactions:

Before receiving POSANAT INJECTION, inform your doctor if you are taking any of the following medicines:

  • terfenadine, astemizole (used to treat allergies)
  • cisapride (used to treat stomach problems)
  • pimozide (used to treat symptoms of tourette’s and mental illness)
  • halofantrine (to treat malaria)
  • quinidine (to treat abnormal heart rhythms), diltiazem, verapamil, nifedipine, nisoldipine or other calcium channel blockers (used to treat high blood pressure), digoxin (to treat heart failure)
  • any medicines that contain ergot alkaloids (Ex. ergotamine or dihydroergotamine) (used to treat migraines)
  • statins (Ex. simvastatin, atorvastatin or lovastatin) (used to treat high cholesterol)
  • rifabutin and rifampicin (used to treat certain infections)
  • medicines used to prevent or treat fits (Ex. phenytoin, carbamazepine, phenobarbital or primidone)
  • efavirenz and fosamprenavir, protease inhibitors such as lopinavir and atazanavir, which are given with ritonavir (used to treat HIV infection)
  • vincristine, vinblastine and other vinca alkaloids (used to treat cancer), tretinoin (used to treat certain blood cancers)
  • ciclosporin, tacrolimus and sirolimus (used during or after transplant surgery to prevent organ rejection)
  • midazolam, triazolam, alprazolam or other benzodiazepines (Ex. clonazepam) (used as sedatives or muscle relaxants)
  • glipizide or other sulfonylureas (Ex. glibenclamide) (used to treat high blood sugar)

Overdosage:

POSANAT INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, inform your doctor immediately if you experience any unusual symptoms after receiving POSANAT INJECTION.

SYNOPSIS

Drug :   Posaconazole
Pharmacological Category :   Azole antifungals
Therapeutic Indication :   Prevent and treat various fungal Infections
Dosage Forms :   Injection, Suspension, Syrup, Tablet

MORE INFORMATION

  • Store POSANAT INJECTION in a refrigerator at 2°C to 8°C

FAQs ABOUT POSANAT INJECTION

Can POSANAT INJECTION be used in pregnant women?

POSANAT INJECTION is not recommended for use in pregnant women unless advised by the doctor. If you are a woman of childbearing age, use effective contraception to avoid pregnancy during treatment with POSANAT INJECTION. Consult your doctor before receiving POSANAT INJECTION.

Is POSANAT INJECTION an antibiotic?

No, POSANAT INJECTION is an antifungal medicine which acts by blocking the synthesis of ergosterol, a key component of the fungal cell membrane, and kills or stops the growth of fungi causing infection.

Does POSANAT INJECTION affects my ability to drive or use machines?

Do not drive or use machines if you feel sleepy, dizzy or blurring of vision after receiving POSANAT INJECTION. You can resume doing your activities once you feel normal again. Consult your doctor for advice before receiving POSANAT INJECTION.   

Is POSANAT INJECTION safe to use in patients with heart problems?                  

POSANAT INJECTION should be used with caution in patients with abnormal heart rhythm, weakness of the heart muscle or heart failure and very slow heartbeat. Consult your doctor before receiving POSANAT INJECTION.

How much time does it take to administer POSANAT INJECTION?

POSANAT INJECTION will be given to you only by a doctor or a nurse into the vein as a slow intravenous infusion approximately over 30 to 90 minutes depending on the site at which it is administered. Your doctor will decide the right dose and duration of POSANAT INJECTION for you depending upon your age, body weight and disease condition.

REFERENCES

1. KD Tripathi. Antifungal Drugs. Essentials of medical pharmacology. Eighth Edition. 2019. Page – 847

2. Lu Chen, Elke H. J. Krekels, Paul. E. Verweij, Jochem B. Buil, Catherijne A. J. Knibbe, and Roger J. M. Bruggemann. Pharmacokinetics and Pharmacodynamics of Posaconazole. April 2020 [Accessed on 5th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183491/

3. Nickie D. Greer. Posaconazole (Noxafil): a new triazole antifungal agent. April 2007. [Accessed on 5th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1849883/

4. SP Labo N.V. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 5th August 2022] https://www.medicines.org.uk/emc/files/pil.3435.pdf

5. Merck & Co., Inc. U.S. Food & Drug Administration. [Revised in November 2015] [Accessed on 5th August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022003s018s020,0205053s002s004,0205596s001s003lbl.pdf

6. Merck & Co. Inc. U.S. Food & Drug Administration. [Revised in September 2022] [Accessed on 5th August 2022] https://www.merck.com/product/usa/pi_circulars/n/noxafil/noxafil_pi.pdf

USEFUL DIAGNOSTIC TESTS

  • Complete blood count
  • Fungal culture test

PRODUCT DETAILS

    Country Of Origin
    India
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